Details of the Target

General Information of Target

Target ID LDTP15090
Target Name 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)
Gene Name OGFOD2
Gene ID 79676
Synonyms
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2; EC 1.14.11.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNE
LLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACL
LGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDSRQDPASQKRLLVE
SLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYM
AFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF
GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASL
RCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVG
VDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEIQRHLKPTE
KIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGV
DPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPP
TNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQC
RQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRG
EIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEP
PAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVG
EV
Target Bioclass
Enzyme
Family
OGFOD2 family
Uniprot ID
Q6N063
Ensemble ID
ENST00000228922.12
HGNC ID
HGNC:25823

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.P207H DBIA    Probe Info 
MEC1 SNV: p.G296S DBIA    Probe Info 
MFE296 Insertion: p.Q58PfsTer8 DBIA    Probe Info 
NCIH1703 SNV: p.V344M .
T98G Substitution: p.A6G .
U118MG SNV: p.G50R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C51(5.86)  LDD0209  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		C209(0.00); C51(0.00); C150(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C13(1.05); C15(1.05); C17(1.05)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C13(0.74); C15(0.74); C17(0.74); C317(1.01)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C13(0.90); C15(0.90); C17(0.90); C317(1.04)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C13(0.86); C15(0.86); C17(0.86); C317(0.98)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C13(0.84); C15(0.84); C17(0.84); C317(1.03)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C13(0.92); C15(0.92); C17(0.92); C317(1.07)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C13(0.76); C15(0.76); C17(0.76); C317(0.90)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C13(0.81); C15(0.81); C17(0.81); C317(0.84)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C13(0.80); C15(0.80); C17(0.80); C317(0.91)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C13(0.85); C15(0.85); C17(0.85); C317(0.88)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C13(1.37); C15(1.37); C17(1.37); C317(1.12)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C13(1.03); C15(1.03); C17(1.03)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C13(0.99); C15(0.99); C17(0.99); C317(1.00)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C13(0.84); C15(0.84); C17(0.84); C317(0.94)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C13(0.81); C15(0.81); C17(0.81); C317(0.87)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C317(0.96); C320(0.96); C321(0.96)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C317(1.12); C320(0.97); C321(0.97)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C317(1.15); C320(0.95); C321(0.95)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C317(1.15); C320(1.05); C321(1.05)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C317(1.13); C320(1.01); C321(1.01)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C317(1.15); C320(0.90); C321(0.90)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C317(1.12); C320(1.16); C321(1.16)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C13(0.89); C15(0.89); C17(0.89)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C317(1.20); C320(1.12); C321(1.12)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C317(1.13); C320(0.94); C321(0.94)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C317(1.12); C320(0.96); C321(0.96)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C317(1.75); C320(0.87); C321(0.87)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C317(1.14); C320(0.97); C321(0.97)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C317(1.11); C320(0.88); C321(0.88)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C317(1.15); C320(0.92); C321(0.92)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C317(1.12); C320(0.99); C321(0.99)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C317(1.37); C320(1.37); C321(1.50)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C317(1.28); C320(1.28); C321(1.26)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C317(1.16); C320(1.16); C321(1.09)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C317(1.39); C320(1.39); C321(1.50)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C317(1.36); C320(1.36); C321(1.35)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C317(1.22); C320(1.22); C321(1.19)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C317(1.19); C320(1.19); C321(1.18)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C317(1.32); C320(1.32); C321(1.30)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C317(1.42); C320(1.42); C321(1.33)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C317(1.19); C320(1.19); C321(1.18)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C317(1.29); C320(1.29); C321(1.23)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C317(1.20); C320(1.20); C321(1.13)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C13(0.83); C15(0.83); C17(0.83)  LDD0857  [4]
 LDCM0260  AC140 HCT 116 C317(1.30); C320(1.30); C321(1.22)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C317(1.51); C320(1.51); C321(1.55)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C317(1.29); C320(1.29); C321(1.15)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C13(0.96); C15(0.96); C17(0.96); C317(1.02)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C13(0.86); C15(0.86); C17(0.86); C317(1.19)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C13(1.15); C15(1.15); C17(1.15); C317(1.39)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C317(1.05); C320(1.05); C321(1.05); C13(1.08)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C13(1.17); C15(1.17); C17(1.17); C317(1.22)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C13(1.15); C15(1.15); C17(1.15); C317(1.19)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C317(0.91); C320(0.91); C321(0.91); C13(0.94)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C13(1.21); C15(1.21); C17(1.21)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C317(0.76); C320(0.76); C321(0.76); C13(0.81)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C13(0.83); C15(0.83); C17(0.83); C317(1.25)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C13(0.92); C15(0.92); C17(0.92); C317(1.07)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C13(0.93); C15(0.93); C17(0.93); C317(1.16)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C13(1.06); C15(1.06); C17(1.06); C317(1.30)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C13(0.98); C15(0.98); C17(0.98); C317(1.18)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C13(0.93); C15(0.93); C17(0.93); C317(1.16)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C13(1.08); C15(1.08); C17(1.08); C317(1.28)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C13(0.66); C15(0.66); C17(0.66)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C13(0.61); C15(0.61); C17(0.61)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C13(0.73); C15(0.73); C17(0.73)  LDD0876  [4]
 LDCM0280  AC20 HEK-293T C13(0.88); C15(0.88); C17(0.88)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C13(0.87); C15(0.87); C17(0.87)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C13(0.80); C15(0.80); C17(0.80)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C13(1.02); C15(1.02); C17(1.02)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C13(0.80); C15(0.80); C17(0.80)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C13(0.82); C15(0.82); C17(0.82)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C13(1.19); C15(1.19); C17(1.19)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C13(0.88); C15(0.88); C17(0.88)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C13(0.91); C15(0.91); C17(0.91)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C13(0.75); C15(0.75); C17(0.75)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C234(1.17)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C13(1.06); C15(1.06); C17(1.06)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C13(0.99); C15(0.99); C17(0.99)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C13(0.78); C15(0.78); C17(0.78)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C13(0.82); C15(0.82); C17(0.82)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C13(0.94); C15(0.94); C17(0.94)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C317(1.05); C320(1.05); C321(1.05)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C317(1.12); C320(1.12); C321(1.12)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C317(1.05); C320(1.05); C321(1.05)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C317(1.12); C320(1.12); C321(1.12)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C317(1.10); C320(1.10); C321(1.10)  LDD0617  [4]
 LDCM0302  AC40 HCT 116 C317(1.14); C320(1.14); C321(1.14)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C317(1.03); C320(1.03); C321(1.03)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C317(1.12); C320(1.12); C321(1.12)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C317(1.26); C320(1.26); C321(1.26)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C317(1.11); C320(1.11); C321(1.11)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C317(1.01); C320(1.01); C321(1.01)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C317(0.96); C320(0.96); C321(0.96)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C317(0.91); C320(0.91); C321(0.91)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C317(1.06); C320(1.06); C321(1.06)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C317(1.37); C320(1.37); C321(1.37)  LDD0628  [4]
 LDCM0313  AC50 HCT 116 C317(1.10); C320(1.10); C321(1.10)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C317(1.17); C320(1.17); C321(1.17)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C317(0.98); C320(0.98); C321(0.98)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C317(0.93); C320(0.93); C321(0.93)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C317(1.05); C320(1.05); C321(1.05)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C317(0.94); C320(0.94); C321(0.94)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C317(0.76); C320(0.76); C321(0.76)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C317(1.02); C320(1.02); C321(1.05); C13(1.14)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C321(1.11); C13(1.20); C15(1.20); C17(1.20)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C13(1.04); C15(1.04); C17(1.04); C321(1.05)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C13(1.09); C15(1.09); C17(1.09)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C317(1.02); C320(1.02); C13(1.04); C15(1.04)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C13(0.90); C15(0.90); C17(0.90); C317(1.13)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C13(1.10); C15(1.10); C17(1.10); C317(1.16)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C13(1.12); C15(1.12); C17(1.12); C321(1.18)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C13(1.01); C15(1.01); C17(1.01); C317(1.21)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C321(1.01); C13(1.04); C15(1.04); C17(1.04)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C13(1.06); C15(1.06); C17(1.06); C321(1.20)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C13(1.00); C15(1.00); C17(1.00); C317(1.02)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C13(0.79); C17(0.89); C15(0.95); C317(1.09)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C17(0.79); C13(0.83); C15(0.84); C317(1.14)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C13(0.87); C15(0.87); C17(0.87)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C17(0.83); C15(0.84); C13(0.87); C317(0.96)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C17(0.96); C13(1.02); C317(1.04); C320(1.04)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C317(0.81); C320(0.81); C321(0.81); C13(0.99)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C317(0.81); C320(0.81); C321(0.81); C17(0.99)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C317(0.92); C320(0.92); C321(0.92); C15(0.93)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C15(0.84); C13(0.89); C317(0.93); C320(0.93)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C317(1.03); C320(1.03); C321(1.03); C17(1.09)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C13(0.96); C317(1.09); C320(1.09); C321(1.09)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C317(0.73); C320(0.73); C321(0.73); C17(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C317(0.87); C320(0.87); C321(0.87); C17(1.03)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C13(0.91); C15(0.91); C17(0.91)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C317(0.87); C320(0.87); C321(0.87); C17(0.92)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C15(0.68); C17(0.69); C13(0.76); C317(1.23)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C15(0.79); C317(0.85); C320(0.85); C321(0.85)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C13(0.79); C17(0.79); C317(0.90); C320(0.90)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C13(0.65); C17(0.65); C317(0.97); C320(0.97)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C13(0.66); C17(0.66); C317(1.07); C320(1.07)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C317(1.20); C320(1.20); C321(1.20); C13(1.33)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C13(0.86); C17(0.86); C317(0.99); C320(0.99)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C13(0.84); C17(0.84); C317(1.03); C320(1.03)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C13(0.77); C17(0.77); C317(1.26); C320(1.26)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C317(1.04); C320(1.04); C321(1.04); C13(1.36)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C13(0.86); C17(0.86); C317(1.06); C320(1.06)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C13(0.76); C17(0.76); C317(1.02); C320(1.02)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C13(0.53); C17(0.53); C317(0.86); C320(0.86)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C13(0.73); C17(0.73); C317(1.19); C320(1.19)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C13(0.68); C17(0.68); C317(1.19); C320(1.19)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C13(0.73); C17(0.73); C317(1.55); C320(1.55)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C13(0.88); C17(0.88); C317(1.01); C320(1.01)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C13(0.77); C15(0.77); C17(0.77); C321(0.84)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C317(0.90); C320(0.90); C321(0.90); C13(0.95)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C13(0.85); C15(0.85); C17(0.85)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C13(0.94); C15(0.94); C17(0.94)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C13(0.93); C15(0.93); C17(0.93)  LDD0873  [4]
 LDCM0632  CL-Sc Hep-G2 C347(20.00)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C13(0.85); C15(0.85); C17(0.85)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C13(0.80); C15(0.80); C17(0.80)  LDD0966  [4]
 LDCM0370  CL101 HEK-293T C13(1.09); C15(1.09); C17(1.09)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C13(0.86); C15(0.86); C17(0.86)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C13(0.83); C15(0.83); C17(0.83)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C13(0.97); C15(0.97); C17(0.97)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C13(1.10); C15(1.10); C17(1.10)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C13(0.81); C15(0.81); C17(0.81)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C13(0.75); C15(0.75); C17(0.75)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C13(0.88); C15(0.88); C17(0.88)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C13(0.84); C15(0.84); C17(0.84)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C13(0.91); C15(0.91); C17(0.91)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C13(0.68); C15(0.68); C17(0.68)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C13(0.67); C15(0.67); C17(0.67)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C13(0.76); C15(0.76); C17(0.76)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C13(0.89); C15(0.89); C17(0.89)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C13(0.87); C15(0.87); C17(0.87)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C13(1.04); C15(1.04); C17(1.04)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C13(0.97); C15(0.97); C17(0.97)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C317(1.14); C320(1.14); C321(1.14)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C317(1.30); C320(1.30); C321(1.30)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C317(1.18); C320(1.18); C321(1.18)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C13(1.09); C15(1.09); C17(1.09)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C317(1.21); C320(1.21); C321(1.21)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C317(0.96); C320(0.96); C321(0.96)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C317(0.79); C320(0.79); C321(0.79)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C317(0.86); C320(0.86); C321(0.86)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C317(0.87); C320(0.87); C321(0.87)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C321(0.90); C13(1.00); C15(1.00); C17(1.00)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C321(0.92); C13(1.00); C15(1.00); C17(1.00)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C13(0.96); C15(0.96); C17(0.96); C321(1.07)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C13(0.91); C15(0.91); C17(0.91); C321(1.03)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C13(1.09); C15(1.09); C17(1.09)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C13(0.86); C15(0.86); C17(0.86)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C13(0.88); C15(0.88); C17(0.88)  LDD1000  [4]
 LDCM0403  CL16 HCT 116 C13(0.92); C15(0.92); C17(0.92); C317(0.97)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C13(0.99); C15(0.99); C17(0.99); C317(1.03)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C13(1.16); C15(1.16); C17(1.16); C317(1.25)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C317(1.45); C320(1.45); C321(1.45); C13(1.46)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C13(0.93); C15(0.93); C17(0.93)  LDD1005  [4]
 LDCM0408  CL20 HCT 116 C317(1.12); C320(1.12); C321(1.12); C13(1.14)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C13(1.29); C15(1.29); C17(1.29); C317(1.41)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C13(1.05); C15(1.05); C17(1.05); C317(1.10)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C317(1.02); C320(1.02); C321(1.02); C13(1.27)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C13(0.93); C15(0.93); C17(0.93); C317(0.99)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C13(1.03); C15(1.03); C17(1.03); C317(0.91)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C13(1.13); C15(1.13); C17(1.13); C317(0.99)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C13(1.00); C15(1.00); C17(1.00); C317(1.14)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C13(1.23); C15(1.23); C17(1.23); C317(1.13)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C13(1.10); C15(1.10); C17(1.10); C317(1.21)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C13(1.01); C15(1.01); C17(1.01)  LDD1016  [4]
 LDCM0419  CL30 HCT 116 C13(1.07); C15(1.07); C17(1.07); C317(1.10)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C13(1.20); C15(1.20); C17(1.20)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C13(1.11); C15(1.11); C17(1.11)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C13(0.86); C15(0.86); C17(0.86)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C13(1.39); C15(1.39); C17(1.39)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C13(1.28); C15(1.28); C17(1.28)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C13(1.32); C15(1.32); C17(1.32)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C13(1.15); C15(1.15); C17(1.15)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C13(1.11); C15(1.11); C17(1.11)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C13(1.01); C15(1.01); C17(1.01)  LDD1027  [4]
 LDCM0430  CL40 HCT 116 C13(1.20); C15(1.20); C17(1.20)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C13(1.35); C15(1.35); C17(1.35)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C13(1.17); C15(1.17); C17(1.17)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C13(1.11); C15(1.11); C17(1.11)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C13(1.15); C15(1.15); C17(1.15)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C13(1.09); C15(1.09); C17(1.09)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C317(0.85); C320(0.85); C321(0.85)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C317(1.02); C320(1.02); C321(1.02)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C317(1.00); C320(1.00); C321(1.00)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C317(1.00); C320(1.00); C321(1.00)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C13(0.79); C15(0.79); C17(0.79)  LDD1038  [4]
 LDCM0441  CL50 HCT 116 C317(0.91); C320(0.91); C321(0.91)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C317(1.19); C320(1.19); C321(1.19)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C317(1.04); C320(1.04); C321(1.04)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C317(1.18); C320(1.18); C321(1.18)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C317(1.04); C320(1.04); C321(1.04)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C317(1.19); C320(1.19); C321(1.19)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C317(1.01); C320(1.01); C321(1.01)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C317(1.02); C320(1.02); C321(1.02)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C317(1.16); C320(1.16); C321(1.16)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C317(1.11); C320(1.11); C321(1.11)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C13(0.91); C15(0.91); C17(0.91)  LDD1049  [4]
 LDCM0452  CL60 HCT 116 C317(1.04); C320(1.04); C321(1.04)  LDD0769  [4]
 LDCM0459  CL67 HEK-293T C234(1.12)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C13(1.16); C15(1.16); C17(1.16)  LDD1060  [4]
 LDCM0464  CL71 HEK-293T C234(1.24)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C234(1.01)  LDD1668  [5]
 LDCM0469  CL76 HCT 116 C13(1.00); C15(1.00); C17(1.00)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C13(1.04); C15(1.04); C17(1.04)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C13(0.84); C15(0.84); C17(0.84)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C13(1.23); C15(1.23); C17(1.23)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C13(0.75); C15(0.65); C17(0.91)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C13(1.14); C15(1.14); C17(1.14)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C13(1.12); C15(1.12); C17(1.12)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C13(1.16); C15(1.16); C17(1.16)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C13(1.05); C15(1.05); C17(1.05)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C13(1.06); C15(1.06); C17(1.06)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C13(1.02); C15(1.02); C17(1.02)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C13(0.91); C15(0.91); C17(0.91)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C13(1.30); C15(1.30); C17(1.30)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C13(1.30); C15(1.30); C17(1.30)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C13(1.32); C15(1.32); C17(1.32)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C13(0.94); C15(0.76); C17(1.11)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C13(1.00); C15(1.00); C17(1.00)  LDD0802  [4]
 LDCM0486  CL91 HEK-293T C234(1.10)  LDD1689  [5]
 LDCM0490  CL95 HEK-293T C234(0.99)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C234(1.25)  LDD1694  [5]
 LDCM0427  Fragment51 HCT 116 C13(1.24); C15(1.24); C17(1.24)  LDD0744  [4]
 LDCM0022  KB02 697 C51(1.16)  LDD2245  [6]
 LDCM0023  KB03 Jurkat C51(5.86)  LDD0209  [1]
 LDCM0024  KB05 MOLM-16 C51(1.19)  LDD3334  [6]
 LDCM0131  RA190 MM1.R C347(1.42)  LDD0304  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.