Details of the Target

General Information of Target

Target ID LDTP14232
Target Name AP-4 complex subunit beta-1 (AP4B1)
Gene Name AP4B1
Gene ID 10717
Synonyms
AP-4 complex subunit beta-1; AP-4 adaptor complex subunit beta; Adaptor-related protein complex 4 subunit beta-1; Beta subunit of AP-4; Beta4-adaptin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT
SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT
DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV
LKRQGYGEGFRWMAQYID
Target Bioclass
Transporter and channel
Family
Adaptor complexes large subunit family
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Uniprot ID
Q9Y6B7
Ensemble ID
ENST00000256658.8
HGNC ID
HGNC:572

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.G444C DBIA    Probe Info 
HCC44 SNV: p.E350Ter .
HEC1 SNV: p.I734T DBIA    Probe Info 
ICC10 SNV: p.N605K .
ICC106 SNV: p.N605K .
ICC108 SNV: p.N605K .
IGR1 SNV: p.E528Ter DBIA    Probe Info 
LS513 Deletion: p.F405SfsTer53 .
MFE319 SNV: p.L168V .
RKO SNV: p.W648Ter DBIA    Probe Info 
SKMEL30 SNV: p.L240Ter DBIA    Probe Info 
SNU1 Insertion: p.A581GfsTer5 .
T98G SNV: p.F318L; p.C691Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C144(0.49)  LDD2125  [1]
DBIA
 Probe Info  		C144(5.19)  LDD0204  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
Lodoacetamide azide
 Probe Info  		C18(0.00); C382(0.00); C144(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
TFBX
 Probe Info  		C534(0.00); C584(0.00)  LDD0148  [6]
AOyne
 Probe Info  		12.60  LDD0443  [7]
NAIA_5
 Probe Info  		C18(0.00); C584(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C18(0.97); C144(1.06); C179(1.09); C285(1.24)  LDD1507  [9]
 LDCM0215  AC10 PaTu 8988t C94(0.91)  LDD1094  [10]
 LDCM0216  AC100 PaTu 8988t C94(0.91); C293(1.28); C298(1.28)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C94(0.81); C293(1.06); C298(1.06)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C94(0.76); C293(1.16); C298(1.16)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C94(1.11); C293(0.90); C298(0.90)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C94(1.21); C293(1.04); C298(1.04)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C94(1.09); C293(1.09); C298(1.09)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C94(0.89); C293(1.07); C298(1.07)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C94(1.14); C293(1.08); C298(1.08)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C94(0.70); C293(1.21); C298(1.21)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C94(0.68); C293(1.08); C298(1.08)  LDD1104  [10]
 LDCM0226  AC11 PaTu 8988t C94(1.00)  LDD1105  [10]
 LDCM0227  AC110 PaTu 8988t C94(0.74); C293(0.96); C298(0.96)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C94(0.90); C293(1.48); C298(1.48)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C94(1.25); C293(1.04); C298(1.04)  LDD1108  [10]
 LDCM0230  AC113 PaTu 8988t C293(1.34); C298(1.34)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C293(0.82); C298(0.82)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C293(1.21); C298(1.21)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C293(0.96); C298(0.96)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C293(1.23); C298(1.23)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C293(1.00); C298(1.00)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C293(1.42); C298(1.42)  LDD1115  [10]
 LDCM0237  AC12 PaTu 8988t C94(1.00)  LDD1116  [10]
 LDCM0238  AC120 PaTu 8988t C293(1.41); C298(1.41)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C293(1.62); C298(1.62)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C293(0.95); C298(0.95)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C293(1.28); C298(1.28)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C293(1.44); C298(1.44)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C293(1.10); C298(1.10)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C293(1.07); C298(1.07)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C293(1.25); C298(1.25)  LDD1124  [10]
 LDCM0246  AC128 PaTu 8988t C293(0.92); C298(0.92)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C293(1.29); C298(1.29)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C293(1.07); C298(1.07)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C293(1.14); C298(1.14)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C293(0.93); C298(0.93)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C293(1.64); C298(1.64)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C293(1.55); C298(1.55)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C293(1.36); C298(1.36)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C293(1.13); C298(1.13)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C293(1.53); C298(1.53)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C293(1.22); C298(1.22)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C293(1.17); C298(1.17)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C94(0.62)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C293(1.13); C298(1.13)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C293(1.17); C298(1.17)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C293(1.25); C298(1.25)  LDD1141  [10]
 LDCM0263  AC143 PaTu 8988t C94(0.42); C293(1.06); C298(1.06)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C94(0.54); C293(0.77); C298(0.77)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C94(0.97); C293(1.48); C298(1.48)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C94(0.38); C293(0.63); C298(0.63)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C94(0.49); C293(0.61); C298(0.61)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C94(0.55); C293(0.89); C298(0.89)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C94(0.48); C293(0.86); C298(0.86)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C94(0.85)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C94(0.59); C293(1.10); C298(1.10)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C94(0.66); C293(1.66); C298(1.66)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C94(0.51); C293(1.10); C298(1.10)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C94(0.52); C293(1.00); C298(1.00)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C94(0.62); C293(1.29); C298(1.29)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C94(0.46); C293(1.05); C298(1.05)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C94(0.40); C293(0.67); C298(0.67)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C94(0.54); C293(1.16); C298(1.16)  LDD2169  [10]
 LDCM0276  AC17 HEK-293T C18(0.90); C144(1.02); C179(1.12); C285(1.17)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C18(1.00); C144(0.97); C179(1.05); C285(0.87)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C491(1.03); C144(1.16); C285(1.64); C691(1.22)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C18(1.03); C144(1.00); C179(0.99); C285(0.95)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C18(0.91); C94(1.00); C144(1.00); C337(0.93)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C179(0.98); C337(0.91); C691(1.09); C298(0.91)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C94(1.43); C144(1.04); C179(0.97); C285(1.01)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C144(0.97); C179(1.02); C285(0.92); C337(0.92)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C94(1.30); C491(0.95); C144(0.96); C285(0.92)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C18(0.91); C144(1.06); C179(1.07); C285(0.96)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C18(0.99); C144(1.00); C179(1.19); C285(0.88)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C491(0.89); C144(1.01); C285(0.90); C691(1.06)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C18(1.02); C94(1.13); C144(0.99); C337(0.89)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C179(0.89); C337(0.87); C691(0.99); C298(0.97)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C491(1.00); C144(0.97); C285(0.99); C691(1.00)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C94(1.22); C144(0.97); C179(0.87); C285(0.97)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C144(1.02); C179(1.07); C285(1.16); C337(1.10)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C94(1.08); C491(0.82); C144(1.00); C285(0.97)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C18(0.94); C144(1.06); C179(1.09); C285(1.06)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C18(0.94); C144(1.05); C179(0.99); C285(0.88)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C94(1.32)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C94(1.05)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C94(0.77)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C94(0.82)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C94(1.15)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C18(0.99); C94(1.06); C144(1.07); C337(1.01)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C94(1.15)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C94(0.88)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C94(1.27)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C94(0.92)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C94(1.06)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C94(1.37)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C94(1.03)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C94(1.12)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C94(1.27)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C94(1.30)  LDD0628  [10]
 LDCM0312  AC5 HEK-293T C179(1.03); C337(0.99); C691(1.12); C298(0.95)  LDD1551  [9]
 LDCM0313  AC50 HCT 116 C94(1.03)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C94(0.91)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C94(1.02)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C94(1.02)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C94(1.49)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C94(1.16)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C94(1.31)  LDD0636  [10]
 LDCM0320  AC57 PaTu 8988t C94(0.87)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C94(0.86)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C94(0.88)  LDD1201  [10]
 LDCM0323  AC6 PaTu 8988t C94(0.79)  LDD1202  [10]
 LDCM0324  AC60 PaTu 8988t C94(1.15)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C94(0.84)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C94(0.82)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C94(0.93)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C94(0.90)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C94(1.15)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C94(1.09)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C94(1.05)  LDD1210  [10]
 LDCM0332  AC68 HCT 116 C293(0.83); C298(0.83)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C293(0.92); C298(0.92)  LDD0650  [10]
 LDCM0334  AC7 PaTu 8988t C94(1.24)  LDD1213  [10]
 LDCM0335  AC70 HCT 116 C293(1.17); C298(1.17)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C293(0.99); C298(0.99)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C293(1.03); C298(1.03)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C293(1.27); C298(1.27)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C293(1.23); C298(1.23)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C293(1.66); C298(1.66)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C293(1.11); C298(1.11)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C293(0.84); C298(0.84)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C293(0.85); C298(0.85)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C293(1.00); C298(1.00)  LDD0661  [10]
 LDCM0345  AC8 PaTu 8988t C94(0.72)  LDD1224  [10]
 LDCM0346  AC80 HCT 116 C293(1.03); C298(1.03)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C293(1.09); C298(1.09)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C293(1.73); C298(1.73)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C293(1.34); C298(1.34)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C293(1.19); C298(1.19)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C293(0.86); C298(0.86)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C293(1.14); C298(1.14)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C293(0.97); C298(0.97)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C293(0.94); C298(0.94)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C293(1.31); C298(1.31)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C293(1.02); C298(1.02)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C293(1.20); C298(1.20)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C293(1.26); C298(1.26)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C293(1.13); C298(1.13)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C293(0.93); C298(0.93)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C293(0.68); C298(0.68)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C293(1.06); C298(1.06)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C293(1.07); C298(1.07)  LDD0681  [10]
 LDCM0365  AC98 PaTu 8988t C94(0.83); C293(0.71); C298(0.71)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C94(0.98); C293(1.15); C298(1.15)  LDD1245  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C94(0.75)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C94(1.03)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C94(0.96)  LDD1154  [10]
 LDCM0102  BDHI 8 Jurkat C144(5.19)  LDD0204  [2]
 LDCM0632  CL-Sc Hep-G2 C584(2.06)  LDD2227  [8]
 LDCM0367  CL1 PaTu 8988t C293(1.00); C298(1.00)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C293(1.20); C298(1.20)  LDD1247  [10]
 LDCM0369  CL100 HEK-293T C491(1.11); C144(0.97); C285(1.09); C320(1.18)  LDD1573  [9]
 LDCM0370  CL101 PaTu 8988t C94(1.36)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C94(0.91)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C94(1.04)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C94(1.02)  LDD1252  [10]
 LDCM0374  CL105 HEK-293T C18(1.00); C94(0.92); C491(0.90); C144(0.92)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C18(1.00); C285(1.00); C691(1.05); C298(1.10)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C18(1.05); C94(0.93); C144(0.92); C179(1.07)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C491(1.09); C144(0.99); C285(0.84); C320(0.86)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C18(1.04); C94(1.12); C491(1.01); C144(1.02)  LDD1582  [9]
 LDCM0379  CL11 PaTu 8988t C293(1.35); C298(1.35)  LDD1258  [10]
 LDCM0380  CL110 HEK-293T C18(0.90); C285(1.06); C691(1.05); C298(0.91)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C18(1.04); C94(1.08); C144(1.05); C179(0.88)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C491(1.05); C144(0.96); C285(0.96); C320(0.96)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C18(1.05); C94(0.77); C491(1.04); C144(1.02)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C18(1.09); C285(1.10); C691(0.97); C298(1.00)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C18(0.98); C94(1.10); C144(1.01); C179(0.89)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C491(1.17); C144(1.14); C285(0.96); C320(1.05)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C94(1.27)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C94(0.89)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C94(1.02)  LDD0706  [10]
 LDCM0390  CL12 PaTu 8988t C293(0.96); C298(0.96)  LDD1269  [10]
 LDCM0391  CL120 HCT 116 C94(1.03)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C94(1.02)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C94(1.63)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C94(1.45)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C94(1.13)  LDD0712  [10]
 LDCM0396  CL125 PaTu 8988t C94(0.75)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C94(0.98)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C94(1.00)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C94(0.89)  LDD1278  [10]
 LDCM0400  CL13 PaTu 8988t C293(1.32); C298(1.32)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C293(1.55); C298(1.55)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C293(1.60); C298(1.60)  LDD1281  [10]
 LDCM0403  CL16 HCT 116 C94(1.02)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C94(1.29)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C94(1.02)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C94(0.90)  LDD0723  [10]
 LDCM0407  CL2 PaTu 8988t C293(0.94); C298(0.94)  LDD1286  [10]
 LDCM0408  CL20 HCT 116 C94(1.44)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C94(1.10)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C94(1.48)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C94(1.00)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C94(1.06)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C94(1.12)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C94(1.17)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C94(1.04)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C94(1.12)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C94(1.02)  LDD0734  [10]
 LDCM0418  CL3 PaTu 8988t C293(0.85); C298(0.85)  LDD1297  [10]
 LDCM0419  CL30 HCT 116 C94(1.33)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C293(0.98); C298(0.98)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C293(1.01); C298(1.01)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C293(0.82); C298(0.82)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C293(1.14); C298(1.14)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C293(0.96); C298(0.96)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C293(1.04); C298(1.04)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C293(0.99); C298(0.99)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C293(0.94); C298(0.94)  LDD0745  [10]
 LDCM0429  CL4 PaTu 8988t C293(0.66); C298(0.66)  LDD1308  [10]
 LDCM0430  CL40 HCT 116 C293(1.02); C298(1.02)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C293(1.12); C298(1.12)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C293(1.23); C298(1.23)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C293(1.00); C298(1.00)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C293(1.07); C298(1.07)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C293(0.96); C298(0.96)  LDD0752  [10]
 LDCM0436  CL46 HEK-293T C94(1.71); C144(1.14); C179(0.80); C285(1.14)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C144(1.09); C179(1.04); C285(1.47); C337(0.95)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C94(1.36); C491(1.20); C144(1.12); C285(1.10)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C18(0.95); C94(1.45); C491(1.12); C144(1.08)  LDD1643  [9]
 LDCM0440  CL5 PaTu 8988t C293(1.36); C298(1.36)  LDD1319  [10]
 LDCM0441  CL50 HEK-293T C18(1.00); C285(1.08); C691(0.89); C298(1.19)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C491(1.05); C144(1.01); C285(0.94); C320(1.11)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C18(0.87); C144(1.49); C179(1.11); C285(1.02)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C18(0.91); C144(1.41); C179(1.03); C285(1.06)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C491(1.23); C144(1.11); C285(1.00); C691(1.05)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C18(0.96); C94(1.13); C144(1.17); C337(1.16)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C179(1.08); C337(1.66); C691(1.07); C298(1.06)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C94(1.47); C144(1.27); C179(0.88); C285(1.16)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C144(1.27); C179(0.97); C285(1.06); C337(0.91)  LDD1653  [9]
 LDCM0451  CL6 PaTu 8988t C293(1.24); C298(1.24)  LDD1330  [10]
 LDCM0452  CL60 HEK-293T C94(1.24); C491(1.01); C144(1.27); C285(1.19)  LDD1655  [9]
 LDCM0453  CL61 HCT 116 C293(1.73); C298(1.73); C94(0.98)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C293(1.98); C298(1.98); C94(0.94)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C293(1.32); C298(1.32); C94(0.82)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C293(1.46); C298(1.46); C94(1.00)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C293(1.47); C298(1.47); C94(1.26)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C293(1.75); C298(1.75); C94(1.01)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C293(1.07); C298(1.07); C94(0.87)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C293(1.26); C298(1.26); C94(0.89)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C293(1.84); C298(1.84); C94(0.68)  LDD0778  [10]
 LDCM0462  CL7 PaTu 8988t C293(1.47); C298(1.47)  LDD1341  [10]
 LDCM0463  CL70 HCT 116 C293(1.45); C298(1.45); C94(0.84)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C293(1.45); C298(1.45); C94(1.02)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C293(1.36); C298(1.36); C94(0.91)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C293(1.42); C298(1.42); C94(0.97)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C293(1.18); C298(1.18); C94(0.99)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C293(0.88); C298(0.88)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C293(1.11); C298(1.11)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C293(0.95); C298(0.95)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C293(0.94); C298(0.94)  LDD0789  [10]
 LDCM0473  CL8 PaTu 8988t C293(0.89); C298(0.89)  LDD1352  [10]
 LDCM0474  CL80 HCT 116 C293(1.17); C298(1.17)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C293(0.82); C298(0.82)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C293(0.99); C298(0.99)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C293(1.08); C298(1.08)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C293(1.25); C298(1.25)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C293(0.95); C298(0.95)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C293(0.92); C298(0.92)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C293(1.17); C298(1.17)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C293(0.89); C298(0.89)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C293(1.11); C298(1.11)  LDD0800  [10]
 LDCM0484  CL9 PaTu 8988t C293(1.60); C298(1.60)  LDD1363  [10]
 LDCM0485  CL90 HCT 116 C293(1.53); C298(1.53)  LDD0802  [10]
 LDCM0486  CL91 HEK-293T C491(0.91); C144(1.06); C285(0.94); C691(1.18)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C18(1.06); C94(1.27); C144(1.25); C337(1.27)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C179(1.08); C337(0.98); C691(1.07); C298(1.06)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C94(1.71); C144(1.24); C179(0.85); C285(1.16)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C144(2.28); C179(1.50); C285(2.11); C337(1.07)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C94(1.54); C491(1.22); C144(1.35); C285(1.66)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C18(1.01); C94(1.04); C491(1.08); C144(1.19)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C18(0.96); C285(0.89); C691(0.92); C298(1.04)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C18(1.04); C94(1.36); C144(0.90); C179(0.88)  LDD1697  [9]
 LDCM0634  CY-0357 Hep-G2 C584(1.09)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C18(1.05); C94(1.18); C144(0.98); C179(1.15)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C293(1.35); C298(1.35); C94(1.00)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C293(1.66); C298(1.66)  LDD0744  [10]
 LDCM0022  KB02 HEK-293T C18(0.96)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C285(10.21)  LDD0209  [2]
 LDCM0024  KB05 MKN-1 C18(2.57)  LDD3331  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C144(0.49)  LDD2125  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C144(0.70)  LDD2129  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C144(0.80)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C144(0.74)  LDD2137  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C144(0.50)  LDD2146  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 576 (ZNF576) Krueppel C2H2-type zinc-finger protein family Q9H609

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840