Details of the Target

General Information of Target

Target ID LDTP14160
Target Name U5 small nuclear ribonucleoprotein TSSC4 (TSSC4)
Gene Name TSSC4
Gene ID 10078
Synonyms
U5 small nuclear ribonucleoprotein TSSC4; Tumor-suppressing STF cDNA 4 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD
NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM
AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD
LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS
QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG
GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD
NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE
YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI
NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT
PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR
QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL
DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD
IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL
Target Bioclass
Other
Family
TSSC4 family
Function
Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.
Uniprot ID
Q9Y5U2
Ensemble ID
ENST00000333256.11
HGNC ID
HGNC:12386

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SKNSH SNV: p.P79Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K217(7.14); K234(4.52)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C99(2.58)  LDD0168  [3]
DBIA
 Probe Info  		C99(0.98)  LDD0531  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0147  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C99(2.58)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C99(4.98)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C99(0.98)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C99(0.96)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C99(0.84)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C99(0.84)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C99(1.08)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C99(1.25)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C99(0.83)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C99(1.02)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C99(1.07)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C99(1.17)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C99(0.71)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C99(0.72)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C99(1.19)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C99(0.77)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C99(0.75)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C99(0.81)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C99(0.97)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C99(1.02)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C99(0.96)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C99(1.05)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C99(1.03)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C99(1.22)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C99(1.23)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C99(1.33)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C99(1.29)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C99(1.18)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C99(1.15)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C99(1.09)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C99(1.14)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C99(1.84)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C99(1.22)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C99(1.31)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C99(1.02)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C99(1.12)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C99(0.59)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C99(0.68)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C99(0.76)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C99(1.05)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C99(0.70)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C99(0.56)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C99(0.63)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C99(0.61)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C99(0.64)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C99(0.97)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C99(0.93)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C99(0.99)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C99(1.07)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C99(0.99)  LDD1528  [15]
 LDCM0290  AC3 HCT 116 C99(0.98)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C99(0.96)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C99(1.01)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C99(0.99)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C99(1.05)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C99(0.95)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C99(1.08)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C99(1.03)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C99(1.13)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C99(1.07)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C99(1.01)  LDD1539  [15]
 LDCM0301  AC4 HCT 116 C99(0.89)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C99(1.05)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C99(0.99)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C99(0.92)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C99(0.97)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C99(1.05)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C99(0.94)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C99(0.97)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C99(1.02)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C99(1.10)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C99(0.99)  LDD1550  [15]
 LDCM0312  AC5 HCT 116 C99(1.06)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C99(0.99)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C99(1.05)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C99(1.01)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C99(1.09)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C99(0.94)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C99(1.08)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C99(0.98)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C99(0.98)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C99(0.97)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C99(1.07)  LDD1561  [15]
 LDCM0323  AC6 HCT 116 C99(1.04)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C99(0.95)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C99(0.95)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C99(1.02)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C99(1.04)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C99(1.02)  LDD1567  [15]
 LDCM0332  AC68 HCT 116 C99(1.13)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C99(1.30)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C99(0.99)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C99(0.98)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C99(1.02)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C99(1.31)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C99(2.21)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C99(1.74)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C99(2.91)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C99(1.56)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C99(1.43)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C99(1.14)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C99(1.23)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C99(1.17)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C99(1.50)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C99(0.94)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C99(1.87)  LDD0665  [4]
 LDCM0365  AC98 HCT 116 C99(2.01)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C99(0.73)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C99(1.19)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C99(1.22)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C99(1.04)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 10.41  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C99(3.09)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C99(0.90)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C99(0.88)  LDD1572  [15]
 LDCM0369  CL100 HCT 116 C99(0.90)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C99(1.06)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C99(0.96)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C99(1.05)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C99(1.03)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C99(0.69)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C99(0.62)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C99(0.68)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C99(0.62)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C99(0.78)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C99(1.00)  LDD1583  [15]
 LDCM0380  CL110 HCT 116 C99(0.55)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C99(0.70)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C99(0.88)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C99(1.01)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C99(0.85)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C99(0.94)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C99(1.04)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C99(0.98)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C99(0.95)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C99(1.03)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C99(0.96)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C99(1.05)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C99(0.96)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C99(0.93)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C99(0.89)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C99(0.89)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C99(0.98)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C99(0.90)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C99(0.97)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C99(0.99)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C99(0.92)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C99(1.07)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C99(0.85)  LDD1606  [15]
 LDCM0403  CL16 HCT 116 C99(0.91)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C99(0.68)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C99(0.91)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C99(0.89)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C99(0.96)  LDD1611  [15]
 LDCM0408  CL20 HCT 116 C99(0.86)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C99(0.87)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C99(0.88)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C99(0.93)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C99(1.02)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C99(0.90)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C99(1.05)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C99(0.97)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C99(1.16)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C99(1.06)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C99(0.85)  LDD1622  [15]
 LDCM0419  CL30 HCT 116 C99(1.14)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C99(1.05)  LDD1624  [15]
 LDCM0421  CL32 HCT 116 C99(0.99)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C99(0.85)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C99(0.88)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C99(1.04)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C99(0.78)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C99(1.20)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C99(0.94)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C99(0.90)  LDD1633  [15]
 LDCM0430  CL40 HCT 116 C99(0.84)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C99(0.87)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C99(0.96)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C99(0.91)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C99(0.91)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C99(0.98)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C99(1.02)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C99(1.02)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C99(1.17)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C99(1.02)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C99(0.97)  LDD1644  [15]
 LDCM0441  CL50 HCT 116 C99(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C99(0.98)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C99(1.04)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C99(0.91)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C99(0.85)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C99(0.97)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C99(0.91)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C99(0.96)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C99(1.10)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C99(1.07)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C99(0.91)  LDD1654  [15]
 LDCM0452  CL60 HCT 116 C99(1.09)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C99(1.09)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C99(1.06)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C99(1.09)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C99(0.93)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C99(1.08)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C99(1.03)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C99(1.12)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C99(1.08)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C99(1.07)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C99(1.01)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C99(1.10)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C99(1.13)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C99(1.19)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C99(0.91)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C99(0.97)  LDD1670  [15]
 LDCM0469  CL76 HCT 116 C99(0.89)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C99(0.90)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C99(0.91)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C99(1.03)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C99(0.76)  LDD1676  [15]
 LDCM0474  CL80 HCT 116 C99(1.05)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C99(1.01)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C99(1.02)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C99(1.03)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C99(1.02)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C99(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C99(0.99)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C99(0.96)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C99(0.93)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C99(1.04)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C99(1.06)  LDD1687  [15]
 LDCM0485  CL90 HCT 116 C99(0.87)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C99(0.78)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C99(0.87)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C99(0.96)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C99(0.92)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C99(0.73)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C99(0.80)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C99(0.87)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C99(0.94)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C99(0.97)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C99(1.05)  LDD1698  [15]
 LDCM0625  F8 Ramos C99(0.99)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C99(0.84)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C99(0.27)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C99(0.88)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C99(1.03)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C99(0.75)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C99(0.72)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C99(1.26)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C99(1.36)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C99(1.36)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C99(0.69)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C99(1.01)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C99(0.99)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C99(0.80)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C99(0.97)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C99(0.89)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C99(0.79)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C99(0.67)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C99(0.76)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C99(0.92)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C99(0.79)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C99(0.71)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C99(1.02)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C99(0.98)  LDD1497  [15]
 LDCM0024  KB05 HMCB C99(1.65)  LDD3312  [17]
 LDCM0131  RA190 MM1.R C99(1.47)  LDD0304  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.