Details of the Target

General Information of Target

Target ID LDTP14037
Target Name Microtubule cross-linking factor 1 (MTCL1)
Gene Name MTCL1
Gene ID 23255
Synonyms
CCDC165; KIAA0802; SOGA2; Microtubule cross-linking factor 1; Coiled-coil domain-containing protein 165; PAR-1-interacting protein; SOGA family member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDESASGSDPDLDPDVELEDAEEEEEEEEVAVEECDRDDEEDLLDDPSLEGMCGTEHAQ
LGEDGQQPPRCTSTTSSQSEPSEQLRRHQGKNLASEDPKKKRAQKPSHMRRNIRKLLRED
QLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLEFLPEEIALRASDGPQLPPRVLAQ
EVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEDDEEEEKGGTHVNDVLN
QRDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFG
CILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPAD
NKPEEVQPRFFKVHILNDEHKTMASRAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATGR
PKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALK
NIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQD
VRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRD
CGSSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKESLANEQDLDVEELGSAGTSARCPPQ
GTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTGVLENS
PKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQKWVRNI
SYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNP
CHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTR
KEVENLLHFVEKEPAPQVSLNVKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKL
TKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPV
ASVRPVQSTPIPMMPRHVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQKVVTTTDIVIP
GLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKVPEDGRMAASGSQG
PSCESTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNA
ALPGPPAQLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLAT
PPAAQESSRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFM
GSTPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILP
SYSLPFSQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQVPPFD
SHEVAEVGFSSNDDEDKDDDVIEVTGK
Target Bioclass
Other
Family
SOGA family
Subcellular location
Lateral cell membrane
Function
Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Required for faithful chromosome segregation during mitosis.
Uniprot ID
Q9Y4B5
Ensemble ID
ENST00000306329.16
HGNC ID
HGNC:29121

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.70  LDD0403  [1]
Sulforaphane-probe2
 Probe Info  		1.97  LDD0160  [2]
DBIA
 Probe Info  		C729(1.02)  LDD0078  [3]
NAIA_4
 Probe Info  		C215(0.00); C729(0.00); C800(0.00); C1615(0.00)  LDD2226  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
IPM
 Probe Info  		C507(0.00); C729(0.00)  LDD0005  [5]
TFBX
 Probe Info  		C1615(0.00); C729(0.00); C507(0.00)  LDD0148  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C507(1.00)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C507(0.90)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C507(1.09)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C507(0.98)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C507(0.88)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C507(0.89)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C507(0.96)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C507(0.94)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C507(1.00)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C507(0.98)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C507(1.01)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C507(0.94)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C507(1.00)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C507(0.96)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C507(1.00)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C507(1.15)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C507(1.02)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C507(1.14)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C507(1.15)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C507(0.97)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C729(1.32)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C729(1.79)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C729(1.57)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C729(1.77)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C729(1.80)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C729(2.05)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C729(2.57)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C507(0.94)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C729(1.54)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C729(1.22)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C729(1.25)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C729(2.59)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C729(1.64)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C729(1.59)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C729(1.12)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C729(1.34)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C729(1.07)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C729(0.77)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C729(1.22)  LDD0595  [3]
 LDCM0280  AC20 HCT 116 C729(1.03)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C729(1.12)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C729(1.11)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C729(1.03)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C729(1.12)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C507(1.01)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C507(1.06)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C507(1.20)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C507(1.23)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C507(1.22)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C507(1.27)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C507(1.10)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C507(1.26)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C507(1.06)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C507(1.04)  LDD0612  [3]
 LDCM0297  AC36 HEK-293T C507(0.86)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C507(1.02)  LDD1537  [7]
 LDCM0301  AC4 HEK-293T C507(0.93)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C507(1.07)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C507(0.96)  LDD1542  [7]
 LDCM0306  AC44 HEK-293T C507(0.99)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C507(1.02)  LDD1546  [7]
 LDCM0310  AC48 HEK-293T C507(1.01)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C507(0.97)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C507(1.04)  LDD1551  [7]
 LDCM0315  AC52 HEK-293T C507(1.03)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C507(0.94)  LDD1555  [7]
 LDCM0319  AC56 HEK-293T C507(0.96)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C507(0.97)  LDD1559  [7]
 LDCM0323  AC6 HCT 116 C507(1.15)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C507(0.93)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C507(1.15)  LDD1564  [7]
 LDCM0328  AC64 HEK-293T C507(0.93)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C507(0.92); C729(1.10)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C507(0.81); C729(1.14)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C507(1.02)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C507(1.00); C729(1.39)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C507(0.81); C729(1.43)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C507(0.98); C729(1.08)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C507(0.98); C729(1.77)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C507(0.77); C729(1.89)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C507(1.13); C729(1.99)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C507(0.85); C729(1.39)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C507(0.95); C729(1.65)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C507(0.93); C729(1.14)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C507(0.97); C729(1.23)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C507(1.01)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C507(0.74); C729(1.27)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C729(0.80); C507(0.88)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C507(0.73); C729(2.18)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C729(1.82)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C729(1.48)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C729(1.30)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C729(1.37)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C729(0.91)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C729(1.02)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C729(1.22)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C729(1.01)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C729(1.68)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C729(1.54)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C729(0.86)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C729(0.97)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C729(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C729(1.05)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C729(1.20)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C507(1.13)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C507(1.15)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C507(1.02)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 12.70  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C729(1.02)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C507(0.98)  LDD1571  [7]
 LDCM0369  CL100 HEK-293T C1314(1.18)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C507(0.90)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C507(1.03)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C507(1.05)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C507(0.96)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C729(1.43)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C729(1.31)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C729(1.35)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C729(1.20)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C729(1.19)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C729(1.25)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C729(1.10)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C507(0.93)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C507(1.15)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C507(1.15)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C507(1.04)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C507(1.02)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C507(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C507(1.09)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C507(0.95)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1314(1.10)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C507(1.01)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C507(1.02)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C1314(1.07)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C507(1.03)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C507(1.02)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C1314(0.92)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C507(1.14)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C507(1.02)  LDD1605  [7]
 LDCM0403  CL16 HCT 116 C507(1.01)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C507(1.21)  LDD1608  [7]
 LDCM0407  CL2 HEK-293T C507(1.01)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C507(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C507(1.18)  LDD1613  [7]
 LDCM0412  CL24 HEK-293T C507(0.96)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C507(1.03)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C507(0.94)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C1314(0.90)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C507(0.92)  LDD1621  [7]
 LDCM0421  CL32 HCT 116 C507(1.10)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C507(1.11)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C507(1.07)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C507(1.03)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C507(1.05)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C507(1.03)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C507(1.03)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C1314(1.03)  LDD1633  [7]
 LDCM0430  CL40 HCT 116 C507(0.97)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C507(1.28)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C507(1.00)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C507(1.11)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C507(0.99)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C507(0.97)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C729(0.88)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C729(0.84)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C729(0.90)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C729(0.89)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C507(1.05)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C729(1.07)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C729(1.06)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C729(1.25)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C729(1.02)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C729(0.97)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C729(0.90)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C729(0.94)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C729(1.12)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C729(1.17)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C729(1.09)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C729(0.92)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C507(0.79)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C507(0.82)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C507(0.89)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C507(0.88)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C507(1.01)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C507(0.82)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C507(0.83)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C507(0.70)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C507(0.87)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C507(0.79)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C507(0.83)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C507(0.86)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C507(0.77)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C507(0.86)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C507(0.92)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C507(1.00)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C507(1.28)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C507(1.05)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C507(1.21)  LDD1676  [7]
 LDCM0474  CL80 HCT 116 C507(0.91)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C507(1.00)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C507(0.88)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C507(0.84)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C507(1.03)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C507(0.95)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C507(0.96)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C507(0.96)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C507(0.90)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C507(1.02)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C507(1.09)  LDD1687  [7]
 LDCM0485  CL90 HCT 116 C507(1.18)  LDD0802  [3]
 LDCM0487  CL92 HEK-293T C507(0.84)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C507(1.17)  LDD1691  [7]
 LDCM0491  CL96 HEK-293T C507(0.99)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C507(1.18)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C507(1.05)  LDD1696  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1705(1.38); C1704(1.38); C729(1.32)  LDD1702  [8]
 LDCM0468  Fragment33 HCT 116 C507(0.79)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C507(1.08)  LDD0744  [3]
 LDCM0022  KB02 42-MG-BA C565(1.54)  LDD2244  [9]
 LDCM0023  KB03 42-MG-BA C565(2.17)  LDD2661  [9]
 LDCM0024  KB05 NCI-H1155 C507(7.85)  LDD3342  [9]
 LDCM0003  Sulforaphane MDA-MB-231 1.97  LDD0160  [2]
 LDCM0021  THZ1 HCT 116 C729(0.77)  LDD2173  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840