Details of the Target

General Information of Target

Target ID LDTP13977
Target Name Mediator of RNA polymerase II transcription subunit 31 (MED31)
Gene Name MED31
Gene ID 51003
Synonyms
SOH1; Mediator of RNA polymerase II transcription subunit 31; Mediator complex subunit 31; Mediator complex subunit SOH1; hSOH1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDF
MIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQ
WLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG
Target Bioclass
Other
Family
Mediator complex subunit 31 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
Q9Y3C7
Ensemble ID
ENST00000225728.8
HGNC ID
HGNC:24260

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.08  LDD0066  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C93(1.23)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
W1
 Probe Info  		N.A.  LDD0236  [2]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C27(0.00); C93(0.00); C72(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C93(1.23)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C93(1.01)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C93(1.15)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C93(0.95)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C93(1.45)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C93(1.38)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C93(0.92)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C93(1.19)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C93(1.41)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C93(1.14)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C93(1.08)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C93(1.45)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C93(1.04)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C93(1.31)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C93(1.45)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C93(1.27)  LDD1108  [3]
 LDCM0230  AC113 HCT 116 C93(0.89)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C93(0.94)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C93(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C93(1.00)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C93(0.90)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C93(0.94)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C93(0.95)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C93(0.95)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C93(1.10)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C93(0.77)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C93(0.95)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C93(0.85)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C93(1.05)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C93(1.12)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C93(0.88)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C93(0.95)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C93(1.15)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C93(1.09)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C93(0.87)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C93(0.69)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C93(0.68)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C93(1.07)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C93(0.78)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C93(0.71)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C93(0.66)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C93(0.72)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C93(0.86)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C93(1.08)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C93(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C93(1.07)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C93(1.01)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C93(1.09)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C93(1.10)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C93(1.05)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C93(1.26)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C93(1.27)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C93(1.43)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C93(1.42)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C93(0.93)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C93(1.31)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C93(1.40)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C93(1.17)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C93(1.41)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C93(1.19)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C93(1.40)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C93(1.07)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C93(1.30)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C93(2.20)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C93(1.97)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C93(1.57)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C93(1.16)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C93(1.25)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C93(1.12)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C93(0.72)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C93(1.18)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C93(1.02)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C93(0.80)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C93(0.99)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C93(1.02)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C93(0.84)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C93(0.97)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C93(0.93)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C93(1.26)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C72(1.09); C93(1.23)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C93(1.13)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C93(1.06)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C93(1.22)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C72(1.05)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C72(1.07); C93(1.14)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C93(1.36)  LDD1566  [8]
 LDCM0332  AC68 HCT 116 C93(1.13)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C93(0.99)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C93(1.04)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C93(1.05)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C93(1.05)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C93(1.05)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C93(1.10)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C93(1.08)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C93(0.90)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C93(0.85)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C93(0.93)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C93(1.10)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C93(1.12)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C93(1.13)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C93(1.09)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C93(1.04)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C93(1.15)  LDD0665  [3]
 LDCM0365  AC98 PaTu 8988t C93(1.10)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C93(1.41)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C93(0.98)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C93(1.04)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C93(1.42)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C93(0.71)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C93(1.02)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C93(1.20)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C93(1.11)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C93(0.86)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C93(0.95)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C93(0.97)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C93(1.07)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C93(0.63)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C93(0.85)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C93(0.85)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C93(0.76)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C93(1.04)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C93(0.78)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C93(0.97)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C93(1.05)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C93(1.25)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C93(0.94)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C93(1.15)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C93(1.28)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C93(1.20)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C93(1.36)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C93(1.37)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C93(1.00)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C93(0.97)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C93(0.97)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C93(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C93(0.80)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C93(1.03)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C72(1.21)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C93(1.32)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C72(1.00); C93(1.08)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C93(0.97)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C93(1.09)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C93(0.95)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C72(1.08); C93(1.16)  LDD1607  [8]
 LDCM0404  CL17 HCT 116 C93(0.79)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C93(0.92)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C93(0.89)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C93(0.80)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C93(0.88)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C93(0.90)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C93(0.95)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C93(1.15)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C93(0.93)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C93(0.87)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C93(0.83)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C93(0.83)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C93(0.85)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C93(0.82)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C93(0.76)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C93(0.88)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C93(0.99)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C93(1.05)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C93(1.18)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C93(1.06)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C93(1.02)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C93(1.16)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C93(1.23)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C93(1.22)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C93(0.86)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C93(1.04)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C93(0.84)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C93(0.88)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C93(1.05)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C93(1.02)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C93(1.11)  LDD0752  [3]
 LDCM0436  CL46 PaTu 8988t C93(1.68)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C93(1.29)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C93(1.03)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C93(1.32)  LDD1318  [3]
 LDCM0440  CL5 HCT 116 C93(0.71)  LDD0757  [3]
 LDCM0441  CL50 PaTu 8988t C93(1.62)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C93(1.68)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C93(1.71)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C93(1.31)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C93(1.20)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C93(1.48)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C93(1.17)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C93(1.25)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C93(1.19)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C93(1.05)  LDD1329  [3]
 LDCM0451  CL6 HCT 116 C93(0.88)  LDD0768  [3]
 LDCM0452  CL60 PaTu 8988t C93(1.59)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C93(0.89)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C93(0.85)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C93(0.92)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C93(1.24)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C93(1.03)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C93(1.18)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C93(1.00)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C93(1.08)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C93(1.07)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C93(1.13)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C93(1.05)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C93(1.15)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C93(1.00)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C93(0.97)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C93(0.99)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C93(0.90)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C93(0.82)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C93(1.09)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C93(1.24)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C93(1.00)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C93(1.41)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C93(0.79)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C93(1.67)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C93(1.45)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C93(1.62)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C93(1.09)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C93(1.85)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C93(0.98)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C93(1.61)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C93(1.93)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C93(1.04)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C93(0.79)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C93(1.03)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C93(1.01)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C93(1.01)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C93(1.11)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C93(1.07)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C93(1.05)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C93(1.08)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C93(1.19)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C93(1.11)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C93(1.31)  LDD1698  [8]
 LDCM0625  F8 Ramos C93(0.97)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C93(0.55)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C93(0.66)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C93(0.47)  LDD2191  [9]
 LDCM0576  Fragment14 Ramos C93(0.69)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C93(0.29)  LDD2194  [9]
 LDCM0582  Fragment23 Ramos C93(0.45)  LDD2196  [9]
 LDCM0590  Fragment32 Ramos C93(0.47)  LDD2201  [9]
 LDCM0468  Fragment33 HCT 116 C93(0.87)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C93(0.79)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C93(0.75)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C93(1.24)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C93(0.75)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C93(0.45)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C93(0.41)  LDD2188  [9]
 LDCM0022  KB02 Ramos C93(0.36)  LDD2182  [9]
 LDCM0023  KB03 MDA-MB-231 C93(1.33)  LDD1701  [10]
 LDCM0024  KB05 NCI-H1792 C93(3.27)  LDD3348  [11]
 LDCM0628  OTUB2-COV-1 HEK-293T C93(0.79)  LDD2207  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Mediator of RNA polymerase II transcription subunit 7 (MED7) Mediator complex subunit 7 family O43513
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.