Details of the Target

General Information of Target

Target ID LDTP13937
Target Name Tyrosine--tRNA ligase, mitochondrial (YARS2)
Gene Name YARS2
Gene ID 51067
Synonyms
Tyrosine--tRNA ligase, mitochondrial; EC 6.1.1.1; Tyrosyl-tRNA synthetase; TyrRS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFYFRGCGRWVAVSFTKQQFPLARLSSDSAAPRTPHFDVIVIGGGHAGTEAATAAARCGS
RTLLLTHRVDTIGQMSCNPSFGGIGKGHLMREVDALDGLCSRICDQSGVHYKVLNRRKGP
AVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEGAVEDLILTEPEPEHTGKCRVSGVVLVD
GSTVYAESVILTTGTFLRGMIVIGLETHPAGRLGDQPSIGLAQTLEKLGFVVGRLKTGTP
PRIAKESINFSILNKHIPDNPSIPFSFTNETVWIKPEDQLPCYLTHTNPRVDEIVLKNLH
LNSHVKETTRGPRYCPSIESKVLRFPNRLHQVWLEPEGMDSDLIYPQGLSMTLPAELQEK
MITCIRGLEKAKVIQPDGVLLLLPRMECNGAISAHHNLPLPGYGVQYDYLDPRQITPSLE
THLVQRLFFAGQINGTTGYEEAAAQGVIAGINASLRVSRKPPFVVSRTEGYIGVLIDDLT
TLGTSEPYRMFTSRVEFRLSLRPDNADSRLTLRGYKDAGCVSQQRYERACWMKSSLEEGI
SVLKSIEFLSSKWKKLIPEASISTSRSLPVRALDVLKYEEVDMDSLAKAVPEPLKKYTKC
RELAERLKIEATYESVLFHQLQEIKGVQQDEALQLPKDLDYLTIRDVSLSHEVREKLHFS
RPQTIGAASRIPGVTPAAIINLLRFVKTTQRRQSAMNESSKTDQYLCDADRLQEREL
Target Bioclass
Enzyme
Family
Class-I aminoacyl-tRNA synthetase family
Subcellular location
Mitochondrion matrix
Function Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Uniprot ID
Q9Y2Z4
Ensemble ID
ENST00000324868.13
HGNC ID
HGNC:24249

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.87  LDD0403  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C413(0.61)  LDD0531  [3]
ATP probe
 Probe Info  		K284(0.00); K355(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C369(0.00); C413(0.00); C78(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C369(0.00); C413(0.00); C78(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		C369(0.00); C413(0.00)  LDD2156  [10]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		5.80  LDD0443  [12]
NAIA_5
 Probe Info  		C369(0.00); C413(0.00); C78(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C369(2.83)  LDD0372  [14]
 LDCM0214  AC1 HCT 116 C413(0.61)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C413(0.49)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C413(0.55)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C413(0.45)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C413(0.44)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C413(0.22)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C413(0.37)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C413(0.29)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C413(0.30)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C413(0.36)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C413(0.43)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C413(0.42)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C413(0.63)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C413(0.39)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C413(0.34)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C413(0.38)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C413(1.35)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C413(1.27)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C413(1.32)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C413(1.02)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C413(0.96)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C413(1.17)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C413(1.66)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C413(0.64)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C413(1.64)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C413(1.37)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C413(1.23)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C413(1.93)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C413(1.05)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C413(0.91)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C413(1.33)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C413(1.27)  LDD1124  [3]
 LDCM0259  AC14 PaTu 8988t C413(0.80)  LDD1138  [3]
 LDCM0263  AC143 HCT 116 C413(0.94)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C413(0.33)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C413(0.52)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C413(0.31)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C413(0.37)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C413(0.15)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C413(0.25)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C413(0.66)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C413(0.54)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C413(0.82)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C413(0.24)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C413(0.17)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C413(0.31)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C413(0.40)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C413(0.96)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C413(1.49)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C413(0.77)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C413(0.46)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C413(0.74)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C413(1.12)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C413(1.04)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C413(0.70)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C413(1.19)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C413(0.95)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C413(1.31)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C413(0.89)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C413(0.88)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C413(0.73)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C413(0.71)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C413(0.69)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C413(0.79)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C413(0.72)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C413(0.68)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C413(0.46)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C413(0.65)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C413(0.47)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C413(1.29)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C413(1.11)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C413(1.11)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C413(0.89)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C413(1.55)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C413(0.58)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C413(0.88)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C413(1.37)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C413(1.13)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C413(1.27)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C413(1.01)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C413(0.90)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C413(1.28)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C413(1.05)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C413(0.91)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C413(0.47)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C413(0.55)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C413(0.45)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C413(1.94)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C413(0.88)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C413(0.62)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C413(0.59)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C413(0.43)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C413(0.45)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C413(0.50)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C413(0.41)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C413(0.39)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C413(0.80)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C413(0.46)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C413(0.37)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C413(0.31)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C413(0.47)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C413(0.38)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C413(0.39)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C413(0.45)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C413(0.24)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C413(0.84)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C413(0.68)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C413(0.99)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C413(0.46)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C413(0.92)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C413(0.75)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C413(0.41)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C413(0.43)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C413(0.46)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C413(0.56)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C413(0.51)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C413(0.71)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C413(1.01)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C413(1.06)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C413(0.89)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C413(0.84)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C413(0.46)  LDD0665  [3]
 LDCM0349  AC83 PaTu 8988t C413(0.99)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C413(1.14)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C413(1.24)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C413(1.19)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C413(1.24)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C413(1.00)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C413(1.10)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C413(0.97)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C413(1.09)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C413(1.29)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C413(1.12)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C413(1.11)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C413(1.05)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C413(1.23)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C413(1.08)  LDD1243  [3]
 LDCM0365  AC98 HCT 116 C413(0.13)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C413(0.61)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C413(0.64)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C413(0.55)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C413(0.56)  LDD1154  [3]
 LDCM0156  Aniline NCI-H1299 9.87  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C413(0.97)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C413(0.49)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C413(0.52)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C413(0.86)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C413(0.75)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C413(0.45)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C413(0.75)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C413(0.60)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C413(0.41)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C413(0.64)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C413(0.42)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C413(0.75)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C413(0.45)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C413(0.59)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C413(0.64)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C413(0.89)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C413(0.59)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C413(0.78)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C413(0.85)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C413(0.94)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C413(0.62)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C413(1.44)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C413(0.74)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C413(0.33)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C413(1.58)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C413(0.49)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C413(0.60)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C413(0.55)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C413(0.51)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C413(0.91)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C413(0.62)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C413(0.68)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C413(0.42)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C413(0.42)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C413(0.76)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C413(0.54)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C413(0.67)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C413(0.67)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C413(0.48)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C413(0.56)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C413(1.79)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C413(0.46)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C413(0.40)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C413(0.34)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C413(0.59)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C413(0.39)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C413(0.42)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C413(0.61)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C413(0.73)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C413(0.50)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C413(0.52)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C413(0.81)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C413(0.69)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C413(0.38)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C413(0.34)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C413(0.30)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C413(0.21)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C413(0.19)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C413(0.23)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C413(0.19)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C413(0.20)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C413(0.87)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C413(0.22)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C413(0.33)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C413(0.16)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C413(0.17)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C413(0.23)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C413(0.23)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C413(1.63)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C413(1.37)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C413(1.45)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C413(1.26)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C413(0.94)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C413(1.38)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C413(1.26)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C413(1.59)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C413(1.53)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C413(1.66)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C413(1.42)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C413(1.01)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C413(1.33)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C413(1.65)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C413(1.21)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C413(0.47)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C413(1.24)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C413(1.14)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C413(0.90)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C413(0.78)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C413(0.61)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C413(0.86)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C413(0.49)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C413(0.59)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C413(0.81)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C413(1.42)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C413(0.40)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C413(0.60)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C413(0.91)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C413(1.06)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C413(0.96)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C413(0.80)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C413(0.60)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C413(0.72)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C413(0.66)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C413(0.35)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C413(0.39)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C413(0.77)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C413(0.67)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C413(0.24)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C413(0.27)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C413(0.21)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C413(0.46)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C413(0.79)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C413(0.47)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C413(0.33)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C413(0.26)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C413(0.71)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C413(1.02)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C413(0.90)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C413(0.69)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C413(0.76)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C413(0.60)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C413(0.56)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C413(0.71)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C413(0.65)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C413(0.57)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C413(0.57)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C369(0.92); C413(1.03); C78(0.97)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C413(0.58)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C413(0.15)  LDD0744  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C369(1.09); C413(0.93); C78(1.06)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C369(1.03); C413(0.98); C78(0.99)  LDD1497  [15]
 LDCM0024  KB05 NALM-6 C413(0.88)  LDD3339  [16]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tyrosine Small molecular drug DB00135

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840