Details of the Target

General Information of Target

Target ID LDTP13777
Target Name Myotubularin-related protein 6 (MTMR6)
Gene Name MTMR6
Gene ID 9107
Synonyms
Myotubularin-related protein 6; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; EC 3.1.3.95; Phosphatidylinositol-3-phosphate phosphatase; EC 3.1.3.64
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDPRKETWILHSQISTIEK
QATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDK
EEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSS
KFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSARCLEDEQMLQAIRKANPGSDFVYVVD
TRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDF
LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHY
RTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFN
ERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHS
QTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEE
RLEKIQKVQLNCTKVKSKQSEPSKHSGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDED
SALILTQDNLKSSDPDLSANSDQESGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Subcellular location
Cytoplasm
Function
Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.
Uniprot ID
Q9Y217
Ensemble ID
ENST00000381801.6
HGNC ID
HGNC:7453

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 Deletion: p.T566LfsTer13 DBIA    Probe Info 
HEC1B Deletion: p.K196RfsTer48 .
MEWO SNV: p.G587D DBIA    Probe Info 
NUGC3 SNV: p.M234I DBIA    Probe Info 
PC9 SNV: p.G350D .
TE4 SNV: p.E613K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.52  LDD0402  [1]
C-Sul
 Probe Info  		4.17  LDD0066  [2]
STPyne
 Probe Info  		K171(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y261(8.09)  LDD3495  [4]
Acrolein
 Probe Info  		N.A.  LDD0224  [5]
DBIA
 Probe Info  		C383(1.01)  LDD0531  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C214(0.00); C203(0.00); C88(0.00); C156(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C336(0.00); C383(0.00); C214(0.00); C203(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C336(0.00); C383(0.00); C214(0.00); C203(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C214(0.00); C569(0.00)  LDD2226  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
AOyne
 Probe Info  		12.00  LDD0443  [10]
NAIA_5
 Probe Info  		C214(0.00); C203(0.00); C88(0.00); C201(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C383(1.01)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C72(0.66)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C66(0.64); C72(0.64)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C66(0.75); C72(0.75)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C66(0.77); C72(0.77)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C66(0.62); C72(0.62)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C66(0.98); C72(0.98)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C66(0.61); C72(0.61)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C66(0.59); C72(0.59)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C66(0.64); C72(0.64)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C66(0.85); C72(0.85)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C66(0.91); C72(0.91)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C72(0.58)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C66(0.64); C72(0.64)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C66(0.81); C72(0.81)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C66(0.97); C72(0.97)  LDD0546  [6]
 LDCM0237  AC12 HEK-293T C72(0.66)  LDD0835  [6]
 LDCM0246  AC128 HCT 116 C66(2.20); C72(2.20)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C66(2.44); C72(2.44)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C66(1.47); C72(1.47)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C66(1.67); C72(1.67)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C66(1.47); C72(1.47)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C66(1.46); C72(1.46)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C66(1.23); C72(1.23)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C66(1.36); C72(1.36)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C66(0.82); C72(0.82)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C66(1.03); C72(1.03)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C66(0.93); C72(0.93)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C66(1.08); C72(1.08)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C72(0.57)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C66(0.82); C72(0.82)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C66(0.81); C72(0.81)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C66(0.90); C72(0.90)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C66(1.09); C72(1.09)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C66(0.63); C72(0.63)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C66(0.80); C72(0.80)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C66(0.63); C72(0.63)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C66(0.67); C72(0.67)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C66(0.40); C72(0.40)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C66(0.53); C72(0.53)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C72(0.83)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C66(0.92); C72(0.92)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C66(1.01); C72(1.01)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C66(0.66); C72(0.66)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C66(0.44); C72(0.44)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C66(0.79); C72(0.79)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C66(0.77); C72(0.77)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C66(0.90); C72(0.90)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C66(0.85); C72(0.85)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C72(0.48)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C72(0.45)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C72(0.49)  LDD0876  [6]
 LDCM0279  AC2 HCT 116 C383(1.12)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C72(0.51)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C72(0.46)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C72(0.49)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C72(0.53)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C72(0.60)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C347(1.46); C383(1.26)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C347(0.84); C383(1.04)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C347(1.35); C383(1.41)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C347(1.32); C383(1.36)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C347(1.12); C383(1.40)  LDD0887  [6]
 LDCM0290  AC3 HCT 116 C383(1.31)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C347(1.42); C383(1.41)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C347(1.19); C383(1.25)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C347(1.32); C383(1.52)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C347(1.69); C383(1.25)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C347(1.72); C383(1.57)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C383(0.60)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C383(0.49)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C383(0.52)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C383(0.68)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C383(0.67)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C383(1.36)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C383(0.51)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C383(0.58)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C383(0.45)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C383(0.63)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C383(0.63)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C383(0.69)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C383(1.45); C72(0.71)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C383(1.31); C72(0.64)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C383(1.47); C72(0.63)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C383(1.59); C72(0.56)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C383(1.33)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C383(1.39); C72(0.57)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C383(1.52); C72(0.56)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C383(1.64); C72(0.58)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C383(1.23); C72(0.56)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C383(1.43); C72(0.60)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C383(1.46); C72(0.59)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C383(1.65); C72(0.58)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C66(0.70); C72(0.70)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C66(0.52); C72(0.52)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C66(0.57); C72(0.57)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C72(0.86)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C66(0.55); C72(0.55)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C66(0.52); C72(0.52)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C66(0.38); C72(0.38)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C66(0.44); C72(0.44)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C66(0.58); C72(0.58)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C66(0.71); C72(0.71)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C66(0.68); C72(0.68)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C66(0.44); C72(0.44)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C383(0.57); C66(0.85); C72(0.85)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C383(0.56); C66(0.68); C72(0.68)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C72(0.75)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C66(0.48); C72(0.48); C383(0.63)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C383(0.69); C66(0.96); C72(0.96)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C383(0.65); C66(0.79); C72(0.79)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C66(0.44); C72(0.44); C383(0.73)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C66(0.48); C72(0.48); C383(0.74)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C66(0.51); C72(0.51); C383(0.74)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C66(0.62); C72(0.62); C383(0.74)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C383(0.62); C66(0.63); C72(0.63)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C383(0.69); C66(0.75); C72(0.75)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C383(0.61); C66(0.89); C72(0.89)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C72(0.67)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C66(0.71); C72(0.71); C383(0.79)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C383(0.79); C66(0.96); C72(0.96)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C66(0.53); C72(0.53); C383(0.74)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C347(0.87); C72(0.61)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C347(1.24); C72(2.37)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C347(1.07); C72(1.41)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C347(1.01); C72(1.28)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C347(0.99); C72(0.85)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C347(0.86); C72(1.09)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C347(1.08); C72(1.17)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C347(1.38); C72(1.55)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C347(1.34); C72(1.05)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C347(1.33); C72(1.31)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C347(0.89); C72(1.06)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C347(1.15); C72(0.98)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C347(1.06); C72(0.97)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C347(1.30); C72(1.43)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C347(3.00); C72(1.89)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C66(0.73); C72(0.73)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C66(0.64); C72(0.64)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C72(0.76)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C72(0.73)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C72(0.56)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 8.88  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C214(1.90)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C383(1.08); C66(1.14); C72(1.14)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C66(0.59); C72(0.59); C383(1.23)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C383(0.99)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C72(0.89)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C72(0.43)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C72(0.90)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C72(0.99)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C72(0.65)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C72(0.54)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C72(0.55)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C72(0.51)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C72(0.55)  LDD0976  [6]
 LDCM0379  CL11 HCT 116 C66(0.54); C72(0.54); C383(1.24)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C72(0.50)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C72(0.63)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C347(1.35); C383(1.29)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C347(1.47); C383(1.37)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C347(1.49); C383(1.00)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C347(1.53); C383(1.51)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C347(1.24); C383(1.07)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C383(0.67)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C383(0.52)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C383(0.65)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C66(0.50); C72(0.50); C383(1.01)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C383(0.83)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C383(1.74); C72(0.59)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C383(1.64); C72(0.61)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C383(1.19); C72(0.53)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C383(1.61); C72(0.60)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C66(0.75); C72(0.75)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C66(0.64); C72(0.64)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C66(0.81); C72(0.81)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C66(0.55); C72(0.55)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C66(0.55); C72(0.55); C383(1.52)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C66(0.89); C72(0.89); C383(1.39)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C66(0.58); C72(0.58); C383(1.29)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C66(0.78); C72(0.78)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C66(0.63); C72(0.63)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C66(0.49); C72(0.49)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C66(0.62); C72(0.62)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C66(0.90); C72(0.90); C383(1.33)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C66(0.59); C72(0.59)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C66(0.47); C72(0.47)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C66(0.44); C72(0.44)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C66(0.74); C72(0.74)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C66(0.44); C72(0.44)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C66(0.51); C72(0.51)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C66(0.57); C72(0.57)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C66(0.72); C72(0.72)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C66(0.61); C72(0.61)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C66(0.52); C72(0.52)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C383(1.10); C66(0.98); C72(0.98)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C66(0.67); C72(0.67)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C383(0.86); C66(0.60); C72(0.60)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C383(0.67); C66(0.52); C72(0.52)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C383(0.85); C66(0.54); C72(0.54)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C383(0.73); C66(0.41); C72(0.41)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C383(0.78); C66(0.45); C72(0.45)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C383(1.02); C66(0.48); C72(0.48)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C383(0.99); C66(0.71); C72(0.71)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C383(0.73); C66(0.50); C72(0.50)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C383(1.41); C66(0.71); C72(0.71)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C383(0.96); C66(0.44); C72(0.44)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C383(1.00); C66(0.63); C72(0.63)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C383(0.75); C66(0.38); C72(0.38)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C383(0.71); C66(0.36); C72(0.36)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C383(0.63); C66(0.53); C72(0.53)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C383(0.71); C66(0.47); C72(0.47)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C347(1.35)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C347(1.19)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C347(1.14)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C347(1.05)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C383(1.25); C66(1.10); C72(1.10)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C347(1.43)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C347(0.99)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C347(0.77)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C347(0.83)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C347(0.99)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C347(1.31)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C347(0.84)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C347(1.10)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C347(0.85)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C347(1.30)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C383(1.19); C66(0.67); C72(0.67)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C347(1.57)  LDD1050  [6]
 LDCM0453  CL61 PaTu 8988t C66(0.69); C72(0.69)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C66(1.18); C72(1.18)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C66(1.36); C72(1.36)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C66(1.12); C72(1.12)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C66(1.01); C72(1.01)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C66(1.08); C72(1.08)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C66(0.72); C72(0.72)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C66(0.54); C72(0.54)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C66(0.60); C72(0.60)  LDD1340  [6]
 LDCM0462  CL7 HCT 116 C383(1.17); C66(0.59); C72(0.59)  LDD0779  [6]
 LDCM0463  CL70 PaTu 8988t C66(0.62); C72(0.62)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C66(1.38); C72(1.38)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C66(1.84); C72(1.84)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C66(0.65); C72(0.65)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C66(0.82); C72(0.82)  LDD1346  [6]
 LDCM0469  CL76 HCT 116 C66(0.62); C72(0.62)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C66(0.71); C72(0.71)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C66(0.59); C72(0.59)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C66(0.53); C72(0.53)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C383(1.02); C66(0.59); C72(0.59)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C66(0.79); C72(0.79)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C66(0.65); C72(0.65)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C66(0.42); C72(0.42)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C66(0.53); C72(0.53)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C66(0.40); C72(0.40)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C66(0.61); C72(0.61)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C66(0.66); C72(0.66)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C66(0.75); C72(0.75)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C66(0.49); C72(0.49)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C66(0.42); C72(0.42)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C383(1.17); C66(0.65); C72(0.65)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C66(1.17); C72(1.17)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C383(0.89)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C383(1.07)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C383(1.16)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C383(0.98)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C383(1.32)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C383(1.25)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C383(1.14)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C383(0.96)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C383(0.95)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C88(1.08)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C569(1.77)  LDD1702  [12]
 LDCM0468  Fragment33 PaTu 8988t C66(0.85); C72(0.85)  LDD1347  [6]
 LDCM0427  Fragment51 HCT 116 C383(0.75); C66(0.37); C72(0.37)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C214(1.19)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C214(1.05)  LDD1497  [11]
 LDCM0024  KB05 G361 C156(2.25)  LDD3311  [13]
 LDCM0109  NEM HeLa N.A.  LDD0224  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myotubularin-related protein 9 (MTMR9) Protein-tyrosine phosphatase family Q96QG7
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
N-myc-interactor (NMI) NMI family Q13287

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840