Details of the Target

General Information of Target

Target ID LDTP13646
Target Name LINE-1 retrotransposable element ORF1 protein (L1RE1)
Gene Name L1RE1
Synonyms
LRE1; LINE-1 retrotransposable element ORF1 protein; L1ORF1p; LINE retrotransposable element 1; LINE1 retrotransposable element 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSAD
PQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLS
SDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAML
FEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLP
VTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPK
APELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQL
LHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRN
SSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARL
SRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMS
SSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYR
YSEDEDSEGEEKSDGELVVLTD
Target Bioclass
Enzyme
Family
Transposase 22 family
Subcellular location
Nucleus, nucleolus
Function
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Uniprot ID
Q9UN81

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y52(28.02); Y152(61.70); Y329(34.86)  LDD3495  [1]
DBIA
 Probe Info  		C76(0.91)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
W1
 Probe Info  		E324(0.00); R325(0.00)  LDD0236  [6]
NAIA_5
 Probe Info  		C76(0.00); C111(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C76(0.99); C111(1.04)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C111(0.97)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C111(1.08)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C111(1.06)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C111(1.03)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C111(1.14)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C111(1.17)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C111(0.80)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C111(1.14)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C111(0.66)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C111(0.73)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C111(0.61)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C111(0.92)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C111(0.80)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C111(0.82)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C111(0.79)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C111(1.14)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C111(0.70)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C111(0.67)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C111(0.78)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C111(0.54)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C111(0.66)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C111(0.71)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C111(0.84)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C111(0.63)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C111(0.69)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C111(0.68)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C111(0.98)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C111(0.59)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C111(0.73)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C111(0.77)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C111(0.70)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C111(0.93)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C111(0.81)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C111(1.35)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C111(1.24)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C111(1.19)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C111(1.48)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C111(0.81)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C111(1.04)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C111(0.91)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C111(1.29)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C111(1.09)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C111(1.22)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C111(0.99)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C111(1.13)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C111(1.01)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C111(0.99)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C111(1.18)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C111(1.20)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C111(1.23)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C111(1.17)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C76(0.95); C111(1.09)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C111(1.12)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C111(1.10)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C111(1.20)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C111(0.93)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C111(0.79)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C111(0.92)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C111(0.98)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C111(0.76)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C111(0.88)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C111(0.97)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C76(0.98); C111(1.10)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C111(1.03)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C111(0.95)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C111(0.99)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C111(0.81)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C111(0.64)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C111(0.86)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C111(0.85)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C111(0.81)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C111(1.02)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C111(1.28)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C111(1.07)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C111(0.93)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C111(0.95)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C111(0.87)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C111(1.09)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C111(0.87)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C111(1.01)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C111(1.07)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C111(0.98)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C111(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C111(1.06)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C76(0.99)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C111(1.07)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C111(0.91)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C111(0.87)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C111(0.79)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C111(1.01)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C111(0.86)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C111(0.96)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C76(1.01); C111(1.11)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C76(0.95); C111(1.05)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C76(0.97); C111(1.19)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C111(0.86)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C111(0.95)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C76(1.03)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C76(1.00)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C111(1.12)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C76(1.02); C111(1.07)  LDD1567  [8]
 LDCM0332  AC68 HCT 116 C111(0.87)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C111(0.69)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C111(0.95)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C111(0.60)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C111(0.76)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C111(0.82)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C111(0.62)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C111(0.58)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C111(0.71)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C111(0.66)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C111(0.65)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C111(0.67)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C111(0.73)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C111(1.17)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C111(0.67)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C111(0.55)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C111(0.78)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C111(1.38)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C111(1.42)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C111(1.63)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C111(1.31)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C111(1.62)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C111(1.47)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C111(1.25)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C111(1.45)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C111(1.54)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C111(1.54)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C111(1.49)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C111(1.24)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C111(1.53)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C111(1.20)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C111(1.57)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C111(1.45)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C111(1.49)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C111(1.00)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C111(0.81)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C111(0.99)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C76(0.91)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C76(0.53)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C76(1.06)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C76(0.90)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C76(1.03)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C111(0.96)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C111(0.80)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C111(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C111(1.06)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C111(1.00)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C111(1.04)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C111(1.26)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C111(1.19)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C111(1.24)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C111(1.13)  LDD1583  [8]
 LDCM0380  CL110 HCT 116 C111(1.17)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C111(1.29)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C111(0.96)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C111(0.79)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C111(0.74)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C111(0.75)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C111(0.77)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C111(1.10)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C111(1.08)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C111(1.06)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C76(1.01); C111(1.08)  LDD1594  [8]
 LDCM0391  CL120 HCT 116 C111(1.30)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C111(1.02)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C111(0.91)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C111(0.80)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C111(0.87)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C76(0.87)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C76(0.99)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C76(0.95); C111(1.00)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C76(0.95)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C76(0.94)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C76(1.02)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C76(1.07); C111(0.97)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C76(1.07)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C76(1.00); C111(1.10)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C76(1.12); C111(1.04)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C76(1.11); C111(1.20)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C76(0.95)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C111(1.14)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C76(0.89)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C76(0.91)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C111(1.24)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C76(0.98); C111(1.01)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C76(0.90)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C76(0.99)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C76(1.08); C111(1.12)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C76(0.92)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C76(1.10); C111(1.11)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C76(0.96); C111(1.03)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C76(1.15); C111(1.09)  LDD1623  [8]
 LDCM0420  CL31 HCT 116 C111(0.90)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C111(1.09)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C111(1.82)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C111(1.16)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C111(0.76)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C111(1.24)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C111(0.83)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C111(1.11)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C76(1.05)  LDD1633  [8]
 LDCM0430  CL40 HCT 116 C111(1.32)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C111(1.18)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C111(1.04)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C111(1.30)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C111(1.30)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C111(1.17)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C76(0.85)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C111(1.16)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C76(0.96); C111(1.01)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C76(0.91)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C76(1.06); C111(1.12)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C76(1.02)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C76(1.14)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C76(1.08); C111(1.23)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C76(1.06); C111(1.29)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C76(1.12); C111(1.18)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C111(1.14)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C76(0.96)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C76(1.00)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C111(1.23)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C76(0.95); C111(1.00)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C76(1.04); C111(1.10)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C76(0.92)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C76(1.10)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C76(0.95); C111(1.15)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C76(1.11)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C76(1.10); C111(1.22)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C76(1.03); C111(1.18)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C76(1.12); C111(1.16)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C111(1.06)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C76(0.94)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C76(1.09); C111(1.07)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C76(1.06)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C111(1.40)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C76(1.03); C111(1.09)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C76(0.91)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C76(0.95)  LDD1670  [8]
 LDCM0469  CL76 HCT 116 C111(1.04)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C111(1.15)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C111(0.92)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C111(0.84)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C111(0.75)  LDD1676  [8]
 LDCM0474  CL80 HCT 116 C111(1.12)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C111(0.73)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C111(1.63)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C111(0.87)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C111(0.95)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C111(0.87)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C111(0.70)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C111(0.61)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C111(0.94)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C111(0.76)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C76(0.89)  LDD1687  [8]
 LDCM0485  CL90 HCT 116 C111(0.58)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C76(1.21); C111(1.16)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C111(1.14)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C76(1.09)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C76(0.88)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C111(1.13)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C76(0.96); C111(0.98)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C76(0.96)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C76(1.03)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C76(0.89); C111(0.98)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C76(0.96); C111(0.99)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C76(1.16); C111(0.97)  LDD1671  [8]
 LDCM0427  Fragment51 HCT 116 C111(0.64)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C111(0.95); C76(1.05)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C111(0.92); C76(1.12)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C76(1.21)  LDD3310  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Regulator of nonsense transcripts 1 (UPF1) DNA2/NAM7 helicase family Q92900
LINE-1 retrotransposable element ORF1 protein (L1RE1) Transposase 22 family Q9UN81

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840