Details of the Target

General Information of Target

Target ID LDTP13341
Target Name Adenine DNA glycosylase (MUTYH)
Gene Name MUTYH
Gene ID 4595
Synonyms
MYH; Adenine DNA glycosylase; EC 3.2.2.31; MutY homolog; hMYH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTFKEAVTFKDVAVFFTEEELGLLDPAQRKLYQDVMLENFTNLLSVGHQPFHPFHFLRE
EKFWMMETATQREGNSGGKTIAEAGPHEDCPCQQIWEQTASDLTQSQDSIINNSHFFEQG
DVPSQVEAGLSIIHTGQKPSQNGKCKQSFSDVAIFDPPQQFHSGEKSHTCNECGKSFCYI
SALRIHQRVHLREKLSKCDMRGKEFSQSSCLQTRERVHTGEKPFKCEQCGKGFRCRAILQ
VHCKLHTGEKPYICEKCGRAFIHDFQLQKHQIIHTGEKPFKCEICGKSFCLRSSLNRHCM
VHTAEKLYKSEECGKGFTDSLDLHKHQIIHTGQKPYNCKECGKSFRWSSYLLIHQRIHSG
EKPYRCEECGKGYISKSGLNLHQRVHTGERPYNCKECGKSFSRASSILNHKKLHCRKKPF
KCEDCGKRLVHRSFCKDQQGDHNGENSSKCEDCGKRYKRRLNLDIILSLFLNDM
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Nth/MutY family
Subcellular location
Nucleus
Function
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
TTD ID
T66743
Uniprot ID
Q9UIF7
DrugMap ID
TTNB0ZK
Ensemble ID
ENST00000354383.10
HGNC ID
HGNC:7527

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C514(143.62)  LDD0209  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C514(0.23)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C514(0.53)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C502(0.89)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C502(0.95)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C502(0.99)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C502(1.11)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C502(0.99)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C502(0.94)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C502(1.08)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C502(0.93)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C502(0.99)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C502(0.99)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C514(0.61)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C502(0.97)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C502(0.96)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C502(1.10)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C514(0.77)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C514(0.63)  LDD0576  [5]
 LDCM0263  AC143 PaTu 8988t C502(1.00)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C502(0.89)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C502(1.01)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C502(0.74)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C502(0.79)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C502(1.13)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C502(1.46)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C514(0.40)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C502(0.93)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C502(0.90)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C502(0.88)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C502(1.21)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C502(0.95)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C502(0.97)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C502(1.08)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C502(0.91)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C514(0.40); C502(1.00)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C514(0.52); C502(1.33)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C514(0.44); C502(1.10)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C514(0.31)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C514(0.84); C502(0.91)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C514(0.43); C502(0.93)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C514(0.33); C502(1.29)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C514(0.24); C502(1.38)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C514(0.21); C502(1.14)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C502(0.69)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C502(0.73)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C502(0.68)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C502(0.64)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C502(0.79)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C514(0.49)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C502(0.98)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C502(0.63)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C502(0.57)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C502(0.73)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C502(0.89)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C502(1.11)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C502(1.20)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C502(1.18)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C502(1.12)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C502(1.10)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C514(0.23)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C502(1.40)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C502(1.28)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C502(1.18)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C502(1.26)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C502(1.48)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C502(1.43)  LDD0624  [5]
 LDCM0312  AC5 HCT 116 C514(0.39)  LDD0629  [5]
 LDCM0320  AC57 HCT 116 C502(0.99)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C502(0.81)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C502(1.14)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C514(0.73)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C502(1.00)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C502(0.80)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C502(1.03)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C502(1.08)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C502(1.09)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C502(0.94)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C502(1.02)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C502(1.00)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C514(0.80); C502(0.92)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C514(0.78); C502(0.84)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C514(0.54)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C514(0.78); C502(0.95)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C502(0.77); C514(1.12)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C502(0.93); C514(1.24)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C502(1.01); C514(1.03)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C502(0.90); C514(1.01)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C502(1.00); C514(1.25)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C514(0.94); C502(1.08)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C514(0.78); C502(0.92)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C514(0.77); C502(0.94)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C514(0.67); C502(0.94)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C514(0.64)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C514(0.82); C502(0.96)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C514(0.83); C502(0.97)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C502(0.95); C514(1.80)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C514(0.96)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C514(1.40)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C514(0.98)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C514(0.90)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C514(0.67)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C514(0.98)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C514(1.06)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C514(1.13)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C514(0.90)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C514(0.71)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C514(0.74)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C514(0.84)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C514(0.79)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C514(0.81)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C514(1.10)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C502(1.08)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C502(1.07)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C514(0.69)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C514(0.58)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C514(0.52)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C514(1.17)  LDD2171  [5]
 LDCM0367  CL1 HCT 116 C514(0.99); C502(1.08)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C514(0.74); C502(0.97)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C514(0.72)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C514(0.67)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C514(0.57)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C514(0.44)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C514(0.56)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C514(0.69); C502(1.13)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C514(0.56); C502(1.36)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C514(0.59); C502(1.27)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C514(0.67); C502(1.12)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C514(0.13); C502(1.36)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C514(0.97); C502(1.07)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C514(0.22); C502(1.14)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C514(0.15); C502(1.37)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C502(0.61)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C502(0.61)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C502(0.83)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C502(0.72)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C502(0.73)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C502(1.33)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C502(1.15)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C502(1.15)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C514(0.61); C502(1.04)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C502(1.14)  LDD0708  [5]
 LDCM0396  CL125 HCT 116 C502(1.09)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C502(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C502(1.05)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C502(0.88)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C514(0.72); C502(0.81)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C514(0.65); C502(0.92)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C514(0.57); C502(0.91)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C514(0.93); C502(1.05)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C502(0.92); C514(1.31)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C502(0.87); C514(1.05)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C502(0.88); C514(0.96)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C514(0.95); C502(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C502(0.82); C514(0.99)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C502(0.96); C514(1.25)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C514(0.91); C502(0.97)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C502(0.92); C514(1.39)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C514(0.77); C502(0.89)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C502(1.02); C514(1.22)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C502(1.13); C514(1.00)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C502(0.78); C514(0.80)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C502(0.95); C514(1.14)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C502(0.89); C514(0.75)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C502(0.92); C514(0.70)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C502(0.95); C514(0.93)  LDD0736  [5]
 LDCM0421  CL32 HCT 116 C502(1.07); C514(0.97)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C502(1.03); C514(1.26)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C502(0.87); C514(1.21)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C502(1.08); C514(0.67)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C502(0.74); C514(0.71)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C502(0.87); C514(0.71)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C502(1.03); C514(0.88)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C502(0.84); C514(0.73)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C502(1.26); C514(1.00)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C502(0.79); C514(0.88)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C502(1.03); C514(0.80)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C502(0.83); C514(0.71)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C502(1.00); C514(0.74)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C502(0.94); C514(0.83)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C502(0.95)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C502(0.77)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C502(0.78)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C502(0.82)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C502(0.80); C514(0.73)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C502(0.78)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C502(0.81)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C502(1.09)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C502(0.95)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C502(0.91)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C502(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C502(0.80)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C502(0.71)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C502(0.85)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C502(0.81)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C502(0.97); C514(0.76)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C502(0.76)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C502(1.02)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C502(1.09)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C502(1.00)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C502(0.83)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C502(0.98)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C502(0.87)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C502(0.92)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C502(0.89)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C502(1.11)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C502(0.85); C514(0.65)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C502(0.88)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C502(1.00)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C502(1.03)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C502(0.87)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C502(1.01)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C502(0.98); C514(0.66)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C502(0.79); C514(0.45)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C502(0.90); C514(0.64)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C502(0.97); C514(0.61)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C502(1.55); C514(1.30)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C502(0.83); C514(0.45)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C502(0.91); C514(0.42)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C502(0.89); C514(0.61)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C502(0.85); C514(0.57)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C502(0.90); C514(0.50)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C502(1.05); C514(0.54)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C502(0.86); C514(0.50)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C502(0.89); C514(0.45)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C502(0.88); C514(0.39)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C502(0.85); C514(0.47)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C502(0.97); C514(0.75)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C502(0.98); C514(0.58)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C514(0.82)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C514(0.96)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C514(0.85)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C514(1.35)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C514(0.91)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C514(0.72)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C514(0.98)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C514(0.90)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C514(0.78)  LDD0811  [5]
 LDCM0625  F8 Ramos C502(1.88)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C514(1.77); C502(1.42)  LDD2189  [6]
 LDCM0574  Fragment12 Ramos C514(1.09); C502(0.77)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C514(1.06); C502(1.31)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C514(1.60); C502(1.10)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C514(1.08)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C514(1.17); C502(1.14)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C514(0.81); C502(0.97)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C514(0.93); C502(0.99)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C514(1.02); C502(1.20)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C514(0.95); C502(1.22)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C514(0.86); C502(1.15)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C514(1.55); C502(1.34)  LDD2201  [6]
 LDCM0468  Fragment33 HCT 116 C502(0.81)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C514(0.99); C502(1.70)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C514(1.01)  LDD2184  [6]
 LDCM0427  Fragment51 HCT 116 C502(1.18); C514(1.05)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C514(1.18)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C514(1.68)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C502(1.17)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C514(1.34)  LDD2188  [6]
 LDCM0022  KB02 T cell-activated C514(5.68)  LDD1704  [7]
 LDCM0023  KB03 Jurkat C514(143.62)  LDD0209  [1]
 LDCM0024  KB05 MOLM-16 C514(1.70)  LDD3334  [8]
 LDCM0021  THZ1 HCT 116 C514(1.17)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840