Details of the Target

General Information of Target

Target ID LDTP13322
Target Name Importin-11 (IPO11)
Gene Name IPO11
Gene ID 51194
Synonyms
RANBP11; Importin-11; Imp11; Ran-binding protein 11; RanBP11
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA
VIIQEPLVLTEPTRNRLQKKGGKDKT
Target Bioclass
Transporter and channel
Family
Importin beta family
Subcellular location
Cytoplasm
Function
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12.
Uniprot ID
Q9UI26
Ensemble ID
ENST00000325324.11
HGNC ID
HGNC:20628

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.L459S DBIA    Probe Info 
IGROV1 Deletion: p.S807LfsTer22 .
Ishikawa (Heraklio) 02 ER Deletion: p.S807LfsTer22
SNV: p.D511G;p.I964V		 DBIA    Probe Info 
JHH1 Deletion: p.E812DfsTer13 DBIA    Probe Info 
KNS42 SNV: p.T742R .
LUDLU1 SNV: p.K334T .
MOLT4 Deletion: p.S807LfsTer22 IA-alkyne    Probe Info 
NUGC3 SNV: p.E364V DBIA    Probe Info 
OV90 SNV: p.Q973R DBIA    Probe Info 
SISO SNV: p.V44L DBIA    Probe Info 
SKMEL24 SNV: p.R118K DBIA    Probe Info 
TOV21G Deletion: p.S807LfsTer22 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.89  LDD0402  [1]
TH211
 Probe Info  		Y333(20.00); Y331(16.31); Y152(8.62)  LDD0257  [2]
STPyne
 Probe Info  		K216(6.27)  LDD0277  [3]
BTD
 Probe Info  		C262(2.20)  LDD1700  [4]
DBIA
 Probe Info  		C252(7.78)  LDD0204  [5]
HHS-475
 Probe Info  		Y331(0.57); Y938(1.17)  LDD0264  [6]
HHS-465
 Probe Info  		Y938(10.00)  LDD2237  [7]
ATP probe
 Probe Info  		K220(0.00); K268(0.00); K156(0.00); K216(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C621(0.00); C894(0.00); C868(0.00); C366(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C621(0.00); C252(0.00); C366(0.00); C521(0.00)  LDD0036  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C621(0.00); C894(0.00); C252(0.00); C366(0.00)  LDD0037  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		C894(0.00); C262(0.00); C252(0.00)  LDD0005  [11]
TFBX
 Probe Info  		C252(0.00); C262(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Acrolein
 Probe Info  		C262(0.00); H80(0.00)  LDD0217  [13]
AOyne
 Probe Info  		14.10  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.71  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe3
 Probe Info  		8.61  LDD0465  [15]
JN0003
 Probe Info  		6.17  LDD0469  [15]
STS-1
 Probe Info  		N.A.  LDD0137  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]
OEA-DA
 Probe Info  		3.20  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C262(1.03)  LDD2117  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C521(2.28)  LDD0372  [19]
 LDCM0214  AC1 HEK-293T C262(1.19); C252(0.98); C894(0.99); C586(1.03)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C262(1.09); C252(1.03); C894(1.02); C586(0.84)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C262(1.07); C252(1.06); C894(1.03); C586(0.91)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C262(1.01); C252(1.07); C894(1.00); C586(0.92)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C262(0.93); C252(1.03); C894(1.01); C586(0.98)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C262(0.93); C252(1.00); C894(1.05); C586(0.98)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C262(1.10); C252(1.04); C894(1.02); C586(0.97)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C262(1.15); C252(0.98); C894(1.03); C586(0.88)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C262(1.04); C252(1.48); C894(1.17); C586(0.90)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C262(1.08); C252(1.05); C894(1.03); C586(0.93)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C262(0.98); C252(1.02); C894(0.99); C586(0.98)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C262(1.06); C252(1.01); C894(1.00); C586(0.94)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C262(0.92); C252(1.02); C894(0.99); C586(1.03)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C262(1.02); C252(1.01); C894(1.01); C586(0.96)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C262(0.98); C252(0.95); C894(0.93); C586(0.99)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C262(1.06); C252(1.02); C894(1.01); C586(0.97)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C262(1.00); C252(1.02); C894(1.00); C586(0.88)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C262(1.00); C252(0.97); C894(1.02); C586(0.85)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C262(1.05); C252(1.02); C894(0.98); C586(0.89)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C262(1.09); C252(1.06); C894(0.98); C586(0.91)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C262(1.05); C252(0.94); C894(0.99); C586(0.99)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C262(0.94); C252(0.97); C894(0.99); C586(0.93)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C262(1.01); C252(0.99); C894(1.02); C586(0.94)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C262(0.99); C252(0.95); C894(0.99); C586(0.99)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C262(1.07); C252(1.05); C894(0.98); C586(0.99)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C262(1.15); C252(1.06); C894(1.05); C586(0.96)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C262(1.09); C252(0.96); C894(0.97); C586(0.96)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C262(0.95); C252(1.07); C894(0.97); C586(0.98)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C262(0.98); C252(0.95); C894(0.97); C586(0.94)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C262(0.94); C252(0.98); C894(0.96); C586(0.98)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C262(0.98); C252(0.98); C894(1.03); C586(1.02)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C262(0.96); C252(1.03); C894(0.98); C586(0.93)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C262(1.08); C252(0.93); C894(0.97); C586(1.13)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C262(1.05); C252(1.04); C894(1.02); C586(1.00)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C262(1.22); C252(1.08); C894(1.04); C586(0.89)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C262(1.10); C252(1.01); C894(1.00); C586(0.95)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C262(1.03); C252(1.03); C894(0.98); C586(0.90)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C262(0.99); C252(1.02); C894(0.98); C586(0.86)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C262(1.00); C252(0.99); C894(0.97); C586(1.05)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C262(0.99); C252(0.97); C894(1.01); C586(0.89)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C262(0.96); C252(0.97); C894(0.96); C586(1.01)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C262(1.07); C252(0.99); C894(1.02); C586(1.00)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C262(0.96); C252(0.98); C894(0.97); C586(0.92)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C262(1.04); C252(0.97); C894(1.03); C586(0.94)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C262(1.05); C252(1.04); C894(0.97); C586(0.99)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C262(1.03); C252(1.12); C894(1.00); C586(1.01)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C262(1.02); C252(1.05); C894(1.00); C586(0.90)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C262(0.97); C252(1.03); C894(1.03); C586(0.98)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C262(0.92); C252(0.97); C894(1.02); C586(0.94)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C262(0.98); C252(0.97); C894(0.96); C586(0.99)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C262(1.02); C252(1.08); C894(1.00); C586(1.06)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C262(1.11); C252(1.09); C894(1.02); C586(0.92)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C262(1.06); C252(1.01); C894(0.95); C586(0.93)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C262(1.03); C252(1.00); C894(1.04); C586(0.94)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C262(1.03); C252(1.02); C894(0.98); C586(0.92)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C262(1.07); C252(1.07); C894(0.99); C586(0.97)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C262(0.94); C252(1.03); C894(0.97); C586(0.93)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C262(1.06); C252(0.95); C894(1.03); C586(1.01)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C262(1.01); C252(0.85); C894(0.94); C586(0.91)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C262(0.95); C252(0.97); C894(1.05); C586(0.98)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C262(0.94); C252(0.96); C894(0.97); C586(0.97)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C262(0.99); C252(0.99); C894(1.02); C586(0.88)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C262(1.08); C252(1.01); C894(1.00); C586(0.95)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C262(1.01); C252(1.02); C894(1.00); C586(1.01)  LDD1514  [20]
 LDCM0102  BDHI 8 Jurkat C252(7.78)  LDD0204  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C262(0.98); C252(1.08); C894(1.08); C586(1.09)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C262(2.08); C252(1.23); C894(1.47); C586(2.10)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C262(1.02); C252(0.94); C894(1.02); C586(1.09)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C262(1.02); C252(1.00); C894(1.03); C586(1.07)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C262(1.23); C252(1.12); C894(1.13); C586(1.50)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C262(0.91); C252(1.05); C894(1.01); C586(0.95)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C262(0.97); C252(0.98); C894(0.99); C586(0.91)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C262(1.00); C252(1.04); C894(1.03); C586(1.06)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C262(1.07); C252(1.08); C894(1.10); C586(1.11)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C262(0.95); C252(1.07); C894(0.98); C586(0.99)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C262(0.99); C252(0.99); C894(0.97); C586(0.94)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C262(1.01); C252(0.90); C894(1.10); C586(1.19)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C262(1.25); C252(1.10); C894(1.18); C586(1.80)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C262(1.22); C252(1.18); C894(1.29); C586(1.64)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C262(0.97); C252(1.06); C894(1.06); C586(1.26)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C262(1.02); C252(0.97); C894(1.02); C586(1.14)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C262(1.00); C252(0.96); C894(0.98); C586(1.01)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C262(1.40); C252(1.11); C894(1.10); C586(1.69)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C262(0.99); C252(1.01); C894(1.00); C586(0.98)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C262(0.95); C252(0.96); C894(0.93); C586(0.99)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C262(0.98); C252(1.07); C894(0.98); C586(0.96)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C262(1.00); C252(1.12); C894(1.01); C586(0.95)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C262(0.87); C252(1.01); C894(0.97); C586(0.85)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C262(1.41); C252(1.02); C894(1.03); C586(1.60)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C262(0.97); C252(0.94); C894(0.94); C586(0.92)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C262(1.03); C252(1.06); C894(1.00); C586(1.09)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C262(1.07); C252(1.08); C894(1.07); C586(1.02)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C262(1.00); C252(1.15); C894(1.21); C586(1.15)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C262(1.08); C252(1.00); C894(1.12); C586(1.17)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C262(1.00); C252(0.99); C894(0.99); C586(1.03)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C262(1.07); C252(1.12); C894(1.01); C586(1.02)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C262(0.93); C252(1.00); C894(0.98); C586(0.91)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C262(0.95); C252(1.03); C894(0.92); C586(0.95)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C262(0.95); C252(1.04); C894(1.08); C586(1.02)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C262(0.97); C252(0.93); C894(0.99); C586(1.05)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C262(0.87); C252(1.40); C894(1.25); C586(2.32)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C262(0.91); C252(0.93); C894(0.96); C586(0.92)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C262(0.98); C252(1.22); C894(1.40); C586(2.56)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C262(1.09); C252(0.95); C894(1.07); C586(1.14)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C262(1.06); C252(1.03); C894(1.07); C586(1.28)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C262(1.00); C252(0.87); C894(1.03); C586(1.11)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C262(1.06); C252(1.02); C894(1.08); C586(1.87)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C262(1.48); C252(1.11); C894(1.46); C586(1.72)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C262(1.11); C252(0.96); C894(1.17); C586(1.59)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C262(1.00); C252(1.02); C894(1.14); C586(1.38)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C262(1.21); C252(0.93); C894(1.09); C586(1.54)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C262(0.99); C252(1.17); C894(1.04); C586(1.23)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C262(1.00); C252(1.01); C894(1.03); C586(0.86)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C262(0.99); C252(1.01); C894(0.98); C586(0.97)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C262(0.97); C252(0.93); C894(0.97); C586(0.87)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C262(1.03); C252(0.98); C894(1.02); C586(1.07)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C262(0.89); C252(1.01); C894(1.06); C586(1.10)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C262(1.03); C252(0.96); C894(1.04); C586(1.08)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C262(1.14); C252(0.99); C894(1.15); C586(1.07)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C262(1.04); C252(1.05); C894(1.08); C586(1.29)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C262(1.85); C252(1.34); C894(1.67); C586(1.55)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C262(1.24); C252(1.05); C894(1.20); C586(1.58)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C262(1.19); C252(0.92); C894(1.10); C586(1.63)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C262(1.54); C252(0.99); C894(1.14); C586(1.32)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C262(0.99); C252(0.94); C894(1.00); C586(1.15)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C262(0.92); C252(1.02); C894(1.04); C586(0.96)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C262(0.91); C252(1.02); C894(1.02); C586(1.07)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C262(0.91); C252(0.94); C894(0.93); C586(0.84)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C262(1.03); C252(1.04); C894(1.15); C586(1.14)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C262(1.08); C252(1.10); C894(1.03); C586(1.03)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C262(1.07); C252(0.93); C894(1.06); C586(1.06)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C262(1.13); C252(1.11); C894(1.06); C586(1.20)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C262(1.33); C252(1.05); C894(1.20); C586(1.09)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C262(1.12); C252(0.99); C894(1.11); C586(1.45)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C262(1.11); C252(1.00); C894(1.08); C586(1.52)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C262(1.47); C252(1.10); C894(1.09); C586(1.34)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C262(0.96); C252(1.01); C894(0.98); C586(0.98)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C262(0.99); C252(1.04); C894(1.03); C586(1.18)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C262(1.11); C252(0.99); C894(1.13); C586(1.14)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C262(0.99); C252(0.96); C894(0.96); C586(0.98)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C262(1.04); C252(1.12); C894(1.28); C586(1.40)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C262(1.99); C252(1.47); C894(1.43); C586(1.62)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C262(1.12); C252(1.07); C894(1.03); C586(1.20)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C262(1.05); C252(1.05); C894(1.04); C586(1.33)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C262(1.47); C252(1.14); C894(1.33); C586(1.29)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C262(1.10); C252(0.98); C894(1.18); C586(1.50)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C262(1.15); C252(1.01); C894(1.13); C586(1.49)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C262(1.80); C252(1.14); C894(1.27); C586(2.06)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C262(1.26); C252(1.00); C894(1.10); C586(1.41)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C262(0.94); C252(0.97); C894(0.94); C586(1.01)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C262(1.03); C252(0.95); C894(0.98); C586(1.00)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C262(0.89); C252(1.01); C894(0.96); C586(0.89)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C262(0.99); C252(1.04); C894(1.10); C586(1.45)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C262(1.02); C252(1.01); C894(0.99); C586(1.03)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C262(1.14); C252(1.05); C894(1.03); C586(1.04)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C262(1.10); C252(1.07); C894(1.03); C586(0.99)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C262(1.09); C252(1.04); C894(1.07); C586(1.21)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C262(1.20); C252(0.99); C894(1.15); C586(1.12)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C262(1.15); C252(1.06); C894(1.04); C586(1.28)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C262(1.17); C252(1.03); C894(1.12); C586(1.30)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C262(1.16); C252(1.03); C894(1.12); C586(1.63)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C262(1.13); C252(0.98); C894(1.04); C586(1.38)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C262(1.06); C252(0.98); C894(1.04); C586(1.40)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C262(0.96); C252(0.98); C894(0.99); C586(1.00)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C262(0.94); C252(1.00); C894(0.98); C586(0.88)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C262(1.10); C252(1.12); C894(1.24); C586(1.50)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C262(1.05); C252(1.01); C894(1.03); C586(1.07)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C262(1.06); C252(1.01); C894(1.03); C586(0.97)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C262(2.22); C252(1.45); C894(2.07); C586(10.25)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C262(0.95); C252(1.09); C894(1.01); C586(1.12)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C262(1.05); C252(1.02); C894(1.07); C586(1.13)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C262(1.02); C252(0.94); C894(1.06); C586(1.22)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C262(1.47); C252(0.98); C894(1.11); C586(1.45)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C262(1.74); C252(0.94); C894(1.11); C586(1.52)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C262(0.96); C252(1.05); C894(0.97); C586(1.11)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C262(1.02); C252(1.05); C894(0.96); C586(1.02)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C262(0.92); C252(1.04); C894(1.01); C586(0.96)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C262(0.90); C252(0.94); C894(1.01); C586(0.91)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C262(1.07); C252(1.01); C894(1.02); C586(1.00)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C262(1.13); C252(0.95); C894(1.13); C586(1.33)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C262(2.58); C252(1.96); C894(1.65); C586(2.16)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C262(1.12); C252(1.01); C894(0.99); C586(0.96)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C262(1.29); C252(1.10); C894(1.11); C586(1.15)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C262(1.22); C252(1.06); C894(1.14); C586(1.14)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C262(1.00); C252(0.94); C894(1.03); C586(1.32)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C262(3.09); C252(1.57); C894(1.52); C586(1.97)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C262(1.98); C252(0.96); C894(1.12); C586(1.76)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C262(1.04); C252(1.14); C894(1.15); C586(1.27)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C262(1.07); C252(1.03); C894(1.03); C586(1.09)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C262(1.03); C252(1.05); C894(1.00); C586(0.89)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C262(0.91); C252(1.03); C894(1.01); C586(0.88)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C894(7.86); C262(3.09)  LDD1702  [4]
 LDCM0625  F8 Ramos C252(1.40); C320(0.64); C262(0.61); C366(0.97)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C252(0.88); C320(0.51); C262(1.28); C366(1.45)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C252(0.34); C320(0.74); C366(0.88); C621(4.69)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C252(1.57); C320(0.74); C262(1.85); C366(0.82)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C252(0.84); C320(0.78); C262(0.89); C366(0.58)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C252(2.25); C320(1.23); C262(1.17); C366(1.92)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C252(1.48); C320(0.54); C262(1.29); C366(0.70)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C252(1.00); C320(0.74); C262(1.81); C366(0.52)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C252(0.99); C320(0.86); C262(1.62); C366(1.13)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C252(0.77); C320(0.79); C262(0.90); C366(0.44)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C252(0.78); C320(1.17); C262(0.69); C366(1.13)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C252(0.98); C320(0.69); C262(1.20); C366(0.67)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C252(0.94); C320(0.99); C262(1.45); C366(0.57)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C252(1.45); C320(0.41); C262(2.01); C366(0.71)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C262(0.97); C252(1.02); C894(0.98); C586(0.86)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C252(1.23); C320(0.45); C262(1.36); C366(0.95)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C252(2.21); C320(0.89); C262(1.49); C366(1.06)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C262(0.97); C252(1.01); C894(0.98); C586(0.95)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C252(0.97); C320(0.53); C262(1.33); C366(0.68)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C252(1.14); C320(0.61); C262(1.01); C366(0.86)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C252(1.80); C320(0.67); C262(1.18); C366(0.47)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C252(0.66); C320(0.71); C262(2.14); C366(0.86)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y331(0.57); Y938(1.17)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y938(0.63); Y331(2.19)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y938(0.44); Y331(0.92)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y331(0.31); Y938(0.86)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y331(1.06); Y938(1.64)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C262(0.66); C252(0.93); C894(0.89); C586(0.92)  LDD1492  [20]
 LDCM0023  KB03 Jurkat C252(18.77)  LDD0209  [5]
 LDCM0024  KB05 MKN-1 C661(2.00); C934(1.58); C302(1.68)  LDD3331  [22]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C262(0.86); C252(1.09)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C262(0.89)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C252(0.51)  LDD2109  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C262(2.13)  LDD2115  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C262(1.21); C252(0.81)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C262(1.13); C252(0.79)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C262(1.34)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C262(1.39)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C262(0.98)  LDD2133  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C262(1.92); C252(1.34)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C262(1.21); C252(0.96)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C262(2.20)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C252(0.96)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C252(0.87)  LDD2146  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C252(0.52)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C252(0.61); C262(0.42)  LDD2207  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic initiation factor 4A-II (EIF4A2) DEAD box helicase family Q14240
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.