Details of the Target

General Information of Target

Target ID LDTP13289
Target Name Sedoheptulokinase (SHPK)
Gene Name SHPK
Gene ID 23729
Synonyms
CARKL; Sedoheptulokinase; SHK; EC 2.7.1.14; Carbohydrate kinase-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAV
RTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAP
EGIRDKVSDWDEFLRQTLIGACSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLSTW
IVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHLKN
EAEWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKV
FDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQDFDWAD
YLKQCGAEAAPQRCFPPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEG
SKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARVYKQRKIAVVQPEKQVPSSRTVH
EGLRNQELNSTESVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLRE
VLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFC
RQTCIKLECCPNLFGPRMVLDKCSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACA
LKKASKRRKRRKNVFVHKKKRSSASVDNTPAGSPQGSGGEDEDDPDEGDDDSLSEGSTSE
QQDELQEESEMSEKKSCSSSPTQSEISTSLPPDRQRRKRELRTFSFSDDENKPPSPKEIR
IEVAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMD
LKLGPAIKLCHHIERIKFAFYEQFAN
Target Bioclass
Enzyme
Family
FGGY kinase family
Subcellular location
Cytoplasm
Function Acts as a modulator of macrophage activation through control of glucose metabolism.
Uniprot ID
Q9UHJ6
Ensemble ID
ENST00000225519.5
HGNC ID
HGNC:1492

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
Probe 1
 Probe Info  		Y164(18.92)  LDD3495  [2]
DBIA
 Probe Info  		C38(0.76)  LDD0531  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C38(0.00); C132(0.00); C187(0.00); C105(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C38(0.00); C132(0.00); C187(0.00); C105(0.00)  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		C132(0.00); C38(0.00)  LDD2156  [9]
AOyne
 Probe Info  		7.30  LDD0443  [10]
NAIA_5
 Probe Info  		C132(0.00); C72(0.00); C105(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C38(0.76)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C105(1.10)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C105(1.20)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C105(0.98)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C105(0.80)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C105(0.88)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C105(0.73)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C105(0.82)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C105(0.89)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C105(0.84)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C105(0.70)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C105(0.67)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C105(1.08)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C105(0.74)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C105(0.79)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C105(0.73)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C105(0.93)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C105(0.96)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C105(0.81)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C105(0.83)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C105(0.92)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C105(0.81)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C105(0.95)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C105(1.04)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C105(1.08)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C105(1.00)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C105(0.75)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C105(0.89)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C105(0.88)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C105(0.86)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C105(0.84)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C105(0.87)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C105(1.04)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C105(1.03)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C105(0.81)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C105(1.70)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C105(1.04)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C105(1.22)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C105(1.07)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C105(0.71)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C105(0.89)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C105(0.82)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C105(1.05)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C105(1.06)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C105(0.95)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C105(0.89)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C105(1.20)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C105(0.98)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C38(1.07); C105(2.27)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C105(0.76); C38(0.80)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C38(0.77); C105(1.17)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C38(0.91); C105(1.24)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C38(0.70); C105(1.52)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C105(0.42); C38(0.77)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C38(0.72); C105(1.46)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C105(0.98)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C38(0.72); C105(1.82)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C38(0.88); C105(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C38(0.78); C105(0.91)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C105(0.33); C38(0.92)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C105(1.21); C38(0.96)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C105(1.78); C38(0.76)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C105(1.14); C38(0.79)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C105(1.18); C38(0.87)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C105(0.64)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C105(0.49)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C105(0.67)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C38(0.77)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C105(0.57)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C105(0.63)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C105(0.54)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C105(0.61)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C105(0.47)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C38(0.95); C132(0.97); C187(0.97); C267(1.00)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C132(1.06); C72(1.03); C187(0.90); C267(0.93)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C132(1.07); C187(1.04); C267(1.03)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C132(1.00); C187(1.09); C267(0.88)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C38(0.93); C132(0.99); C72(1.03); C267(1.06)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C38(0.93)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C132(1.03); C72(1.01); C187(1.05); C267(0.94)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C132(1.03); C72(0.96); C187(0.92)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C38(1.02); C132(1.15); C72(0.94); C267(0.91)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C38(1.03); C132(0.95); C187(1.03); C267(0.92)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C132(0.94); C72(1.06); C187(1.00); C267(0.94)  LDD1534  [12]
 LDCM0296  AC35 HCT 116 C105(0.74)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C105(1.04)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C105(1.27)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C105(1.46)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C105(1.12)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C38(0.71)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C105(1.04)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C105(1.15)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C105(1.11)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C105(1.02)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C105(0.95)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C105(0.89)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C105(0.96)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C105(0.95)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C105(0.86)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C105(0.62)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C38(0.74)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C105(0.64)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C105(1.03)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C105(0.95)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C105(0.78)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C105(0.90)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C105(0.63)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C105(0.56)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C38(1.12)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C38(0.85)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C38(1.08)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C105(0.99)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C38(0.74)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C38(0.93)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C38(0.65)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C38(1.04)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C38(0.81)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C38(0.92)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C38(0.80)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C38(0.90)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C105(1.14)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C105(0.94)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C105(0.97)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C105(0.18)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C105(0.87)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C105(0.27)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C105(0.34)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C105(1.17)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C105(0.58)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C105(0.61)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C105(0.85)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C105(1.36)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C105(0.64)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C105(1.00)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C105(0.86)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C105(0.56)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C105(0.31)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C105(0.70)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C105(0.82)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C105(0.86)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C105(0.80)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C105(1.04)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C105(0.76)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C105(0.92)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C105(0.89)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C105(0.58)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C105(0.74)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C105(0.82)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C105(0.75)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C105(0.89)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C105(0.89)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C105(0.77)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C105(0.51)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C105(0.76)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C105(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C105(1.04)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C105(0.94)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C105(0.87)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C105(0.57)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C38(0.70)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C105(0.92)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C105(0.96)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C105(1.01)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C105(0.84)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C105(0.48)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C105(0.49)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C105(0.68)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C105(0.54)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C105(0.58)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C105(0.59)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C105(0.65)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C105(0.72)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C38(0.99); C132(0.97); C72(0.82); C187(1.24)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C38(0.99); C132(1.06)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C38(1.01); C132(0.94)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C132(0.78); C105(1.08); C72(0.95); C187(0.89)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C38(0.98); C132(0.87); C72(1.02); C187(1.07)  LDD1590  [12]
 LDCM0387  CL117 HCT 116 C105(0.32)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C105(0.97)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C105(1.04)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C105(0.76)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C105(1.25)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C105(1.13)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C105(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C105(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C105(0.82)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C38(0.97)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C38(0.81)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C38(0.94)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C38(0.98)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C105(0.85)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C105(0.76)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C105(0.55)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C105(0.71)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C105(0.88); C38(0.88)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C38(0.91); C105(0.94)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C38(0.76); C105(1.08)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C105(0.80)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C38(0.70); C105(0.96)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C105(0.78); C38(0.88)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C105(0.27); C38(0.89)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C38(0.81); C105(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C105(0.56); C38(0.93)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C105(0.87); C38(0.94)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C105(0.65); C38(0.87)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C105(1.41); C38(0.86)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C105(0.77); C38(0.99)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C105(1.15); C38(0.93)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C105(0.68)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C105(0.72); C38(0.98)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C105(1.15); C38(0.97)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C105(0.84)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C105(0.78)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C105(0.67)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C105(0.61)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C105(0.68)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C105(0.75)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C105(0.65)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C105(0.66)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C105(0.93)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C105(0.88)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C105(0.21)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C105(0.45)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C105(0.59)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C105(0.80)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C105(1.12)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C105(0.85)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C105(0.77)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C105(0.93)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C105(0.89)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C105(0.98)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C105(0.81)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C105(0.84)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C105(0.74)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C105(0.60)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C105(0.94)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C105(0.70)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C105(0.95)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C105(0.97)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C105(0.87)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C105(0.58)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C105(0.80)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C38(1.21); C132(1.13)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C38(1.15); C132(0.99)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C132(1.00); C105(0.92); C72(1.12); C187(0.77)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C38(1.01); C132(0.85); C72(0.89); C187(1.01)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C38(1.32); C132(0.96); C187(1.05); C267(0.94)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C132(0.97); C72(1.04); C187(0.96); C267(1.15)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C132(1.00); C187(1.08); C267(1.06)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C132(1.01); C187(0.96); C267(0.84)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C38(0.99); C132(1.03); C72(1.13); C267(1.52)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C105(0.79)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C132(1.06); C72(1.21); C187(1.05); C267(1.37)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C132(1.08); C72(1.14); C187(1.14)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C38(1.02); C132(1.06); C72(0.68); C267(1.33)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C38(1.03); C132(1.05)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C38(1.05); C132(0.99)  LDD1670  [12]
 LDCM0469  CL76 HCT 116 C105(1.17)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C105(0.87)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C105(1.71)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C105(1.23)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C105(0.96)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C105(0.50)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C105(0.69)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C105(0.79)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C105(0.69)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C105(0.36)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C105(0.79)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C105(1.08)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C105(0.85)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C105(0.78)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C105(0.26)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C105(0.98)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C105(1.07)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C38(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C38(0.83)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C38(0.81)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C38(0.85)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C38(0.59)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C38(0.64)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C38(0.79)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C38(0.69)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C38(0.71)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C132(1.01); C105(2.02); C72(0.92); C187(0.75)  LDD1698  [12]
 LDCM0625  F8 Ramos C105(1.01); C38(0.89)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C105(0.64); C38(1.31)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C105(0.73); C72(1.99)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C105(0.88); C38(1.98)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C105(0.78); C38(0.98)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C105(0.85); C38(0.60); C72(0.49)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C105(0.81); C38(2.26)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C105(0.80); C38(1.20)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C105(0.59); C38(1.15)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C105(0.81); C38(0.93)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C105(0.69); C38(0.75); C72(2.97)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C105(0.96); C38(1.05)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C105(0.77)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C105(0.69); C38(1.40)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C132(0.93); C105(0.82); C72(1.11); C187(0.89)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C105(0.87); C38(1.10)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C105(1.07); C38(1.60); C72(0.25)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C105(0.32)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C105(1.00); C38(1.01)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C105(0.91); C38(1.01)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C105(0.76); C38(1.31); C72(0.15)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C105(0.89); C38(2.05)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C132(1.01); C187(1.08)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C132(1.11); C187(0.89)  LDD1497  [12]
 LDCM0024  KB05 G361 C132(1.57)  LDD3311  [14]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840