Details of the Target

General Information of Target

Target ID LDTP13104
Target Name Origin recognition complex subunit 3 (ORC3)
Gene Name ORC3
Gene ID 23595
Synonyms
LATHEO; ORC3L; Origin recognition complex subunit 3; Origin recognition complex subunit Latheo
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIF
ITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG
Target Bioclass
Other
Family
ORC3 family
Subcellular location
Nucleus
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Uniprot ID
Q9UBD5
Ensemble ID
ENST00000257789.4
HGNC ID
HGNC:8489

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
SNU478 Insertion: p.C345FfsTer4 DBIA    Probe Info 
THP1 SNV: p.K616R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y482(20.00); Y527(20.00); Y608(20.00); Y607(11.06)  LDD0257  [2]
STPyne
 Probe Info  		K537(5.08)  LDD0277  [3]
BTD
 Probe Info  		C483(4.26)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C639(2.12)  LDD0170  [5]
DBIA
 Probe Info  		C639(6.86); C141(160.58)  LDD0209  [6]
HHS-475
 Probe Info  		Y527(0.96)  LDD0264  [7]
HHS-465
 Probe Info  		Y527(10.00)  LDD2237  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C561(0.00); C363(0.00); C639(0.00); C483(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C561(0.00); C10(0.00); C363(0.00); C639(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C561(0.00); C10(0.00); C639(0.00); C363(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
IPM
 Probe Info  		C483(0.00); C159(0.00); C158(0.00); C363(0.00)  LDD0005  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
TFBX
 Probe Info  		C639(0.00); C483(0.00); C561(0.00); C363(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C561(0.00); C363(0.00); C483(0.00); C141(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		8.30  LDD0443  [16]
NAIA_5
 Probe Info  		C141(0.00); C561(0.00); C10(0.00); C363(0.00)  LDD2223  [10]
HHS-482
 Probe Info  		Y482(0.74)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C322
 Probe Info  		5.94  LDD1988  [17]
JN0003
 Probe Info  		12.73  LDD0469  [18]
STS-1
 Probe Info  		N.A.  LDD0136  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]
OEA-DA
 Probe Info  		7.30  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C639(1.03); C483(1.09); C363(1.09)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C639(1.28)  LDD2152  [4]
 LDCM0025  4SU-RNA DM93 C639(2.12)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C561(2.13)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C483(0.98); C561(0.95); C363(0.91); C272(1.17)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C483(1.04); C561(0.93); C363(0.90); C272(0.93)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C483(0.85); C561(0.97); C621(1.00); C440(0.96)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C483(0.91); C561(0.88); C363(0.90); C621(0.96)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C483(1.03); C561(0.91); C363(1.08); C272(1.00)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C483(0.99); C561(0.97); C621(1.02); C440(1.04)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C483(1.03); C561(0.90); C363(1.03); C272(1.09)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C483(0.94); C561(1.00); C363(0.97); C272(0.84)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C483(0.93); C561(0.82); C621(1.00); C440(0.93)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C483(1.06); C561(1.04); C363(1.06); C272(1.76)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C483(0.92); C561(0.98); C363(1.13); C621(0.81)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C483(0.96); C561(0.85); C363(0.96); C272(0.86)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C483(1.02); C561(0.86); C363(0.90); C272(1.10)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C483(0.98); C561(0.94); C621(0.92); C440(0.95)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C483(0.95); C561(0.98); C363(1.05); C639(1.15)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C483(0.96); C561(0.85); C363(0.99); C272(1.05)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C483(1.01); C561(0.99); C363(0.95); C272(1.13)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C483(1.04); C561(1.02); C621(0.97); C440(0.97)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C483(0.88); C561(0.88); C363(0.83); C621(0.93)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C483(0.99); C561(0.88); C363(0.90); C272(0.77)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C483(0.99); C561(0.99); C621(0.97); C440(0.91)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C483(0.95); C561(0.90); C363(0.96); C272(0.98)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C483(1.03); C561(0.91); C621(0.99); C440(0.95)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C483(0.95); C561(0.99); C363(0.90); C639(1.07)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C483(1.03); C561(0.93); C363(0.94); C272(1.13)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C483(0.99); C561(1.06); C363(1.14); C272(0.99)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C483(0.98); C561(1.02); C621(1.02); C440(0.92)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C483(0.87); C561(0.99); C363(1.06); C621(0.92)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C483(0.98); C561(1.04); C363(1.06); C272(0.84)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C483(0.93); C561(0.91); C363(1.14); C272(0.74)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C483(0.98); C561(0.87); C621(0.94); C440(0.96)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C483(1.00); C561(0.98); C363(1.25); C621(0.98)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C483(0.96); C561(1.04); C363(1.04); C639(1.15)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C483(1.01); C561(0.93); C363(1.07); C272(0.97)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C483(0.98); C561(0.94); C363(0.98); C272(1.06)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C483(0.94); C561(0.98); C621(1.05); C440(0.87)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C483(0.83); C561(0.86); C363(1.14); C621(0.89)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C483(1.01); C561(0.91); C363(1.02); C272(0.83)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C483(0.95); C561(0.91); C363(1.01); C272(0.88)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C483(0.92); C561(0.88); C621(0.89); C440(0.95)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C483(0.88); C561(0.96); C363(1.15); C639(1.09)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C483(0.98); C561(0.73); C363(1.08); C272(1.10)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C483(1.01); C561(0.97); C363(1.01); C272(0.84)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C483(0.96); C561(0.99); C363(0.90); C272(0.99)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C483(0.94); C561(0.99); C621(0.95); C440(0.95)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C483(0.86); C561(0.94); C363(0.97); C621(0.80)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C483(0.96); C561(0.92); C363(1.03); C272(1.03)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C483(0.99); C561(0.86); C363(1.02); C272(0.65)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C483(0.96); C561(0.76); C621(1.01); C440(0.99)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C483(1.00); C561(0.95); C363(1.01); C639(1.11)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C483(1.05); C561(1.00); C363(1.12); C272(1.06)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C483(0.97); C561(0.99); C363(0.94); C272(1.10)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C483(0.88); C561(0.99); C621(0.96); C440(1.06)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C483(0.93); C561(0.99); C363(1.01); C272(0.98)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C483(0.92); C561(1.06); C363(0.93); C621(0.90)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C483(0.94); C561(0.85); C363(1.02); C272(0.80)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C483(0.97); C561(0.97); C363(1.25); C272(0.87)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C483(0.93); C561(1.02); C621(0.97); C440(1.06)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C483(0.92); C561(0.99); C363(1.10); C639(1.04)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C483(0.96); C561(1.02); C621(0.95); C440(1.04)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C483(0.99); C561(1.00); C363(0.95); C639(1.09)  LDD1569  [22]
 LDCM0520  AKOS000195272 MDA-MB-231 C639(0.90)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C483(0.91); C561(0.99); C363(1.04); C272(0.92)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C483(1.05); C561(0.85); C363(1.02); C272(0.94)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C483(0.94); C561(0.94); C363(0.99); C639(0.97)  LDD1514  [22]
 LDCM0108  Chloroacetamide HeLa C363(0.00); C483(0.00); H590(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C561(0.90)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C483(0.85); C561(0.85); C363(1.12); C272(0.92)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C483(1.04); C561(1.00); C363(1.04); C272(1.17)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C483(0.97); C561(0.91); C639(0.99); C621(1.04)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C483(0.90); C561(0.95); C363(1.13); C272(0.85)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C483(1.00); C561(0.89); C363(0.97); C272(1.14)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C483(0.97); C561(1.01); C363(1.00); C272(0.72)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C483(0.89); C561(0.94); C639(1.08); C621(1.02)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C483(0.90); C561(0.90); C363(1.07); C272(1.04)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C483(1.01); C561(0.82); C363(1.06); C272(1.73)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C483(0.92); C561(0.99); C363(0.96); C272(1.06)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C483(0.90); C561(0.93); C639(1.01); C621(1.04)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C483(0.91); C561(0.95); C363(1.02); C272(0.88)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C483(1.05); C561(1.07); C621(1.05); C440(0.97)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C483(1.03); C561(0.87); C363(1.10); C272(1.14)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C483(0.98); C561(0.88); C363(1.07); C272(1.04)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C483(1.11); C561(0.99); C639(1.00); C621(1.05)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C483(0.93); C561(0.91); C363(0.96); C272(0.95)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C483(0.94); C561(1.06); C363(1.24); C272(1.02)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C483(0.95); C561(0.94); C363(0.96); C272(1.13)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C483(0.90); C561(1.03); C639(1.09); C621(0.99)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C483(0.88); C561(0.94); C363(1.11); C272(0.96)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C483(0.94); C561(0.75); C363(1.07); C272(1.28)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C483(1.02); C561(0.99); C363(1.02); C272(0.76)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C483(0.86); C561(1.05); C363(0.92); C639(1.17)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C483(0.89); C561(0.93); C639(1.13); C621(1.00)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C483(0.86); C561(0.97); C363(1.01); C272(1.02)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C483(0.87); C561(0.72); C363(1.21); C272(0.84)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C483(0.86); C561(0.87); C363(1.13); C272(1.01)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C483(0.82); C561(0.97); C639(1.03); C621(0.94)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C483(0.78); C561(0.90); C363(1.19); C272(1.06)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C483(0.92); C561(1.07); C363(1.06); C272(1.07)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C483(0.89); C561(1.01); C363(1.13); C272(0.94)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C483(0.90); C561(1.10); C639(1.04); C621(1.01)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C483(0.85); C561(0.81); C363(0.95); C272(0.84)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C483(0.94); C561(0.85); C363(1.09); C272(0.91)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C483(0.98); C561(0.93); C363(1.33); C272(0.72)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C483(0.86); C561(0.95); C639(0.94); C621(1.04)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C483(1.01); C561(0.83); C363(1.07); C272(1.00)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C483(0.98); C561(0.99); C363(1.02); C272(0.96)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C483(0.93); C561(0.93); C621(1.05); C440(0.93)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C483(0.91); C561(1.05); C363(1.04); C272(1.23)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C483(0.91); C561(1.00); C363(1.06); C621(1.05)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C483(0.94); C561(0.82); C363(0.94); C272(0.84)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C483(0.93); C561(0.99); C363(1.28); C272(1.02)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C483(1.03); C561(1.14); C621(1.12); C440(1.00)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C483(0.85); C561(1.09); C363(0.89); C639(1.25)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C483(0.82); C561(0.95); C363(0.97); C272(1.02)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C483(0.88); C561(0.94); C363(1.02); C272(1.09)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C483(0.92); C561(0.96); C363(0.97); C272(0.76)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C483(0.91); C561(0.99); C639(1.01); C621(1.07)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C483(1.04); C561(0.83); C363(1.05); C272(1.37)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C483(0.99); C561(1.01); C363(1.15); C272(1.20)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C483(0.97); C561(1.03); C363(0.95); C272(0.92)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C483(0.92); C561(0.95); C621(1.02); C440(0.95)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C483(0.90); C561(0.90); C363(0.96); C621(0.94)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C483(0.86); C561(0.91); C363(1.08); C272(0.99)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C483(0.89); C561(0.93); C363(1.04); C272(2.21)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C483(1.06); C561(1.00); C621(1.06); C440(0.97)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C483(1.01); C561(1.11); C363(0.87); C639(1.07)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C483(0.93); C561(0.91); C363(0.97); C272(0.83)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C483(0.98); C561(0.96); C363(1.11); C272(0.69)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C483(0.82); C561(0.90); C639(0.96); C621(1.06)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C483(1.12); C561(0.92); C639(0.96); C621(0.94)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C483(1.10); C561(0.91); C363(1.07); C272(0.88)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C483(0.95); C561(0.95); C363(0.98); C272(1.06)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C483(0.98); C561(0.98); C621(1.01); C440(0.92)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C483(0.90); C561(0.97); C363(1.26); C621(0.94)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C483(0.94); C561(0.98); C363(0.99); C272(0.70)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C483(0.98); C561(1.04); C363(1.16); C272(1.06)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C483(1.06); C561(0.99); C621(0.98); C440(1.00)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C483(0.93); C561(1.01); C363(0.91); C639(1.09)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C483(0.76); C561(0.84); C363(1.18); C272(0.92)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C483(1.05); C561(0.94); C363(1.09); C272(1.27)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C483(0.87); C561(0.91); C363(1.04); C272(1.22)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C483(0.96); C561(0.90); C639(0.95); C621(1.08)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C483(1.00); C561(0.86); C363(0.96); C272(0.83)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C483(0.89); C561(0.82); C363(1.17); C272(0.97)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C483(0.97); C561(1.03); C621(1.04); C440(0.90)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C483(0.95); C561(0.89); C363(0.96); C621(0.89)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C483(0.94); C561(0.89); C363(0.98); C272(0.82)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C483(1.01); C561(0.86); C363(1.01); C272(0.77)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C483(1.00); C561(0.97); C621(0.95); C440(1.04)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C483(0.96); C561(0.98); C363(1.38); C272(1.68)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C483(0.93); C561(1.06); C363(0.96); C639(1.01)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C483(0.84); C561(0.91); C363(1.01); C272(1.13)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C483(0.93); C561(0.90); C363(1.15); C272(1.12)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C483(1.00); C561(1.00); C363(1.01); C272(0.87)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C483(0.92); C561(0.91); C639(1.06); C621(1.16)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C483(0.98); C561(0.89); C363(1.12); C272(1.17)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C483(1.00); C561(0.95); C363(0.94); C272(1.34)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C483(0.96); C561(1.00); C621(1.04); C440(1.03)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C483(0.89); C561(0.98); C363(1.32); C621(0.93)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C483(0.91); C561(0.93); C363(1.02); C272(0.97)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C483(0.89); C561(0.97); C621(1.10); C440(0.98)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C483(0.97); C561(1.04); C363(1.08); C272(1.59)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C483(0.99); C561(0.82); C621(0.98); C440(1.01)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C483(0.87); C561(1.08); C363(0.93); C639(1.10)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C483(0.77); C561(0.87); C363(1.10); C272(0.90)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C483(0.93); C561(0.99); C363(1.06); C272(1.32)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C483(0.91); C561(0.89); C639(1.17); C621(0.99)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C483(0.97); C561(0.93); C363(1.14); C272(1.11)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C483(0.97); C561(0.93); C363(1.18); C272(0.98)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C483(0.93); C561(0.98); C621(1.06); C440(0.98)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C483(0.75); C561(0.93); C363(1.79); C621(0.93)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C483(0.83); C561(1.01); C363(1.03); C621(0.90)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C483(0.93); C561(0.88); C363(0.90); C272(1.10)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C483(0.87); C561(0.89); C363(0.98); C272(0.86)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C483(0.97); C561(1.01); C621(1.05); C440(1.05)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C483(0.91); C561(0.98); C363(0.88); C639(1.09)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C483(0.79); C561(0.99); C363(1.16); C272(1.07)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C483(0.91); C561(1.04); C363(1.23); C272(1.05)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C483(0.86); C561(0.97); C363(1.12); C272(0.85)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C483(0.77); C561(1.03); C639(1.14); C621(1.02)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C483(0.97); C561(0.96); C363(1.14); C272(1.09)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C483(1.02); C561(0.91); C363(1.05); C272(0.92)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C483(0.82); C561(0.71); C363(1.16); C272(0.99)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C483(0.84); C561(0.99); C621(1.03); C440(0.87)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C483(0.85); C561(0.98); C363(1.22); C621(0.83)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C483(0.92); C561(0.90); C363(1.07); C272(0.75)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C483(0.95); C561(1.00); C363(1.22); C272(1.05)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C483(0.99); C561(1.10); C621(1.08); C440(1.07)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C483(0.81); C561(1.02); C363(1.12); C639(1.10)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C483(0.90); C561(0.88); C363(1.05); C272(1.04)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C483(0.94); C561(0.98); C363(0.89); C272(1.00)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C483(1.00); C561(0.90); C363(0.92); C272(0.79)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C483(0.96); C561(0.91); C363(1.00); C272(1.05)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C363(3.45); C483(1.16)  LDD1702  [4]
 LDCM0625  F8 Ramos C639(0.91); C10(1.40); C483(1.67); C561(1.34)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C639(0.60); C10(0.75); C561(1.04); C363(0.68)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C639(10.86); C10(0.17); C561(13.86); C363(0.99)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C639(0.51); C10(0.54); C561(0.54)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C639(0.50); C10(0.69); C561(1.22); C363(0.74)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C639(0.49); C10(1.45); C483(1.13); C561(0.61)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C639(0.79); C561(2.49); C363(1.40)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C639(0.70); C10(0.78); C561(1.55); C363(0.73)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C639(1.07); C10(1.26); C561(2.12); C363(1.12)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C639(0.90); C10(0.74); C561(0.99); C363(0.70)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C639(0.54); C10(0.69); C483(0.61); C561(1.14)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C639(0.93); C10(0.72); C561(1.63); C363(0.83)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C639(0.88); C10(1.07); C561(1.40); C363(0.82)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C639(0.59); C10(0.90); C561(0.57); C363(0.67)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C483(0.97); C561(0.96); C363(1.11); C272(0.81)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C639(0.74); C10(1.07); C561(0.82); C363(0.53)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C639(0.82); C10(1.10); C483(0.96)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C483(0.91); C561(0.93); C363(1.06); C272(1.60)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C639(1.04); C561(2.29); C363(0.85)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C639(0.66); C10(0.79); C561(1.55)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C639(0.57); C10(1.11); C483(1.11); C363(0.89)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C10(1.24); C561(1.49)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y527(0.96)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y527(0.66)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y527(0.59)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y527(0.80)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y527(0.78)  LDD0268  [7]
 LDCM0107  IAA HeLa C363(0.00); H590(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C483(1.04); C639(0.96); C363(0.98); C561(0.92)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C639(6.86); C141(160.58)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C562(2.39); C640(3.23); C712(4.25)  LDD3310  [24]
 LDCM0109  NEM HeLa N.A.  LDD0224  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C639(1.05)  LDD2093  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C639(1.02)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C639(1.27); C483(1.25)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C483(0.67)  LDD2109  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C639(1.84)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C639(0.92)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C639(1.15); C483(1.15)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C639(1.12); C483(1.11)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C639(1.13)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C639(0.50)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C483(1.54)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C639(1.03)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C483(4.26)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C639(1.22); C483(1.07)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C639(1.63)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C639(0.85); C483(1.03)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C639(0.53)  LDD2148  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Origin recognition complex subunit 1 (ORC1) ORC1 family Q13415
Origin recognition complex subunit 2 (ORC2) ORC2 family Q13416
Origin recognition complex subunit 4 (ORC4) ORC4 family O43929
Origin recognition complex subunit 5 (ORC5) ORC5 family O43913
Origin recognition complex subunit 6 (ORC6) ORC6 family Q9Y5N6

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840