Details of the Target

General Information of Target

Target ID LDTP12974
Target Name TBC1 domain family member 7 (TBC1D7)
Gene Name TBC1D7
Gene ID 107080638
Synonyms
TBC7; TBC1 domain family member 7; Cell migration-inducing protein 23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSD
GPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPR
PLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIA
LTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKV
AEETPV
Target Bioclass
Other
Subcellular location
Cytoplasmic vesicle
Function
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.
Uniprot ID
Q9P0N9
Ensemble ID
ENST00000343141.8
HGNC ID
HGNC:21066

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K165(8.32)  LDD0277  [1]
DBIA
 Probe Info  		C43(72.51)  LDD0209  [2]
HHS-475
 Probe Info  		Y180(1.03)  LDD0264  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
IA-alkyne
 Probe Info  		C195(0.00); C232(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		C210(0.00); C232(0.00); C286(0.00); C43(0.00)  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C43(0.88)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C151(1.24); C210(0.88); C214(0.88); C43(1.37)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C151(1.22); C214(0.92); C43(0.84)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C151(1.20); C214(1.20); C43(0.71)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C151(1.12); C214(1.09); C43(0.70)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C151(1.41); C214(0.84); C43(0.92)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C151(1.21); C214(1.29); C43(0.93)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C151(0.93); C214(1.48); C43(0.92)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C151(0.88); C214(0.76); C43(0.67)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C151(1.10); C214(0.92); C43(0.81)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C151(0.94); C214(1.01); C43(0.77)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C151(1.01); C214(0.68); C43(0.81)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C151(1.11); C210(0.99); C214(0.99); C43(1.29)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C151(1.78); C214(1.14); C43(0.72)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C151(2.57); C214(1.48); C43(0.86)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C151(2.06); C214(1.59); C43(0.92)  LDD0827  [8]
 LDCM0230  AC113 HEK-293T C151(1.12); C214(1.25); C43(0.90)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C151(1.10); C214(1.30); C43(0.89)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C151(1.12); C214(1.13); C43(0.88)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C151(1.20); C214(1.13); C43(0.83)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C151(1.28); C214(1.60); C43(0.73)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C151(1.49); C214(1.40); C43(0.83)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C151(1.60); C214(1.78); C43(0.79)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C151(1.21); C210(1.04); C214(1.04); C43(1.57)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C151(1.38); C214(1.70); C43(0.72)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C151(1.39); C214(2.24); C43(0.87)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C151(1.70); C214(1.55); C43(0.87)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C151(1.84); C214(1.53); C43(0.87)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C151(1.44); C214(1.16); C43(0.95)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C151(1.78); C214(1.93); C43(0.88)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C151(2.27); C214(2.05); C43(0.95)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C151(2.53); C214(2.43); C43(0.94)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C151(0.95)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C151(1.06)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C151(1.17)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C151(1.08)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C151(1.12)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C151(1.39)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C151(1.44)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C151(1.26)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C151(1.46)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C151(1.61)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C151(2.19)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C151(1.72)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C151(1.27); C210(0.87); C214(0.87); C43(1.78)  LDD0857  [8]
 LDCM0260  AC140 HEK-293T C151(1.40)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C151(1.83)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C151(1.52)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C151(1.31); C210(0.72); C214(0.72)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C151(1.47); C210(0.91); C214(0.91)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C151(1.54); C210(0.87); C214(0.87)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C151(1.70); C210(0.77); C214(0.77)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C151(1.94); C210(0.97); C214(0.97)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C151(1.67); C210(0.62); C214(0.62)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C151(1.15); C210(0.87); C214(0.87)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C151(1.50); C210(0.89); C214(0.89); C43(1.19)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C151(1.41); C210(0.75); C214(0.75)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C151(1.35); C210(0.99); C214(0.99)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C151(1.25); C210(1.06); C214(1.06)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C151(1.39); C210(0.88); C214(0.88)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C151(1.19); C210(0.87); C214(0.87)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C151(1.36); C210(0.87); C214(0.87)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C151(1.84); C210(0.91); C214(0.91)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C151(2.39); C210(0.92); C214(0.92)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C43(1.15)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C43(1.03)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C43(1.13)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C43(0.95)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C43(1.26)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C43(0.96)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C43(1.07)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C43(1.07)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C43(1.17)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C43(1.13)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C43(1.05)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C43(0.82)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C43(1.60)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C43(1.08)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C43(0.86)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C43(0.90)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C43(0.83)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C43(0.98)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C43(0.82)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C43(0.65)  LDD0612  [8]
 LDCM0296  AC35 HEK-293T C151(1.20); C210(1.13)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C151(1.02); C210(1.35)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C151(1.22); C210(1.26)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C151(1.00); C210(1.04)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C151(1.22); C210(1.04)  LDD0898  [8]
 LDCM0301  AC4 HCT 116 C43(1.10)  LDD0618  [8]
 LDCM0302  AC40 HEK-293T C151(0.91); C210(1.27)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C151(1.09); C210(1.24)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C151(1.03); C210(1.21)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C151(1.15); C210(1.21)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C151(1.44); C210(1.46)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C151(1.03); C210(1.04)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C151(1.10); C210(0.84); C214(0.84)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C151(1.21); C210(0.77); C214(0.77)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C151(1.29); C210(0.76); C214(0.76)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C151(1.20); C210(0.68); C214(0.68)  LDD0909  [8]
 LDCM0312  AC5 HCT 116 C43(0.82)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C151(1.30); C210(0.81); C214(0.81)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C151(1.39); C210(0.83); C214(0.83)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C151(1.28); C210(0.67); C214(0.67)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C151(1.26); C210(0.70); C214(0.70)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C151(1.43); C210(0.61); C214(0.61)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C151(1.38); C210(0.73); C214(0.73)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C151(1.21); C210(0.82); C214(0.82)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C151(1.12); C214(0.97)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C151(1.04); C214(1.01)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C151(1.17); C214(1.02)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C151(0.90); C210(0.99); C214(0.99); C43(0.94)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C151(1.08); C214(0.83)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C151(1.45); C214(1.37)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C151(1.14); C214(1.03)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C151(1.25); C214(1.16)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C151(1.11); C214(1.09)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C151(1.26); C214(1.14)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C151(1.06); C214(0.96)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C151(1.25); C214(1.42)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C43(1.31)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C43(0.89)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C151(1.17); C210(0.82); C214(0.82); C43(1.13)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C43(0.89)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C43(1.14)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C43(1.45)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C43(1.09)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C43(0.98)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C43(1.20)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C43(0.92)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C43(1.00)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C43(0.80)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C43(0.87)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C151(1.32); C210(0.88); C214(0.88); C43(1.51)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C43(1.18)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C43(1.12)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C43(0.79)  LDD0665  [8]
 LDCM0349  AC83 HEK-293T C151(1.05); C210(0.81)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C151(1.33); C210(0.92)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C151(1.31); C210(0.68)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C151(1.18); C210(0.83)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C151(1.20); C210(0.87)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C151(1.42); C210(1.19)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C151(1.61); C210(0.84)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C151(1.34); C210(0.91)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C151(1.31); C210(0.82)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C151(1.29); C210(0.59)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C151(1.44); C210(0.68)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C151(1.58); C210(1.00)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C151(1.40); C210(0.75)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C151(1.57); C210(0.89)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C151(2.69); C210(1.01)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C151(0.98); C214(0.78); C43(1.04)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C151(0.98); C214(1.04); C43(0.81)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C151(1.18); C210(0.96); C214(0.96); C43(1.31)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C151(1.44); C210(0.85); C214(0.85); C43(1.41)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C151(1.32); C210(0.99); C214(0.99); C43(1.13)  LDD0873  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C43(0.72)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C43(1.10)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C43(0.74)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C151(1.17); C210(0.81); C214(0.81); C43(1.24)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C151(1.38); C210(0.95); C214(0.95); C43(1.31)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C151(1.30); C210(0.84); C214(0.84); C43(1.31)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C151(1.24); C210(0.97); C214(0.97); C43(0.94)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C43(0.99)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C43(0.95)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C43(1.06)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C43(1.15)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C43(1.10)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C43(1.04)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C43(1.01)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C43(0.99)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C43(1.17)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C43(0.94)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C43(0.75)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C43(0.85)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C43(1.01)  LDD0703  [8]
 LDCM0387  CL117 HEK-293T C151(1.06); C210(1.09)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C151(0.95); C210(1.11)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C151(1.24); C210(1.44)  LDD0987  [8]
 LDCM0390  CL12 HCT 116 C43(0.98)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C151(1.15); C210(1.03)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C151(1.39); C210(0.59); C214(0.59)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C151(1.28); C210(0.91); C214(0.91)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C151(1.00); C210(0.68); C214(0.68)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C151(1.20); C210(0.80); C214(0.80)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C151(1.18); C214(1.09)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C151(1.13); C214(0.95)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C151(1.25); C214(1.02)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C151(1.05); C214(1.07)  LDD0997  [8]
 LDCM0400  CL13 HCT 116 C43(0.87)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C43(0.97)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C43(1.65)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C151(0.87); C210(1.01); C43(0.97)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C151(0.97); C210(1.51); C43(0.79)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C151(1.11); C210(0.84); C43(1.63)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C151(1.09); C210(1.19); C43(0.95)  LDD1004  [8]
 LDCM0407  CL2 HCT 116 C43(0.86)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C151(1.01); C210(1.05); C43(1.04)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C151(1.17); C210(1.15); C43(1.04)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C151(1.13); C210(1.14); C43(1.25)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C151(1.05); C210(1.02); C43(1.21)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C151(1.00); C210(1.35); C43(0.88)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C151(1.02); C210(0.89); C43(1.60)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C151(1.16); C210(0.97); C43(1.26)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C151(1.12); C210(0.96); C43(0.89)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C151(1.04); C210(0.93); C43(1.36)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C151(1.15); C210(0.99); C43(0.99)  LDD1015  [8]
 LDCM0418  CL3 HCT 116 C43(0.98)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C151(1.36); C210(1.10); C43(1.38)  LDD1017  [8]
 LDCM0420  CL31 HCT 116 C43(0.75)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C43(0.66)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C43(0.85)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C43(1.25)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C43(0.85)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C43(1.30)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C43(1.00)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C43(0.88)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C43(1.05)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C43(0.78)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C43(0.91)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C43(0.88)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C43(1.01)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C43(0.84)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C43(0.78)  LDD0752  [8]
 LDCM0436  CL46 HEK-293T C151(1.03); C214(1.51)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C151(1.12); C214(1.13)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C151(1.09); C214(1.08)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C151(1.15); C214(1.21)  LDD1037  [8]
 LDCM0440  CL5 HCT 116 C43(0.94)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C151(1.60); C214(1.10)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C151(1.26); C214(1.34)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C151(0.92); C214(0.88)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C151(0.93); C214(0.79)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C151(1.28); C214(0.94)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C151(1.21); C214(1.29)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C151(0.91); C214(0.89)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C151(1.05); C214(0.99)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C151(1.07); C214(0.98)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C151(1.23); C214(1.27)  LDD1048  [8]
 LDCM0451  CL6 HCT 116 C43(1.04)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C151(1.67); C214(1.24)  LDD1050  [8]
 LDCM0453  CL61 HCT 116 C43(2.54)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C43(2.74)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C43(2.31)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C43(3.04)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C43(2.60)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C43(2.50)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C43(1.59)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C43(1.86)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C43(2.76)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C43(1.00)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C43(2.77)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C43(2.38)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C43(2.84)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C43(3.04)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C43(2.65)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C43(1.20)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C43(1.04)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C43(1.26)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C43(1.36)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C43(1.41)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C43(0.82)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C43(1.11)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C43(1.28)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C43(1.20)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C43(1.19)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C43(0.95)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C43(1.05)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C43(1.31)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C43(1.05)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C43(1.18)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C43(1.14)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C43(1.07)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C43(0.89)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C43(1.07)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C43(0.75)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C43(0.76)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C43(0.83)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C43(0.82)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C43(1.06)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C43(1.05)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C43(0.89)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C195(1.12)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C43(2.45)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C43(1.15)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y180(1.03)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y180(1.07)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y180(1.10)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y180(0.86)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y180(1.43)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 697 C43(2.60)  LDD2245  [10]
 LDCM0023  KB03 Jurkat C43(72.51)  LDD0209  [2]
 LDCM0024  KB05 UACC257 C43(3.74)  LDD3325  [10]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) Lipoxygenase family P09917
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
E3 ubiquitin-protein ligase TRIM62 (TRIM62) TRIM/RBCC family Q9BVG3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin-45 (BLZF1) . Q9H2G9
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Cobalamin trafficking protein CblD (MMADHC) . Q9H3L0
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840