Details of the Target

General Information of Target

Target ID LDTP12684
Target Name Protein arginine N-methyltransferase 7 (PRMT7)
Gene Name PRMT7
Gene ID 54496
Synonyms
KIAA1933; Protein arginine N-methyltransferase 7; EC 2.1.1.321; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPEENAGSELLLQSFKRRFLAARALRSFRWQSLEAKLRDSSDSELLRDILQKHEAVHTE
PLDELYEVLVETLMAKESTQGHRSYLLTCCIAQKPSCRWSGSCGGWLPAGSTSGLLNSTW
PLPSATQRCASCSPPSYAGLGSDGKRKLIMTRNCFPTESTWRWQS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT7 subfamily
Subcellular location
Cytoplasm, cytosol
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
TTD ID
T79501
Uniprot ID
Q9NVM4
DrugMap ID
TTAR2P0
Ensemble ID
ENST00000339507.9
HGNC ID
HGNC:25557
ChEMBL ID
CHEMBL3562175

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.A337T DBIA    Probe Info 
JHH1 SNV: p.P635L DBIA    Probe Info 
MFE319 SNV: p.S249N .
MOLT4 SNV: p.S234L IA-alkyne    Probe Info 
NCIH1155 SNV: p.A688V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C262(0.89)  LDD2093  [1]
DBIA
 Probe Info  		C534(1.04); C537(1.04)  LDD0078  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C171(0.00); C571(0.00); C136(0.00); C262(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C571(0.00); C171(0.00); C262(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C171(0.00); C262(0.00)  LDD0037  [3]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Ox-W18
 Probe Info  		N.A.  LDD2175  [7]
Acrolein
 Probe Info  		C171(0.00); C136(0.00)  LDD0217  [8]
Methacrolein
 Probe Info  		C171(0.00); C262(0.00); C136(0.00)  LDD0218  [8]
AOyne
 Probe Info  		10.80  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C262(0.97)  LDD2117  [1]
 LDCM0214  AC1 HCT 116 C534(0.99); C537(0.99)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C534(1.04); C537(1.04)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C366(0.88); C368(0.88); C537(1.20)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C366(0.97); C368(0.97); C537(0.90)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C366(1.00); C368(1.00); C537(1.00)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C366(0.88); C368(0.88); C537(1.30)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C366(0.98); C368(0.98); C537(0.83)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C366(0.93); C368(0.93); C537(1.04)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C366(0.84); C368(0.84); C537(1.51)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C366(0.91); C368(0.91); C537(0.90)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C366(1.10); C368(1.10); C537(1.25)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C366(0.86); C368(0.86); C537(1.21)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C534(1.02); C537(1.02)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C366(0.82); C368(0.82); C537(1.47)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C366(0.97); C368(0.97); C537(1.42)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C366(0.89); C368(0.89); C537(1.20)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C534(0.94); C537(0.94)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C534(0.87); C537(0.84)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C534(0.91); C537(0.94)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C534(0.90); C537(0.90)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C534(1.02); C537(0.99)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C534(0.93); C537(0.91)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C534(1.09); C537(0.85)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C534(0.88); C537(0.88)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C534(0.91); C537(0.79)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C534(0.96); C537(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C534(0.95); C537(0.89)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C534(0.83); C537(0.69)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C534(0.97); C537(0.89)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C534(0.84); C537(0.77)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C534(0.95); C537(0.86)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C534(0.82); C537(0.82)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C534(1.07); C537(1.07)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C534(0.91); C537(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C534(0.79); C537(0.79)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C534(0.83); C537(0.83)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C534(0.85); C537(0.85)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C534(0.77); C537(0.77)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C534(0.67); C537(0.67)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C534(0.74); C537(0.74)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C534(1.00); C537(1.00)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C534(0.78); C537(0.78)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C534(0.92); C537(0.92)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C534(0.76); C537(0.76)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C534(0.66); C537(0.66)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C534(0.82); C537(0.82)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C534(0.77); C537(0.77)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C534(0.93); C537(0.93)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C534(0.78); C537(0.78)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C534(0.86); C537(0.86)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C534(1.08); C537(1.08)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C534(0.93); C537(0.93)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C534(0.95); C537(0.95)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C534(0.92); C537(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C534(0.83); C537(0.83)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C534(0.85); C537(0.85)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C534(0.89); C537(0.89)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C534(0.85); C537(0.85)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C534(1.35); C537(1.35)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C534(1.51); C537(1.51)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C534(1.24); C537(1.24)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C534(1.39); C537(1.39)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C534(1.11); C537(1.11)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C534(0.98); C537(0.98)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C534(1.30); C537(1.30)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C534(1.42); C537(1.42)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C534(1.07); C537(1.07)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C534(1.15); C537(1.15)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C534(1.04); C537(1.04)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C534(0.95); C537(0.95)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C534(1.05); C537(1.05)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C534(1.02); C537(1.02)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C534(0.79); C537(0.79)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C534(0.89); C537(0.89)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C534(0.95); C537(0.95)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C534(0.86); C537(0.86)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C534(1.09); C537(1.09)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C534(1.09); C537(1.09)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C534(0.95); C537(0.95)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C534(0.90); C537(0.90)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C534(0.88); C537(0.88)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C534(0.89); C537(0.89)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C534(0.99); C537(0.99)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C534(1.06); C537(1.06)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C534(0.97); C537(0.97)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C534(0.91); C537(0.91)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C534(0.90); C537(0.90)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C534(0.89); C537(0.89)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C534(0.94); C537(0.94)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C534(0.96); C537(0.96)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C534(1.03); C537(1.03)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C534(1.01); C537(1.01)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C534(0.95); C537(0.95)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C534(0.81); C537(0.81)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C534(0.89); C537(0.89)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C534(0.96); C537(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C534(1.09); C537(1.09)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C534(0.92); C537(0.92)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C534(0.93); C537(0.93)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C534(0.82); C537(0.82)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C534(0.93); C537(0.93)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C534(0.89); C537(0.89)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C534(1.22); C537(1.22)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C534(1.07); C537(1.07)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C534(0.70); C537(0.70)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C534(0.83); C537(0.83)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C534(0.87); C537(0.87)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C534(0.96); C537(0.96)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C534(0.77); C537(0.77)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C534(0.79); C537(0.79)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C534(0.82); C537(0.82)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C534(0.66); C537(0.66)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C534(0.71); C537(0.71)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C534(0.86); C537(0.86)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C534(0.90); C537(0.90)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C534(0.81); C537(0.81)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C534(0.92); C537(0.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C534(1.02); C537(1.02)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C534(0.91); C537(0.91)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C534(0.75); C537(0.75)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C534(0.77); C537(0.77)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C534(0.87); C537(0.87)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C534(1.04); C537(1.04)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C534(1.04); C537(1.04)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C534(1.06); C537(1.06)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C534(1.02); C537(1.02)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C534(0.97); C537(0.97)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C534(0.89); C537(0.89)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C534(0.94); C537(0.94)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C534(0.91); C537(0.91)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C534(1.00); C537(1.00)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C534(0.89); C537(0.89)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C534(1.19); C537(1.19)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C534(1.20); C537(1.20)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C534(1.12); C537(1.12)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C534(1.06); C537(1.06)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C534(0.99); C537(0.99)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C366(1.03); C368(1.03); C537(1.09)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C366(0.85); C368(0.85); C537(1.15)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C534(1.04); C537(1.04)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C534(1.10); C537(1.10)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C534(1.08); C537(1.08)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C534(1.04); C537(1.04)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa C136(0.00); C171(0.00)  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C534(0.82); C537(0.82)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C534(0.90); C537(0.90)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C534(0.97); C537(0.97)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C534(1.09); C537(1.09)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C534(1.01); C537(1.01)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C534(1.03); C537(1.03)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C534(1.15); C537(1.15)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C534(0.88); C537(0.88)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C534(0.82); C537(0.82)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C534(0.91); C537(0.91)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C534(1.03); C537(1.03)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C534(0.90); C537(0.90)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C534(0.91); C537(0.91)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C534(0.87); C537(0.87)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C534(0.82); C537(0.82)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C534(1.17); C537(1.17)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C534(1.11); C537(1.11)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C534(1.25); C537(1.25)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C534(1.41); C537(1.41)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C534(1.59); C537(1.59)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C534(0.84); C537(0.84)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C534(0.92); C537(0.92)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C534(0.97); C537(0.97)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C534(1.01); C537(1.01)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C534(1.04); C537(1.04)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C534(1.76); C537(1.76)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C534(0.93); C537(0.93)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C534(0.77); C537(0.77)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C534(0.98); C537(0.98)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C534(1.20); C537(1.20)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C534(0.84); C537(0.84)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C534(0.97); C537(0.97)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C534(0.90); C537(0.90)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C534(0.96); C537(0.96)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C534(0.90); C537(0.90)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C534(0.95); C537(0.95)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C534(1.14); C537(1.14)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C534(1.02); C537(1.02)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C534(0.98); C537(0.98)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C534(1.17); C537(1.17)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C534(0.98); C537(0.98)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C534(1.12); C537(1.12)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C534(1.06); C537(1.06)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C534(1.12); C537(1.12)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C534(1.10); C537(1.10)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C534(1.04); C537(1.04)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C534(1.12); C537(1.12)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C534(1.05); C537(1.05)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C534(1.14); C537(1.14)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C534(1.05); C537(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C534(1.08); C537(1.08)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C534(0.98); C537(0.98)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C534(1.04); C537(1.04)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C534(0.91); C537(0.91)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C534(1.00); C537(1.00)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C534(0.92); C537(0.92)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C534(1.09); C537(1.09)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C534(0.99); C537(0.99)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C534(1.04); C537(1.04)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C534(0.97); C537(0.97)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C534(0.94); C537(0.94)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C534(1.00); C537(1.00)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C534(0.96); C537(0.96)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C534(0.96); C537(0.96)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C534(0.89); C537(0.89)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C534(0.98); C537(0.98)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C534(0.98); C537(0.98)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C534(0.91); C537(0.91)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C534(1.15); C537(1.15)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C534(1.14); C537(1.14)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C534(1.01); C537(1.01)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C534(1.04); C537(1.04)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C534(0.97); C537(0.97)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C534(1.08); C537(1.08)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C534(1.11); C537(1.11)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C534(1.15); C537(1.15)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C534(0.94); C537(0.94)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C534(0.94); C537(0.94)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C534(1.07); C537(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C534(1.01); C537(1.01)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C534(1.01); C537(1.01)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C534(1.17); C537(1.17)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C534(1.05); C537(1.05)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C534(0.91); C537(0.91)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C534(0.97); C537(0.97)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C534(0.96); C537(0.96)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C534(0.98); C537(0.98)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C534(0.94); C537(0.94)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C534(1.07); C537(1.07)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C534(0.94); C537(0.94)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C534(0.99); C537(0.99)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C534(0.99); C537(0.99)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C534(0.93); C537(0.93)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C534(0.92); C537(0.92)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C534(1.01); C537(1.01)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C534(0.95); C537(0.95)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C534(0.92); C537(0.92)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C534(0.93); C537(0.93)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C534(0.94); C537(0.94)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C534(0.93); C537(0.93)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C534(0.75); C537(0.75)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C534(0.76); C537(0.76)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C534(0.85); C537(0.85)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C534(0.88); C537(0.88)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C534(0.89); C537(0.89)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C534(0.84); C537(0.84)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C534(0.81); C537(0.81)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C534(1.00); C537(1.00)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C534(0.82); C537(0.82)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C534(0.87); C537(0.87)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C534(0.91); C537(0.91)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C534(0.88); C537(0.88)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C534(0.89); C537(0.89)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C534(0.76); C537(0.76)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C534(0.87); C537(0.87)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C534(0.87); C537(0.87)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C534(0.97); C537(0.97)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C534(0.96); C537(0.96)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C534(0.82); C537(0.82)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C534(0.86); C537(0.86)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C534(0.84); C537(0.84)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C534(0.83); C537(0.83)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C534(0.96); C537(0.96)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C534(0.93); C537(0.93)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C534(0.92); C537(0.92)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C534(1.03); C537(1.03)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C262(1.06); C571(1.03)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C262(1.48)  LDD1702  [1]
 LDCM0468  Fragment33 HCT 116 C534(0.86); C537(0.86)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C534(0.91); C537(0.91)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C534(1.61); C537(1.61)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C534(0.99); C537(0.99)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C534(0.90); C537(0.90)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C262(0.89)  LDD2093  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C262(0.79)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C262(0.96)  LDD2107  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C262(0.58)  LDD2109  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C262(1.62)  LDD2119  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C262(0.74)  LDD2123  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C262(0.93)  LDD2127  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C262(0.82)  LDD2129  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C262(0.73)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C262(0.99)  LDD2136  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C262(0.64)  LDD2140  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C262(0.72)  LDD2146  [1]
 LDCM0021  THZ1 HCT 116 C534(1.24); C537(1.24)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Argininosuccinate synthase (ASS1) Argininosuccinate synthase family P00966
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) EIF-2-alpha family P05198

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ds-437 Small molecular drug D00QZA

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402