Details of the Target

General Information of Target

Target ID LDTP12410
Target Name Transcription factor 7-like 2 (TCF7L2)
Gene Name TCF7L2
Gene ID 6934
Synonyms
TCF4; Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV
LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA
LHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD
KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT
HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI
LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV
IDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ
EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE
GDGEEVYHF
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
TCF/LEF family
Subcellular location
Nucleus, PML body
Function
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
TTD ID
T54646
Uniprot ID
Q9NQB0
DrugMap ID
TT80QAL
Ensemble ID
ENST00000352065.10
HGNC ID
HGNC:11641
ChEMBL ID
CHEMBL3038511

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.K485SfsTer23
SNV: p.V369I		 .
DOTC24510 SNV: p.S207C .
JURKAT Insertion: p.C486VfsTer8
SNV: p.A566T		 .
L428 SNV: p.F445Y .
LS180 Deletion: p.K485SfsTer23 .
MCC13 SNV: p.S596F .
MFE319 Deletion: p.L200SfsTer25 .
NUGC3 SNV: p.H145Y .
SKMM2 SNV: p.A222S .
SKNAS SNV: p.D61N .
SKOV3 SNV: p.N475S .
SUDHL6 SNV: p.D508V .
SUPT1 Deletion: p.K485SfsTer23 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C372(0.90); C480(0.86)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C372(0.90); C480(0.86)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C372(1.03)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C480(0.47)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C480(0.56)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C480(0.83)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C480(1.47)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C480(0.60)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C480(0.86)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C480(1.14)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C480(0.64)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C480(0.64)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C480(0.51)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C372(1.29)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C480(0.67)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C480(0.60)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C480(0.51)  LDD0546  [1]
 LDCM0237  AC12 HCT 116 C372(1.08)  LDD0554  [1]
 LDCM0246  AC128 HCT 116 C372(1.25)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C372(0.88)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C372(1.11)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C372(0.80)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C372(0.96)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C372(1.10)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C372(1.19)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C372(1.08)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C372(1.13)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C372(0.99)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C372(1.08)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C372(1.07)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C372(0.92)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C372(1.18)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C372(1.01)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C372(0.95)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C372(1.28)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C372(1.35)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C372(1.09)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C372(1.56)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C372(1.61)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C372(1.81)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C372(1.43)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C372(0.86)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C372(1.27)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C372(1.06)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C372(1.52)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C372(1.88)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C372(1.34)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C372(1.44)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C372(1.12)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C372(1.00)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C372(1.03)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C372(1.02)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C372(0.97)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C480(1.07); C372(1.12)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C372(1.00)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C372(0.86)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C372(0.94)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C372(0.95)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C372(1.05)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C372(0.98)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C372(0.91)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C372(1.01)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C372(1.02)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C372(0.95)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C480(0.83); C372(1.07)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C372(1.03)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C372(0.98)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C372(1.00)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C372(0.89)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C372(0.93)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C372(1.04)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C372(1.21)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C372(0.90)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C372(1.19)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C372(1.16)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C480(0.80); C372(0.98)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C372(0.95)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C372(0.95)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C372(1.07)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C372(1.07)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C372(0.97)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C372(0.98)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C372(0.99)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C372(1.15)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C372(1.05)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C372(0.89)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C480(0.91); C372(1.01)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C372(0.73)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C372(0.89)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C372(0.94)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C372(0.77)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C372(0.60)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C372(0.76)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C372(1.21)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C372(0.97)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C372(0.94)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C372(0.94)  LDD1561  [2]
 LDCM0323  AC6 HCT 116 C372(1.00)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C372(0.90)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C372(0.96)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C372(0.99)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C372(0.96)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C372(1.12)  LDD1567  [2]
 LDCM0332  AC68 HCT 116 C480(0.98)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C480(1.02)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C372(0.94)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C480(0.86)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C480(0.90)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C480(1.14)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C480(1.14)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C480(1.05)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C480(1.15)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C480(0.98)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C480(1.14)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C480(0.99)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C480(0.85)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C372(1.00)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C480(1.08)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C480(1.29)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C480(0.87)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C372(1.60)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C372(1.57)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C372(1.41)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C372(1.62)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C372(1.42)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C372(1.46)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C372(1.72)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C372(1.53)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C372(1.61)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C372(1.76)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C372(1.29)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C372(1.17)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C372(1.51)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C372(1.33)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C372(1.86)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C480(1.32)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C480(0.40)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C372(1.07)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C372(1.08)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C372(0.91)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C444(1.14); C449(1.14); C477(1.25); C480(1.25)  LDD2171  [1]
 LDCM0367  CL1 HCT 116 C372(0.89)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C372(1.27)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C480(0.84); C372(1.06)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C372(0.66)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C372(0.65)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C372(0.80)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C372(0.76)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C372(1.02)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C372(1.09)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C372(1.09)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C372(1.15)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C372(1.00)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C372(1.24)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C372(1.09)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C372(1.01)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C372(0.88)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C372(0.87)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C372(0.94)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C372(1.01)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C372(0.94)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C372(1.09)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C372(0.98)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C372(1.10)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C372(1.11)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C372(1.14)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C372(1.71)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C372(0.81)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C372(0.89)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C372(1.27)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C372(0.95)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C372(0.99)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C372(1.02)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C372(0.97)  LDD1603  [2]
 LDCM0400  CL13 HCT 116 C372(0.92)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C372(1.03)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C372(1.11)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C372(1.08)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C372(1.07)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C372(1.12)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C372(1.10)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C372(0.88)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C372(1.32)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C372(1.38)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C372(1.43)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C372(1.24)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C372(1.14)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C372(1.09)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C372(1.00)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C372(1.10)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C372(1.15)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C372(1.19)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C372(0.86)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C372(1.03)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C372(0.95)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C372(0.98)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C372(1.03)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C372(1.16)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C372(1.02)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C372(1.05)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C372(0.97)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C372(0.89)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C372(0.91)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C372(0.97)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C372(0.99)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C372(0.86)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C372(0.96)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C372(0.93)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C372(1.10)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C372(0.71); C480(0.80)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C372(0.82); C480(0.71)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C372(1.07); C480(0.75)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C372(0.78); C480(0.76)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C372(0.96)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C372(0.90); C480(0.73)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C372(0.83); C480(0.83)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C372(0.94); C480(0.68)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C372(0.87); C480(0.66)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C372(0.80); C480(0.62)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C372(0.88); C480(0.80)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C372(0.90); C480(0.60)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C372(1.12); C480(0.78)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C372(1.02); C480(0.66)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C372(0.94); C480(0.92)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C372(0.97)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C372(0.95); C480(0.83)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C372(0.91)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C372(1.00)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C372(1.04)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C372(0.90)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C372(0.93)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C372(0.94)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C372(0.98)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C372(0.91)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C372(0.94)  LDD1664  [2]
 LDCM0462  CL7 HCT 116 C372(0.97)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C372(1.13)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C372(0.97)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C372(0.94)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C372(0.85)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C372(0.98)  LDD1670  [2]
 LDCM0469  CL76 HCT 116 C372(0.78)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C372(0.84)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C372(0.95)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C372(0.81)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C372(1.30)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C372(0.88)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C372(0.87)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C372(0.77)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C372(0.72)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C372(0.86)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C372(0.86)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C372(0.83)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C372(0.85)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C372(0.79)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C372(0.89)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C372(0.97)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C372(0.93)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C372(1.12); C480(0.86)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C372(0.87); C480(0.71)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C372(0.88); C480(0.95)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C372(0.84); C480(0.97)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C372(1.02); C480(0.93)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C372(1.04); C480(0.85)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C372(1.09); C480(0.82)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C372(1.04); C480(0.86)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C372(0.94); C480(0.98)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C372(1.13)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C372(1.02)  LDD1671  [2]
 LDCM0427  Fragment51 HCT 116 C372(1.28)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C372(0.99)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C372(1.04)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C372(0.91)  LDD1502  [2]
 LDCM0021  THZ1 HCT 116 C444(1.14); C449(1.14); C477(1.25); C480(1.25)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
X-ray repair cross-complementing protein 6 (XRCC6) Ku70 family P12956
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
TRAF2 and NCK-interacting protein kinase (TNIK) STE Ser/Thr protein kinase family Q9UKE5
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hypermethylated in cancer 1 protein (HIC1) Krueppel C2H2-type zinc-finger protein family Q14526
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Runt-related transcription factor 3 (RUNX3) . Q13761
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Junction plakoglobin (JUP) Beta-catenin family P14923
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cornifelin (CNFN) Cornifelin family Q9BYD5
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402