Details of the Target

General Information of Target

Target ID LDTP12230
Target Name Nuclear receptor coactivator 5 (NCOA5)
Gene Name NCOA5
Gene ID 57727
Synonyms
KIAA1637; Nuclear receptor coactivator 5; NCoA-5; Coactivator independent of AF-2; CIA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQ
DNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELE
SMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMV
PVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYA
DGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADV
QGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLL
SPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPA
GPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCS
CLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEP
VAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLA
KASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQE
PEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRF
HGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLR
SAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCR
SCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Uniprot ID
Q9HCD5
Ensemble ID
ENST00000290231.11
HGNC ID
HGNC:15909

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y16(19.19); Y107(18.79); Y136(11.80); Y144(27.43)  LDD3495  [1]
m-APA
 Probe Info  		11.35  LDD0403  [2]
BTD
 Probe Info  		C301(1.00)  LDD2091  [3]
AHL-Pu-1
 Probe Info  		C137(2.67)  LDD0171  [4]
DBIA
 Probe Info  		C266(0.77)  LDD0532  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C200(0.00); C266(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		C200(0.00); C266(0.00)  LDD0037  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		N.A.  LDD0005  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		C301(0.00); C137(0.00)  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		C200(0.00); C137(0.00); C301(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.85  LDD1838  [15]
C338
 Probe Info  		13.64  LDD2001  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		16.50  LDD0464  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C266(0.87); C200(0.35)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C266(0.99); C200(0.77)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C301(1.12); C200(1.00); C137(1.08)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C266(1.83)  LDD2152  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C137(2.67)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C200(0.73); C266(0.83)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C266(0.77)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C200(0.88); C266(0.76)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C200(0.85); C266(0.77)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C200(0.99); C266(0.75)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C200(1.00); C266(0.72)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C200(0.91); C266(0.72)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C200(1.07); C266(0.81)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C200(1.33); C266(0.79)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C200(0.97); C266(0.73)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C200(1.15); C266(0.76)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C200(1.16); C266(0.81)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C266(0.72)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C200(0.95); C266(0.79)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C200(0.95); C266(0.75)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C200(0.91); C266(0.81)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C200(1.04); C266(0.82)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C200(1.07); C266(1.11)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C200(0.98); C266(0.91)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C200(0.83); C266(0.85)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C200(0.86); C266(0.90)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C200(0.96); C266(0.95)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C200(0.88); C266(0.92)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C266(0.78)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C200(0.81); C266(0.87)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C200(0.80); C266(0.87)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C200(0.94); C266(0.93)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C200(0.90); C266(0.83)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C200(0.91); C266(0.93)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C200(0.78); C266(0.98)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C200(0.88); C266(0.92)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C200(0.96); C266(0.95)  LDD0843  [5]
 LDCM0246  AC128 PaTu 8988t C200(0.84); C266(0.85)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C200(0.83); C266(0.68)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C200(0.82); C266(0.94)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C200(0.88); C266(0.85)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C200(0.97); C266(0.71)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C200(0.91); C266(0.94)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C200(0.86); C266(0.69)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C200(0.80); C266(0.62)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C200(0.88); C266(0.99)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C200(0.87); C266(0.69)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C200(0.91); C266(0.88)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C200(1.00); C266(0.75)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C266(1.05)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C200(0.96); C266(0.72)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C200(0.80); C266(0.77)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C200(0.83); C266(0.82)  LDD1141  [5]
 LDCM0263  AC143 HEK-293T C200(1.00)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C200(1.06)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C200(1.08)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C200(1.01)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C200(1.01)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C200(0.85)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C200(1.13)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C266(0.89)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C200(0.97)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C200(0.98)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C200(1.17)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C200(0.96)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C200(1.01)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C200(1.09)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C200(1.09)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C200(0.97)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C266(1.02)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C266(0.75)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C266(1.09)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C200(0.70); C266(0.87)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C266(1.30)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C266(0.67)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C266(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C266(0.77)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C266(0.88)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C200(0.78)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C200(0.75)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C200(0.83)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C200(0.52)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C200(0.58)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C200(0.87); C266(1.02)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C200(0.71)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C200(0.78)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C200(0.76)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C200(0.67)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C200(0.63)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C200(0.97); C266(1.18)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C200(0.93); C266(1.02)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C200(0.88); C266(0.86)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C200(0.91); C266(1.02)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C200(0.82); C266(0.91)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C200(1.01); C266(1.25)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C200(0.93); C266(1.07)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C200(0.93); C266(1.05)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C200(0.91); C266(1.41)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C200(0.88); C266(0.99)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C200(0.91); C266(1.06)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C200(0.92); C266(0.96)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C200(0.82)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C200(0.78)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C200(0.83)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C200(0.86)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C200(0.75); C266(0.85)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C200(0.78)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C200(0.77)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C200(0.68)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C200(0.82)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C200(0.80)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C200(0.76)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C200(0.84)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C200(1.28)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C200(1.24)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C200(1.37)  LDD0920  [5]
 LDCM0323  AC6 HCT 116 C266(0.76)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C200(1.09)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C200(1.00)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C200(1.28)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C200(0.91)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C200(1.13)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C200(0.97)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C200(1.26)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C200(1.01)  LDD0929  [5]
 LDCM0332  AC68 HCT 116 C266(0.89)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C266(0.80)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C266(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C266(0.75)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C266(0.81)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C266(0.92)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C266(0.85)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C266(0.83)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C266(0.87)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C266(0.80)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C266(0.82)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C266(0.76)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C266(0.91)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C266(0.72)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C266(0.93)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C266(1.11)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C266(0.87)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C266(0.77)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C266(0.62)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C266(0.52)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C266(0.66)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C266(0.97)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C266(0.64)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C266(1.06)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C266(0.72)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C266(0.90)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C266(0.82)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C266(0.71)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C266(0.64)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C266(0.64)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C266(0.58)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C266(0.65)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C200(0.98); C266(0.78)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C200(0.97); C266(0.66)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C266(0.81)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C266(0.83)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C266(0.70)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.35  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C301(1.00)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C200(0.00); C301(0.00); C137(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C266(1.33)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C266(0.60)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C200(0.66); C266(0.79)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C266(0.74)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C266(0.90)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C266(0.91)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C266(0.95)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C266(0.76)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C266(0.67)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C266(0.72)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C266(0.64)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C266(0.75)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C266(0.91)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C266(0.71)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C266(0.61)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C200(0.71)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C200(0.90)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C200(0.65)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C200(0.65)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C200(0.70)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C200(0.85); C266(1.20)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C200(0.94); C266(0.93)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C200(0.90); C266(0.88)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C266(0.79)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C200(1.04); C266(1.15)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C200(0.78)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C200(0.85)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C200(0.86)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C200(0.78)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C200(1.24)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C200(1.12)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C200(1.50)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C200(1.24)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C266(0.68)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C266(0.86)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C266(0.49)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C266(0.87)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C266(0.73)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C266(0.82)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C266(0.78)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C266(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C266(0.72)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C266(0.63)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C266(0.62)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C266(0.74)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C266(0.75)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C266(0.72)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C266(0.87)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C266(0.70)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C266(0.67)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C266(0.70)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C266(0.59)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C266(0.78)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C266(0.80)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C266(0.68)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C266(0.68)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C266(0.84)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C266(0.82)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C266(0.68)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C266(0.70)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C266(0.75)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C266(0.68)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C266(0.82)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C266(0.72)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C266(0.58)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C266(0.83)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C266(0.79)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C266(0.50)  LDD0752  [5]
 LDCM0436  CL46 PaTu 8988t C266(0.79)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C266(0.84)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C266(0.73)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C266(0.80)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C266(0.80)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C266(0.71)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C266(0.70)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C266(0.64)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C266(0.68)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C266(0.89)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C266(0.69)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C266(0.65)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C266(0.78)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C266(0.65)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C266(0.91)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C266(0.66)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C266(0.77)  LDD1331  [5]
 LDCM0453  CL61 HEK-293T C200(1.26); C266(1.23)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C200(1.25); C266(1.19)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C200(1.14); C266(1.24)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C200(1.31); C266(1.30)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C200(1.14); C266(1.11)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C200(1.25); C266(1.17)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C200(1.14); C266(1.32)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C200(0.95); C266(0.92)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C200(1.13); C266(1.01)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C266(0.75)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C200(1.32); C266(1.20)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C200(1.00); C266(1.02)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C200(1.23); C266(1.52)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C200(1.03); C266(1.01)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C200(1.00); C266(1.07)  LDD1065  [5]
 LDCM0469  CL76 PaTu 8988t C266(0.83)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C266(1.01)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C266(0.77)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C266(1.12)  LDD1351  [5]
 LDCM0473  CL8 HCT 116 C266(0.79)  LDD0790  [5]
 LDCM0474  CL80 PaTu 8988t C266(0.85)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C266(1.03)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C266(1.27)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C266(0.83)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C266(0.95)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C266(0.95)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C266(0.94)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C266(0.83)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C266(0.83)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C266(1.17)  LDD1362  [5]
 LDCM0484  CL9 HCT 116 C266(0.68)  LDD0801  [5]
 LDCM0485  CL90 PaTu 8988t C266(0.97)  LDD1364  [5]
 LDCM0486  CL91 HEK-293T C200(1.11); C266(1.00)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C200(1.05); C266(0.99)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C200(0.95); C266(0.85)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C200(0.75); C266(0.85)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C200(0.61); C266(0.77)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C200(0.77); C266(0.88)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C200(0.94); C266(0.92)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C200(0.83); C266(0.94)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C200(0.82); C266(1.03)  LDD1092  [5]
 LDCM0468  Fragment33 HEK-293T C200(0.90); C266(0.98)  LDD1066  [5]
 LDCM0427  Fragment51 HCT 116 C266(0.65)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C200(1.15)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C200(1.01)  LDD1497  [17]
 LDCM0024  KB05 SKMEL24 C137(2.66)  LDD3323  [18]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C301(0.37)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C266(1.11)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C301(1.19); C266(1.91); C200(1.25)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C266(0.76); C137(1.08)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C301(0.73); C266(0.62); C200(0.59)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C200(0.29)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C301(1.41); C266(1.11)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C266(0.89); C200(0.49)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C301(0.79); C266(0.96); C200(0.62)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C200(0.66)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C301(1.16); C200(1.02)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C301(1.74); C266(1.56)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C301(0.49); C200(0.63)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C301(1.24); C266(1.03)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C301(0.84); C266(1.17); C137(0.96)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C301(0.37)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C301(1.29); C266(0.94); C200(1.19)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C301(1.44)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C301(1.95)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C301(1.12); C200(0.96)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C301(1.17)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C301(0.34); C266(0.89); C137(0.86)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C200(1.18)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C266(1.67); C200(2.25)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C200(0.83)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C301(0.80)  LDD2146  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C301(0.92)  LDD2150  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
17alpha-estriol . DB07702

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840