Details of the Target

General Information of Target

Target ID LDTP12019
Target Name Ribosome production factor 2 homolog (RPF2)
Gene Name RPF2
Gene ID 84154
Synonyms
BXDC1; Ribosome production factor 2 homolog; Brix domain-containing protein 1; Ribosome biogenesis protein RPF2 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIRLEILTSTGIKQKKPWPRVSWLGKEKEAVFLLDDKFINEINLLSGKIKKKIPSLQPF
LKDVIVLTTSSNDAWLAGVLTTGELFLWNKDQDCLKTIPITEKPKEMIKATVASSLRLYL
YVSGNGKRIVLITPSGCIFLWEYLELKNILSSKSLSLAGRWSQVIPEEAVLLPSTEDKEA
VVNAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTSVRSLPYHVHWAQQDCH
LCSLIPKCESVKSRGALISAFSRDGLTLAVTLNQKDPKATQVLFINTLNFVTLCGSLKGC
SNKSPVVPATLIRSYWVGDISWTHDSLFLACMLKRGSLVLLTCQGELLTLITFGCSIEFG
PAEFIPLHPLITYRPQQFTFQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLVISDGYMV
TTLRFLDSLSPSVHMRSLLLDSTQRLEKIYQSVILSKPKGKGLNLRSLNSLRSSLLEHQG
NESSADFTVPKFLQAEETINENAADFQDFEAEETNEGRHFPDNLCPFWNKRDDVLCSSMK
EGRLEFASMFDTIHAKDDSEETDRTITELHSIQKSLLAAWTIGISKTVTEKNLMLNYIVV
CITHFFYILQFIKCPFPKLDLVLSKSSRHNAWILCIFQLFHQCLSIHYWDIRYKQDVGHL
IKLTSNTVKLLLTQQQKGQLFSEKLLACFYLLKMVADNLNGVYILQPEVISASADGSKIT
AQDSLVVPIFQMFQDSGFQKNWSWNSFFKIHPQVVNPVQQPGHRLLILWRILYKKTLWYQ
AQLNRRVPEADSQLTEKMTHEASTVKSLLCHLQANLQSTGDCLNQTLELKSINGEECFLL
GSYEKSVQLWKKALQEIEEKGGRRTYFLQIRYYLSLLYCHLYSYNLNDAQGLCDQLAREI
LRWSQLPVKENKDFSGAAKSHFECGMVGGVHPEAAVRVVQSMARFMAAYFTNQQLCILPP
HHVNVLPPLHIKTEQSFRLIPLQHSKVASVVRDQNLSNVWTVEYALELLFIGGLVPEAVW
LAYKLGDWKTSVSIGVAFQLFCKRDSNFMRSKKKSLNLPLRMTPAQIFQEKLQCVLGQPA
SLEAKNEMGSKYKQFTDPIEEEDANLLFGSVQEVLKASVMADADILSETFQLLIDSAKDF
SKRLWGLVPFGLYLPAPPLYCPQPAILSEEDGDDLLLKAEKNNRQKVSGILQRVLLLFRA
AQCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPQSLLNYCKGGIAFFRPGAAGDH
KLDEVSIRAIGCFRELCALCWMLHVRDKLSYSCRQYQKARENVKGEKDLEVEFDSCMIEH
CLSAVEWAYRMLPFSRFFNMEELIQDIILSLIGELPPIRKVAEIFVKAFPYPEDVRVPLR
DKYHSLHQRLRHCVVKGPQTEEMMSVVMHSIQKVRVKALKRVQRNIGSFEVNIWEPIEEE
KPDEAPGVDRYSLGTSLSRSTLTELGDSVVHSDADTFSEALSVEEKSRINIYQRNAPNHM
ELTSIHKPTDKRKMCNQKENPTKKEDHEKLSQNTLPVIGVWEFERDDDEYIKFLDLFLSY
ILERDLPYSRDADIPFLTSFSGKLREHELNSLLFDVHTTLKRHQSKTKSQNVFRAGSCFV
VAPESYESEKSSSLNDEYGMHLENQKLSSSVLVNQGIKPFLQYPSNEVNKNEGMSGLFGL
KQRSIYKIQDDTREKCLIQRSSNHIFWTPKSIKTRRCIFKAIQCNDINPQEDLPLALNTF
GSIGRLLEWMIRWSNRRLLCDSGITESSSEYSPVIRVKTSTAAILTSLWLLEQPYFATYK
AKNAIIKMVENRDTGCQIGPNIERESKSDAGGSVAVATPGGTEERNGQNKSCQNILNRMP
TEAKNPDIKEINDDIISITHNTKKEFIDIDENLLEVEAFTEEEMDMHISDYEEDIEESVG
GFRSPSLAICMMTLPQQLEEEFTEEVQCQREEPLETIMEEKSTEQKGMIEAFSHPGHTTP
QSMQVDTSSEISSAQISTYKEKSSSVPLLISNGVNVASQPPAPTPQKTQRNEFTAQLPDC
SESVRQMLQDEMFKLVQLQQINFMSLMQIVGSSFANLPDTQQLVQQSQSVHLGESQESNL
RGCGDVEDSNKNLKERFFIKPQSMGENAREPRKNSPHCHEGTIPSGQNSTGNVQNVPHGS
IPLCQLNGQPRKKGPIPSSQNLPSTSFYPAPAGNTHLYLLSTPSVVQKAPRLIPHAKTFS
PGDGFPLLQFKSKQEFQPLFLHTGSIPQVPFRPLPQPREAWGLSDSFQPALPQRAAQTTP
ASHLNVSQYNTEARKKEVEQKTWAETVITEIPNHVNLDQYVGQENLTPQQDSSVFIKPEK
LFDVKPGTLEISPHHSFGLPLLYLPLKPPNMFPSTSRASITVPSTPIQPIAEERKYPRLS
LLHSHLSPENRCKKTQLIPLENLIAFKQSQQKLTHNLFEQGDAGHLQLLKVKIEPPEVRQ
GKDSKKRQRRRAEKELQEKRCEKLRRKPNVTFRPENSIINNDDSEIIKKPKEQQEHCGSH
PLDDFDVPFEMLQDDNTSAGLHFMASVKKKAIGSQDASTNTDPEHEPLTAPQLLVPDVYL
NLKLSSEMSEKPWSPSIPHTVTNLELPVREEPSNDNVIKQQSDHLAVPSSAELHYMAASV
TNAVPPHNFKSQGLPKPEFRFKGQSTKSDSAEDYLLWKRLQGVSAACPAPSSAAHQLEHL
SAKLQKIDEQLLAIQNIAENIEQDFPKPEMLDLHCDKIGPVDHIEFSSGPEFKKTLASKT
ISISEEVRFLTHMDEEDQSDKKETSEPEFSITENYSGQKTCVFPTADSAVSLSSSSDQNT
TSPGMNSSDELCESVSVHPLQMTGLTDIADIIDDLIIKDGVSSEELGLTEQAMGTSRIQH
YSGRHSQRTDKERREIQAWMKRKRKERMAKYLNELAEKRGQEHDPFCPRSNPLYMTSREI
RLRQKMKHEKDRLLLSEHYSRRISQAYGLMNELLSESVQLPTLPQKPLPNKPSPTQSSSC
QHCPSPRGENQHGHSFLINRPGKVKYMSKPSYIHKRKSFGQPQGSPWPHGTATFTIQKKA
GGAKAAVRKATQSPVTFQKGSNAPCHSLQHTKKHGSAGLAPQTKQVCVEYEREETVVSPW
TIPSEIHKILHESHNSLLQDLSPTEEEEPEHPFGVGGVDSVSESTGSILSKLDWNAIEDM
VASVEDQGLSVHWALDL
Target Bioclass
Other
Family
RPF2 family
Subcellular location
Nucleus, nucleolus
Function Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
Uniprot ID
Q9H7B2
Ensemble ID
ENST00000441448.7
HGNC ID
HGNC:20870

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C87(0.96)  LDD2099  [2]
DBIA
 Probe Info  		C87(0.54)  LDD0533  [3]
ATP probe
 Probe Info  		K252(0.00); K270(0.00); K237(0.00); K66(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C87(0.00); C135(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
SF
 Probe Info  		Y236(0.00); Y263(0.00)  LDD0028  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
AOyne
 Probe Info  		10.40  LDD0443  [11]
NAIA_5
 Probe Info  		C135(0.00); C87(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C87(0.48)  LDD2112  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C87(1.16)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C87(1.08)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C87(0.95)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C87(0.54)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C87(0.58)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C87(0.68)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C87(0.45)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C87(0.92)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C87(0.59)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C87(0.47)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C87(0.56)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C87(0.57)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C87(0.83)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C87(0.85)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C87(0.52)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C87(0.44)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C87(0.48)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C87(1.01)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C87(1.17)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C87(1.23)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C87(1.10)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C87(0.84)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C87(1.11)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C87(0.96)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C87(0.97)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C87(1.16)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C87(0.80)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C87(1.12)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C87(1.00)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C87(0.89)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C87(1.22)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C87(1.18)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C87(1.06)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C87(0.92)  LDD0857  [3]
 LDCM0263  AC143 HCT 116 C87(1.02)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C87(0.71)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C87(0.90)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C87(0.81)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C87(0.64)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C87(0.15)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C87(0.46)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C87(0.80)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C87(1.00)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C87(0.91)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C87(0.45)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C87(0.16)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C87(0.75)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C87(0.84)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C87(1.06)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C87(0.90)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C87(0.77)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C87(0.80)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C87(0.71)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C87(0.72)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C87(1.04)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C87(0.76)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C87(0.78)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C87(0.92)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C87(0.71)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C87(1.08)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C87(1.08)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C87(0.99)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C87(0.94)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C87(0.88)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C87(0.78)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C87(0.91)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C87(0.91)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C87(1.03)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C87(0.94)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C87(0.93)  LDD0893  [3]
 LDCM0296  AC35 HCT 116 C87(0.90)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C87(1.12)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C87(1.05)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C87(1.21)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C87(1.01)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C87(1.01)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C87(0.66)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C87(0.70)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C87(0.92)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C87(0.94)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C87(0.97)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C87(0.58)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C87(1.16)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C87(0.99)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C87(1.09)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C87(0.35)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C87(0.87)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C87(0.39)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C87(1.52)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C87(0.98)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C87(0.65)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C87(0.56)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C87(0.34)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C87(0.36)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C87(0.68)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C87(1.00)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C87(0.41)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C87(0.84)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C87(1.13)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C87(0.99)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C87(0.38)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C87(0.76)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C87(0.39)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C87(0.65)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C87(0.84)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C87(0.15)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C87(0.76)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C87(0.79)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C87(0.95)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C87(0.22)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C87(1.05)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C87(0.67)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C87(0.19)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C87(0.20)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C87(0.19)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C87(0.37)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C87(0.31)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C87(1.01)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C87(0.90)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C87(1.06)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C87(0.51)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C87(1.06)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C87(0.20)  LDD0665  [3]
 LDCM0349  AC83 HEK-293T C87(1.00)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C87(1.09)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C87(1.33)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C87(1.03)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C87(0.98)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C87(1.05)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C87(1.15)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C87(1.04)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C87(1.08)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C87(1.19)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C87(1.14)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C87(1.10)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C87(1.01)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C87(1.00)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C87(1.40)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C87(0.48)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C87(0.69)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C87(0.79)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C87(1.01)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C87(0.87)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 11.97  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C87(0.49)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C87(0.13)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C87(1.17)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C87(0.93)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C87(0.82)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C87(0.89)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C87(0.90)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C87(0.79)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C87(1.07)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C87(0.76)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C87(0.87)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C87(0.72)  LDD0976  [3]
 LDCM0379  CL11 PaTu 8988t C87(20.00)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C87(0.76)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C87(0.91)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C87(0.91)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C87(1.04)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C87(0.92)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C87(0.90)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C87(0.99)  LDD0984  [3]
 LDCM0387  CL117 HCT 116 C87(0.39)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C87(0.81)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C87(0.76)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C87(0.51)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C87(0.83)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C87(1.01)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C87(1.20)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C87(0.65)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C87(0.44)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C87(1.19)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C87(1.40)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C87(1.33)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C87(0.51)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C87(0.11)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C87(0.14)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C87(0.36)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C87(0.82)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C87(0.68)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C87(0.62)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C87(0.57)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C87(0.60)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C87(0.47)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C87(0.48)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C87(0.46)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C87(0.57)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C87(0.95)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C87(0.88)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C87(0.45)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C87(0.86)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C87(0.52)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C87(0.55)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C87(0.41)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C87(0.99)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C87(1.16)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C87(1.30)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C87(1.19)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C87(0.81)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C87(0.77)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C87(0.90)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C87(0.61)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C87(0.68)  LDD0745  [3]
 LDCM0429  CL4 PaTu 8988t C87(0.41)  LDD1308  [3]
 LDCM0430  CL40 HCT 116 C87(0.76)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C87(0.99)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C87(0.41)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C87(0.63)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C87(1.18)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C87(0.84)  LDD0752  [3]
 LDCM0436  CL46 PaTu 8988t C87(1.11)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C87(0.84)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C87(0.68)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C87(0.92)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C87(0.12)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C87(0.60)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C87(0.66)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C87(0.77)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C87(0.58)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C87(0.85)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C87(0.98)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C87(0.15)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C87(0.17)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C87(0.61)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C87(0.20)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C87(0.20)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C87(0.19)  LDD1331  [3]
 LDCM0454  CL62 HEK-293T C87(0.97)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C87(0.99)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C87(1.39)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C87(1.03)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C87(1.12)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C87(0.78)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C87(0.81)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C87(0.76)  LDD1664  [14]
 LDCM0462  CL7 PaTu 8988t C87(0.15)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C87(0.52); C135(0.73)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C87(0.55)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C87(0.83); C135(0.74)  LDD1668  [14]
 LDCM0467  CL74 HEK-293T C87(1.08)  LDD1670  [14]
 LDCM0469  CL76 HCT 116 C87(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C87(1.46)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C87(0.90)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C87(0.62)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C87(0.56)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C87(1.03)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C87(0.89)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C87(0.31)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C87(0.43)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C87(0.31)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C87(0.87)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C87(1.08)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C87(0.88)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C87(0.49)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C87(0.22)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C87(0.14)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C87(0.75)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C87(0.91)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C87(0.89)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C87(0.79)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C87(0.81)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C87(0.81)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C87(0.99)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C87(0.55)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C87(0.64)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C87(0.67)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C87(0.76)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C87(0.94)  LDD1671  [14]
 LDCM0427  Fragment51 HCT 116 C87(0.44)  LDD0744  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C87(0.96)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C87(1.09)  LDD1497  [14]
 LDCM0024  KB05 SKMEL24 C135(2.50)  LDD3323  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C87(0.96)  LDD2099  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C87(0.42)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C87(1.10)  LDD2105  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C87(1.28)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C87(0.65)  LDD2109  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C87(0.49)  LDD2114  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C87(0.32)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C87(0.93)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C87(0.83)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C87(1.02)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C87(1.68)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C87(0.97)  LDD2137  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disks large homolog 2 (DLG2) MAGUK family Q15700
Ribosome biogenesis regulatory protein homolog (RRS1) RRS1 family Q15050

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840