Details of the Target

General Information of Target

Target ID LDTP11860
Target Name Band 4.1-like protein 4B (EPB41L4B)
Gene Name EPB41L4B
Gene ID 54566
Synonyms
EHM2; LULU2; Band 4.1-like protein 4B; Erythrocyte membrane protein band 4.1-like 4B; FERM-containing protein CG1; Protein EHM2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP
PRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARP
HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY
VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT
LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT
LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM
AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR
FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG
SRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD
CPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD
GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAG
YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQ
GPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ
CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC
DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSC
GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCG
VGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPL
VLKFQFCSRAYFRQMCCKTCHGH
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing. May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation.
Uniprot ID
Q9H329
Ensemble ID
ENST00000374557.4
HGNC ID
HGNC:19818

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.H362N .
CAL51 SNV: p.W310Ter .
COLO678 SNV: p.A708P DBIA    Probe Info 
HCC44 SNV: p.G20V; p.G30W .
HCT15 SNV: p.E212D; p.P727H .
HEC1B SNV: p.R461Q .
HG3 Substitution: p.F90_L91delinsLV .
HT3 SNV: p.D330E .
JHH7 SNV: p.E753Q .
JURKAT SNV: p.P551H .
LOXIMVI SNV: p.P653T .
MCC13 Substitution: p.G825E .
MELJUSO SNV: p.L128F .
MIAPACA2 SNV: p.W247Ter .
MOLT4 SNV: p.A740V .
NCIH716 SNV: p.A708P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C437(0.99)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
NAIA_5
 Probe Info  		C437(0.00); C357(0.00); C781(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C437(0.99)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C357(0.89); C437(1.00)  LDD1508  [5]
 LDCM0216  AC100 HCT 116 C437(0.90)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C437(1.07)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C437(0.97)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C437(1.30)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C437(1.09)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C437(1.08)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C437(0.98)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C437(1.21)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C437(0.99)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C437(0.79)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C357(1.05); C437(1.18)  LDD1509  [5]
 LDCM0227  AC110 HCT 116 C437(0.93)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C437(0.88)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C437(0.96)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C357(1.27); C437(1.04)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C357(0.84); C437(1.18)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C357(0.85); C437(1.06)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C357(0.93); C437(1.07)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C357(0.96); C437(1.08)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C357(0.80); C437(0.96)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C357(1.13); C437(1.06)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C357(1.10); C437(1.16)  LDD1510  [5]
 LDCM0238  AC120 HCT 116 C357(0.93); C437(1.15)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C357(1.00); C437(1.18)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C357(0.42); C437(0.94)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C357(1.08); C437(0.83)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C357(1.12); C437(1.18)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C357(1.08); C437(1.05)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C357(1.65); C437(1.26)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C357(1.31); C437(1.11)  LDD0562  [1]
 LDCM0259  AC14 HEK-293T C357(1.02); C437(1.07)  LDD1512  [5]
 LDCM0263  AC143 HCT 116 C437(1.06)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C437(0.96)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C437(0.91)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C437(0.75)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C437(0.93)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C437(0.75)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C437(0.80)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C357(1.02); C437(1.09)  LDD1513  [5]
 LDCM0271  AC150 HCT 116 C437(0.92)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C437(0.82)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C437(0.77)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C437(0.66)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C437(0.84)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C437(0.79)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C437(0.82)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C437(0.78)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C357(1.03)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C357(1.02); C437(1.09)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C357(0.92); C437(1.11)  LDD1517  [5]
 LDCM0279  AC2 HCT 116 C437(0.89)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C357(0.94); C437(0.97)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C357(1.10)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C357(0.96); C437(0.85)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C357(1.01); C437(1.06)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C357(1.01); C437(1.18)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C437(1.12)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C437(1.02)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C437(1.09)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C437(1.03)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C437(1.51)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C437(0.82)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C437(0.94)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C437(0.89)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C437(1.16)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C437(1.10)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C437(1.29)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C437(1.07)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C437(1.05)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C437(1.06)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C437(1.24)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C437(1.11)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C437(0.76)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C437(1.28)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C437(1.20)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C437(1.17)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C437(1.23)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C437(1.07)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C437(1.26)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C357(1.28)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C357(1.13)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C357(1.20)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C357(0.98)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C437(0.81)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C357(1.32)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C357(0.99)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C357(1.13)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C357(1.09)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C357(0.96)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C357(1.04)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C357(1.40)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C357(1.11)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C357(1.03); C437(1.11)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C357(1.13); C437(0.86)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C357(0.87); C437(0.98)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C357(0.98); C437(1.12)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C357(1.07)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C357(0.98); C437(1.04)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C357(1.02); C437(1.28)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C357(1.18); C437(1.15)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C357(0.99); C437(1.18)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C357(0.72); C437(1.10)  LDD1569  [5]
 LDCM0365  AC98 HCT 116 C437(1.12)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C437(0.96)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C357(1.03)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C357(1.02)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C357(1.12); C437(1.48)  LDD1514  [5]
 LDCM0632  CL-Sc Hep-G2 C437(0.47)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C357(0.92)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C357(0.80); C437(1.21)  LDD1572  [5]
 LDCM0369  CL100 HCT 116 C437(0.99)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C357(0.94)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C357(0.93); C437(1.14)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C357(0.92)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C357(1.00); C437(1.08)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C357(0.92)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C357(0.92); C437(0.98)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C357(0.90)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C357(0.96); C437(0.82)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C357(0.95)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C357(0.86); C437(1.25)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C357(0.86); C437(0.87)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C357(0.93)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C437(1.03)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C437(0.84)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C437(1.09)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C437(1.16)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C437(1.12)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C437(1.40)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C437(1.22)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C437(1.10)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C357(1.01); C437(1.47)  LDD1594  [5]
 LDCM0391  CL120 HCT 116 C437(1.16)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C357(1.08)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C357(1.24)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C357(1.02)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C357(1.04)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C357(1.05)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C357(1.10); C437(1.10)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C357(1.04)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C357(1.01); C437(1.07)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C357(1.00)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C357(1.04); C437(1.11)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C357(0.87)  LDD1606  [5]
 LDCM0403  CL16 HCT 116 C437(0.93)  LDD0720  [1]
 LDCM0404  CL17 HEK-293T C357(1.20)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C357(0.96); C437(1.17)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C357(1.09); C437(0.88)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C357(1.09); C437(0.94)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C357(0.98); C437(1.45)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C357(0.98)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C357(0.95); C437(1.53)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C357(0.92); C437(1.24)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C357(0.88); C437(1.44)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C357(0.91)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C357(1.13); C437(1.32)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C357(0.99)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C357(1.00); C437(1.05)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C357(1.02)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C357(0.99)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C357(0.97); C437(0.79)  LDD1623  [5]
 LDCM0420  CL31 HCT 116 C437(1.05)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C437(0.99)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C437(1.02)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C437(0.97)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C437(0.94)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C437(1.14)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C437(1.13)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C437(0.99)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C357(1.04); C437(0.79)  LDD1633  [5]
 LDCM0430  CL40 HCT 116 C437(1.13)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C437(1.05)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C437(0.87)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C437(1.08)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C437(0.93)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C437(0.93)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C357(0.83); C437(1.05)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C357(0.90); C437(1.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C357(0.87); C437(0.97)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C357(1.13); C437(0.89)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C357(0.98)  LDD1644  [5]
 LDCM0441  CL50 HCT 116 C357(1.05); C437(1.01)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C357(0.83); C437(1.11)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C357(0.98); C437(0.86)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C357(0.77); C437(1.15)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C357(0.74); C437(1.09)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C357(0.85); C437(0.98)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C357(0.90); C437(1.03)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C357(1.11); C437(1.24)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C357(0.80); C437(1.00)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C357(0.96); C437(0.94)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C357(1.00); C437(1.10)  LDD1654  [5]
 LDCM0452  CL60 HCT 116 C357(0.81); C437(1.16)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C357(1.14)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C357(1.07)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C357(2.31)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C357(0.79)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C357(0.04)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C357(2.06)  LDD0775  [1]
 LDCM0459  CL67 HEK-293T C357(1.07); C437(1.03)  LDD1662  [5]
 LDCM0460  CL68 HCT 116 C357(1.60)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C357(1.15)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C357(1.08); C437(1.18)  LDD1665  [5]
 LDCM0463  CL70 HCT 116 C357(2.34)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C357(0.95)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C357(0.92)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C357(2.96)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C357(1.56)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C437(0.77)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C437(0.72)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C437(1.00)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C437(0.79)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C357(0.69); C437(1.02)  LDD1676  [5]
 LDCM0474  CL80 HCT 116 C437(0.73)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C437(0.72)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C437(0.79)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C437(0.85)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C437(0.81)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C437(0.84)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C437(0.85)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C437(0.74)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C437(0.82)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C437(0.72)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C357(1.02)  LDD1687  [5]
 LDCM0485  CL90 HCT 116 C437(0.87)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C437(1.26)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C437(0.90)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C437(0.84)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C437(0.95)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C437(1.10)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C437(0.90)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C437(0.96)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C437(1.13)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C437(1.03)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C357(0.98)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C357(1.28)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C437(1.45)  LDD0744  [1]
 LDCM0022  KB02 AGS C285(1.59)  LDD2263  [6]
 LDCM0023  KB03 22RV1 C285(1.61)  LDD2660  [6]
 LDCM0024  KB05 NCI-N87 C285(1.63)  LDD3364  [6]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840