Details of the Target

General Information of Target

Target ID LDTP11730
Target Name Probable ATP-dependent RNA helicase DDX47 (DDX47)
Gene Name DDX47
Gene ID 51202
Synonyms
Probable ATP-dependent RNA helicase DDX47; EC 3.6.4.13; DEAD box protein 47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFQYKEDHPFEYRKKEGEKIRKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQF
YFLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDNHEEDYFLYVAYSDESVYGK
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX47/RRP3 subfamily
Subcellular location
Nucleus, nucleolus
Function Required for efficient ribosome biogenesis. May have a role in mRNA splicing. Involved in apoptosis.
Uniprot ID
Q9H0S4
Ensemble ID
ENST00000352940.8
HGNC ID
HGNC:18682

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.K214T .
HCC15 Deletion: p.K210RfsTer11
SNV: p.K210N		 .
KMRC20 SNV: p.V224M .
KYSE410 SNV: p.A357P .
SBC5 SNV: p.K384E .
SW756 SNV: p.K74N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.90  LDD0402  [1]
STPyne
 Probe Info  		K142(10.00); K308(8.56)  LDD0277  [2]
IPM
 Probe Info  		C36(0.00); C39(0.00)  LDD0241  [3]
BTD
 Probe Info  		C226(1.05)  LDD1700  [4]
DBIA
 Probe Info  		C36(0.77); C39(0.77)  LDD0532  [5]
ATP probe
 Probe Info  		K308(0.00); K301(0.00); K161(0.00)  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C39(0.00); C36(0.00)  LDD0037  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		12.10  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C226(0.77)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C226(0.98)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C226(0.72)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C226(0.90)  LDD2130  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C226(1.35)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C226(0.90)  LDD2103  [4]
 LDCM0214  AC1 PaTu 8988t C36(0.26); C39(0.26)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C36(0.77); C39(0.77)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C36(1.16); C39(1.16)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C36(0.91); C39(0.91)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C36(0.65); C39(0.65)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C36(0.37); C39(0.37)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C36(0.37); C39(0.37)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C36(0.53); C39(0.53)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C36(0.39); C39(0.39)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C36(0.86); C39(0.68)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C36(0.42); C39(0.49)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C36(0.40); C39(0.46)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C36(0.78); C39(0.78)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C36(0.39); C39(0.39)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C36(0.41); C39(0.46)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C36(0.53); C39(0.51)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C36(0.99); C39(0.99)  LDD0554  [5]
 LDCM0246  AC128 PaTu 8988t C36(0.54); C39(0.54)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C36(0.59); C39(0.59)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C36(0.79); C39(0.79)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C36(1.05); C39(1.05)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C36(1.01); C39(1.01)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C36(0.91); C39(0.91)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C36(0.76); C39(0.76)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C36(0.64); C39(0.64)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C36(0.52); C39(0.52)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C36(0.62); C39(0.62)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C36(0.47); C39(0.47)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C36(0.56); C39(0.56)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C36(0.71); C39(0.71)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C36(0.57); C39(0.57)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C36(0.80); C39(0.80)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C36(0.67); C39(0.67)  LDD1141  [5]
 LDCM0270  AC15 HCT 116 C36(0.78); C39(0.78)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C36(1.05); C39(1.05)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C36(0.34); C39(0.34)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C36(0.72); C39(0.72)  LDD0595  [5]
 LDCM0279  AC2 PaTu 8988t C36(0.42); C39(0.42)  LDD1158  [5]
 LDCM0280  AC20 HCT 116 C36(0.92); C39(0.92)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C36(0.43); C39(0.43)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C36(0.53); C39(0.53)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C36(0.40); C39(0.40)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C36(0.70); C39(0.70)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C36(0.76); C39(0.76)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C36(0.80); C39(0.80)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C36(0.72); C39(0.72)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C36(0.73); C39(0.73)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C36(0.72); C39(0.72)  LDD0606  [5]
 LDCM0290  AC3 PaTu 8988t C36(0.47); C39(0.47)  LDD1169  [5]
 LDCM0291  AC30 HCT 116 C36(0.74); C39(0.74)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C36(0.54); C39(0.54)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C36(0.47); C39(0.47)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C36(0.56); C39(0.56)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C36(0.40); C39(0.40)  LDD0612  [5]
 LDCM0297  AC36 HEK-293T C36(1.39)  LDD1536  [15]
 LDCM0301  AC4 PaTu 8988t C36(0.51); C39(0.51)  LDD1180  [5]
 LDCM0306  AC44 HEK-293T C36(1.25)  LDD1545  [15]
 LDCM0308  AC46 HCT 116 C36(0.92); C39(0.92)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C36(0.81); C39(0.81)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C36(0.39); C39(0.39)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C36(0.48); C39(0.48)  LDD0628  [5]
 LDCM0312  AC5 PaTu 8988t C36(0.34); C39(0.34)  LDD1191  [5]
 LDCM0313  AC50 HCT 116 C36(0.45); C39(0.45)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C36(1.08); C39(1.08)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C36(0.95); C39(0.95)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C36(0.58); C39(0.58)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C36(0.68); C39(0.68)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C36(0.41); C39(0.41)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C36(0.48); C39(0.48)  LDD0636  [5]
 LDCM0323  AC6 HCT 116 C36(0.73); C39(0.73)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C36(1.26)  LDD1563  [15]
 LDCM0332  AC68 HCT 116 C36(0.57); C39(0.57)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C36(0.42); C39(0.42)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C36(0.76); C39(0.76)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C36(0.32); C39(0.32)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C36(0.64); C39(0.64)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C36(0.54); C39(0.54)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C36(0.28); C39(0.28)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C36(0.29); C39(0.29)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C36(0.29); C39(0.29)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C36(0.38); C39(0.38)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C36(0.37); C39(0.37)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C36(0.48); C39(0.48)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C36(0.67); C39(0.67)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C36(0.85); C39(0.85)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C36(0.56); C39(0.56)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C36(1.08); C39(1.08)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C36(0.42); C39(0.42)  LDD0665  [5]
 LDCM0365  AC98 HCT 116 C36(0.19); C39(0.19)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C36(0.75); C39(0.75)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C226(0.62)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C36(1.05); C39(1.05)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C36(0.80); C39(0.80)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C36(0.31); C39(0.31)  LDD0592  [5]
 LDCM0498  BS-3668 MDA-MB-231 C226(0.05)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0369  CL100 PaTu 8988t C36(0.47); C39(0.47)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C36(0.65); C39(0.65)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C36(1.16); C39(1.16)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C36(1.04); C39(1.04)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C36(0.81); C39(0.81)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C36(0.40); C39(0.40)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C36(0.20); C39(0.20)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C36(0.26); C39(0.26)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C36(0.20); C39(0.20)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C36(0.52); C39(0.52)  LDD0695  [5]
 LDCM0380  CL110 HCT 116 C36(0.28); C39(0.28)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C36(0.43); C39(0.43)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C36(1.04); C39(1.04)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C36(0.56); C39(0.56)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C36(0.99); C39(0.99)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C36(0.95); C39(0.95)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C36(0.69); C39(0.69)  LDD0703  [5]
 LDCM0389  CL119 HEK-293T C36(1.12)  LDD1593  [15]
 LDCM0391  CL120 HEK-293T C36(1.20)  LDD1595  [15]
 LDCM0392  CL121 HCT 116 C36(2.69); C39(2.69)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C36(0.68); C39(0.68)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C36(0.47); C39(0.47)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C36(0.49); C39(0.49)  LDD0712  [5]
 LDCM0398  CL127 HEK-293T C36(0.97)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C36(1.33)  LDD1603  [15]
 LDCM0402  CL15 HEK-293T C36(0.64)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C36(1.41)  LDD1607  [15]
 LDCM0408  CL20 HEK-293T C36(0.91)  LDD1612  [15]
 LDCM0415  CL27 HEK-293T C36(0.80)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C36(1.23)  LDD1620  [15]
 LDCM0418  CL3 HEK-293T C36(1.01)  LDD1622  [15]
 LDCM0421  CL32 HEK-293T C36(0.95)  LDD1625  [15]
 LDCM0428  CL39 HEK-293T C36(0.81)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C36(1.26)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C36(1.32)  LDD1634  [15]
 LDCM0434  CL44 HEK-293T C36(1.01)  LDD1638  [15]
 LDCM0443  CL52 HEK-293T C36(1.29)  LDD1646  [15]
 LDCM0447  CL56 HEK-293T C36(0.99)  LDD1650  [15]
 LDCM0453  CL61 HCT 116 C36(0.99); C39(0.99)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C36(0.85); C39(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C36(0.80); C39(0.80)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C36(0.66); C39(0.66)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C36(0.93); C39(0.93)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C36(0.47); C39(0.47)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C36(0.55); C39(0.55)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C36(0.50); C39(0.50)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C36(0.43); C39(0.43)  LDD0778  [5]
 LDCM0463  CL70 HCT 116 C36(0.51); C39(0.51)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C36(0.98); C39(0.98)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C36(1.39); C39(1.39)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C36(0.66); C39(0.66)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C36(0.70); C39(0.70)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C36(0.54); C39(0.54)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C36(0.73); C39(0.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C36(0.75); C39(0.75)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C36(0.46); C39(0.46)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C36(0.85)  LDD1676  [15]
 LDCM0474  CL80 HCT 116 C36(0.48); C39(0.48)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C36(0.62); C39(0.62)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C36(0.36); C39(0.36)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C36(0.29); C39(0.29)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C36(0.28); C39(0.28)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C36(0.51); C39(0.51)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C36(0.73); C39(0.73)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C36(0.52); C39(0.52)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C36(0.31); C39(0.31)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C36(0.35); C39(0.35)  LDD0800  [5]
 LDCM0485  CL90 HCT 116 C36(1.22); C39(1.22)  LDD0802  [5]
 LDCM0486  CL91 PaTu 8988t C36(0.50); C39(0.50)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C36(0.39); C39(0.39)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C36(0.46); C39(0.46)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C36(0.40); C39(0.40)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C36(0.30); C39(0.30)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C36(0.44); C39(0.44)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C36(0.53); C39(0.53)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C36(0.28); C39(0.28)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C36(0.57); C39(0.57)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C36(1.09)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C36(0.75); C39(0.75)  LDD0785  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C226(0.91)  LDD2102  [4]
 LDCM0109  NEM HeLa H156(0.00); H380(0.00)  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C226(0.79)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C226(1.26)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C226(0.86)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C226(0.93)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C226(1.08)  LDD2094  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C226(0.94)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C226(0.88)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C226(0.86)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C226(0.90)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C226(0.77)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C226(0.76)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C226(1.47)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C226(0.67)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C226(0.86)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C226(0.74)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C226(0.68)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C226(1.51)  LDD2110  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C226(0.77)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C226(0.74)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C226(0.09)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C226(0.08)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C226(1.04)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C226(0.76)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C226(0.68)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C226(0.90)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C226(0.88)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C226(0.89)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C226(1.05)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C226(1.05)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C226(0.95)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C226(1.05)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C226(0.50)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C226(0.90)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C226(0.30)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C226(0.69)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C226(0.18)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C226(0.13)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C226(2.10)  LDD2153  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402