Details of the Target

General Information of Target

Target ID LDTP11564
Target Name UBX domain-containing protein 6 (UBXN6)
Gene Name UBXN6
Gene ID 80700
Synonyms
UBXD1; UBXDC2; UBX domain-containing protein 6; UBX domain-containing protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS
LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV
HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD
STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ
SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE
APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL
NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR
PSRCSNPTPGP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
Uniprot ID
Q9BZV1
Ensemble ID
ENST00000301281.11
HGNC ID
HGNC:14928

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.E90Ter DBIA    Probe Info 
MM1S SNV: p.T214N .
TOV21G SNV: p.R329Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K166(0.96); K3(3.56)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C125(2.66)  LDD0172  [2]
DBIA
 Probe Info  		C347(29.47); C210(11.97)  LDD0209  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C125(0.00); C210(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C125(0.00); C210(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C210(0.00); C347(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		C125(0.00); C210(0.00)  LDD2226  [8]
NAIA_5
 Probe Info  		C125(0.00); C210(0.00)  LDD2224  [8]
Compound 10
 Probe Info  		C125(0.00); C210(0.00)  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C125(2.66)  LDD0172  [2]
 LDCM0214  AC1 PaTu 8988t C347(1.63)  LDD1093  [10]
 LDCM0215  AC10 HCT 116 C347(0.64)  LDD0532  [10]
 LDCM0216  AC100 HEK-293T C347(0.78)  LDD0814  [10]
 LDCM0217  AC101 HEK-293T C347(0.72)  LDD0815  [10]
 LDCM0218  AC102 HEK-293T C347(0.84)  LDD0816  [10]
 LDCM0219  AC103 HEK-293T C347(0.75)  LDD0817  [10]
 LDCM0220  AC104 HEK-293T C347(1.18)  LDD0818  [10]
 LDCM0221  AC105 HEK-293T C347(0.80)  LDD0819  [10]
 LDCM0222  AC106 HEK-293T C347(0.68)  LDD0820  [10]
 LDCM0223  AC107 HEK-293T C347(0.72)  LDD0821  [10]
 LDCM0224  AC108 HEK-293T C347(0.74)  LDD0822  [10]
 LDCM0225  AC109 HEK-293T C347(0.86)  LDD0823  [10]
 LDCM0226  AC11 HCT 116 C347(0.72)  LDD0543  [10]
 LDCM0227  AC110 HEK-293T C347(0.86)  LDD0825  [10]
 LDCM0228  AC111 HEK-293T C347(0.95)  LDD0826  [10]
 LDCM0229  AC112 HEK-293T C347(0.94)  LDD0827  [10]
 LDCM0230  AC113 HCT 116 C347(1.05)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C347(0.89)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C347(1.03)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C347(0.93)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C347(0.85)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C347(0.84)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C347(0.86)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C347(0.74)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C347(1.19)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C347(1.14)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C347(1.04)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C347(1.44)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C347(0.91)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C347(1.26)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C347(1.14)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C347(1.02)  LDD0562  [10]
 LDCM0259  AC14 HCT 116 C347(0.78)  LDD0576  [10]
 LDCM0270  AC15 HCT 116 C347(1.17)  LDD0587  [10]
 LDCM0276  AC17 HCT 116 C347(1.15)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C347(1.08)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C347(1.25)  LDD0595  [10]
 LDCM0279  AC2 PaTu 8988t C347(1.29)  LDD1158  [10]
 LDCM0280  AC20 HCT 116 C347(1.31)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C347(1.14)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C347(1.08)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C347(1.14)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C347(1.29)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C347(1.03)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C347(0.96)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C347(1.29)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C347(0.99)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C347(1.33)  LDD0606  [10]
 LDCM0290  AC3 PaTu 8988t C347(1.39)  LDD1169  [10]
 LDCM0291  AC30 HCT 116 C347(1.16)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C347(1.14)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C347(1.19)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C347(1.29)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C347(1.42)  LDD0612  [10]
 LDCM0296  AC35 HEK-293T C210(0.97); C125(1.15); C347(0.99)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C210(1.03); C347(1.03)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C210(1.15); C125(1.20); C347(1.06)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C210(0.93); C347(1.08)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C210(0.98); C347(0.98)  LDD1539  [11]
 LDCM0301  AC4 PaTu 8988t C347(1.37)  LDD1180  [10]
 LDCM0302  AC40 HEK-293T C210(1.01); C125(1.03); C347(1.01)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C210(0.91); C125(1.12); C347(1.23)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C210(0.92); C125(1.13); C347(0.96)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C210(1.02); C125(1.32); C347(1.15)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C210(0.99); C347(1.11)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C210(1.03); C125(0.98); C347(1.10)  LDD1546  [11]
 LDCM0308  AC46 HCT 116 C347(1.17)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C347(0.79)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C347(0.89)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C347(1.14)  LDD0628  [10]
 LDCM0312  AC5 PaTu 8988t C347(1.75)  LDD1191  [10]
 LDCM0313  AC50 HCT 116 C347(1.18)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C347(0.98)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C347(0.89)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C347(1.26)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C347(1.04)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C347(1.21)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C347(1.45)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C347(1.01)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C347(1.73)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C347(1.01)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C347(0.82)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C347(1.12)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C347(1.07)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C347(1.35)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C347(1.12)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C347(1.07)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C347(0.95)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C347(1.24)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C347(0.95)  LDD0648  [10]
 LDCM0332  AC68 HEK-293T C347(0.87)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C347(1.13)  LDD0931  [10]
 LDCM0334  AC7 HCT 116 C347(0.86)  LDD0651  [10]
 LDCM0335  AC70 HEK-293T C347(1.05)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C347(0.92)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C347(1.02)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C347(1.01)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C347(0.88)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C347(1.04)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C347(0.81)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C347(0.98)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C347(0.84)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C347(0.78)  LDD0942  [10]
 LDCM0345  AC8 HCT 116 C347(1.02)  LDD0662  [10]
 LDCM0346  AC80 HEK-293T C347(0.84)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C347(0.80)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C347(0.92)  LDD0946  [10]
 LDCM0349  AC83 HCT 116 C347(1.13)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C347(1.07)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C347(1.03)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C347(1.08)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C347(0.98)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C347(1.10)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C347(1.21)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C347(1.22)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C347(1.27)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C347(1.24)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C347(1.06)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C347(1.09)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C347(0.99)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C347(1.11)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C347(1.15)  LDD0681  [10]
 LDCM0365  AC98 HEK-293T C347(0.79)  LDD0963  [10]
 LDCM0366  AC99 HEK-293T C347(0.75)  LDD0964  [10]
 LDCM0248  AKOS034007472 HCT 116 C347(0.72)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C347(0.74)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C347(0.87)  LDD0592  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C210(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C210(0.93); C125(1.28)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C210(0.79); C347(1.07)  LDD1572  [11]
 LDCM0369  CL100 PaTu 8988t C347(1.13)  LDD1248  [10]
 LDCM0370  CL101 HCT 116 C347(0.86)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C347(0.59)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C347(0.76)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C347(0.68)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C347(1.22)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C347(1.38)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C347(1.29)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C347(1.51)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C347(1.24)  LDD0695  [10]
 LDCM0379  CL11 HEK-293T C210(1.05); C347(1.28)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C347(1.24)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C347(1.20)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C347(0.84)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C347(1.25)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C347(1.12)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C347(1.08)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C347(1.09)  LDD0703  [10]
 LDCM0387  CL117 HEK-293T C210(0.96); C125(1.56)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C210(0.90); C125(0.90)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C210(1.02); C125(0.88); C347(1.06)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C210(0.99); C125(1.07); C347(1.14)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C210(1.06); C125(1.12); C347(1.05)  LDD1595  [11]
 LDCM0392  CL121 HCT 116 C347(0.86)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C347(1.00)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C347(1.27)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C347(1.19)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C347(0.92)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C347(1.00)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C347(1.11)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C347(1.10)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C210(0.91); C125(0.88)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C210(1.02); C125(0.85)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C210(0.88); C125(1.18); C347(1.12)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C347(1.04)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C347(0.82)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C347(0.94)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C347(1.23)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C210(0.98); C125(1.03)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C347(1.19)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C347(0.97)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C347(1.39)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C347(1.06)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C347(1.19)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C347(1.00)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C347(0.92)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C347(1.01)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C347(0.97)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C347(1.12)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C210(1.02); C125(1.14); C347(1.22)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C347(0.91)  LDD1017  [10]
 LDCM0420  CL31 HCT 116 C347(0.91)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C347(0.75)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C347(0.88)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C347(0.88)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C347(1.17)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C347(0.94)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C347(0.98)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C347(1.02)  LDD0745  [10]
 LDCM0429  CL4 HEK-293T C210(1.15); C125(1.08); C347(1.13)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C347(1.02)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C347(1.11)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C347(1.39)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C347(1.16)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C347(1.01)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C347(0.76)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C347(0.87)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C347(1.19)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C347(0.73)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C347(0.81)  LDD0756  [10]
 LDCM0440  CL5 HEK-293T C210(0.92); C125(1.13); C347(1.08)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C347(0.82)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C347(0.79)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C347(0.94)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C347(1.39)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C347(1.01)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C347(1.09)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C347(1.56)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C347(1.65)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C347(1.15)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C347(1.01)  LDD0767  [10]
 LDCM0451  CL6 HEK-293T C210(0.92); C125(1.26); C347(1.33)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C347(0.79)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C347(1.06)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C347(1.03)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C347(1.13)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C347(1.13)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C347(1.37)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C347(1.07)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C347(1.69)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C347(1.82)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C347(1.89)  LDD0778  [10]
 LDCM0462  CL7 HEK-293T C210(1.05); C125(1.37); C347(1.39)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C347(1.47)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C347(1.52)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C347(2.27)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C347(1.94)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C347(1.54)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C347(1.20)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C347(1.61)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C347(1.17)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C347(1.03)  LDD0789  [10]
 LDCM0473  CL8 HEK-293T C210(0.79); C347(1.09)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C347(0.80)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C347(1.00)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C347(0.83)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C347(0.91)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C347(0.81)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C347(1.07)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C347(1.19)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C347(1.07)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C347(1.48)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C347(1.17)  LDD0800  [10]
 LDCM0484  CL9 HEK-293T C210(1.08); C125(1.04); C347(1.03)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C347(1.53)  LDD0802  [10]
 LDCM0486  CL91 PaTu 8988t C347(1.41)  LDD1365  [10]
 LDCM0487  CL92 PaTu 8988t C347(1.37)  LDD1366  [10]
 LDCM0488  CL93 PaTu 8988t C347(1.51)  LDD1367  [10]
 LDCM0489  CL94 PaTu 8988t C347(2.18)  LDD1368  [10]
 LDCM0490  CL95 PaTu 8988t C347(1.61)  LDD1369  [10]
 LDCM0491  CL96 PaTu 8988t C347(1.04)  LDD1370  [10]
 LDCM0492  CL97 PaTu 8988t C347(1.21)  LDD1371  [10]
 LDCM0493  CL98 PaTu 8988t C347(1.72)  LDD1372  [10]
 LDCM0494  CL99 PaTu 8988t C347(1.43)  LDD1373  [10]
 LDCM0495  E2913 HEK-293T C210(0.85); C125(0.98); C347(1.25)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C347(1.16)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C347(1.01)  LDD0744  [10]
 LDCM0022  KB02 HEK-293T C125(1.21); C210(1.02)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C347(29.47); C210(11.97)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C347(2.04)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
Ubiquitin thioesterase OTU1 (YOD1) . Q5VVQ6
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UBX domain-containing protein 2B (UBXN2B) NSFL1C family Q14CS0
Small VCP/p97-interacting protein (SVIP) SVIP family Q8NHG7
UBX domain-containing protein 10 (UBXN10) UBXN10 family Q96LJ8
DAZ-associated protein 2 (DAZAP2) . Q15038
Melanoma-associated antigen 4 (MAGEA4) . P43358
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Sushi domain-containing protein 6 (SUSD6) . Q92537
UBX domain-containing protein 2A (UBXN2A) . P68543

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840