Details of the Target

General Information of Target

Target ID LDTP11501
Target Name Centrosomal protein of 41 kDa (CEP41)
Gene Name CEP41
Gene ID 95681
Synonyms
TSGA14; Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTT
VEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVT
YRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNV
NYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDLDGTAYNMGN
SFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQ
PLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQIN
AFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLN
APEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHF
FYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITP
NQNESNFILVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
Target Bioclass
Other
Family
CEP41 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.
Uniprot ID
Q9BYV8
Ensemble ID
ENST00000223208.10
HGNC ID
HGNC:12370

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R4W .
HEC1 SNV: p.M239I .
HEC1B SNV: p.M239I .
HS839T SNV: p.I310K DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.D55MfsTer7 DBIA    Probe Info 
LN18 SNV: p.G130E DBIA    Probe Info 
MEWO SNV: p.P279S DBIA    Probe Info 
MKN1 SNV: p.I197V DBIA    Probe Info 
RD Deletion: p.R286HfsTer22 DBIA    Probe Info 
TCCSUP SNV: p.E86Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.85  LDD0402  [1]
STPyne
 Probe Info  		K27(3.33); K42(10.00)  LDD0277  [2]
BTD
 Probe Info  		C240(1.37)  LDD2107  [3]
HHS-475
 Probe Info  		Y12(3.89)  LDD0264  [4]
DBIA
 Probe Info  		C171(8.63); C240(1.90)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C171(0.00); C240(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C171(0.00); C240(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C171(0.00); C240(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
NAIA_4
 Probe Info  		C171(0.00); C187(0.00); C274(0.00)  LDD2226  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
NAIA_5
 Probe Info  		C171(0.00); C240(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C171(1.09); C240(1.21)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C171(1.01)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C240(0.65)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C240(0.68)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C240(0.75)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C240(0.76)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C240(0.65)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C240(0.64)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C240(0.76)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C240(0.55)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C240(0.89)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C240(0.87)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C171(0.79)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C240(0.77)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C240(0.80)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C240(0.53)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C171(1.01); C240(1.15)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C171(0.82); C240(0.98)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C171(1.12); C240(1.10)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C171(0.94); C240(0.88)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C171(1.09); C240(0.71)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C171(0.95); C240(0.64)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C171(1.13); C240(0.74)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C171(0.86)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C171(1.01); C240(0.99)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C171(1.53); C240(0.91)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C171(1.40); C240(0.87)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C171(1.65); C240(0.82)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C171(1.22); C240(0.71)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C171(1.46); C240(0.81)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C171(1.57); C240(1.15)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C171(1.67); C240(0.99)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C171(1.29); C240(1.05); C274(0.95)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C171(1.25); C240(1.48); C274(1.17)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C171(1.13); C240(1.27); C274(1.20)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C171(1.03); C240(1.10); C274(0.96)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C171(1.28); C240(1.05); C274(1.27)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C171(1.29); C240(1.30); C274(1.38)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C171(1.16); C240(1.33); C274(1.12)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C171(1.54); C240(1.17); C274(1.43)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C171(1.59); C240(1.30); C274(1.45)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C171(1.76); C240(1.67); C274(1.55)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C171(1.85); C240(2.15); C274(2.11)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C171(1.45); C240(1.84); C274(1.60)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C171(0.81)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C171(1.34); C240(1.49); C274(1.36)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C171(1.59); C240(1.62); C274(1.58)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C171(1.35); C240(1.59); C274(1.30)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C171(1.20); C240(1.39); C274(1.30)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C171(1.55); C240(0.95); C274(1.31)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C171(1.36); C240(1.17); C274(1.59)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C171(1.35); C240(1.29); C274(1.57)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C171(1.58); C240(1.24); C274(2.01)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C171(1.60); C240(1.42); C274(1.66)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C171(1.12); C240(0.85); C274(0.94)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C171(0.83)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C171(1.21); C240(1.12); C274(1.31)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C171(1.21); C240(0.95); C274(1.29)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C171(1.22); C240(0.94); C274(1.13)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C171(1.37); C240(0.95); C274(1.22)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C171(1.27); C240(0.94); C274(1.07)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C171(1.35); C240(1.20); C274(1.14)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C171(1.53); C240(1.55); C274(1.83)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C171(1.83); C240(1.28); C274(1.78)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C171(1.10); C240(1.16)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C171(0.75); C240(1.54)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C171(1.28); C240(1.32)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C171(0.90); C240(0.97)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C171(1.01); C240(1.42)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C171(0.85); C240(1.11)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C171(0.84); C240(1.17)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C171(0.75); C240(1.23)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C171(1.17); C240(1.19)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C171(0.78); C240(0.84)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C240(0.95); C171(1.06)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C240(1.10); C171(1.23)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C240(0.97); C171(1.32)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C240(0.99); C171(1.43)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C171(0.96); C240(1.03)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C240(0.80); C171(1.68)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C240(1.03); C171(1.11)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C240(1.09); C171(1.21)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C240(0.91); C171(1.13)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C171(1.12); C240(1.16)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C240(0.88)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C240(0.78)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C240(0.75)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C240(0.96)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C240(0.79)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C171(1.34); C240(1.37)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C240(1.01)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C240(0.94)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C240(1.03)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C240(0.84)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C240(0.87)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C240(1.03)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C240(0.98)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C240(1.06)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C240(1.02)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C240(1.21)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C240(1.33); C171(1.37)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C240(1.20)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C240(1.03)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C240(0.83)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C240(0.94)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C240(1.10)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C240(1.12)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C240(1.34)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C171(0.98); C240(0.92); C274(1.31)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C171(1.07); C240(1.13); C274(1.13)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C171(1.13); C240(1.37); C274(1.01)  LDD0920  [5]
 LDCM0323  AC6 HCT 116 C171(1.01)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C171(0.90); C240(1.11); C274(1.21)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C171(1.54); C240(0.91); C274(1.55)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C171(1.45); C240(1.11); C274(1.53)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C171(1.37); C240(0.94); C274(1.62)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C171(1.18); C240(1.07); C274(1.22)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C171(1.36); C240(0.90); C274(1.76)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C171(1.14); C240(0.91); C274(1.26)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C171(1.32); C240(0.81); C274(1.42)  LDD0929  [5]
 LDCM0332  AC68 HCT 116 C240(0.97)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C240(1.15)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C171(0.97)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C240(1.06)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C240(1.20)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C240(1.13)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C240(1.36)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C240(1.18)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C240(1.10)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C240(1.26)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C240(1.08)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C240(1.09)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C240(1.08)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C171(0.84)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C240(1.06)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C240(1.13)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C240(1.22)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C171(0.98); C240(1.25); C274(0.99)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C171(1.26); C240(1.08); C274(1.12)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C171(1.10); C240(1.01); C274(0.88)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C171(1.02); C240(1.08); C274(1.44)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C171(1.07); C240(1.09); C274(1.04)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C171(1.14); C240(1.10); C274(1.07)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C171(1.04); C240(1.27); C274(1.17)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C171(1.10); C240(1.11); C274(1.48)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C171(1.04); C240(1.20); C274(1.35)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C171(1.02); C240(1.38); C274(1.29)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C171(1.09); C240(2.07); C274(1.31)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C171(1.60); C240(1.10); C274(1.80)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C171(0.98); C240(1.14); C274(1.14)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C171(1.19); C240(1.90); C274(1.31)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C171(1.45); C240(1.76); C274(1.73)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C240(0.60)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C240(0.75)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C171(0.81)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C171(0.85)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C171(1.08)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.23  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C171(0.81)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C171(0.91); C240(0.89); C274(0.65)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C171(1.76); C240(0.73); C274(1.11)  LDD0966  [5]
 LDCM0369  CL100 HCT 116 C171(1.04); C240(1.05)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C171(0.94)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C171(1.47)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C171(0.79)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C171(0.83)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C171(0.81); C240(1.21)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C171(0.81); C240(1.28)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C171(0.70); C240(1.32)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C171(0.79); C240(1.50)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C171(0.91); C240(1.07)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C171(1.69); C240(0.66); C274(1.37)  LDD0977  [5]
 LDCM0380  CL110 HCT 116 C171(1.00); C240(1.25)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C171(0.88); C240(1.15)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C240(0.77); C171(1.14)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C240(0.88); C171(1.45)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C240(0.81); C171(1.37)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C240(0.79); C171(1.32)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C240(0.91); C171(0.91)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C240(1.17)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C240(0.78)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C240(0.87)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C171(1.10); C240(0.72); C274(0.95)  LDD0988  [5]
 LDCM0391  CL120 HCT 116 C240(1.03)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C240(0.77)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C240(1.04)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C240(0.97)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C240(1.19)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C171(1.04); C240(1.16); C274(1.04)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C171(1.07); C240(0.90); C274(1.29)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C171(1.08); C240(1.01); C274(0.99)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C171(0.87); C240(1.08); C274(1.25)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C171(1.04); C240(0.74); C274(0.69)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C171(1.03); C240(0.70); C274(0.88)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C171(1.19); C240(0.69); C274(0.97)  LDD1000  [5]
 LDCM0403  CL16 HCT 116 C240(0.75)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C240(1.02)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C240(0.93)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C240(0.73)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C171(1.00); C240(1.05); C274(0.70)  LDD1005  [5]
 LDCM0408  CL20 HCT 116 C240(0.91)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C240(1.03)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C240(1.04)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C240(1.05)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C240(1.01)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C240(0.93)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C240(0.93)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C240(1.09)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C240(0.87)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C240(0.89)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C171(0.95); C240(0.65); C274(0.74)  LDD1016  [5]
 LDCM0419  CL30 HCT 116 C240(0.65)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C171(0.80)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C171(0.88)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C171(0.93)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C171(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C171(0.99)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C171(0.92)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C171(0.95)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C171(1.10)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C171(1.12); C240(0.69); C274(0.80)  LDD1027  [5]
 LDCM0430  CL40 HCT 116 C171(0.85)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C171(0.84)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C171(0.94)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C171(0.89)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C171(0.89)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C171(0.91)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C171(0.90); C240(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C171(0.67); C240(0.79)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C171(0.92); C240(0.80)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C171(0.94); C240(0.88)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C171(1.06); C240(0.67); C274(0.80)  LDD1038  [5]
 LDCM0441  CL50 HCT 116 C171(0.94); C240(0.94)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C171(0.85); C240(0.89)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C171(0.88); C240(0.83)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C171(0.98); C240(0.90)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C171(1.12); C240(0.79)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C171(0.79); C240(0.86)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C171(0.95); C240(0.81)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C171(0.93); C240(0.82)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C171(0.92); C240(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C171(1.03); C240(0.88)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C171(1.18); C240(0.78); C274(0.81)  LDD1049  [5]
 LDCM0452  CL60 HCT 116 C171(0.85); C240(0.93)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C171(1.23); C240(0.85); C274(1.01)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C171(1.08); C240(0.86); C274(1.16)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C171(1.06); C240(0.82); C274(0.99)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C171(0.97); C240(0.91); C274(1.08)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C171(0.97); C240(0.79); C274(1.32)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C171(1.02); C240(0.95); C274(1.29)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C171(1.09); C240(0.97); C274(1.01)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C171(1.26); C240(1.08); C274(1.32)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C171(0.96); C240(0.94); C274(1.19)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C171(1.28); C240(0.65); C274(0.73)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C171(1.03); C240(1.00); C274(1.11)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C171(1.09); C240(0.94); C274(1.14)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C171(1.74); C240(1.06); C274(1.49)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C171(1.11); C240(1.00); C274(1.31)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C171(1.50); C240(0.90); C274(1.57)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C171(1.47)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C171(1.32)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C171(1.17)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C171(1.67)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C171(1.52); C240(0.75); C274(1.08)  LDD1071  [5]
 LDCM0474  CL80 HCT 116 C171(1.71)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C171(1.72)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C171(2.44)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C171(2.12)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C171(2.26)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C171(1.74)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C171(1.15)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C171(1.74)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C171(1.72)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C171(2.35)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C171(1.11); C240(0.86); C274(1.45)  LDD1082  [5]
 LDCM0485  CL90 HCT 116 C171(1.26)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C171(0.84); C240(0.94)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C171(0.86); C240(1.11)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C171(1.01); C240(1.22)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C171(1.28); C240(0.94)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C171(1.50); C240(0.97)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C171(0.91); C240(1.16)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C171(0.87); C240(1.19)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C171(0.98); C240(1.40)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C171(1.18); C240(1.12)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C240(1.18); C274(1.05); C171(0.95)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C171(1.67)  LDD1702  [3]
 LDCM0573  Fragment11 Ramos C274(2.64)  LDD2190  [13]
 LDCM0576  Fragment14 Ramos C274(0.76)  LDD2193  [13]
 LDCM0586  Fragment28 Ramos C274(1.47)  LDD2198  [13]
 LDCM0468  Fragment33 HEK-293T C171(1.38); C240(1.05); C274(1.43)  LDD1066  [5]
 LDCM0566  Fragment4 Ramos C274(0.76)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C171(1.28)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C274(0.42)  LDD2186  [13]
 LDCM0116  HHS-0101 DM93 Y12(3.89)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y12(2.56)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y12(3.04)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y12(3.29)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y12(2.41)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C171(8.63); C240(1.90)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C171(1.56); C240(2.32)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C171(2.32); C240(2.04)  LDD0082  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C240(1.37)  LDD2107  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578