Details of the Target

General Information of Target

Target ID LDTP11459
Target Name Partitioning defective 6 homolog beta (PARD6B)
Gene Name PARD6B
Gene ID 84612
Synonyms
PAR6B; Partitioning defective 6 homolog beta; PAR-6 beta; PAR-6B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDV
TIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGA
LRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASV
RVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANS
HNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDND
VVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSL
ALPPGGVEEHGPAVTL
Target Bioclass
Other
Family
PAR6 family
Subcellular location
Cytoplasm
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Uniprot ID
Q9BYG5
Ensemble ID
ENST00000371610.7
HGNC ID
HGNC:16245

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.P304HfsTer17 .
HEC1B SNV: p.K80R .
NCIH1155 SNV: p.V119I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y172(12.15)  LDD0257  [1]
STPyne
 Probe Info  		K113(1.23); K188(9.22); K22(4.70)  LDD0277  [2]
Probe 1
 Probe Info  		Y101(7.82)  LDD3495  [3]
IPM
 Probe Info  		C13(1.60)  LDD1702  [4]
DBIA
 Probe Info  		C13(1.02)  LDD0531  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C13(1.02)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C13(1.04)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C13(0.99)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C13(1.09)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C13(1.17)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C13(1.45)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C13(1.38)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C13(1.46)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C13(1.36)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C13(1.54)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C13(0.97)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C13(0.90)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C13(1.10)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C13(0.92)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C13(1.05)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C13(1.36)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C13(1.12)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C13(1.31)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C13(1.63)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C13(1.57)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C13(1.37)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C13(1.34)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C13(1.37)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C13(0.94)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C13(1.42)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C13(1.32)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C13(1.26)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C13(1.19)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C13(1.14)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C13(1.29)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C13(1.46)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C13(1.46)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C13(1.42)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C13(1.39)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C13(1.10)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C13(1.43)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C13(1.10)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C13(2.01)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C13(1.88)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C13(2.38)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C13(1.65)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C13(1.97)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C13(1.50)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C13(1.27)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C13(1.01)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C13(1.14)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C13(1.05)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C13(1.40)  LDD1141  [5]
 LDCM0270  AC15 HCT 116 C13(1.10)  LDD0587  [5]
 LDCM0276  AC17 PaTu 8988t C13(1.19)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C13(1.61)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C13(1.39)  LDD1157  [5]
 LDCM0279  AC2 HCT 116 C13(1.08)  LDD0596  [5]
 LDCM0280  AC20 PaTu 8988t C13(1.53)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C13(1.82)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C13(1.96)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C13(2.02)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C13(1.34)  LDD1163  [5]
 LDCM0285  AC25 HCT 116 C13(0.97)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C13(1.15)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C13(1.13)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C13(1.23)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C13(1.28)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C13(1.06)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C13(1.39)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C13(1.29)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C13(1.54)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C13(1.16)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C13(1.52)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C13(0.83)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C13(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C13(0.76)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C13(1.13)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C13(1.06)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C13(1.20)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C13(0.91)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C13(0.83)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C13(0.87)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C13(0.90)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C13(0.70)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C13(0.67)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C13(1.11)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C13(1.03)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C13(1.13)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C13(1.62)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C13(1.16)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C13(1.48)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C13(0.91)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C13(1.17)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C13(1.19)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C13(1.30)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C13(1.28)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C13(1.96)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C13(1.33)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C13(1.38)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C13(1.51)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C13(1.33)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C13(1.60)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C13(1.35)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C13(1.51)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C13(1.40)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C13(1.61)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C13(1.52)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C13(1.42)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C13(1.88)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C13(1.31)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C13(1.33)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C13(1.04)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C13(1.61)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C13(1.25)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C13(1.37)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C13(2.16)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C13(2.25)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C13(3.07)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C13(1.56)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C13(1.52)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C13(1.21)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C13(1.52)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C13(1.17)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C13(1.50)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C13(1.27)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C13(3.10)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C13(1.81)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C13(1.68)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C13(1.37)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C13(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C13(0.98)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C13(1.00)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C13(1.38)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C13(0.86)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C13(1.78)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C13(1.48)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C13(1.20)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C13(1.03)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C13(1.07)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C13(1.23)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C13(1.46)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C13(2.58)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C13(1.06)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C13(0.88)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C13(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C13(1.64)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C13(1.16)  LDD2171  [5]
 LDCM0632  CL-Sc Hep-G2 C13(2.25); C13(1.56)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C13(0.77)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C13(1.37)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C13(1.11)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C13(1.25)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C13(1.10)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C13(0.89)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C13(0.99)  LDD0690  [5]
 LDCM0374  CL105 PaTu 8988t C13(1.25)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C13(1.17)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C13(1.12)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C13(1.36)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C13(1.23)  LDD1257  [5]
 LDCM0379  CL11 HEK-293T C13(1.51)  LDD1583  [11]
 LDCM0380  CL110 PaTu 8988t C13(1.50)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C13(2.13)  LDD1260  [5]
 LDCM0382  CL112 HCT 116 C13(1.19)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C13(1.49)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C13(1.53)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C13(1.40)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C13(1.16)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C13(1.05)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C13(0.90)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C13(0.78)  LDD0706  [5]
 LDCM0390  CL12 HEK-293T C13(1.51)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C13(0.99)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C13(1.04)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C13(1.36)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C13(1.33)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C13(1.51)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C13(1.16)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C13(1.16)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C13(1.24)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C13(1.41)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C13(1.18)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C13(0.99)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C13(1.07)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C13(0.90)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C13(0.80)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C13(0.88)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C13(0.94)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C13(1.12)  LDD1611  [11]
 LDCM0408  CL20 HCT 116 C13(0.98)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C13(0.85)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C13(0.79)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C13(0.94)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C13(0.96)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C13(0.94)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C13(0.96)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C13(0.90)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C13(0.98)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C13(1.04)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C13(1.08)  LDD1622  [11]
 LDCM0419  CL30 HCT 116 C13(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C13(1.05)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C13(0.93)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C13(1.03)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C13(1.02)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C13(1.17)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C13(1.11)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C13(1.19)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C13(0.92)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C13(0.93)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C13(1.17)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C13(0.94)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C13(1.12)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C13(0.86)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C13(0.94)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C13(0.93)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C13(0.79)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C13(0.82)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C13(0.73)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C13(0.81)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C13(1.03)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C13(0.83)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C13(0.81)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C13(0.79)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C13(1.04)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C13(0.74)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C13(0.78)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C13(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C13(0.85)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C13(0.80)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C13(0.83)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C13(0.88)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C13(0.81)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C13(1.01)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C13(0.92)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C13(0.93)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C13(0.88)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C13(0.88)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C13(0.84)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C13(0.82)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C13(1.11)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C13(0.93)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C13(1.03)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C13(0.95)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C13(0.97)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C13(1.03)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C13(0.92)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C13(0.80)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C13(1.21)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C13(1.43)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C13(1.00)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C13(1.20)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C13(0.78)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C13(1.06)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C13(1.01)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C13(1.10)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C13(1.22)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C13(1.05)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C13(1.22)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C13(1.16)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C13(1.19)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C13(1.18)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C13(1.02)  LDD0800  [5]
 LDCM0485  CL90 HCT 116 C13(1.17)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C13(1.28)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C13(1.21)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C13(1.01)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C13(1.21)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C13(1.44)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C13(1.21)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C13(1.19)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C13(1.13)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C13(1.12)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C13(2.56)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C13(1.21)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(1.60)  LDD1702  [4]
 LDCM0576  Fragment14 Ramos C13(0.39)  LDD2193  [12]
 LDCM0586  Fragment28 Ramos C13(0.66)  LDD2198  [12]
 LDCM0468  Fragment33 HCT 116 C13(0.90)  LDD0785  [5]
 LDCM0566  Fragment4 Ramos C13(0.77)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C13(1.31)  LDD0744  [5]
 LDCM0569  Fragment7 Ramos C13(1.36)  LDD2186  [12]
 LDCM0022  KB02 CAL-51 C13(2.97)  LDD2288  [13]
 LDCM0023  KB03 Ramos C13(0.82)  LDD2183  [12]
 LDCM0024  KB05 ZR-75-1 C13(1.96)  LDD3493  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C13(1.12)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C13(1.03)  LDD2207  [14]
 LDCM0021  THZ1 HCT 116 C13(1.16)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C iota type (PRKCI) AGC Ser/Thr protein kinase family P41743
Protein kinase C zeta type (PRKCZ) AGC Ser/Thr protein kinase family Q05513
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Ras-related C3 botulinum toxin substrate 3 (RAC3) Rho family P60763
Rho-related GTP-binding protein RhoJ (RHOJ) Rho family Q9H4E5
Rho-related GTP-binding protein RhoQ (RHOQ) Rho family P17081
Cell division control protein 42 homolog (CDC42) Rho family P60953
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Partitioning defective 3 homolog (PARD3) PAR3 family Q8TEW0
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
Heat shock factor 2-binding protein (HSF2BP) . O75031
Ras association domain-containing protein 3 (RASSF3) . Q86WH2

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.