Details of the Target

General Information of Target

Target ID LDTP11453
Target Name Polycomb group RING finger protein 6 (PCGF6)
Gene Name PCGF6
Gene ID 84108
Synonyms
MBLR; RNF134; Polycomb group RING finger protein 6; Mel18 and Bmi1-like RING finger; RING finger protein 134
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCQQNQQQCQPPPKCPSPKCPPKSPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHRRH
HRCRRQRPNSCDRGSGQQGGGSGCGHGSGGCC
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Uniprot ID
Q9BYE7
Ensemble ID
ENST00000337211.8
HGNC ID
HGNC:21156

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P130A .
HUH28 SNV: p.S59F .
IGROV1 Insertion: p.Q209AfsTer4 .
LNCaP clone FGC Deletion: p.K208SfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.18  LDD0402  [1]
DBIA
 Probe Info  		C150(0.76); C155(0.76); C302(0.79); C308(0.79)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
AOyne
 Probe Info  		13.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C150(0.76); C155(0.76); C302(0.79); C308(0.79)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C150(0.92); C155(0.92); C302(0.50); C308(0.50)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C150(1.01); C155(1.01)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C150(0.66); C155(0.66)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C150(0.93); C155(0.93)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C150(0.79); C155(0.79)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C150(0.75); C155(0.75)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C150(0.72); C155(0.72)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C150(0.79); C155(0.79)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C150(0.69); C155(0.69)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C150(0.84); C155(0.84)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C150(0.70); C155(0.70)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C150(1.02); C155(1.02); C302(0.54); C308(0.54)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C150(0.74); C155(0.74)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C150(0.74); C155(0.74)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C150(0.65); C155(0.65)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C150(0.75)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C150(0.96)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C150(0.95)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C150(0.92)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C150(0.95)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C150(1.18)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C150(0.95)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C150(1.11); C155(1.11); C302(0.56); C308(0.56)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C150(0.91)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C150(1.10)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C150(1.02)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C150(0.95)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C150(1.16)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C150(1.17)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C150(1.16)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C150(1.20)  LDD0843  [2]
 LDCM0246  AC128 PaTu 8988t C150(0.99); C155(0.99)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C150(1.01); C155(1.01)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C150(0.99); C155(0.99)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C150(1.05); C155(1.05)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C150(1.02); C155(1.02)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C150(1.24); C155(1.24)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C150(1.06); C155(1.06)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C150(1.16); C155(1.16)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C150(1.16); C155(1.16)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C150(1.21); C155(1.21)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C150(1.00); C155(1.00)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C150(1.06); C155(1.06)  LDD1137  [2]
 LDCM0259  AC14 HCT 116 C150(1.11); C155(1.11); C302(0.57); C308(0.57)  LDD0576  [2]
 LDCM0260  AC140 PaTu 8988t C150(1.01); C155(1.01)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C150(1.02); C155(1.02)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C150(1.14); C155(1.14)  LDD1141  [2]
 LDCM0263  AC143 HEK-293T C150(1.15)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C150(1.38)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C150(1.28)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C150(1.27)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C150(1.38)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C150(1.26)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C150(1.14)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C302(0.49); C308(0.49); C150(1.06); C155(1.06)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C150(1.24)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C150(1.36)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C150(1.18)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C150(1.21)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C150(1.09)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C150(1.25)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C150(1.43)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C150(1.45)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C150(0.79); C155(0.79)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C150(0.75); C155(0.75)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C150(0.73); C155(0.73)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C150(0.77); C155(0.77); C302(0.83); C308(0.83)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C150(0.69); C155(0.69)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C150(1.02); C155(1.02)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C150(1.21); C155(1.21)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C150(0.98); C155(0.98)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C150(1.40); C155(1.40)  LDD0601  [2]
 LDCM0285  AC25 PaTu 8988t C302(1.20); C308(1.20); C150(1.03); C155(1.03)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C302(0.93); C308(0.93); C150(1.04); C155(1.04)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C302(0.86); C308(0.86); C150(1.03); C155(1.03)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C302(1.04); C308(1.04); C150(1.00); C155(1.00)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C302(0.94); C308(0.94); C150(1.05); C155(1.05)  LDD1168  [2]
 LDCM0290  AC3 HCT 116 C302(0.79); C308(0.79); C150(0.80); C155(0.80)  LDD0607  [2]
 LDCM0291  AC30 PaTu 8988t C302(0.96); C308(0.96); C150(0.97); C155(0.97)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C302(1.11); C308(1.11); C150(0.93); C155(0.93)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C302(1.58); C308(1.58); C150(1.13); C155(1.13)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C302(0.79); C308(0.79); C150(1.05); C155(1.05)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C302(0.84); C308(0.84); C150(1.11); C155(1.11)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C150(1.05)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C150(0.92)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C150(0.92)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C150(0.83)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C150(1.06)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C150(0.74); C155(0.74); C302(0.79); C308(0.79)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C150(1.30)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C150(0.92)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C150(0.95)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C150(0.95)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C150(1.34)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C150(1.02)  LDD0905  [2]
 LDCM0308  AC46 PaTu 8988t C302(1.12); C308(1.12); C150(0.95); C155(0.95)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C302(1.04); C308(1.04); C150(0.89); C155(0.89)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C302(1.15); C308(1.15); C150(0.87); C155(0.87)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C302(1.00); C308(1.00); C150(0.93); C155(0.93)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C302(0.60); C308(0.60); C150(0.75); C155(0.75)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C302(0.95); C308(0.95); C150(0.94); C155(0.94)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C302(0.67); C308(0.67); C150(0.67); C155(0.67)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C302(1.04); C308(1.04); C150(1.00); C155(1.00)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C302(0.92); C308(0.92); C150(0.89); C155(0.89)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C302(1.45); C308(1.45); C150(1.04); C155(1.04)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C302(0.97); C308(0.97); C150(0.93); C155(0.93)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C302(1.01); C308(1.01); C150(0.97); C155(0.97)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C150(0.94); C155(0.94)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C150(0.78); C155(0.78)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C150(0.94); C155(0.94)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C302(0.52); C308(0.52); C150(0.98); C155(0.98)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C150(0.75); C155(0.75)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C150(0.98); C155(0.98)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C150(0.90); C155(0.90)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C150(0.85); C155(0.85)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C150(1.03); C155(1.03)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C150(0.93); C155(0.93)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C150(0.89); C155(0.89)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C150(0.85); C155(0.85)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C150(0.97); C155(0.97); C302(1.75); C308(1.75)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C150(0.92); C155(0.92); C302(1.23); C308(1.23)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C302(0.48); C308(0.48); C150(1.02); C155(1.02)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C150(0.81); C155(0.81); C302(1.57); C308(1.57)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C150(0.73); C155(0.73); C302(1.03); C308(1.03)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C150(0.94); C155(0.94); C302(1.11); C308(1.11)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C302(0.97); C308(0.97); C150(1.00); C155(1.00)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C302(0.90); C308(0.90); C150(1.12); C155(1.12)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C302(0.97); C308(0.97); C150(1.21); C155(1.21)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C150(0.89); C155(0.89); C302(1.05); C308(1.05)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C302(0.84); C308(0.84); C150(0.88); C155(0.88)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C150(0.71); C155(0.71); C302(0.95); C308(0.95)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C150(0.84); C155(0.84); C302(0.89); C308(0.89)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C302(0.73); C308(0.73); C150(1.08); C155(1.08)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C150(0.85); C155(0.85); C302(0.89); C308(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C150(0.75); C155(0.75); C302(0.93); C308(0.93)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C302(1.23); C308(1.23); C150(1.30); C155(1.30)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C150(1.11)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C150(1.20)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C150(1.21)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C150(1.11)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C150(1.22)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C150(1.47)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C150(1.35)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C150(1.43)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C150(1.37)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C150(1.19)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C150(1.23)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C150(1.48)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C150(1.33)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C150(1.39)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C150(1.68)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C150(0.31); C155(0.31)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C150(0.68); C155(0.68)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C150(1.05); C155(1.05); C302(0.52); C308(0.52)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C302(0.56); C308(0.56); C150(1.00); C155(1.00)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C302(0.53); C308(0.53); C150(1.23); C155(1.23)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 13.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C150(1.13); C155(1.13)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C150(1.01); C155(1.01)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C150(0.73); C155(0.73)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C302(0.74); C308(0.74); C150(0.75); C155(0.75)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C302(0.74); C308(0.74); C150(1.05); C155(1.05)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C302(0.49); C308(0.49); C150(1.00); C155(1.00)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C302(0.52); C308(0.52); C150(1.04); C155(1.04)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C302(0.67); C308(0.67); C150(0.95); C155(0.95)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C150(1.23); C155(1.23)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C150(0.91); C155(0.91)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C150(0.77); C155(0.77)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C150(0.90); C155(0.90)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C150(0.92); C155(0.92)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C150(0.85); C155(0.85)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C150(0.94); C155(0.94)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C150(0.99); C155(0.99)  LDD0698  [2]
 LDCM0382  CL112 PaTu 8988t C302(0.89); C308(0.89); C150(0.91); C155(0.91)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C302(0.87); C308(0.87); C150(0.94); C155(0.94)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C302(1.00); C308(1.00); C150(0.99); C155(0.99)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C302(1.19); C308(1.19); C150(0.92); C155(0.92)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C302(0.77); C308(0.77); C150(0.89); C155(0.89)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C150(0.87)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C150(0.95)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C150(1.15)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C150(0.89); C155(0.89)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C150(0.91)  LDD0989  [2]
 LDCM0392  CL121 PaTu 8988t C302(1.15); C308(1.15); C150(0.94); C155(0.94)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C302(0.93); C308(0.93); C150(0.80); C155(0.80)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C302(0.98); C308(0.98); C150(0.96); C155(0.96)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C302(1.01); C308(1.01); C150(0.96); C155(0.96)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C150(0.88); C155(0.88)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C150(0.77); C155(0.77)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C150(0.73); C155(0.73)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C150(0.90); C155(0.90)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C150(0.77); C155(0.77)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C150(0.93); C155(0.93)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C150(0.86); C155(0.86)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C302(1.15); C308(1.15); C150(1.35); C155(1.35)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C150(1.01); C155(1.01); C302(1.49); C308(1.49)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C302(0.85); C308(0.85); C150(1.08); C155(1.08)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C302(0.82); C308(0.82); C150(1.13); C155(1.13)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C150(1.02); C155(1.02)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C302(1.09); C308(1.09); C150(1.22); C155(1.22)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C302(0.94); C308(0.94); C150(1.31); C155(1.31)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C302(1.03); C308(1.03); C150(1.60); C155(1.60)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C150(1.12); C155(1.12); C302(1.14); C308(1.14)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C302(0.95); C308(0.95); C150(1.33); C155(1.33)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C150(1.28); C155(1.28); C302(1.00); C308(1.00)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C150(1.22); C155(1.22); C302(0.97); C308(0.97)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C150(1.11); C155(1.11); C302(0.94); C308(0.94)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C150(1.18); C155(1.18); C302(1.10); C308(1.10)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C150(1.16); C155(1.16); C302(0.91); C308(0.91)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C150(0.98); C155(0.98)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C150(1.23); C155(1.23); C302(1.01); C308(1.01)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C150(0.69); C155(0.69)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C150(0.87); C155(0.87)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C150(0.71); C155(0.71)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C150(0.86); C155(0.86)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C150(0.83); C155(0.83)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C150(0.69); C155(0.69)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C150(0.81); C155(0.81)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C150(0.94); C155(0.94)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C150(1.10); C155(1.10)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C150(0.53); C155(0.53)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C150(0.68); C155(0.68)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C150(0.72); C155(0.72)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C150(0.80); C155(0.80)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C150(0.86); C155(0.86)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C150(0.81); C155(0.81)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C302(1.13); C308(1.13)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C302(1.09); C308(1.09)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C302(0.99); C308(0.99)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C302(0.92); C308(0.92)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C150(0.98); C155(0.98)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C302(0.94); C308(0.94)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C302(0.90); C308(0.90)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C302(1.12); C308(1.12)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C302(0.82); C308(0.82)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C302(1.10); C308(1.10)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C302(0.96); C308(0.96)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C302(1.08); C308(1.08)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C302(0.97); C308(0.97)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C302(0.94); C308(0.94)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C302(0.82); C308(0.82)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C150(0.73); C155(0.73)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C302(0.97); C308(0.97)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C302(0.81); C308(0.81)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C302(0.76); C308(0.76)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C302(0.80); C308(0.80)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C302(0.78); C308(0.78)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C302(0.86); C308(0.86)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C302(0.62); C308(0.62)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C302(0.79); C308(0.79)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C302(0.73); C308(0.73)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C302(0.98); C308(0.98)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C150(0.96); C155(0.96)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C302(0.83); C308(0.83)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C302(0.67); C308(0.67)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C302(0.84); C308(0.84)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C302(0.85); C308(0.85)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C302(0.75); C308(0.75)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C150(0.91); C155(0.91)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C150(0.84); C155(0.84)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C150(0.92); C155(0.92)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C150(0.92); C155(0.92)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C150(0.97); C155(0.97)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C150(0.85); C155(0.85)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C150(0.91); C155(0.91)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C150(0.93); C155(0.93)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C150(0.83); C155(0.83)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C150(1.04); C155(1.04)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C150(0.84); C155(0.84)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C150(0.90); C155(0.90)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C150(0.82); C155(0.82)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C150(0.93); C155(0.93)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C150(1.02); C155(1.02)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C150(0.80); C155(0.80)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C150(0.89); C155(0.89)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C150(0.74); C155(0.74); C302(0.90); C308(0.90)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C150(0.77); C155(0.77); C302(0.88); C308(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C150(0.77); C155(0.77); C302(0.72); C308(0.72)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C150(0.80); C155(0.80); C302(0.84); C308(0.84)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C150(0.85); C155(0.85); C302(0.81); C308(0.81)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C150(0.77); C155(0.77); C302(0.97); C308(0.97)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C150(0.99); C155(0.99); C302(0.95); C308(0.95)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C150(0.79); C155(0.79); C302(0.71); C308(0.71)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C150(0.75); C155(0.75); C302(0.83); C308(0.83)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C155(0.95)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C302(0.72); C308(0.72)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C150(1.04); C155(1.04)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C172(0.96)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C172(0.96)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C172(0.95)  LDD1502  [7]
 LDCM0021  THZ1 HCT 116 C150(1.13); C155(1.13)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 7 (CBX7) . O95931
Chromobox protein homolog 8 (CBX8) . Q9HC52

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402