Details of the Target

General Information of Target

Target ID LDTP11289
Target Name Dual specificity protein phosphatase 23 (DUSP23)
Gene Name DUSP23
Gene ID 54935
Synonyms
LDP3; VHZ; Dual specificity protein phosphatase 23; EC 3.1.3.16; EC 3.1.3.48; Low molecular mass dual specificity phosphatase 3; LDP-3; VH1-like phosphatase Z
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK
LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL
NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA
RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK
ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ
NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD
VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL
LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS
EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER
TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFA
GDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRK
DKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPK
VVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Cytoplasm, cytosol
Function
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Uniprot ID
Q9BVJ7
Ensemble ID
ENST00000368107.2
HGNC ID
HGNC:21480
ChEMBL ID
CHEMBL2396506

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C53(0.97)  LDD2091  [1]
HHS-482
 Probe Info  		Y136(0.84)  LDD0285  [2]
HHS-475
 Probe Info  		Y136(0.96)  LDD0264  [3]
DBIA
 Probe Info  		C67(0.82)  LDD0547  [4]
IA-alkyne
 Probe Info  		C67(0.00); C53(0.00); C108(0.00)  LDD0162  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C67(0.00); C53(0.00)  LDD0148  [7]
NAIA_5
 Probe Info  		C95(0.00); C53(0.00); C67(0.00); C108(0.00)  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C53(1.36)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C53(1.25)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C53(1.15)  LDD1105  [4]
 LDCM0230  AC113 HCT 116 C67(0.82)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C67(0.57)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C67(0.57)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C67(1.01)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C67(0.42)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C67(0.55)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C67(0.70)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C53(1.05)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C67(0.57)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C67(0.66)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C67(0.46)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C67(0.46)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C67(0.57)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C67(0.55)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C67(0.51)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C67(0.42)  LDD0562  [4]
 LDCM0246  AC128 PaTu 8988t C53(1.34)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C53(1.19)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C53(1.24)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C53(1.12)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C53(1.28)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C53(1.28)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C53(1.21)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C53(1.50)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C53(1.35)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C53(1.15)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C53(1.16)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C53(1.32)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C53(1.30)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C53(1.15)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C53(0.99)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C53(1.06)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C53(1.04)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C53(1.01)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C53(0.97)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C53(1.19)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C53(1.05)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C53(0.93)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C53(1.04)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C53(1.03)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C53(1.14)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C53(1.17)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C53(1.03)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C53(1.01)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C53(1.21)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C53(1.11)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C53(1.22)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C53(1.08)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C53(0.80)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C53(0.83)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C53(0.79)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C53(1.45)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C53(0.86)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C53(0.74)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C53(0.85)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C53(0.70)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C53(0.92)  LDD1163  [4]
 LDCM0290  AC3 PaTu 8988t C53(1.16)  LDD1169  [4]
 LDCM0301  AC4 PaTu 8988t C53(1.48)  LDD1180  [4]
 LDCM0308  AC46 PaTu 8988t C53(0.93)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C53(1.17)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C53(1.05)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C53(0.98)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C53(1.36)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C53(1.04)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C53(0.27)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C53(1.30)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C53(1.25)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C53(1.01)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C53(1.43)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C53(0.94)  LDD1198  [4]
 LDCM0320  AC57 HCT 116 C67(1.29)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C67(1.49)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C67(1.17)  LDD0639  [4]
 LDCM0323  AC6 PaTu 8988t C53(1.09)  LDD1202  [4]
 LDCM0324  AC60 HCT 116 C67(1.24)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C67(1.51)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C67(1.42)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C67(1.74)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C67(1.97)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C67(1.95)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C67(2.18)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C67(1.49)  LDD0648  [4]
 LDCM0332  AC68 PaTu 8988t C53(1.15)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C53(1.50)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C53(1.16)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C53(1.62)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C53(1.43)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C53(1.48)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C53(1.28)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C53(1.22)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C53(1.36)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C53(1.25)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C53(1.30)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C53(1.15)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C53(1.41)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C53(1.15)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C53(1.30)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C53(1.18)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C53(1.34)  LDD1227  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C53(1.22)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C53(1.14)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C53(1.15)  LDD1154  [4]
 LDCM0498  BS-3668 MDA-MB-231 C53(0.97)  LDD2091  [1]
 LDCM0632  CL-Sc Hep-G2 C67(2.10); C108(0.85); C67(0.81); C53(0.66)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C67(1.22)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C67(1.00)  LDD0685  [4]
 LDCM0369  CL100 PaTu 8988t C53(1.36)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C53(0.95)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C53(1.05)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C53(1.08)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C53(1.13)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C53(1.01)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C53(1.01)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C53(0.77)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C53(0.80)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C53(0.79)  LDD1257  [4]
 LDCM0379  CL11 HCT 116 C67(1.13)  LDD0696  [4]
 LDCM0380  CL110 PaTu 8988t C53(0.66)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C53(0.88)  LDD1260  [4]
 LDCM0390  CL12 HCT 116 C67(1.14)  LDD0707  [4]
 LDCM0392  CL121 PaTu 8988t C53(1.22)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C53(0.96)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C53(1.00)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C53(1.05)  LDD1274  [4]
 LDCM0396  CL125 HCT 116 C67(1.04)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C67(1.29)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C67(1.25)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C67(1.27)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C67(1.00)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C67(1.05)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C67(0.99)  LDD0719  [4]
 LDCM0407  CL2 HCT 116 C67(1.21)  LDD0724  [4]
 LDCM0418  CL3 HCT 116 C67(0.88)  LDD0735  [4]
 LDCM0429  CL4 HCT 116 C67(0.98)  LDD0746  [4]
 LDCM0436  CL46 HCT 116 C67(0.73)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C67(0.85)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C67(0.73)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C67(0.88)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C67(1.11)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C67(0.80)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C67(0.73)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C67(0.73)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C67(0.79)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C67(0.76)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C67(0.74)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C67(0.98)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C67(0.80)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C67(0.81)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C67(0.86)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C67(1.09)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C67(0.78)  LDD0769  [4]
 LDCM0453  CL61 PaTu 8988t C53(1.11)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C53(1.18)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C53(1.11)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C53(1.19)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C53(1.06)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C53(1.08)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C53(1.23)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C53(1.28)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C53(1.05)  LDD1340  [4]
 LDCM0462  CL7 HCT 116 C67(1.10)  LDD0779  [4]
 LDCM0463  CL70 PaTu 8988t C53(1.10)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C53(1.07)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C53(1.12)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C53(1.18)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C53(1.52)  LDD1346  [4]
 LDCM0473  CL8 HCT 116 C67(1.13)  LDD0790  [4]
 LDCM0484  CL9 HCT 116 C67(1.02)  LDD0801  [4]
 LDCM0486  CL91 PaTu 8988t C53(0.96)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C53(1.18)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C53(0.96)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C53(1.20)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C53(1.11)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C53(1.53)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C53(1.22)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C53(1.18)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C53(1.38)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C53(1.03)  LDD1347  [4]
 LDCM0116  HHS-0101 DM93 Y136(0.96)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y136(0.94)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y136(1.22)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y136(0.87)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y136(0.87)  LDD0268  [3]
 LDCM0123  JWB131 DM93 Y136(0.84)  LDD0285  [2]
 LDCM0124  JWB142 DM93 Y136(0.66)  LDD0286  [2]
 LDCM0125  JWB146 DM93 Y136(1.25)  LDD0287  [2]
 LDCM0126  JWB150 DM93 Y136(2.05)  LDD0288  [2]
 LDCM0127  JWB152 DM93 Y136(1.45)  LDD0289  [2]
 LDCM0128  JWB198 DM93 Y136(1.00)  LDD0290  [2]
 LDCM0129  JWB202 DM93 Y136(0.57)  LDD0291  [2]
 LDCM0130  JWB211 DM93 Y136(0.88)  LDD0292  [2]
 LDCM0022  KB02 22RV1 C53(1.94)  LDD2243  [10]
 LDCM0023  KB03 22RV1 C53(2.83)  LDD2660  [10]
 LDCM0024  KB05 COLO792 C95(1.31)  LDD3310  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C95(0.90)  LDD2092  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C95(0.77)  LDD2096  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C95(1.18)  LDD2122  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C95(0.94)  LDD2146  [1]
 LDCM0131  RA190 MM1.R C67(1.19)  LDD0304  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
NEDD8-activating enzyme E1 catalytic subunit (UBA3) Ubiquitin-activating E1 family Q8TBC4
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 6 (ASB6) Ankyrin SOCS box (ASB) family Q9NWX5
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
MRN complex-interacting protein (MRNIP) MRNIP family Q6NTE8
Proteasome activator complex subunit 2 (PSME2) PA28 family Q9UL46

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-nitrophenyl Phosphate Small molecular drug DB04214

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.