Details of the Target

General Information of Target

Target ID LDTP10391
Target Name Sentrin-specific protease 5 (SENP5)
Gene Name SENP5
Gene ID 205564
Synonyms
Sentrin-specific protease 5; EC 3.4.22.-; Sentrin/SUMO-specific protease SENP5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTELQQDVEDTKPAKVLGKRESKLGSAHSEAENGVEEKKKACRSPTAQSPTPSVEADSPD
QKKIISLWSKSSFDGASLASDKNDCKTESKNDPKTERKKSSSSSQYKANMHFHKLFLSVP
TEEPLKQSFTCALQKEILYQGKLFVSENWICFHSKVFGKDTKISIPAFSVTLIKKTKTAL
LVPNALIIATVTDRYIFVSLLSRDSTYKLLKSVCGHLENTSVGNSPNPSSAENSFRADRP
SSLPLDFNDEFSDLDGVVQQRRQDMEGYSSSGSQTPESENSRDFHATESQTVLNVSKGEA
KPTRADAHVNRVPEGKAKSLPVQGLSETVGILHKVKSQKCPMLHHILIFYAIVVCALIIS
TFYMRYRINTLEEQLGLLTSIVDTHNTEQAAPSGLRSQVQFNVEVLCQELTANIVKLEKI
QNNLQKLLENGD
Target Bioclass
Enzyme
Family
Peptidase C48 family
Subcellular location
Nucleus, nucleolus
Function
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Uniprot ID
Q96HI0
Ensemble ID
ENST00000323460.10
HGNC ID
HGNC:28407
ChEMBL ID
CHEMBL4802012

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.E367K DBIA    Probe Info 
COLO320 Deletion: p.C199WfsTer21; p.C200WfsTer12 DBIA    Probe Info 
HCC15 SNV: p.W356L DBIA    Probe Info 
HEC1 SNV: p.L520I DBIA    Probe Info 
HEC1B SNV: p.G515D .
HUH28 SNV: p.E509K .
IM95 SNV: p.G446Ter DBIA    Probe Info 
MDAMB231 SNV: p.K81N .
RKO SNV: p.L637P DBIA    Probe Info 
SKMEL30 Substitution: p.L76F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.91  LDD0402  [1]
STPyne
 Probe Info  		K62(10.00)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C463(2.61)  LDD0169  [3]
DBIA
 Probe Info  		C713(1.01); C721(1.01); C196(0.99); C199(0.99)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_4
 Probe Info  		C77(0.00); C288(0.00)  LDD2226  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		13.30  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C463(2.61)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C196(1.01); C199(1.01); C200(1.01)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C473(1.48)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C196(1.26); C199(1.26); C200(1.26); C672(1.49)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C196(1.28); C199(1.28); C200(1.28); C672(0.69)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C196(1.03); C199(1.03); C200(1.03); C672(0.64)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C196(1.19); C199(1.19); C200(1.19); C672(1.67)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C196(1.33); C199(1.33); C200(1.33); C672(0.91)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C196(1.07); C199(1.07); C200(1.07); C672(1.00)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C196(1.18); C199(1.18); C200(1.18); C672(1.52)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C196(1.06); C199(1.06); C200(1.06); C672(0.94)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C196(1.09); C199(1.09); C200(1.09); C672(0.75)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C196(1.16); C199(1.16); C200(1.16); C672(0.81)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C473(1.24)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C196(1.16); C199(1.16); C200(1.16); C672(0.85)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C196(1.23); C199(1.23); C200(1.23); C672(0.69)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C196(1.09); C199(1.09); C200(1.09); C672(0.81)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C196(0.94); C199(0.94); C200(1.04); C672(0.93)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C196(1.02); C199(1.02); C200(0.92); C672(0.93)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C196(1.02); C199(1.02); C200(0.89); C672(1.14)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C196(1.33); C199(1.33); C200(0.99); C672(1.21)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C196(1.07); C199(1.07); C200(1.05); C672(1.21)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C196(1.02); C199(1.02); C200(0.89); C672(1.30)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C196(1.02); C199(1.02); C200(0.94); C672(1.35)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C473(1.25)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C196(1.19); C199(1.19); C200(0.99); C672(1.12)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C196(1.01); C199(1.01); C200(0.87); C672(0.82)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C196(0.93); C199(0.93); C200(0.91); C672(1.19)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C196(0.94); C199(0.94); C200(0.88); C672(0.87)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C196(1.00); C199(1.00); C200(0.84); C672(0.96)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C196(0.97); C199(0.97); C200(0.89); C672(1.03)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C196(1.12); C199(1.12); C200(0.94); C672(1.06)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C196(1.12); C199(1.12); C200(0.86); C672(1.15)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C196(1.10); C199(1.10); C200(1.10); C672(0.82)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C196(0.57); C199(0.57); C200(0.57); C672(1.34)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C196(0.80); C199(0.80); C200(0.80); C672(1.64)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C196(0.75); C199(0.75); C200(0.75); C672(1.20)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C196(0.59); C199(0.59); C200(0.59); C672(1.46)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C196(0.74); C199(0.74); C200(0.74); C672(1.26)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C196(0.78); C199(0.78); C200(0.78); C672(1.20)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C196(0.83); C199(0.83); C200(0.83); C672(1.32)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C196(0.92); C199(0.92); C200(0.92); C672(1.19)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C196(0.79); C199(0.79); C200(0.79); C672(1.13)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C196(0.82); C199(0.82); C200(0.82); C672(0.67)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C196(0.70); C199(0.70); C200(0.70); C672(1.19)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C473(1.62)  LDD0857  [4]
 LDCM0260  AC140 HCT 116 C196(0.73); C199(0.73); C200(0.73); C672(1.40)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C196(0.64); C199(0.64); C200(0.64); C672(0.93)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C196(0.76); C199(0.76); C200(0.76); C672(1.39)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C196(1.02); C199(1.02); C200(1.05)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C200(0.97); C196(1.03); C199(1.03)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C200(1.04); C196(1.08); C199(1.08)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C200(0.87); C196(1.35); C199(1.35)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C200(1.05); C196(1.37); C199(1.37)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C200(0.88); C196(1.53); C199(1.53)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C200(1.13); C196(1.44); C199(1.44)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C473(1.55)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C200(1.08); C196(1.24); C199(1.24)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C200(1.14); C196(1.18); C199(1.18)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C200(1.16); C196(1.40); C199(1.40)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C200(1.01); C196(1.80); C199(1.80)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C196(1.12); C199(1.12); C200(0.97)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C196(1.38); C199(1.38); C200(1.08)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C196(1.33); C199(1.33); C200(1.07)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C196(1.13); C199(1.13); C200(1.14)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C196(0.92); C199(0.92); C200(0.92)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C196(1.32); C199(1.32); C200(1.32)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C196(1.16); C199(1.16); C200(1.16)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C196(1.17); C199(1.17); C200(1.17)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C196(1.26); C199(1.26); C200(1.26)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C196(1.04); C199(1.04); C200(1.04)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C196(0.98); C199(0.98); C200(0.98)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C196(1.21); C199(1.21); C200(1.21)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C196(1.04); C199(1.04); C200(1.04)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C473(0.96)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C473(0.76)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C473(1.13)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C473(2.21)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C473(0.98)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C196(1.17); C199(1.17); C200(1.17)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C473(0.89)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C473(0.86)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C473(1.84)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C473(1.12)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C473(0.76)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C672(1.05)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C473(1.06); C77(1.09)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C672(0.86); C473(1.07); C77(1.01); C326(0.95)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C672(1.03); C473(0.93)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C672(1.00); C473(1.03)  LDD1539  [10]
 LDCM0301  AC4 HCT 116 C196(1.26); C199(1.26); C200(1.26)  LDD0618  [4]
 LDCM0303  AC41 HEK-293T C473(0.90)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C473(1.09); C77(1.27); C200(0.98)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C672(0.96)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C473(0.96); C77(1.16)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C672(0.91); C473(1.00); C77(1.15); C326(1.04)  LDD1546  [10]
 LDCM0308  AC46 HCT 116 C672(0.76); C196(1.13); C199(1.13); C200(1.13)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C672(0.72); C196(0.86); C199(0.86); C200(0.86)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C196(0.89); C199(0.89); C200(0.89); C672(0.97)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C196(0.89); C199(0.89); C200(0.89); C672(1.02)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C196(1.21); C199(1.21); C200(1.21)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C196(0.83); C199(0.83); C200(0.83); C672(0.91)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C196(0.87); C199(0.87); C200(0.87); C672(0.98)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C672(1.02); C196(1.03); C199(1.03); C200(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C672(0.77); C196(1.29); C199(1.29); C200(1.29)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C672(0.63); C196(1.13); C199(1.13); C200(1.13)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C672(1.03); C196(1.10); C199(1.10); C200(1.10)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C672(0.84); C196(0.99); C199(0.99); C200(0.99)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C196(1.07); C199(1.07); C200(1.07)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C196(0.97); C199(0.97); C200(0.97)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C196(1.16); C199(1.16); C200(1.16)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C473(1.12)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C196(1.28); C199(1.28); C200(1.28)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C196(1.25); C199(1.25); C200(1.25)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C196(1.13); C199(1.13); C200(1.13)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C196(1.36); C199(1.36); C200(1.36)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C196(1.21); C199(1.21); C200(1.21)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C196(1.20); C199(1.20); C200(1.20)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C196(1.28); C199(1.28); C200(1.28)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C196(1.39); C199(1.39); C200(1.39)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C200(0.99); C196(1.02); C199(1.02)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C200(1.07); C196(1.10); C199(1.10)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C473(1.69)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C200(1.35); C196(1.40); C199(1.40)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C200(1.01); C196(1.08); C199(1.08)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C200(0.91); C196(1.05); C199(1.05)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C200(1.16); C196(1.33); C199(1.33)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C200(1.27); C196(1.37); C199(1.37)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C200(1.40); C196(1.55); C199(1.55)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C200(1.20); C196(1.35); C199(1.35)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C200(1.01); C196(1.08); C199(1.08)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C200(0.90); C196(1.01); C199(1.01)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C200(1.17); C196(1.28); C199(1.28)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C473(1.51)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C200(1.11); C196(1.21); C199(1.21)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C200(0.85); C196(1.04); C199(1.04)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C200(1.36); C196(1.63); C199(1.63)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C196(1.27); C199(1.27); C200(1.27)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C196(1.27); C199(1.27); C200(1.27)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C196(1.25); C199(1.25); C200(1.25)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C196(1.01); C199(1.01); C200(1.01)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C196(1.22); C199(1.22); C200(1.22)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C196(1.01); C199(1.01); C200(1.01)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C196(1.18); C199(1.18); C200(1.18)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C196(1.32); C199(1.32); C200(1.32)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C196(1.00); C199(1.00); C200(1.00)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C196(1.16); C199(1.16); C200(1.16)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C196(1.27); C199(1.27); C200(1.27)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C196(1.21); C199(1.21); C200(1.21)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C196(1.09); C199(1.09); C200(1.09)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C196(1.34); C199(1.34); C200(1.34)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C196(1.24); C199(1.24); C200(1.24)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C196(1.20); C199(1.20); C200(1.20); C672(2.03)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C672(0.95); C196(1.14); C199(1.14); C200(1.14)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C473(1.41)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C473(1.80)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C473(1.35)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 13.56  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C713(1.01); C721(1.01); C196(0.99); C199(0.99)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C672(0.91)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C672(1.52); C473(1.21)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C196(0.96); C199(0.96); C200(0.96)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C473(1.41)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C473(1.35)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C473(1.37)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C473(1.63)  LDD0971  [4]
 LDCM0374  CL105 HCT 116 C196(0.96); C199(0.96); C200(0.96)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C196(1.07); C199(1.07); C200(1.07)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C196(0.96); C199(0.96); C200(0.96)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C196(0.80); C199(0.80); C200(0.80)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C196(1.04); C199(1.04); C200(1.04)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C672(1.74); C473(1.11)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C196(0.92); C199(0.92); C200(0.92)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C196(1.34); C199(1.34); C200(1.34)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C473(0.92)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C473(0.99)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C473(0.70)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C473(0.86)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C473(2.00)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C672(0.86)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C473(1.06)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C473(0.94); C77(0.97); C199(1.14)  LDD1593  [10]
 LDCM0391  CL120 HEK-293T C473(0.94)  LDD1595  [10]
 LDCM0392  CL121 HCT 116 C672(0.95); C196(1.26); C199(1.26); C200(1.26)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C196(0.93); C199(0.93); C200(0.93); C672(0.96)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C672(0.73); C196(1.06); C199(1.06); C200(1.06)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C672(0.62); C196(1.41); C199(1.41); C200(1.41)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C196(1.31); C199(1.31); C200(1.31)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C196(1.14); C199(1.14); C200(1.14)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C196(1.27); C199(1.27); C200(1.27)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C196(1.02); C199(1.02); C200(1.02)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C672(0.97)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C473(0.99)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C473(1.03); C77(1.29); C199(1.06)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C672(1.03); C196(1.14); C199(1.14); C200(1.14)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C672(0.82); C196(0.97); C199(0.97); C200(0.97)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C196(0.95); C199(0.95); C200(0.95); C672(1.34)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C196(1.07); C199(1.07); C200(1.07); C672(1.21)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C473(1.02)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C196(1.02); C199(1.02); C200(1.02); C672(1.15)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C196(1.04); C199(1.04); C200(1.04); C672(1.29)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C196(0.84); C199(0.84); C200(0.84); C672(1.43)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C672(0.90); C196(1.00); C199(1.00); C200(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C196(0.94); C199(0.94); C200(0.94); C672(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C196(1.11); C199(1.11); C200(1.11); C672(0.98)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C196(0.86); C199(0.86); C200(0.86); C672(1.57)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C196(1.01); C199(1.01); C200(1.01); C672(0.90)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C196(0.92); C199(0.92); C200(0.92); C672(1.19)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C196(0.99); C199(0.99); C200(0.99); C672(1.23)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C473(1.09); C77(0.87); C199(1.14)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C196(1.13); C199(1.13); C200(1.13); C672(1.58)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C196(0.83); C199(0.83); C200(0.83); C672(1.12)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C672(1.66)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C672(1.00)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C672(1.10)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C672(1.14)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C672(1.02)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C672(0.98)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C672(1.07)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C473(1.04)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C672(0.89)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C672(1.22)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C672(0.91)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C672(1.00)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C672(1.24)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C672(1.56)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C672(1.52); C473(1.00)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C672(1.47); C473(1.14)  LDD1641  [10]
 LDCM0439  CL49 HEK-293T C672(0.95)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C473(0.94)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C473(1.19)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C473(0.99)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C473(1.05)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C473(1.21); C77(1.15); C200(1.02)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C672(1.25)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C473(1.04); C77(1.42)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C672(1.24); C473(0.93); C77(1.35); C326(1.06)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C672(1.61); C473(1.15)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C672(1.55); C473(1.04)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C473(0.98); C77(1.01); C200(1.08)  LDD1654  [10]
 LDCM0453  CL61 HEK-293T C473(0.92); C77(0.97)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C473(1.01); C77(1.60)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C473(1.07); C77(1.44)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C473(1.04); C77(1.13)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C473(1.31); C77(1.81)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C473(1.16); C77(1.32)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C473(1.15); C77(1.18)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C473(1.36); C77(1.29)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C473(0.94); C77(1.01)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C672(1.33)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C473(1.03); C77(1.12)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C473(1.07); C77(1.10)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C473(1.07); C77(0.90)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C473(1.20); C77(1.46)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C473(1.71); C77(1.73)  LDD1065  [4]
 LDCM0469  CL76 HCT 116 C672(1.13)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C672(0.94)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C672(1.04)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C672(0.89)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C473(1.23); C77(1.17)  LDD1676  [10]
 LDCM0474  CL80 HCT 116 C672(1.09)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C672(1.07)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C672(1.13)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C672(1.12)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C672(1.01)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C672(1.22)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C672(1.03)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C672(1.03)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C672(0.93)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C672(0.97)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C672(1.50); C473(1.15); C77(1.36); C326(1.07)  LDD1687  [10]
 LDCM0485  CL90 HCT 116 C672(1.02)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C196(0.76); C199(0.76); C200(0.76)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C196(0.87); C199(0.87); C200(0.87)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C196(1.20); C199(1.20); C200(1.20)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C196(1.21); C199(1.21); C200(1.21)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C196(1.09); C199(1.09); C200(1.09)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C196(1.35); C199(1.35); C200(1.35)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C196(1.25); C199(1.25); C200(1.25)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C196(1.03); C199(1.03); C200(1.03)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C196(1.13); C199(1.13); C200(1.13)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C473(1.03); C77(1.02); C199(1.30)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C463(2.12)  LDD1702  [11]
 LDCM0625  F8 Ramos C131(4.13); C77(1.14)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C131(15.14)  LDD2190  [12]
 LDCM0576  Fragment14 Ramos C131(0.89); C77(0.95)  LDD2193  [12]
 LDCM0586  Fragment28 Ramos C131(0.43); C77(4.21)  LDD2198  [12]
 LDCM0468  Fragment33 HEK-293T C473(1.43); C77(1.56)  LDD1066  [4]
 LDCM0566  Fragment4 Ramos C77(0.70)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C672(1.11)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C473(0.91)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C473(1.05)  LDD1497  [10]
 LDCM0024  KB05 MIA PaCa-2 C326(3.89)  LDD3330  [13]
 LDCM0021  THZ1 HCT 116 C196(1.20); C200(1.20); C199(1.19)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840