Details of the Target

General Information of Target

Target ID LDTP10347
Target Name Centrosomal protein of 95 kDa (CEP95)
Gene Name CEP95
Gene ID 90799
Synonyms
CCDC45; CEP45; Centrosomal protein of 95 kDa; Cep95; Coiled-coil domain-containing protein 45
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Uniprot ID
Q96GE4
Ensemble ID
ENST00000556440.7
HGNC ID
HGNC:25141

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N659T .
HCT15 SNV: p.Q763H .
HEC1 SNV: p.E510K .
HEC1B SNV: p.E510K .
KASUMI1 SNV: p.E616A .
MFE280 SNV: p.R258G .
PC9 SNV: p.S116N .
RKO Insertion: p.A209SfsTer8 .
SF295 Insertion: p.R158EfsTer7 .
SG231 SNV: p.E427Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C678(1.59)  LDD2131  [1]
DBIA
 Probe Info  		C678(44.90)  LDD0209  [2]
IA-alkyne
 Probe Info  		C276(9.30)  LDD1704  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C678(1.59)  LDD2131  [1]
 LDCM0214  AC1 HCT 116 C351(0.78)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C351(0.97); C602(1.15)  LDD0532  [5]
 LDCM0216  AC100 HEK-293T C351(0.89)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C351(1.00)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C351(1.07)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C351(0.94)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C351(1.02)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C351(1.04)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C351(0.93)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C351(0.93)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C351(1.02)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C351(1.10)  LDD0823  [5]
 LDCM0226  AC11 HCT 116 C351(1.50); C602(1.17)  LDD0543  [5]
 LDCM0227  AC110 HEK-293T C351(0.81)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C351(0.47)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C351(0.72)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C351(1.25)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C351(0.84)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C351(1.19)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C351(1.14)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C351(1.16)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C351(1.22)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C351(0.90)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C351(0.91); C602(1.11)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C351(1.40)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C351(1.02)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C351(0.97)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C351(1.21)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C351(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C351(1.93)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C351(1.17)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C351(1.15)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C351(0.31); C602(0.79)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C351(0.41); C602(1.17)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C351(0.42); C602(0.86)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C351(0.40); C602(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C351(0.46); C602(0.80)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C351(0.40); C602(1.09)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C351(0.52); C602(0.69)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C351(0.47); C602(0.71)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C351(0.39); C602(0.64)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C351(0.47); C602(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C351(0.40); C602(0.49)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C351(0.35); C602(0.71)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C351(1.11); C602(1.15)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C351(0.48); C602(0.54)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C351(0.76); C602(0.51)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C351(0.47); C602(0.63)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C351(0.88)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C351(0.94)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C351(1.77)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C351(1.44)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C351(0.92)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C351(3.33)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C351(1.76)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C351(0.79); C602(0.96)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C351(1.27)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C351(1.34)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C351(1.80)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C351(2.05)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C351(1.38)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C351(1.46)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C351(1.58)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C351(1.64)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C602(1.41); C351(1.61)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C351(0.89); C602(1.21)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C602(1.17); C351(1.43)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C351(0.80)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C351(0.98); C602(1.27)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C602(1.68); C351(1.90)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C351(1.09); C602(1.44)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C351(0.76); C602(1.59)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C351(0.95); C602(1.05)  LDD0601  [5]
 LDCM0289  AC29 HEK-293T C529(1.10)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C351(1.03)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C529(0.89)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C529(1.07)  LDD1531  [6]
 LDCM0296  AC35 HEK-293T C351(1.19)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C351(0.97)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C351(0.90)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C351(1.09)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C351(0.92)  LDD0898  [5]
 LDCM0301  AC4 HCT 116 C351(0.73)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C351(1.10)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C351(0.89)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C351(0.86)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C351(0.84)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C351(0.98)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C351(0.94)  LDD0905  [5]
 LDCM0308  AC46 HCT 116 C602(0.54)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C602(0.67)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C602(0.53)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C602(0.51)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C351(0.71)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C602(0.57)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C602(0.59)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C602(0.58)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C602(0.84)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C602(0.53)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C602(0.97)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C602(0.65)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C351(1.36)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C351(1.17)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C351(1.49)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C602(0.85); C351(1.11)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C351(1.86)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C351(1.11)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C351(1.34)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C351(2.17)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C351(1.48)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C351(1.80)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C351(1.13)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C351(1.37)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C602(1.09)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C602(1.16)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C602(0.76); C351(0.94)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C602(0.79)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C602(1.50)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C602(1.03)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C602(0.92)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C602(1.43)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C602(1.00)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C602(1.62)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C602(0.90)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C602(1.29)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C602(0.93)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C602(0.96); C351(1.24)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C602(2.01)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C602(1.30)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C602(1.64)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C351(1.11)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C351(1.06)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C351(1.00)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C351(1.05)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C351(0.88)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C351(1.08)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C351(1.00)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C351(1.24)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C351(0.93)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C351(0.98)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C351(1.02)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C351(1.02)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C351(1.21)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C351(0.96)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C351(1.21)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C351(1.07)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C351(0.90)  LDD0964  [5]
 LDCM0248  AKOS034007472 HCT 116 C351(1.08); C602(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C351(1.53); C602(1.66)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C602(0.74); C351(1.09)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C351(0.88)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C351(0.80)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C351(0.97)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C602(0.88); C351(1.32)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C602(1.00); C351(1.12)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C351(0.83); C602(0.98)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C602(0.80); C351(0.91)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C351(1.00); C602(1.36)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C351(1.26); C602(1.30)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C351(0.74); C602(1.75)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C351(0.86); C602(1.63)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C602(0.97); C351(1.78)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C351(1.25)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C351(0.49); C602(0.88)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C602(1.19); C351(1.35)  LDD0698  [5]
 LDCM0387  CL117 HEK-293T C351(0.74)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C351(0.95)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C351(1.13)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C351(0.86)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C351(0.76)  LDD0989  [5]
 LDCM0392  CL121 HCT 116 C602(0.71)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C602(0.72)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C602(0.56)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C602(0.51)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C351(1.28)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C351(1.15)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C351(1.53)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C351(1.34)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C351(0.94)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C351(0.90)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C351(1.11)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C351(1.30)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C351(1.24)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C351(0.92)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C351(1.10)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C351(0.83)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C351(1.07)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C351(1.04)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C351(0.67)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C351(0.61)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C351(0.91)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C351(0.58)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C351(0.97)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C351(1.17)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C351(0.83)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C351(0.93)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C351(0.82)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C351(0.77)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C351(0.97)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C351(1.11)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C351(1.11)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C351(1.05)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C351(1.06)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C351(1.10)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C351(1.08)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C351(0.99)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C351(0.71)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C351(1.15)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C351(1.00)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C351(0.81)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C351(1.04)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C351(0.91)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C351(1.07)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C351(0.91)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C351(0.96)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C351(0.83)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C351(0.83)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C351(0.58)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C351(0.77)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C351(0.76)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C351(1.06)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C351(0.93)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C351(0.82)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C351(0.88)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C351(0.70)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C351(0.75)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C351(0.68)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C351(0.69)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C351(1.05)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C351(0.72)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C351(0.93)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C351(1.01)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C351(0.94)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C351(0.99)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C351(1.68)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C351(0.90)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C351(0.98)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C351(1.16)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C351(1.00)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C351(0.85)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C351(1.24)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C351(1.08)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C351(0.94)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C351(0.87)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C351(1.28)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C351(0.88)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C351(0.86)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C351(0.94)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C351(0.80)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C351(0.84)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C351(0.75)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C351(0.90)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C351(0.83)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C351(0.93)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C351(1.09)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C351(1.04)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C351(0.89)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C351(0.82)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C351(0.77)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C351(0.91)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C351(0.64)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C351(0.92)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C351(0.88)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C351(1.12)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C351(0.97)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C351(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C351(0.93)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C351(0.87)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C351(0.89)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C351(0.89)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C351(0.86)  LDD0811  [5]
 LDCM0468  Fragment33 HCT 116 C351(0.90)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C351(1.06)  LDD0744  [5]
 LDCM0022  KB02 T cell-activated C276(9.30)  LDD1704  [3]
 LDCM0023  KB03 Jurkat C678(44.90)  LDD0209  [2]
 LDCM0024  KB05 OCUG-1 C529(4.19)  LDD3373  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Colorectal mutant cancer protein (MCC) MCC family P23508
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840