Details of the Target

General Information of Target

Target ID LDTP09254
Target Name Lysine-specific demethylase 2B (KDM2B)
Gene Name KDM2B
Gene ID 84678
Synonyms
CXXC2; FBL10; FBXL10; JHDM1B; NDY1; PCCX2; Lysine-specific demethylase 2B; EC 1.14.11.27; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVE
EIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPD
PDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTD
FHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIEL
KQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQ
EEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEES
VKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAAN
RTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTA
VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP
KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE
HSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSS
LSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEA
PPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQR
TENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPP
RVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQ
DLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQ
LSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTD
NRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT
AVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSV
SVQFGQVEEKLLQKLS
Target Bioclass
Enzyme
Family
JHDM1 histone demethylase family
Subcellular location
Nucleus, nucleolus
Function
Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
Uniprot ID
Q8NHM5
Ensemble ID
ENST00000377069.8
HGNC ID
HGNC:13610
ChEMBL ID
CHEMBL3779760

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.F865SfsTer69; p.I1048SfsTer60 .
CAL51 SNV: p.S1075G DBIA    Probe Info 
COLO792 SNV: p.S322F DBIA    Probe Info 
COLO800 SNV: p.W1161L DBIA    Probe Info 
DU145 SNV: p.G401D DBIA    Probe Info 
HCT116 SNV: p.P224L DBIA    Probe Info 
HCT15 SNV: p.C1035Ter .
HT SNV: p.H781R DBIA    Probe Info 
HUH1 SNV: p.S593F DBIA    Probe Info 
IGROV1 Deletion: p.P1051RfsTer57 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.C363R DBIA    Probe Info 
JURKAT SNV: p.P639T .
KASUMI2 SNV: p.A594T DBIA    Probe Info 
MFE319 Deletion: p.S920AfsTer14 .
MOLT4 SNV: p.S57L; p.G1120D IA-alkyne    Probe Info 
NCIH1048 SNV: p.P450S .
NCIH2052 SNV: p.C716R DBIA    Probe Info 
OE33 Deletion: p.Y851SfsTer82 DBIA    Probe Info 
OZ SNV: p.R377C DBIA    Probe Info 
PEO1 SNV: p.E925K .
RL952 SNV: p.R621Q .
SAOS2 SNV: p.A606S DBIA    Probe Info 
SNGM Insertion: p.K903QfsTer76 DBIA    Probe Info 
SNU1 Deletion: p.K26RfsTer81 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y806(5.11)  LDD0257  [1]
ONAyne
 Probe Info  		K73(1.45)  LDD0274  [2]
DBIA
 Probe Info  		C716(1.39); C719(1.50)  LDD0080  [3]
CY4
 Probe Info  		D392(0.00); E387(0.00); S388(0.00)  LDD0247  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1278(0.00); C1285(0.00); C770(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C1278(0.00); C1110(0.00); C619(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C1110(0.00); C770(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		C770(0.00); C722(0.00)  LDD0148  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1110(0.82)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C1285(1.01); C1292(1.16); C716(1.35); C719(1.35)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C1110(0.80); C1285(0.62)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1110(0.84); C1285(0.63)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1110(0.87); C1285(0.64)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1110(0.83); C1285(0.50)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1110(0.82); C1285(0.52)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1110(0.82); C1285(0.51)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1110(0.92); C1285(0.55)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1110(0.73); C1285(1.10)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1110(0.63); C1285(0.80)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1110(0.65); C1285(0.78)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C1285(1.24); C1292(1.16); C716(1.34); C719(1.34)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C1110(0.69); C1285(0.91)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1110(0.76); C1285(0.79)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1110(0.61); C1285(0.94)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1110(1.05)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1110(1.05)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1110(1.07)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1110(1.11)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1110(1.07)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1110(1.04)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1110(1.07)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C1285(1.32); C1292(1.04); C716(1.39); C719(1.39)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C1110(1.03)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1110(1.00)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1110(0.99)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1110(0.96)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1110(0.99)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1110(1.00)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1110(1.02)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1110(1.04)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C1110(1.34); C1296(1.23); C716(1.23)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C1110(0.92); C1296(0.95); C716(0.95)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C1110(1.03); C1296(1.00); C716(1.00)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C1110(1.08); C1296(1.23); C716(1.23)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C1110(0.96); C1296(1.01); C716(1.01)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C1110(0.87); C1296(0.95); C716(0.95)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C1110(0.90); C1296(1.00); C716(1.00)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C1110(1.11); C1296(0.93); C716(0.93)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C1110(1.00); C1296(1.08); C716(1.08)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C1110(0.89); C1296(0.94); C716(0.94)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C1110(0.99); C1296(0.97); C716(0.97)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C1110(0.90); C1296(0.97); C716(0.97)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C1285(1.01); C1292(0.91); C716(1.62); C719(1.62)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C1110(0.93); C1296(0.94); C716(0.94)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C1110(0.89); C1296(0.94); C716(0.94)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C1110(0.98); C1296(0.92); C716(0.92)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C1110(0.65); C716(0.69); C719(0.69)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C716(0.63); C719(0.63); C1110(1.13)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C716(0.52); C719(0.52); C1110(1.00)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1110(0.77); C716(0.77); C719(0.77)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C716(0.50); C719(0.50); C1110(1.15)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1110(0.62); C716(0.64); C719(0.64)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1110(0.68); C716(1.03); C719(1.03)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C1285(1.12); C1292(0.81); C716(1.35); C719(1.35)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C716(0.58); C719(0.58); C1110(0.96)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C716(0.76); C719(0.76); C1110(0.91)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C716(0.80); C719(0.80); C1110(0.82)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1110(0.36); C716(0.68); C719(0.68)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1110(0.71); C716(0.63); C719(0.63)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1110(0.53); C716(0.55); C719(0.55)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1110(0.76); C716(0.61); C719(0.61)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1110(0.56); C716(0.77); C719(0.77)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C1110(0.92)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C1110(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C1110(0.95)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C1110(0.81)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C1110(0.91)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C1110(0.91)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C1110(0.94)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C1110(0.98)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C1110(0.93)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C1110(0.94)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1110(0.89)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1110(0.94)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1110(0.94)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1110(0.76)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C1110(0.89)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C1110(0.81)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1110(0.78)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1110(0.76)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1110(0.85)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1110(0.85)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1285(1.10); C1110(1.18)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1110(0.93); C1285(1.04)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1110(1.02); C1285(1.07)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1110(1.05); C1285(1.19)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C1285(1.06); C1110(1.23)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C1110(0.97)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1285(0.93); C1110(1.17)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1110(0.90); C1285(1.14)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1285(0.99); C1110(1.13)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1110(1.05); C1285(1.07)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1110(1.04); C1285(1.05)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1285(0.95); C1110(1.05)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C1110(0.96)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C1110(0.86)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C1110(0.96)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C1110(0.74)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C1110(0.89)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C1110(0.92)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C1110(0.70)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C1110(0.79)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C1110(0.88)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C1110(0.81)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C1110(0.91)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C1110(0.80)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C716(0.92); C719(0.92); C1110(0.94)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C716(0.87); C719(0.87); C1110(0.92)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1110(0.98); C716(1.33); C719(1.33)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C1285(0.86); C1292(0.98); C716(1.03); C719(1.03)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C1110(0.96); C716(1.04); C719(1.04)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1110(0.82); C716(0.97); C719(0.97)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1110(0.91); C716(0.98); C719(0.98)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C716(0.86); C719(0.86); C1110(0.93)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C716(0.94); C719(0.94); C1110(0.98)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C716(0.93); C719(0.93); C1110(1.18)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C716(0.84); C719(0.84); C1110(1.13)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C716(0.70); C719(0.70); C1110(1.02)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C1110(0.74); C716(1.10); C719(1.10)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1110(0.84); C716(0.97); C719(0.97)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C1285(1.17); C1292(0.96); C716(0.92); C719(0.92)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C1110(0.87); C716(1.12); C719(1.12)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C716(0.83); C719(0.83); C1110(1.08)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1110(0.79); C716(0.99); C719(0.99)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1110(0.85); C716(1.12); C719(1.12)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1110(0.90); C716(1.46); C719(1.46)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1110(0.82); C716(1.53); C719(1.53)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1110(0.90); C716(1.15); C719(1.15)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1110(0.70); C716(1.10); C719(1.10)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1110(0.65); C716(0.94); C719(0.94)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1110(0.62); C716(0.96); C719(0.96)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C1285(1.17); C1292(0.89); C716(1.04); C719(1.04)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C1110(0.78); C716(1.13); C719(1.13)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1110(0.71); C716(0.81); C719(0.81)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1110(0.68); C716(1.28); C719(1.28)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C1285(0.85); C1110(0.97); C716(1.09); C719(1.09)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C1285(0.93); C1110(0.97); C716(1.25); C719(1.25)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C716(0.87); C719(0.87); C1110(0.97); C1285(1.06)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C1285(0.85); C716(0.87); C719(0.87); C1110(0.95)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C1285(0.98); C1110(1.00); C716(1.09); C719(1.09)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C1285(0.92); C1110(0.99); C716(1.05); C719(1.05)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C1285(0.89); C1110(0.93); C716(1.17); C719(1.17)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C716(0.73); C719(0.73); C1110(0.98); C1285(1.24)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C1285(0.90); C1110(0.91); C716(1.77); C719(1.77)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C1285(0.84); C1110(0.92); C716(1.51); C719(1.51)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C1110(0.89); C1285(1.06); C716(1.27); C719(1.27)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C1110(0.83); C1285(0.99); C716(1.14); C719(1.14)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C716(0.88); C719(0.88); C1285(0.88); C1110(0.94)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C1285(0.91); C1110(0.94); C716(1.26); C719(1.26)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C1110(0.85); C1285(0.91); C716(1.39); C719(1.39)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1285(0.48); C1110(0.80)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1285(0.68); C1110(0.89)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C1285(1.06); C1292(0.99); C716(1.06); C719(1.06)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C1285(0.98); C1292(0.80); C716(1.25); C719(1.25)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C1285(1.03); C1292(0.80); C716(1.50); C719(1.50)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C716(1.41); C719(1.41); C624(1.52); C627(1.52)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C716(1.07); C1285(1.13)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C1285(0.97); C716(1.11)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C1110(0.83)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C1285(0.87); C1292(0.70); C716(1.00); C719(1.00)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C1285(1.02); C1292(0.81); C716(1.24); C719(1.24)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C1285(1.04); C1292(0.85); C716(0.94); C719(0.94)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C1285(1.01); C1292(0.91); C716(0.84); C719(0.84)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C1110(0.98)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C1110(1.08)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C1110(1.00)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C1110(1.02)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C1110(0.94)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C1285(0.60); C716(1.19)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C1110(0.96)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C1110(0.92)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C1110(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1110(0.77)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1110(0.89)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1110(1.03)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1110(0.99)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1285(1.04); C1110(1.07)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1285(1.05); C1110(1.07)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1285(1.00); C1110(1.04)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C1285(0.65); C716(1.53)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1285(0.98); C1110(1.02)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C1110(0.97)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C1110(0.92)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C1110(0.97)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C1110(0.94)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C716(0.83); C719(0.83); C1110(1.00)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C716(0.71); C719(0.71); C1110(0.88)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C716(0.71); C719(0.71); C1110(0.93)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C1110(0.92); C716(1.41); C719(1.41)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C1285(0.58); C716(1.02)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C1285(0.78); C716(1.18)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C1285(0.64); C716(1.13)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C1110(1.13)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C1110(1.02)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C1110(1.02)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C1110(0.95)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C1285(0.66); C716(0.89)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C1110(0.95)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C1110(1.03)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1110(1.30)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1110(0.94)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C1110(1.23)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1110(1.00)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1110(1.09)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1110(1.09)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1110(0.97)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1110(1.09)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C1285(0.68); C716(1.16)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1110(1.10)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1110(1.05); C1285(0.86)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1110(0.90); C1285(0.75)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1110(0.90); C1285(0.68)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1110(1.08); C1285(0.83)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1110(0.83); C1285(0.81)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1110(0.86); C1285(0.73)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1110(1.01); C1285(0.73)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1110(0.97); C1285(0.78)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C1285(0.55); C716(1.02)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1110(0.90); C1285(0.74)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1110(0.98); C1285(0.76)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1110(1.17); C1285(0.85)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1110(0.90); C1285(0.76)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1110(0.93); C1285(0.70)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1110(1.01); C1285(0.75)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C1285(0.76); C1292(0.76); C1296(1.05); C716(1.05)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C1285(0.84); C1292(0.84); C1296(0.81); C716(0.81)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C1285(0.85); C1292(0.85); C1296(0.94); C716(0.94)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C1285(0.78); C1292(0.78); C1296(0.87); C716(0.87)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C1285(0.78); C716(1.13)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C1285(0.80); C1292(0.80); C1296(0.79); C716(0.79)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C1285(0.90); C1292(0.90); C1296(0.93); C716(0.93)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C1285(0.99); C1292(0.99); C1296(1.09); C716(1.09)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C1285(0.99); C1292(0.99); C1296(1.14); C716(1.14)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C1285(0.77); C1292(0.77); C1296(0.90); C716(0.90)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C1285(0.85); C1292(0.85); C1296(0.85); C716(0.85)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C1285(0.89); C1292(0.89); C1296(0.87); C716(0.87)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C1285(0.93); C1292(0.93); C1296(0.94); C716(0.94)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C1285(1.08); C1292(1.08); C1296(0.89); C716(0.89)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C1285(0.75); C1292(0.75); C1296(0.78); C716(0.78)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C1285(0.70); C716(1.29)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C1285(0.77); C1292(0.77); C1296(0.86); C716(0.86)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C1110(0.83); C1285(0.84); C1292(0.82); C1296(1.04)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C1110(0.79); C1285(0.90); C1292(0.71); C1296(0.75)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C1110(0.72); C1285(0.95); C1292(0.68); C1296(0.81)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C1110(0.90); C1285(0.81); C1292(0.94); C1296(1.02)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C1110(0.84); C1285(0.68); C1292(0.66); C1296(0.79)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C1110(0.87); C1285(0.83); C1292(0.66); C1296(0.70)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C1110(0.93); C1285(0.89); C1292(0.77); C1296(0.69)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C1110(0.85); C1285(0.98); C1292(0.84); C1296(0.74)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C1110(0.93); C1285(0.74); C1292(0.75); C1296(0.79)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C1285(0.74); C716(1.14)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C1110(0.94); C1285(1.11); C1292(1.06); C1296(0.74)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C1110(0.86); C1285(0.90); C1292(0.73); C1296(0.63)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C1110(0.79); C1285(0.81); C1292(0.66); C1296(0.96)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C1110(0.84); C1285(0.96); C1292(0.82); C1296(0.65)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C1110(0.61); C1285(1.12); C1292(0.56); C1296(0.56)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C1285(1.04); C1292(1.00)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C1285(0.95); C1292(0.94)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C1285(0.94); C1292(1.01)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C1285(0.99); C1292(0.86)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C1285(0.67); C716(0.96)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C1285(1.24); C1292(1.02)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C1285(1.02); C1292(0.89)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C1285(1.26); C1292(0.99)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C1285(1.37); C1292(0.88)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C1285(0.95); C1292(0.97)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C1285(1.15); C1292(0.99)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C1285(0.87); C1292(0.92)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C1285(1.42); C1292(0.86)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C1285(1.32); C1292(0.90)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C1285(1.12); C1292(0.81)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C1285(0.73); C716(0.86)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C1285(0.90); C1292(0.93)  LDD1083  [3]
 LDCM0486  CL91 HCT 116 C1110(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C1110(1.21)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C1110(1.30)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C1110(0.98)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C1110(0.96)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C1110(0.88)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C1110(0.80)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C1110(0.88)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C1110(0.94)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C770(1.12); C991(1.14); C1285(1.06); C688(1.21)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C991(1.43); C1035(0.67)  LDD1702  [9]
 LDCM0468  Fragment33 HEK-293T C1110(0.66); C1285(1.09); C1292(0.64); C1296(0.55)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C1110(1.00); C1285(0.83)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C716(1.39); C719(1.50)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C716(1.44); C719(1.32)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C716(1.32); C719(1.31)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C716(1.41); C719(1.41); C624(1.52); C627(1.52)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL-6 corepressor (BCOR) BCOR family Q6W2J9

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761