Details of the Target

General Information of Target

Target ID LDTP09232
Target Name Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
Gene Name KBTBD8
Gene ID 84541
Synonyms
KIAA1842; TAKRP; Kelch repeat and BTB domain-containing protein 8; T-cell activation kelch repeat protein; TA-KRP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKT
FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANV
QALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFL
CVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCI
RFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK
KQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDF
WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC
WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYK
DSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRA
TQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKV
L
Target Bioclass
Other
Family
KBTBD8 family
Subcellular location
Cytoplasm, cytoskeleton, spindle
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Uniprot ID
Q8NFY9
Ensemble ID
ENST00000417314.2
HGNC ID
HGNC:30691

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P594S .
CORL88 SNV: p.S128T .
HT115 SNV: p.R92Ter; p.R471K .
IGR1 SNV: p.E227K DBIA    Probe Info 
JHH4 SNV: p.E229K .
MCC13 SNV: p.P133S .
MEWO SNV: p.F453I
Substitution: p.A356T		 .
RL952 SNV: p.V52A .
SHP77 SNV: p.V499L .
SNGM SNV: p.C388R .
SW1271 SNV: p.D148Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C276(2.73)  LDD0080  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C318(0.00); C490(0.00); C276(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C587(0.00); C490(0.00)  LDD0037  [2]
IPM
 Probe Info  		C276(0.00); C490(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C276(0.77)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C490(0.80)  LDD1508  [4]
 LDCM0216  AC100 HEK-293T C276(0.97)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C276(0.88)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C276(0.82)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C276(1.07)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C276(1.17)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C276(0.94)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C276(0.88)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C276(0.79)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C276(0.88)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C276(0.90)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C490(0.88); C596(1.06)  LDD1509  [4]
 LDCM0227  AC110 HEK-293T C276(0.78)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C276(0.94)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C276(0.81)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C276(1.05)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C276(0.86)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C276(0.98)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C276(1.06)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C276(0.97)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C276(0.81)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C276(0.95)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C490(1.18); C596(1.07)  LDD1510  [4]
 LDCM0238  AC120 HCT 116 C276(0.98)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C276(0.88)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C276(0.85)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C276(0.80)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C276(0.82)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C276(0.97)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C276(0.85)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C276(0.97)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C276(0.46)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C276(0.64)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C276(0.69)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C276(0.48)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C276(0.58)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C276(0.67)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C276(0.69)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C276(0.63)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C276(0.49)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C276(0.83)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C276(0.80)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C276(0.64)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C276(0.63)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C276(0.97)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C276(0.69)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C276(1.57)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C276(0.98)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C276(1.77)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C276(0.74)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C276(1.14)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C276(1.09)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C276(0.75)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C490(1.09); C596(1.07)  LDD1513  [4]
 LDCM0271  AC150 HCT 116 C276(0.79)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C276(2.13)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C276(0.94)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C276(0.85)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C276(1.11)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C276(1.24)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C276(1.17)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C276(0.90)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C276(1.26)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C276(1.60)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C276(1.55)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C276(1.17)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C276(1.03)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C276(1.01)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C276(1.12)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C276(1.11)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C276(1.69)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C276(0.80)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C276(0.94)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C276(1.02)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C276(0.99)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C276(1.27)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C276(0.80)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C276(1.48)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C276(1.03)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C276(1.17)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C276(0.98)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C276(1.06)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C276(0.60)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C276(1.05)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C276(0.95)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C276(1.52)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C276(1.38)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C276(0.71)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C276(1.15)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C276(0.97)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C276(0.90)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C276(1.00)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C276(1.04)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C276(1.05)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C276(0.93)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C276(0.77)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C276(0.98)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C276(0.89)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C276(0.66)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C276(1.01)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C276(1.10)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C276(0.95)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C276(0.98)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C276(1.01)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C276(0.89)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C276(0.81)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C276(1.04)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C276(0.87)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C276(0.83)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C276(1.22)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C276(1.01)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C276(0.98)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C276(1.15)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C276(0.96)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C276(1.06)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C276(1.00)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C276(0.93)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C276(0.85)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C276(0.85)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C490(1.12); C596(0.93)  LDD1568  [4]
 LDCM0335  AC70 HEK-293T C276(0.86)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C276(0.88)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C276(1.02)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C276(1.33)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C276(0.86)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C276(1.11)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C276(0.95)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C276(0.78)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C276(0.79)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C276(0.85)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C490(0.99); C318(1.05)  LDD1569  [4]
 LDCM0346  AC80 HEK-293T C276(0.96)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C276(0.87)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C276(0.84)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C276(0.78)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C276(0.72)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C276(0.71)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C276(0.83)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C276(1.11)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C276(0.63)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C276(0.71)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C276(0.87)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C276(0.71)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C276(0.61)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C276(0.60)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C276(0.48)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C276(0.87)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C276(0.44)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C276(0.67)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C276(1.01)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C276(0.94)  LDD0964  [1]
 LDCM0356  AKOS034007680 HEK-293T C490(0.99); C596(0.94)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C490(1.04); C318(1.04)  LDD1514  [4]
 LDCM0367  CL1 HCT 116 C276(0.95)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C276(1.06)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C276(0.69)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C490(0.76); C596(0.98)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C490(0.82); C596(0.98); C276(0.74)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C490(1.22); C596(1.06)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C490(0.91); C596(0.91); C276(1.07)  LDD1577  [4]
 LDCM0374  CL105 HCT 116 C276(0.90)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C276(0.81)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C276(0.98)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C276(1.10)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C276(1.37)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C276(1.17)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C276(1.57)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C276(1.84)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C276(0.83)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C276(1.09)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C276(1.31)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C276(1.20)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C276(1.06)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C276(1.28)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C276(1.18)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C276(1.10)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C276(1.21)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C276(0.80)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C276(0.94)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C276(1.23)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C276(0.72)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C276(1.04)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C276(1.03)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C276(1.29)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C276(1.16)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C276(1.06)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C276(1.37)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C276(1.59)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C276(1.46)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C276(0.74)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C276(1.06)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C276(0.80)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C276(1.30)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C276(1.41)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C276(1.52)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C276(1.33)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C276(1.39)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C276(1.19)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C276(1.54)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C276(1.29)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C276(0.85)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C276(0.92)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C276(1.17)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C276(1.92)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C276(1.42)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C276(0.82)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C276(0.93)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C276(0.92)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C276(0.85)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C276(0.96)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C276(0.92)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C276(0.98)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C276(0.97)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C276(0.89)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C276(1.23)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C276(1.10)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C276(0.85)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C276(0.85)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C276(0.87)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C276(1.08)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C276(1.00)  LDD0752  [1]
 LDCM0437  CL47 HEK-293T C490(1.03); C596(1.07)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C490(1.18); C318(1.10)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C490(0.92); C596(1.06)  LDD1643  [4]
 LDCM0440  CL5 HCT 116 C276(1.29)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C490(0.92); C596(1.04); C276(1.10)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C490(0.89); C596(0.87); C276(0.73)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C490(1.06); C596(0.96)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C490(0.83)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C490(1.00); C596(1.24)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C490(1.23); C596(1.11)  LDD1650  [4]
 LDCM0450  CL59 HEK-293T C490(0.91); C596(0.99)  LDD1653  [4]
 LDCM0451  CL6 HCT 116 C276(1.41)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C490(1.08); C318(1.29)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C490(0.81); C596(0.98)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C490(1.37); C596(1.02); C276(0.91)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C490(1.07); C596(1.01)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C490(0.86); C596(0.95); C276(0.87)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C490(1.21); C596(0.95)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C490(0.89)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C490(1.39); C596(0.88)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C490(0.87); C596(1.05)  LDD1663  [4]
 LDCM0462  CL7 HCT 116 C276(1.35)  LDD0779  [1]
 LDCM0464  CL71 HEK-293T C490(1.07); C596(1.07)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C490(1.01); C318(1.15)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C490(0.74); C596(1.05)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C490(1.27); C596(1.12); C276(0.89)  LDD1670  [4]
 LDCM0469  CL76 HCT 116 C276(0.91)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C276(0.64)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C276(0.76)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C276(0.72)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C276(1.22)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C276(1.02)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C276(0.96)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C276(0.72)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C276(0.76)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C276(1.05)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C276(1.14)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C276(0.91)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C276(0.85)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C276(1.26)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C276(0.67)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C276(1.18)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C276(0.60)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C276(0.60)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C276(0.66)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C276(0.92)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C276(0.68)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C276(0.55)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C276(0.81)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C276(0.72)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C276(0.72)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C276(0.75)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C490(1.75); C596(1.19)  LDD1698  [4]
 LDCM0625  F8 Ramos C490(1.64)  LDD2187  [5]
 LDCM0576  Fragment14 Ramos C490(1.04)  LDD2193  [5]
 LDCM0586  Fragment28 Ramos C490(0.54)  LDD2198  [5]
 LDCM0468  Fragment33 HEK-293T C490(1.73); C596(1.06)  LDD1671  [4]
 LDCM0566  Fragment4 Ramos C490(1.55)  LDD2184  [5]
 LDCM0427  Fragment51 HCT 116 C276(0.87)  LDD0744  [1]
 LDCM0610  Fragment52 Ramos C490(0.76)  LDD2204  [5]
 LDCM0022  KB02 HCT 116 C276(2.73)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C276(1.87)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C276(2.51)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578