Details of the Target

General Information of Target

Target ID LDTP09161
Target Name Phospholipase DDHD1 (DDHD1)
Gene Name DDHD1
Gene ID 80821
Synonyms
KIAA1705; Phospholipase DDHD1; EC 3.1.1.111; EC 3.1.1.32; DDHD domain-containing protein 1; Phosphatidic acid-preferring phospholipase A1 homolog; PA-PLA1; EC 3.1.1.118; Phospholipid sn-1 acylhydrolase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLR
GEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPP
QQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWK
PFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQS
TTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPL
EEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDAVHSFKLSRNHVDWHSVDEVYLY
SDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMD
QGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLR
DMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGC
VITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGL
KASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHP
TDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGIST
IPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDS
MEDEKKPVASPSATTVGTQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVMQNKDNAL
VELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI
Target Bioclass
Enzyme
Family
PA-PLA1 family
Subcellular location
Cytoplasm
Function
Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology. Regulates mitochondrial morphology. These dynamic changes may be due to PA hydrolysis at the mitochondrial surface. May play a regulatory role in spermatogenesis or sperm function.
Uniprot ID
Q8NEL9
Ensemble ID
ENST00000357758.3
HGNC ID
HGNC:19714

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.R653W .
HCT15 SNV: p.R145G .
HEC1 SNV: p.V450F .
HEC1B SNV: p.V450F; p.V534L .
IGROV1 Deletion: p.G132AfsTer28 .
Ishikawa (Heraklio) 02 ER SNV: p.R588Ter .
KELLY Substitution: p.E42Ter .
MM1S SNV: p.D362E .
NB1 SNV: p.K283E .
NCIH1793 SNV: p.R387G .
OAW42 Insertion: p.P829SfsTer8 .
OE33 SNV: p.S28Ter .
OVCAR5 SNV: p.D81A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K375(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C273(0.75)  LDD0532  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C273(0.75)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C273(0.78)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C273(1.01)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C273(0.55)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C273(0.83)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C273(0.67)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C273(0.63)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C273(0.95)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C273(0.70)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C273(0.74)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C273(0.64)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C273(0.68)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C273(0.94)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C273(0.98)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C273(0.77)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C273(0.63)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C273(0.68)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C273(0.66)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C273(0.81); C518(1.55)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C273(0.54); C518(1.41)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C273(0.74); C518(1.13)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C273(1.01); C518(1.28)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C273(0.84); C518(0.94)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C273(0.84); C518(1.17)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C273(0.68); C518(1.01)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C273(0.88); C518(0.96)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C273(0.72); C518(1.00)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C273(0.88); C518(0.99)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C273(0.76); C518(0.96)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C273(1.01); C518(0.83)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C273(0.99)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C273(0.90); C518(0.91)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C273(1.18); C518(0.92)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C273(0.91); C518(0.90)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C518(0.95)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C518(0.94)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C518(1.00)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C518(0.75)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C518(0.99)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C518(0.72)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C518(0.61)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C273(0.71)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C518(0.67)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C518(0.87)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C518(0.93)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C518(0.76)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C518(1.19)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C518(0.99)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C518(0.87)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C518(1.29)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C273(0.77); C518(0.89)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C273(0.93); C518(1.12)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C273(0.69); C518(1.10)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C273(0.69); C518(1.54)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C273(0.76); C518(1.51)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C518(0.73); C273(0.86)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C273(0.58); C518(1.30)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C273(0.79); C518(1.47)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C273(0.52); C518(1.05)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C518(0.59); C273(0.61)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C273(0.60); C518(0.65)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C518(0.57); C273(0.71)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C518(0.51); C273(0.56)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C518(0.53); C273(0.64)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C273(0.59); C518(0.63)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C518(0.47); C273(0.69)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C273(0.72); C518(0.87)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C273(0.77); C518(0.77)  LDD0612  [2]
 LDCM0298  AC37 HEK-293T C83(1.00)  LDD1537  [5]
 LDCM0307  AC45 HEK-293T C83(0.97)  LDD1546  [5]
 LDCM0308  AC46 HCT 116 C518(1.02); C258(1.09)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C258(0.78); C518(0.96)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C258(0.67); C518(0.98)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C518(0.95); C258(1.11)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C83(1.38)  LDD1551  [5]
 LDCM0313  AC50 HCT 116 C258(0.91); C518(1.05)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C258(0.92); C518(1.04)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C258(0.97); C518(1.01)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C518(0.73); C258(1.01)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C258(0.99); C518(1.13)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C518(0.77); C258(0.78)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C258(0.62); C518(1.03)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C518(1.02)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C518(1.34)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C518(1.00)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C273(0.83)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C518(1.18)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C518(0.89)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C518(1.01)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C518(1.07)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C518(0.99)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C518(0.93)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C518(0.90)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C518(1.04)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C518(0.74); C258(0.86)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C518(0.86); C258(1.14)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C273(0.74)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C518(0.45); C258(0.76)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C518(0.73); C258(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C258(1.02); C518(1.17)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C518(0.82); C258(1.30)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C518(0.72); C258(1.42)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C518(0.62); C258(1.42)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C518(0.90); C258(1.00)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C518(0.64); C258(1.20)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C518(0.64); C258(0.82)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C518(0.71); C258(0.89)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C273(0.91)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C518(0.90); C258(1.41)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C258(1.03); C518(1.26)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C518(0.42); C258(1.18)  LDD0665  [2]
 LDCM0248  AKOS034007472 HCT 116 C273(0.80)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C273(0.89)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C273(0.68)  LDD0592  [2]
 LDCM0369  CL100 HEK-293T C83(0.85)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C273(0.87)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C273(1.03)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C273(1.01)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C273(1.10)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C273(0.49); C518(0.67)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C273(0.56); C518(0.66)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C518(0.41); C273(0.54)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C273(0.67); C518(0.82)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C518(0.43); C273(0.68)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C273(0.54); C518(0.63)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C518(0.82); C273(1.06)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C518(0.74); C273(0.91)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C518(0.61); C273(1.23)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C273(0.56); C518(0.57)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C518(0.65); C273(0.99)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C273(0.67); C518(0.86)  LDD0703  [2]
 LDCM0391  CL120 HEK-293T C83(0.92)  LDD1595  [5]
 LDCM0392  CL121 HCT 116 C258(0.68); C518(0.75)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C258(0.90); C518(0.90)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C258(0.94); C518(1.12)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C258(0.80); C518(0.96)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C518(0.96)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C518(1.24)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C518(0.99)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C518(0.79)  LDD0716  [2]
 LDCM0403  CL16 HCT 116 C258(0.95); C518(1.23)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C518(0.68); C258(0.98)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C518(0.96); C258(1.91)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C518(0.80); C258(1.17)  LDD0723  [2]
 LDCM0408  CL20 HCT 116 C518(0.86); C258(1.06)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C518(0.88); C258(1.50)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C518(0.96); C258(1.90)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C258(1.29); C518(1.56)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C518(0.80); C258(1.20)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C258(1.31); C518(0.88)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C258(1.31); C518(0.85)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C258(1.10); C518(1.05)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C258(1.80); C518(0.64)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C258(1.22); C518(1.16)  LDD0734  [2]
 LDCM0419  CL30 HCT 116 C258(1.17); C518(1.00)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C518(0.84)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C518(1.01)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C518(1.39)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C518(1.05)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C518(1.50)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C518(1.22)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C518(1.27)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C518(1.39)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C83(1.18)  LDD1633  [5]
 LDCM0430  CL40 HCT 116 C518(1.08)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C518(1.16)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C518(1.03)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C518(1.26)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C518(1.44)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C518(1.56)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C258(1.17); C518(0.67)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C258(1.03); C518(0.78)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C258(1.06); C518(0.88)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C258(1.40); C518(0.89)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C258(1.22); C518(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C258(1.22); C518(0.69)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C258(1.29); C518(0.69)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C258(1.40); C518(1.21)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C258(1.10); C518(1.14)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C258(1.04); C518(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C258(1.07); C518(1.25)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C258(1.11); C518(1.14)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C258(1.44); C518(1.14)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C258(1.07); C518(1.07)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C258(0.97); C518(0.95)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C518(0.72)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C518(0.69)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C518(0.97)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C518(0.77)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C518(1.13)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C518(0.91)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C518(1.47)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C518(1.20)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C518(0.97)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C518(0.86)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C518(0.99)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C518(0.83)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C518(1.21)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C518(1.02)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C518(1.40)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C518(1.28)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C518(1.14)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C518(1.27)  LDD0789  [2]
 LDCM0474  CL80 HCT 116 C518(1.08)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C518(1.03)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C518(1.18)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C518(1.00)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C518(1.10)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C518(1.24)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C518(1.25)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C518(1.40)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C518(1.37)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C518(1.29)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C83(1.19)  LDD1687  [5]
 LDCM0485  CL90 HCT 116 C518(1.38)  LDD0802  [2]
 LDCM0488  CL93 HEK-293T C83(0.94)  LDD1691  [5]
 LDCM0468  Fragment33 HCT 116 C518(0.76)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C518(1.47)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complement component receptor 1-like protein (CR1L) Receptors of complement activation (RCA) family Q2VPA4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402