Details of the Target

General Information of Target

Target ID LDTP09091
Target Name tRNA-splicing endonuclease subunit Sen2 (TSEN2)
Gene Name TSEN2
Gene ID 80746
Synonyms
SEN2; tRNA-splicing endonuclease subunit Sen2; EC 4.6.1.16; tRNA-intron endonuclease Sen2; HsSen2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQL
YGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQ
DESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKS
GGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGS
QHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLS
LEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGL
KYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELML
CYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL
Target Bioclass
Enzyme
Family
TRNA-intron endonuclease family
Subcellular location
Nucleus
Function
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
Uniprot ID
Q8NCE0
Ensemble ID
ENST00000284995.11
HGNC ID
HGNC:28422

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 SNV: p.P26S .
RVH421 SNV: p.S403F .
SNU5 SNV: p.C286G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C221(1.19); C222(1.19); C223(1.19)  LDD0078  [1]
ATP probe
 Probe Info  		K10(0.00); K361(0.00)  LDD0199  [2]
IPM
 Probe Info  		C192(0.00); C222(0.00); C221(0.00); C265(0.00)  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
HHS-482
 Probe Info  		Y132(0.81)  LDD2239  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C222(0.88); C223(0.88)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C221(1.37); C222(1.37); C223(1.37)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C221(0.98); C222(0.98); C223(0.98)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C221(0.94); C222(1.00); C223(1.00)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C221(1.06); C222(1.12); C223(1.12)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C221(1.18); C222(1.24); C223(1.24)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C221(1.13); C222(1.17); C223(1.17)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C221(1.00); C222(1.09); C223(1.09)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C221(1.10); C222(1.11); C223(1.11)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C221(1.17); C222(1.02); C223(1.23)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C221(0.80); C222(1.00); C223(0.90)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C221(0.77); C222(0.91); C223(0.81)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C221(1.24); C222(1.24); C223(1.24)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C221(0.98); C222(1.07); C223(1.01)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C221(0.92); C222(1.02); C223(0.89)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C221(1.01); C222(1.01); C223(0.97)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C221(1.01); C222(1.02); C223(0.98)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C221(1.04); C222(1.10); C223(1.09)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C221(1.33); C222(1.26); C223(1.27)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C221(1.31); C222(1.42); C223(1.36)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C221(0.97); C222(1.06); C223(1.02)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C221(1.13); C222(1.07); C223(1.09)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C221(1.08); C222(1.12); C223(1.11)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C221(1.21); C222(1.21); C223(1.21)  LDD0835  [1]
 LDCM0238  AC120 HCT 116 C221(1.14); C222(1.17); C223(1.15)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C221(1.04); C222(1.19); C223(1.15)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C221(1.03); C222(1.01); C223(1.00)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C221(1.10); C222(1.04); C223(0.97)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C221(1.08); C222(1.10); C223(1.01)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C221(1.06); C222(1.05); C223(1.03)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C221(1.22); C222(1.36); C223(1.41)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C221(1.19); C222(1.27); C223(1.25)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C221(1.34); C222(1.68); C223(1.68)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C221(0.75); C222(0.93); C223(0.93)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C221(0.99); C222(1.22); C223(1.22)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C221(0.73); C222(0.87); C223(0.87)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C221(0.95); C222(0.85); C223(0.85)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C221(0.94); C222(1.02); C223(1.02)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C221(1.05); C222(1.33); C223(1.33)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C221(1.12); C222(1.37); C223(1.37)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C221(1.00); C222(1.23); C223(1.23)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C221(1.07); C222(1.11); C223(1.11)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C221(1.01); C222(1.24); C223(1.24)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C221(0.93); C222(1.07); C223(1.07)  LDD0575  [1]
 LDCM0259  AC14 HEK-293T C221(1.75); C222(1.75); C223(1.75)  LDD0857  [1]
 LDCM0260  AC140 HCT 116 C221(1.08); C222(1.06); C223(1.06)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C221(1.01); C222(1.22); C223(1.22)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C221(0.81); C222(1.13); C223(1.13)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C222(0.81); C221(1.03); C223(1.03)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C222(0.72); C221(1.00); C223(1.00)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C222(0.70); C221(0.94); C223(0.94)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C222(0.73); C221(1.07); C223(1.07)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C222(0.77); C221(1.07); C223(1.07)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C222(0.79); C221(1.31); C223(1.31)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C222(1.18); C221(1.45); C223(1.45)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C221(1.42); C222(1.42); C223(1.42)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C222(0.82); C221(1.02); C223(1.02)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C222(0.98); C221(1.07); C223(1.07)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C222(0.75); C221(1.10); C223(1.10)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C222(0.81); C221(1.36); C223(1.36)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C221(1.12); C222(0.70); C223(1.12)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C221(1.06); C222(0.69); C223(1.06)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C221(0.96); C222(0.73); C223(0.96)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C221(0.76); C222(0.67); C223(0.76)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C221(0.63); C222(0.63)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C221(0.76); C222(0.76)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C221(0.68); C222(0.68)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C222(0.97); C223(0.97)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C221(0.55); C222(0.55)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C221(0.58); C222(0.58)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C221(0.67); C222(0.67)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C221(0.71); C222(0.71)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C221(0.71); C222(0.71)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C221(0.86); C222(0.86)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C221(0.78); C222(0.78)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C221(1.01); C222(1.01)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C221(0.98); C222(0.98)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C221(0.66); C222(0.66)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C222(1.19); C223(1.19)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C221(0.99); C222(0.99)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C221(0.85); C222(0.85)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C221(0.90); C222(0.90)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C221(0.90); C222(0.90)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C221(0.82); C222(0.82)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C221(0.97); C222(1.00); C223(1.03)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C223(0.85); C222(0.91); C221(0.97)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C221(1.18); C222(1.24); C223(1.31)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C223(0.96); C222(1.14); C221(1.32)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C223(0.88); C222(1.01); C221(1.13)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C222(1.09); C223(1.09)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C223(1.10); C222(1.23); C221(1.36)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C223(1.04); C222(1.19); C221(1.34)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C223(0.96); C222(1.11); C221(1.26)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C221(1.00); C222(1.13); C223(1.27)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C221(1.15); C222(1.25); C223(1.34)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C221(1.10); C222(1.11); C223(1.11)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C221(0.84); C222(0.84); C223(0.84)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C221(0.97); C222(0.97); C223(0.97)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C221(0.91); C222(0.91); C223(0.91)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C221(1.02); C222(1.02); C223(1.02)  LDD0909  [1]
 LDCM0312  AC5 HCT 116 C222(1.10); C223(1.10)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C221(0.97); C222(0.97); C223(0.97)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C221(1.02); C222(1.02); C223(1.02)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C221(1.05); C222(1.05); C223(1.05)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C221(1.20); C222(1.20); C223(1.20)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C221(1.02); C222(1.02); C223(1.02)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C221(1.22); C222(1.22); C223(1.22)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C221(0.84); C222(0.84); C223(0.84)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C221(1.27); C222(1.27); C223(1.27)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C221(0.90); C222(0.90); C223(0.90)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C221(1.21); C222(1.21); C223(1.21)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C221(1.08); C222(1.08); C223(1.08)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C221(0.99); C222(0.99); C223(0.99)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C221(0.78); C222(0.78); C223(0.78)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C221(0.72); C222(0.72); C223(0.72)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C221(0.96); C222(0.96); C223(0.96)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C221(0.80); C222(0.80); C223(0.80)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C221(0.88); C222(0.88); C223(0.88)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C221(0.85); C222(0.85); C223(0.85)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C221(0.87); C222(0.87); C223(0.87)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C221(0.83); C223(0.83); C222(0.87)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C222(0.99); C221(1.01); C223(1.01)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C221(0.91); C222(0.91); C223(0.91)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C222(1.32); C221(1.35); C223(1.35)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C222(0.87); C221(0.90); C223(0.90)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C222(0.99); C221(1.07); C223(1.07)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C221(1.25); C223(1.25); C222(1.26)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C222(1.23); C221(1.31); C223(1.31)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C222(1.45); C221(1.48); C223(1.48)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C222(1.03); C221(1.06); C223(1.06)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C222(1.03); C221(1.04); C223(1.04)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C221(0.88); C223(0.88); C222(0.89)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C222(0.91); C221(0.94); C223(0.94)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C221(0.94); C222(0.94); C223(0.94)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C222(1.04); C221(1.10); C223(1.10)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C222(0.95); C221(0.97); C223(0.97)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C222(1.34); C221(1.36); C223(1.36)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C221(1.90); C222(1.90); C223(1.90)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C221(1.87); C222(1.87); C223(1.87)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C221(1.34); C222(1.34); C223(1.34)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C221(1.32); C222(1.32); C223(1.32)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C221(1.13); C222(1.13); C223(1.13)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C221(1.39); C222(1.39); C223(1.39)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C221(1.55); C222(1.55); C223(1.55)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C221(0.95); C222(0.95); C223(0.95)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C221(2.06); C222(2.06); C223(2.06)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C221(1.86); C222(1.86); C223(1.86)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C221(1.54); C222(1.54); C223(1.54)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C221(1.45); C222(1.45); C223(1.45)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C221(1.24); C222(1.24); C223(1.24)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C221(1.58); C222(1.58); C223(1.58)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C221(1.72); C222(1.72); C223(1.72)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C221(1.13); C222(1.23); C223(1.23)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C221(0.90); C222(0.98); C223(0.98)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C221(1.56); C222(1.56); C223(1.56)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C221(1.30); C222(1.30); C223(1.30)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C221(2.06); C222(2.06); C223(2.06)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C221(1.19); C222(1.19); C223(1.19)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C222(0.77); C223(0.77)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C222(0.89); C223(0.89)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C222(0.95); C223(0.95)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C221(1.47); C222(1.47); C223(1.47)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C221(2.22); C222(2.22); C223(2.22)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C221(0.96); C222(0.96); C223(0.96)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C221(1.05); C222(1.05); C223(1.05)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C221(0.87); C222(0.87)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C221(0.88); C222(0.88)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C221(0.67); C222(0.67)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C221(0.73); C222(0.73)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C221(0.65); C222(0.65)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C222(0.77); C223(0.77)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C221(0.69); C222(0.69)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C221(0.91); C222(0.91)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C221(1.11); C222(1.11)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C221(0.86); C222(0.86)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C221(0.91); C222(0.91)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C221(0.93); C222(0.93)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C221(1.02); C222(1.02)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C223(0.91); C222(1.09); C221(1.26)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C223(0.82); C222(1.05); C221(1.29)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C223(0.97); C222(1.08); C221(1.19)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C222(0.67); C223(0.67)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C223(0.88); C222(0.97); C221(1.06)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C221(1.08); C222(1.08); C223(1.08)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C221(1.10); C222(1.10); C223(1.10)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C221(2.06); C222(2.06); C223(2.06)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C221(1.08); C222(1.08); C223(1.08)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C221(1.33); C222(1.33); C223(1.33)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C221(1.52); C222(1.52); C223(1.52)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C221(1.23); C222(1.23); C223(1.23)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C221(1.40); C222(1.40); C223(1.40)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C222(0.79); C223(0.79)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C222(0.73); C223(0.73)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C222(0.87); C223(0.87)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C221(1.09); C222(1.09); C223(1.20)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C223(0.90); C221(0.91); C222(0.98)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C221(0.88); C222(0.92); C223(0.93)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C222(0.91); C221(1.01); C223(1.02)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C222(0.83); C223(0.83)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C222(0.87); C221(0.89); C223(0.95)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C222(0.85); C221(0.97); C223(0.97)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C223(0.92); C221(0.96); C222(0.99)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C221(0.92); C222(0.92); C223(1.00)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C221(0.83); C222(0.96); C223(0.95)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C221(0.91); C222(1.00); C223(1.04)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C221(0.92); C222(0.97); C223(1.02)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C221(0.91); C222(0.93); C223(0.97)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C221(0.96); C222(1.00); C223(1.05)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C221(0.89); C222(0.90); C223(0.98)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C222(0.69); C223(0.69)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C221(0.82); C222(0.90); C223(0.89)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C221(0.88); C223(0.88)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C221(1.08); C222(1.08); C223(1.08)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C221(2.06); C222(2.06); C223(2.06)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C221(1.19); C222(1.19); C223(1.19)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C221(1.12); C222(1.12); C223(1.12)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C221(1.00); C222(1.00); C223(1.00)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C221(0.94); C222(0.94); C223(0.94)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C221(1.16); C222(1.16); C223(1.16)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C222(0.65); C223(0.65)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C221(1.04); C222(1.04); C223(1.04)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C221(1.18); C222(1.18); C223(1.18)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C221(0.80); C222(0.80); C223(0.80)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C221(1.02); C222(1.02); C223(1.02)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C221(0.84); C222(0.84); C223(0.84)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C221(0.86); C222(0.86); C223(0.86)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C221(0.81); C222(0.81); C223(0.85)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C221(0.86); C222(0.86); C223(0.86)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C221(0.98); C222(0.98); C223(0.79)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C221(0.80); C222(0.80); C223(0.76)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C222(0.93); C223(0.93)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C221(0.82); C222(0.82); C223(0.79)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C221(0.77); C222(0.77); C223(0.73)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C221(1.00); C222(1.00); C223(1.07)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C221(1.01); C222(1.01); C223(0.99)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C221(0.85); C222(0.85); C223(0.91)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C221(0.90); C222(0.90); C223(0.94)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C221(0.84); C222(0.84); C223(0.88)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C221(0.79); C222(0.79); C223(0.76)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C221(0.79); C222(0.79); C223(0.87)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C221(0.88); C222(0.88); C223(0.90)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C222(0.84); C223(0.84)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C221(0.83); C222(0.83); C223(0.83)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C221(1.34); C222(1.34); C223(1.34)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C221(1.27); C222(1.27); C223(1.27)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C221(0.97); C222(0.97); C223(0.97)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C221(1.66); C222(1.66); C223(1.66)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C221(1.22); C222(1.22); C223(1.22)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C221(1.10); C222(1.10); C223(1.10)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C221(1.34); C222(1.34); C223(1.34)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C221(1.09); C222(1.09); C223(1.09)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C221(1.30); C222(1.30); C223(1.30)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C222(0.74); C223(0.74)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C221(1.10); C222(1.10); C223(1.10)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C221(1.23); C222(1.23); C223(1.23)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C221(1.13); C222(1.13); C223(1.13)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C221(1.55); C222(1.55); C223(1.55)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C221(1.30); C222(1.30); C223(1.30)  LDD1065  [1]
 LDCM0469  CL76 HCT 116 C221(1.41); C222(1.41); C223(1.41)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C221(1.38); C222(1.38); C223(1.38)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C221(1.06); C222(1.06); C223(1.06)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C221(1.37); C222(1.37); C223(1.37)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C222(0.83); C223(0.83)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C221(1.00); C222(1.00); C223(1.00)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C221(1.10); C222(1.10); C223(1.10)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C221(1.13); C222(1.13); C223(1.13)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C221(1.25); C222(1.25); C223(1.25)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C221(1.24); C222(1.24); C223(1.24)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C221(1.44); C222(1.44); C223(1.44)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C221(1.35); C222(1.35); C223(1.35)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C221(1.52); C222(1.52); C223(1.52)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C221(1.41); C222(1.41); C223(1.41)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C221(1.16); C222(1.16); C223(1.16)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C222(0.92); C223(0.92)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C221(1.39); C222(1.39); C223(1.39)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C222(1.00); C223(1.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C222(0.85); C223(0.85)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C222(0.90); C223(0.90)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C222(0.83); C223(0.83)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C222(0.97); C223(0.97)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C222(1.00); C223(1.00)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C222(1.05); C223(1.05)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C222(1.03); C223(1.03)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C222(1.03); C223(1.03)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C221(1.14)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C221(1.84); C222(1.84); C223(1.84)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C221(0.88); C222(0.88); C223(0.88)  LDD0744  [1]
 LDCM0022  KB02 CAL-120 C439(2.39)  LDD2284  [7]
 LDCM0023  KB03 CAL-120 C439(3.02)  LDD2701  [7]
 LDCM0024  KB05 CAL-120 C439(2.71)  LDD3118  [7]
 LDCM0021  THZ1 HCT 116 C221(1.12); C222(1.12); C223(1.12)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
tRNA-splicing endonuclease subunit Sen54 (TSEN54) SEN54 family Q7Z6J9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GA-binding protein subunit beta-2 (GABPB2) . Q8TAK5
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840