Details of the Target

General Information of Target

Target ID LDTP08997
Target Name Junction-mediating and -regulatory protein (JMY)
Gene Name JMY
Gene ID 133746
Synonyms
Junction-mediating and -regulatory protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSRE
QAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTR
SLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSV
RIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRA
VHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTC
GWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLD
LYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQK
EDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKL
QYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV
QFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQ
KLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREK
LHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDH
CDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSEL
PPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKD
LPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKR
GSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSI
HEALRRIKEASPESEDEEEALPCTDWEN
Target Bioclass
Other
Family
JMY family
Subcellular location
Nucleus
Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Uniprot ID
Q8N9B5
Ensemble ID
ENST00000396137.5
HGNC ID
HGNC:28916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P858A .
DU145 SNV: p.R79H .
HCT15 SNV: p.G272E .
HUH7 SNV: p.W229L .
IM95 Deletion: p.L882CfsTer6 .
JHH7 SNV: p.P254R .
K562 SNV: p.E281V .
KELLY SNV: p.P143Q DBIA    Probe Info 
KMS27 SNV: p.S56R .
P31FUJ SNV: p.P821Q .
SHP77 SNV: p.E718Ter .
SW403 SNV: p.M364I; p.Q595H .
TF1 SNV: p.R900C .
YSCCC SNV: p.E718Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.30  LDD0402  [1]
DBIA
 Probe Info  		C46(1.02)  LDD0531  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C46(1.02)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C721(1.11); C227(1.01); C498(0.99); C46(1.02)  LDD1508  [10]
 LDCM0216  AC100 HCT 116 C498(0.91)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C498(1.06)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C498(0.76)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C498(1.19)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C498(0.96)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C498(1.14)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C498(1.47)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C498(1.13)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C498(0.80)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C498(1.23)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C721(1.05); C227(1.15); C46(1.05)  LDD1509  [10]
 LDCM0227  AC110 HCT 116 C498(0.86)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C498(0.64)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C498(1.02)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C46(1.06); C498(1.11)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C46(0.83); C498(1.01)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C46(0.88); C498(1.29)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C46(0.95); C498(1.25)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C46(0.95); C498(1.22)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C46(0.82); C498(1.07)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C46(0.92); C498(1.22)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C721(0.98); C227(1.28); C498(1.11); C46(1.07)  LDD1510  [10]
 LDCM0238  AC120 HCT 116 C46(0.89); C498(1.81)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C46(0.94); C498(1.16)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C46(0.91); C498(1.27)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C46(0.82); C498(1.14)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C46(0.87); C498(0.99)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C46(0.99); C498(1.58)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C46(0.93); C498(1.15)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C46(0.84); C498(1.15)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C46(0.91)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C46(0.79)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C46(0.93)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C46(0.76)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C46(0.77)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C46(0.83)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C46(0.89)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C46(0.94)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C46(0.84)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C46(0.76)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C46(1.02)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C46(0.90)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C721(1.17); C227(0.87); C498(0.96); C46(0.79)  LDD1512  [10]
 LDCM0260  AC140 HEK-293T C46(0.88)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C46(0.95)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C46(0.89)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C46(0.88); C498(0.95)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C498(0.84); C46(0.94)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C498(0.92); C46(1.11)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C498(1.06); C46(1.13)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C46(0.95); C498(1.06)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C498(1.17); C46(2.73)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C498(1.31); C46(1.91)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C721(0.97); C227(0.93); C498(0.98); C46(1.05)  LDD1513  [10]
 LDCM0271  AC150 HCT 116 C498(0.97); C46(1.32)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C498(1.00); C46(1.46)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C498(1.07); C46(1.15)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C498(1.05); C46(1.46)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C46(1.00); C498(1.15)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C46(1.15); C498(1.25)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C46(0.99); C498(1.23)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C46(1.05); C498(1.17)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C498(0.90)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C498(0.62)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C498(0.64)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C46(0.98)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C498(0.59)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C498(0.47)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C498(0.51)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C498(0.51)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C498(0.38)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C721(0.85); C227(1.16); C498(1.00)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C721(1.07); C227(0.96); C498(0.98); C46(1.04)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C721(1.08); C227(1.10); C46(1.12)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C721(0.99); C227(0.95); C498(0.91); C46(0.94)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C721(0.97); C227(1.03); C498(1.02); C46(0.99)  LDD1528  [10]
 LDCM0290  AC3 HCT 116 C46(1.01)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C721(0.94); C227(1.14); C498(1.08); C46(1.04)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C721(0.93); C227(0.95); C498(0.98); C46(1.10)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C721(1.04); C227(0.86); C498(1.02)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C721(0.98); C227(1.18); C498(0.95)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C721(1.15); C227(1.01); C498(1.01); C46(1.28)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C721(1.04); C227(0.93); C46(0.84)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C721(0.90); C227(1.33); C498(0.98); C46(0.98)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C721(1.09); C227(0.91); C498(0.92); C46(1.06)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C721(1.05); C227(0.78); C498(0.99); C46(0.74)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C721(0.91); C227(0.80); C498(0.98); C46(1.00)  LDD1539  [10]
 LDCM0301  AC4 HCT 116 C46(1.22)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C721(0.96); C227(0.77); C498(1.00)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C721(0.90); C227(1.01); C498(1.00)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C721(1.08); C227(0.91); C498(1.04); C46(1.03)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C721(1.07); C227(0.96); C46(1.13)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C721(1.00); C227(1.21); C498(1.01); C46(1.11)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C721(1.02); C227(0.91); C498(0.94); C46(0.96)  LDD1546  [10]
 LDCM0308  AC46 HCT 116 C498(1.38)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C498(1.39)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C498(1.60)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C498(2.05)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C46(1.14)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C498(1.71)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C498(1.87)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C498(1.52)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C498(1.39)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C498(2.26)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C498(1.43)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C498(1.98)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C46(1.07)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C46(1.12)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C46(1.13)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C721(1.01); C227(0.84); C498(0.97); C46(0.83)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C46(1.66)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C46(1.50)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C46(1.02)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C46(1.04)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C46(1.37)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C46(2.35)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C46(1.10)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C46(1.30)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C46(0.99)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C46(1.06)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C721(0.96); C227(0.91); C498(0.99); C46(1.03)  LDD1568  [10]
 LDCM0335  AC70 HEK-293T C46(1.00)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C46(1.01)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C46(1.07)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C46(0.96)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C46(0.92)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C46(1.14)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C46(1.01)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C46(1.00)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C46(1.07)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C46(1.01)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C721(1.03); C227(0.78); C498(1.02)  LDD1569  [10]
 LDCM0346  AC80 HEK-293T C46(1.04)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C46(1.19)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C46(1.01)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C46(1.14); C498(1.18)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C498(0.95); C46(0.99)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C498(0.58); C46(0.95)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C498(0.98); C46(1.05)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C498(0.62); C46(1.10)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C498(0.59); C46(1.02)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C498(0.73); C46(0.99)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C498(0.38); C46(1.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C498(0.77); C46(1.00)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C498(0.67); C46(0.94)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C498(0.71); C46(1.06)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C498(0.55); C46(1.15)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C498(0.44); C46(1.09)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C498(0.56); C46(1.06)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C498(0.70); C46(1.10)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C498(1.72)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C498(0.81)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C721(0.96); C227(0.92); C498(0.93); C46(1.02)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C721(0.83); C227(1.12); C498(0.98)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C721(0.99); C227(1.07); C498(0.98)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C721(0.99); C227(0.92); C498(0.91)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C721(1.15); C227(1.21); C498(1.23); C46(0.78)  LDD1572  [10]
 LDCM0369  CL100 HCT 116 C46(0.96)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C721(0.92); C227(1.06); C498(1.16)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C721(1.01); C227(1.02); C498(1.06)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C721(1.06); C227(1.03); C498(0.88); C46(1.04)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C721(0.99); C498(0.96)  LDD1577  [10]
 LDCM0374  CL105 HCT 116 C498(0.74)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C498(0.83)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C498(0.95)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C498(0.94)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C498(0.49)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C721(1.11); C227(0.86); C498(1.07); C46(0.81)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C498(0.56)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C498(0.51)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C721(0.96); C498(0.99)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C721(1.01); C227(1.29); C498(1.00)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C721(1.05); C227(1.30); C498(0.99)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C721(0.97); C227(0.99); C498(0.97); C46(1.15)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C721(1.11); C498(0.90)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C721(1.06); C227(1.05); C498(0.93)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C721(0.99); C227(0.77); C498(0.99)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C721(1.00); C227(1.02); C498(0.86); C46(1.08)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C721(1.13); C227(0.67); C498(0.99)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C721(0.95); C498(1.00)  LDD1595  [10]
 LDCM0392  CL121 HCT 116 C498(1.16)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C498(1.31)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C498(1.18)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C498(1.96)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C46(1.14)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C46(0.93)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C46(1.00)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C46(0.98)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C721(1.02); C227(0.95); C498(0.86)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C721(1.04); C227(1.30); C498(0.91)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C721(0.93); C227(0.89); C498(0.84); C46(1.14)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C721(1.10); C498(0.94)  LDD1607  [10]
 LDCM0404  CL17 HCT 116 C46(0.97); C498(1.14)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C46(0.98); C498(1.21)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C46(1.01); C498(1.25)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C721(1.05); C227(1.35); C498(0.90)  LDD1611  [10]
 LDCM0408  CL20 HCT 116 C498(1.14); C46(1.17)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C498(1.08); C46(1.13)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C498(0.82); C46(1.05)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C498(0.90); C46(1.05)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C498(1.01); C46(1.10)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C46(0.77); C498(0.94)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C46(1.00); C498(1.08)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C46(0.87); C498(1.07)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C46(0.97); C498(0.88)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C46(1.17); C498(1.08)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C721(1.04); C227(1.37); C498(0.90); C46(0.92)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C46(1.20); C498(1.08)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C46(0.94); C498(1.16)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C46(0.98)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C46(0.81)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C46(0.99)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C46(1.10)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C46(1.07)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C46(1.00)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C46(0.91)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C721(1.03); C498(0.95)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C46(0.94)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C46(0.92)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C46(0.99)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C46(0.82)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C46(0.94)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C46(0.83)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C721(1.24); C227(0.91); C498(1.09); C46(0.68)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C721(1.04); C227(0.70); C498(1.08); C46(0.78)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C721(1.00); C227(0.64); C498(1.15)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C721(0.89); C227(1.06); C498(0.95)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C721(0.97); C227(1.08); C498(0.90)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C721(1.08); C227(0.92); C498(0.95)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C721(1.10); C498(0.96)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C721(0.99); C227(1.07); C498(1.08)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C721(1.10); C227(0.50); C498(0.97); C46(0.81)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C721(1.06); C227(0.82); C46(0.94)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C721(1.07); C227(1.48); C498(1.09); C46(0.84)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C721(1.09); C227(0.80); C498(0.23); C46(1.01)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C721(1.01); C227(0.97); C498(1.09); C46(0.77)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C721(1.03); C227(0.72); C498(1.05); C46(0.83)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C721(1.13); C227(0.75); C498(0.96); C46(0.79)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C721(1.00); C227(0.59); C498(1.08)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C721(0.99); C227(0.93); C498(0.85)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C721(1.13); C227(1.22); C498(1.01)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C721(1.07); C227(1.16); C498(0.92); C46(0.89)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C721(1.05); C498(0.99)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C721(0.96); C227(0.98); C498(0.92)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C721(1.09); C227(0.75); C498(1.07); C46(1.02)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C721(1.19); C227(0.99); C46(0.92)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C721(1.12); C227(1.06); C498(1.01); C46(0.88)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C721(1.05); C227(0.96); C498(0.94); C46(0.86)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C721(1.11); C227(1.05); C46(0.72)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C721(0.98); C227(0.83); C498(1.13); C46(0.63)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C721(1.08); C227(0.80); C498(1.04); C46(0.80)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C721(1.03); C227(0.83); C498(1.09)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C721(0.90); C227(1.12); C498(0.89)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C721(1.11); C227(1.15); C498(0.94)  LDD1670  [10]
 LDCM0469  CL76 HCT 116 C498(0.90)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C498(0.80)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C498(0.80)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C498(0.60)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C721(0.86); C227(1.16); C498(1.12); C46(1.00)  LDD1676  [10]
 LDCM0474  CL80 HCT 116 C498(0.88)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C498(0.93)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C498(0.85)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C498(1.21)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C498(0.93)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C498(0.89)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C498(0.93)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C498(0.90)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C498(0.75)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C498(1.00)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C721(1.17); C227(0.85); C498(1.04); C46(0.90)  LDD1687  [10]
 LDCM0485  CL90 HCT 116 C498(0.87)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C46(0.96)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C46(0.99)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C46(0.99)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C46(1.02)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C46(0.97)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C46(0.95)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C46(1.02)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C46(0.81)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C46(1.12)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C721(0.99); C227(1.26); C498(0.86); C46(1.15)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C721(0.92); C227(1.31); C498(0.88); C46(1.00)  LDD1671  [10]
 LDCM0427  Fragment51 HCT 116 C46(0.97)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C498(0.96); C721(1.13)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C498(0.98); C721(0.96)  LDD1497  [10]
 LDCM0024  KB05 MKN-1 C498(3.18)  LDD3331  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
RNA-binding protein 48 (RBM48) RBM48 family Q5RL73
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840