Details of the Target

General Information of Target

Target ID LDTP08379
Target Name E3 ubiquitin-protein ligase DZIP3 (DZIP3)
Gene Name DZIP3
Gene ID 9666
Synonyms
KIAA0675; E3 ubiquitin-protein ligase DZIP3; EC 2.3.2.27; DAZ-interacting protein 3; RING-type E3 ubiquitin transferase DZIP3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNA
INTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQ
AGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSL
VYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIK
TTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKY
PGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLI
SLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPL
LKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVF
PAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRL
GMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIE
IEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQR
KKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFY
SLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQE
NQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHN
LESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNL
ESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEI
LMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVP
PSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKI
SQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDE
EEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGH
PSRQLPKI
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Uniprot ID
Q86Y13
Ensemble ID
ENST00000361582.8
HGNC ID
HGNC:30938

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.K272E .
HEC1B SNV: p.Y743H .
HEPG2 SNV: p.A1008P .
HT115 SNV: p.F719L; p.E973Ter .
IGR1 SNV: p.F480L DBIA    Probe Info 
LNCaP clone FGC SNV: p.Q1180Ter .
LOXIMVI SNV: p.A896V .
LS180 SNV: p.Q585R .
OVCAR8 SNV: p.S528Ter .
PF382 SNV: p.Y680C .
SHP77 SNV: p.Q33P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C1078(3.71)  LDD0170  [1]
DBIA
 Probe Info  		C279(0.69)  LDD0531  [2]
CY-1
 Probe Info  		N.A.  LDD0246  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		C1078(0.00); C583(0.00)  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1078(3.71)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C1078(5.09)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C279(0.69)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C583(0.91)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C252(1.06); C257(1.06); C279(0.75); C583(0.92)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C252(0.96); C257(0.96); C279(0.64); C583(0.82)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C252(0.92); C257(0.92); C279(0.64); C583(0.82)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C252(1.16); C257(1.16); C279(0.86); C583(0.94)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C252(1.02); C257(1.02); C279(1.02); C583(1.00)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C252(1.06); C257(1.06); C279(0.67); C583(0.98)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C252(0.90); C257(0.90); C279(0.67); C583(0.80)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C252(1.01); C257(1.01); C279(0.66); C583(0.73)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C252(0.91); C257(0.91); C279(0.68); C583(0.85)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C252(0.96); C257(0.96); C279(0.69); C583(0.88)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C583(0.89)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C252(1.03); C257(1.03); C279(0.63); C583(0.86)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C252(0.93); C257(0.93); C279(0.68); C583(0.92)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C252(0.96); C257(0.96); C279(0.64); C583(0.87)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C252(0.90); C257(0.90); C583(1.03)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C252(1.29); C257(1.29); C583(0.96)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C252(1.36); C257(1.36); C583(1.03)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C252(1.36); C257(1.36); C583(0.89)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C252(1.19); C257(1.19); C583(0.99)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C252(1.22); C257(1.22); C583(0.90)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C252(1.08); C257(1.08); C583(1.07)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C583(0.89)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C252(1.31); C257(1.31); C583(1.05)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C252(1.05); C257(1.05); C583(0.88)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C252(1.01); C257(1.01); C583(1.00)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C252(1.10); C257(1.10); C583(0.91)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C252(1.03); C257(1.03); C583(0.98)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C252(1.18); C257(1.18); C583(0.89)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C252(1.27); C257(1.27); C583(0.77)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C252(1.43); C257(1.43); C583(0.89)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C252(1.02); C257(1.02); C279(0.95); C583(0.95)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C252(1.05); C257(1.05); C279(0.92); C583(1.03)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C252(0.95); C257(0.95); C279(1.34); C583(1.04)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C252(1.10); C257(1.10); C279(1.38); C583(1.07)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C252(1.00); C257(1.00); C279(1.29); C583(1.04)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C252(1.05); C257(1.05); C279(1.41); C583(1.18)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C252(0.97); C257(0.97); C279(1.01); C583(1.23)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C252(0.98); C257(0.98); C279(1.01); C583(1.07)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C252(0.94); C257(0.94); C279(1.01); C583(1.10)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C252(1.25); C257(1.25); C279(1.04); C583(1.20)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C252(1.00); C257(1.00); C279(1.29); C583(1.34)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C252(0.97); C257(0.97); C279(1.11); C583(1.11)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C583(0.90)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C252(0.99); C257(0.99); C279(1.22); C583(1.06)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C252(0.99); C257(0.99); C279(1.00); C583(1.29)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C252(0.95); C257(0.95); C279(1.28); C583(1.14)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C252(0.99); C257(0.99); C583(1.30)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C252(0.95); C257(0.95); C583(0.97)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C252(0.90); C257(0.90); C583(1.05)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C583(0.92); C252(0.99); C257(0.99)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C252(0.93); C257(0.93); C583(1.31)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C252(1.02); C257(1.02); C583(1.04)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C583(0.97); C252(0.99); C257(0.99)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C583(0.85)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C583(0.95); C252(0.99); C257(0.99)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C583(1.02); C252(1.14); C257(1.14)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C583(0.91); C252(1.00); C257(1.00)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C583(0.85); C252(1.04); C257(1.04)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C252(1.00); C257(1.00); C583(1.11)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C252(0.97); C257(0.97); C583(1.03)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C252(1.12); C257(1.12); C583(0.97)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C252(0.99); C257(0.99); C583(0.82)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C252(1.13); C257(1.13); C583(1.42)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C583(0.99); C252(1.18); C257(1.18)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C252(1.06); C257(1.06); C583(1.25)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C279(0.83)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C252(1.09); C257(1.09); C583(1.55)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C583(1.06); C252(1.15); C257(1.15)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C583(1.03); C252(1.05); C257(1.05)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C252(0.94); C257(0.94); C583(1.09)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C252(1.03); C257(1.03); C583(1.22)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C583(0.95)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C583(1.06)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C583(1.02)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C583(1.01)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C583(0.98)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C279(0.73)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C583(1.11)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C583(1.12)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C583(1.26)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C583(1.13)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C583(1.22)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C279(0.59); C583(1.04)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C279(0.60); C583(0.95)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C279(0.67); C583(1.00)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C279(0.79); C583(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C279(0.67); C583(1.03)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C279(0.59)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C279(0.83); C583(1.08)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C279(1.02); C583(1.19)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C279(0.88); C583(1.16)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C583(1.00); C279(1.12)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C279(0.75); C583(1.17)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C279(1.22); C583(1.33)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C583(1.03); C279(1.03)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C279(0.87); C583(1.03)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C279(0.79); C583(1.11)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C279(1.01); C583(1.40)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C279(0.68)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C279(0.98); C583(1.37)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C583(0.88); C279(0.93)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C583(0.97); C279(1.00)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C279(1.07); C583(1.47)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C279(0.87); C583(1.43)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C279(1.12); C583(1.20)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C279(1.06); C583(1.39)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C583(1.05)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C583(0.88)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C583(0.97)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C583(0.95)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C583(1.03)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C583(0.93)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C583(0.88)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C583(0.91)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C583(0.97)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C583(1.03)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C583(1.01)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C583(0.90)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C583(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C583(0.98)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C583(0.82)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C583(1.25)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C583(1.22)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C583(1.20)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C583(1.36)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C583(1.30)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C583(1.47)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C583(1.26)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C583(1.18)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C583(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C583(1.09)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C583(1.02)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C583(1.13)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C583(1.30)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C583(1.50)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C252(1.08); C257(1.08); C583(1.18)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C252(1.08); C257(1.08); C583(1.25)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C252(1.07); C257(1.07); C583(1.21)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C583(0.95); C252(1.03); C257(1.03)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C252(1.05); C257(1.05); C583(1.14)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C252(0.93); C257(0.93); C583(1.19)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C252(1.01); C257(1.01); C583(1.18)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C252(1.08); C257(1.08); C583(1.14)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C252(1.05); C257(1.05); C583(1.06)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C252(1.06); C257(1.06); C583(1.16)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C252(0.97); C257(0.97); C583(1.16)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C252(1.01); C257(1.01); C583(1.37)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C583(1.02); C252(1.08); C257(1.08)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C252(0.99); C257(0.99); C583(1.14)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C252(1.06); C257(1.06); C583(1.19)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C252(0.89); C257(0.89); C279(0.74); C583(0.82)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C252(0.95); C257(0.95); C279(0.75); C583(0.90)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C583(0.95)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C583(0.90)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C583(1.09)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C252(1.23); C257(1.23)  LDD2171  [2]
 LDCM0367  CL1 PaTu 8988t C252(0.91); C257(0.91); C583(0.87)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C252(1.17); C257(1.17); C583(1.20)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C279(0.65)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C583(1.04)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C583(0.79)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C583(0.72)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C583(0.94)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C252(1.02); C257(1.02); C583(1.22)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C583(0.87); C252(0.98); C257(0.98)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C583(0.76); C252(1.18); C257(1.18)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C252(1.10); C257(1.10); C583(1.26)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C583(1.04); C252(1.36); C257(1.36)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C252(1.18); C257(1.18); C583(1.16)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C583(1.04); C252(1.13); C257(1.13)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C252(1.07); C257(1.07); C583(1.08)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C583(0.78)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C583(1.19)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C583(0.91)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C583(0.99)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C583(0.99)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C279(1.00); C583(1.11)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C279(0.90); C583(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C279(0.85); C583(1.08)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C252(1.48); C257(1.48); C583(1.37)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C279(0.61); C583(0.93)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C583(0.80); C279(1.24)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C279(0.80); C583(1.27)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C279(1.00); C583(1.45)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C279(0.89); C583(1.52)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C583(0.87)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C583(1.10)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C583(0.91)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C583(1.02)  LDD0716  [2]
 LDCM0400  CL13 PaTu 8988t C252(1.42); C257(1.42); C583(1.52)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C252(1.18); C257(1.18); C583(1.36)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C252(1.18); C257(1.18); C583(1.14)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C583(0.82)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C279(1.20)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C279(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C279(1.30)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C252(0.97); C257(0.97); C583(0.97)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C279(1.32)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C279(1.17)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C279(1.57)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C279(1.14)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C279(1.13)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C279(1.02)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C279(1.17)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C279(1.29)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C279(1.37)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C279(1.20)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C252(1.08); C257(1.08); C583(1.01)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C279(1.23)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C279(1.20); C583(1.12)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C583(1.07)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C583(1.20)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C583(1.07)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C583(1.04)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C583(1.06)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C583(1.13)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C583(1.21)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C252(0.90); C257(0.90); C583(0.99)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C583(1.02)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C583(1.09)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C583(1.18)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C583(1.06)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C583(1.13)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C583(1.06)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C252(1.23); C257(1.23); C583(1.62)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C252(1.24); C257(1.24); C583(1.55)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C252(1.17); C257(1.17); C583(1.27)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C252(1.15); C257(1.15); C583(1.36)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C252(1.23); C257(1.23); C583(0.86)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C252(1.02); C257(1.02); C583(1.53)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C252(1.06); C257(1.06); C583(1.66)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C252(1.36); C257(1.36); C583(1.72)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C252(1.06); C257(1.06); C583(0.88)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C252(1.39); C257(1.39); C583(1.69)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C252(1.09); C257(1.09); C583(1.08)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C252(1.03); C257(1.03); C583(1.34)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C252(1.24); C257(1.24); C583(1.78)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C252(1.21); C257(1.21); C583(1.33)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C252(1.25); C257(1.25); C583(1.26)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C252(1.03); C257(1.03); C583(1.05)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C252(1.29); C257(1.29); C583(1.75)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C252(0.99); C257(0.99); C279(0.85); C583(1.04)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C252(0.86); C257(0.86); C279(1.20); C583(1.09)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C252(0.84); C257(0.84); C279(0.91); C583(0.91)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C252(1.00); C257(1.00); C279(0.98); C583(1.20)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C252(0.91); C257(0.91); C279(0.81); C583(1.10)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C252(0.89); C257(0.89); C279(1.11); C583(1.21)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C252(0.91); C257(0.91); C279(1.03); C583(1.09)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C252(0.88); C257(0.88); C279(1.19); C583(1.27)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C252(0.83); C257(0.83); C279(1.12); C583(0.84)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C252(1.14); C257(1.14); C583(1.29)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C252(0.95); C257(0.95); C279(1.05); C583(1.02)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C252(0.84); C257(0.84); C279(1.01); C583(1.08)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C252(0.81); C257(0.81); C279(0.85); C583(1.14)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C252(0.90); C257(0.90); C279(1.28); C583(1.49)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C252(0.85); C257(0.85); C279(2.03); C583(0.92)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C279(1.09)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C279(1.15)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C279(1.47)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C279(1.23)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C252(0.95); C257(0.95); C583(1.24)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C279(1.35)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C279(1.19)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C279(1.20)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C279(0.98)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C279(1.20)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C279(1.25)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C279(1.78)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C279(1.06)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C279(1.33)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C279(1.04)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C252(1.17); C257(1.17); C583(1.06)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C279(1.15)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C279(0.70)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C279(0.69)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C279(0.65)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C279(0.63)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C279(0.62)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C279(0.52)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C279(0.70)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C279(0.73)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C279(0.59)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C252(0.82); C257(0.82); C279(1.61); C583(0.97)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C583(1.00)  LDD0744  [2]
 LDCM0022  KB02 A3-KAW C318(1.32)  LDD2257  [6]
 LDCM0023  KB03 A3-KAW C318(2.00)  LDD2674  [6]
 LDCM0024  KB05 COLO792 C885(2.97)  LDD3310  [6]
 LDCM0021  THZ1 HCT 116 C252(1.23); C257(1.23)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
F-box only protein 17 (FBXO17) . Q96EF6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein 765 (ZNF765) Krueppel C2H2-type zinc-finger protein family Q7L2R6
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8
General transcription factor IIH subunit 2-like protein (GTF2H2C; GTF2H2C_2) GTF2H2 family Q6P1K8
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
RNA-binding protein 4B (RBM4B) . Q9BQ04
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840