Details of the Target

General Information of Target

Target ID LDTP08338
Target Name Nuclear receptor 2C2-associated protein (NR2C2AP)
Gene Name NR2C2AP
Gene ID 126382
Synonyms
TRA16; Nuclear receptor 2C2-associated protein; TR4 orphan receptor-associated 16 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTHSLVCPETVSRVSSVLNRNTRQFGKKHLFDQDEETCWNSDQGPSQWVTLEFPQLIRVS
QLQIQFQGGFSSRRGCLEGSQGTQALHKIVDFYPEDNNSLQTFPIPAAEVDRLKVTFEDA
TDFFGRVVIYHLRVLGEKV
Target Bioclass
Other
Family
NR2C2AP family
Subcellular location
Nucleus
Function May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.
Uniprot ID
Q86WQ0
Ensemble ID
ENST00000331552.12
HGNC ID
HGNC:30763

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V11A .
K562 SNV: p.D34N .
NCIH2170 SNV: p.D122Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K114(1.22)  LDD0277  [1]
Probe 1
 Probe Info  		Y130(21.24)  LDD3495  [2]
m-APA
 Probe Info  		15.00  LDD0403  [3]
BTD
 Probe Info  		C76(0.59)  LDD1700  [4]
DBIA
 Probe Info  		C76(0.81)  LDD0532  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C76(0.00); C38(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		C38(0.00); C76(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		11.30  LDD0443  [14]
NAIA_5
 Probe Info  		C76(0.00); C38(0.00); C7(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C76(0.55)  LDD2142  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C76(1.06)  LDD2117  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C76(0.54)  LDD2132  [4]
 LDCM0215  AC10 HCT 116 C76(0.81)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C76(2.25)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C76(0.73)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C76(0.58)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C76(0.30)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C76(0.48)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C76(0.48)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C76(0.40)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C76(0.41)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C76(0.35)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C76(0.43)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C76(0.78)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C76(0.40)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C76(0.39)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C76(0.51)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C76(1.05)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C76(0.96)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C76(0.80)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C76(0.45)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C76(0.72)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C76(0.65)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C76(0.39)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C76(0.14)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C76(0.32)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C76(0.72)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C76(0.99)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C76(1.09)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C76(0.31)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C76(0.11)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C76(0.48)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C76(0.63)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C76(0.79)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C76(0.76)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C76(0.71)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C76(0.65)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C76(0.61)  LDD0595  [5]
 LDCM0280  AC20 HCT 116 C76(0.67)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C76(0.71)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C76(0.79)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C76(0.68)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C76(0.82)  LDD0601  [5]
 LDCM0296  AC35 HCT 116 C76(1.40)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C76(1.14)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C76(1.18)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C76(1.34)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C76(0.95)  LDD0617  [5]
 LDCM0302  AC40 HCT 116 C76(0.60)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C76(1.08)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C76(0.80)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C76(0.81)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C76(0.85)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C76(0.53)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C76(0.99)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C76(0.85)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C76(1.04)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C76(0.36)  LDD0628  [5]
 LDCM0313  AC50 HCT 116 C76(0.42)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C76(1.46)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C76(0.99)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C76(0.54)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C76(0.59)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C76(0.36)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C76(0.22)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C76(0.71)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C76(0.58)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C76(0.44)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C76(0.72)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C76(0.67)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C76(0.76)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C76(0.36)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C76(0.72)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C76(0.39)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C76(0.45)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C76(0.55)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C76(0.15)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C76(0.59)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C76(0.38)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C76(1.04)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C76(0.25)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C76(0.92)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C76(0.50)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C76(0.16)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C76(0.17)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C76(0.13)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C76(0.34)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C76(0.34)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C76(0.94)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C76(0.67)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C76(1.00)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C76(0.47)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C76(0.80)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C76(0.16)  LDD0665  [5]
 LDCM0365  AC98 HCT 116 C76(0.07)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C76(0.90)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C76(0.52)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C76(0.62)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C76(1.11)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C76(0.95)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C76(0.32)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [3]
 LDCM0498  BS-3668 MDA-MB-231 C76(0.57)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C76(1.23); C7(1.16); C76(0.85)  LDD2227  [10]
 LDCM0367  CL1 PaTu 8988t C76(0.38); C38(0.74)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C76(0.13); C38(0.52)  LDD1247  [5]
 LDCM0370  CL101 HCT 116 C76(0.68)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C76(0.81)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C76(0.90)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C76(1.04)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C76(0.52)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C76(0.31)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C76(0.49)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C76(0.18)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C76(0.56)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C76(0.38); C38(0.76)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C76(0.38)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C76(0.49)  LDD0698  [5]
 LDCM0387  CL117 HCT 116 C76(0.24)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C76(0.61)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C76(0.44)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C76(0.61); C38(0.98)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C76(1.15)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C76(0.77)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C76(0.50)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C76(0.23)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C76(0.40)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C76(0.92)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C76(0.48)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C76(0.38)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C76(0.54)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C76(0.13); C38(0.54)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C76(0.12); C38(0.48)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C76(0.46); C38(0.88)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C38(0.68)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C38(0.74)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C38(0.49)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C38(0.45)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C76(0.23); C38(1.01)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C38(0.36)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C38(0.30)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C38(0.40)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C38(0.59)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C38(1.41)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C38(0.43)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C38(0.33)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C38(0.54)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C38(0.38)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C38(0.38)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C76(0.34); C38(0.84)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C38(0.85)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C76(0.88)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C76(0.68)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C76(0.66)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C76(0.78)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C76(0.93)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C76(1.16)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C76(0.77)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C76(0.74)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C76(0.43); C38(0.86)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C76(0.89)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C76(1.16)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C76(0.79)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C76(0.53)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C76(0.83)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C76(0.70)  LDD1314  [5]
 LDCM0436  CL46 PaTu 8988t C76(0.80); C38(1.16)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C76(0.53); C38(0.79)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C76(0.84); C38(0.86)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C76(0.55); C38(0.83)  LDD1318  [5]
 LDCM0440  CL5 PaTu 8988t C76(0.15); C38(0.61)  LDD1319  [5]
 LDCM0441  CL50 PaTu 8988t C76(1.21); C38(1.31)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C76(1.05); C38(0.94)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C76(0.55); C38(0.89)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C76(0.78); C38(0.81)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C76(0.59); C38(0.95)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C76(0.93); C38(0.79)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C76(0.13); C38(0.13)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C76(0.26); C38(0.58)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C76(0.67); C38(0.75)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C76(0.25); C38(0.57)  LDD1329  [5]
 LDCM0451  CL6 PaTu 8988t C76(0.31); C38(0.89)  LDD1330  [5]
 LDCM0452  CL60 PaTu 8988t C76(0.30); C38(0.63)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C76(1.00)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C76(0.65)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C76(0.75)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C76(1.41)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C76(0.76)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C76(0.65)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C76(0.70)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C76(0.41)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C76(0.34)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C76(0.19); C38(0.72)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C76(0.62)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C76(0.76)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C76(0.96)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C76(0.81)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C76(1.07)  LDD1346  [5]
 LDCM0469  CL76 HCT 116 C76(0.91)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C76(0.72)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C76(0.70)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C76(0.24)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C76(0.34); C38(1.07)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C76(0.85)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C76(0.66)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C76(0.26)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C76(0.29)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C76(0.25)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C76(0.39)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C76(0.90)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C76(0.36)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C76(0.47)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C76(0.21)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C76(0.14); C38(0.44)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C76(0.78)  LDD0802  [5]
 LDCM0634  CY-0357 Hep-G2 C7(1.19)  LDD2228  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C7(0.94)  LDD1702  [4]
 LDCM0625  F8 Ramos C76(2.16)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C76(20.00)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C76(0.55)  LDD2193  [15]
 LDCM0586  Fragment28 Ramos C76(0.82)  LDD2198  [15]
 LDCM0468  Fragment33 PaTu 8988t C76(0.46)  LDD1347  [5]
 LDCM0566  Fragment4 Ramos C76(0.59)  LDD2184  [15]
 LDCM0427  Fragment51 PaTu 8988t C76(0.59)  LDD1306  [5]
 LDCM0569  Fragment7 Ramos C76(0.44)  LDD2186  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 Ramos C76(0.44)  LDD2182  [15]
 LDCM0023  KB03 MDA-MB-231 C7(2.90); C76(0.63)  LDD1701  [4]
 LDCM0024  KB05 NCI-N87 C76(0.99)  LDD3364  [16]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C76(0.60)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C76(0.71)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C76(1.12)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C76(0.97)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C76(0.88)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C76(0.65)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C76(1.19)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C76(0.51)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C76(2.36)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C76(0.76)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C76(0.99)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C76(0.86)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C76(0.99)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C76(0.98)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C76(1.17)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C76(0.67)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C76(0.47)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C76(1.49)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C76(1.07)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C76(0.91)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C76(0.59)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C76(0.92)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C76(0.79)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C76(2.78)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C76(1.35)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C76(1.03)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C76(1.60)  LDD2147  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C76(0.50)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C7(0.77)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C7(0.70)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Monocarboxylate transporter 4 (SLC16A3) Monocarboxylate porter (TC 2.A.1.13) family O15427
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.