Details of the Target

General Information of Target

Target ID LDTP08116
Target Name E3 ubiquitin-protein ligase RBBP6 (RBBP6)
Gene Name RBBP6
Gene ID 5930
Synonyms
P2PR; PACT; RBQ1; E3 ubiquitin-protein ligase RBBP6; EC 2.3.2.27; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADCDLQITNAQTKEEYTDD
NALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPAMATTKAIDDSSASISLAQLTKTANL
AEANASEEDKIKAMMSQSGHEYDPINYMKKPLGPPPPSYTCFRCGKPGHYIKNCPTNGDK
NFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLP
EEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCH
QNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPIPPPRPLIQRNLQPLMRS
PISRQQDPLMIPVTSSSTHPAPSISSLTSNQSSLAPPVSGNPSSAPAPVPDITATVSISV
HSEKSDGPFRDSDNKILPAAALASEHSKGTSSIAITALMEEKGYQVPVLGTPSLLGQSLL
HGQLIPTTGPVRINTARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSE
RSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVP
PPGFPPAPANLSTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDE
FTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFS
RSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQS
PNKRNVPQGETEREYFNRYREVPPPYDMKAYYGRSVDFRDPFEKERYREWERKYREWYEK
YYKGYAAGAQPRPSANRENFSPERFLPLNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPE
KLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS
REPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTK
RKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQK
DEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPL
DNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI
SLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEG
SSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSK
WDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDV
SHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNF
KSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDS
PSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKS
VDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSH
SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA
AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK
HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSVTV
Target Bioclass
Enzyme
Subcellular location
Nucleus, nucleolus
Function
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.; (Microbial infection) [Isoform 1]: Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.
Uniprot ID
Q7Z6E9
Ensemble ID
ENST00000319715.10
HGNC ID
HGNC:9889

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.I1209SfsTer47 .
C4II Deletion: p.L369_T378del DBIA    Probe Info 
CAL72 SNV: p.S1078Y DBIA    Probe Info 
CCK81 SNV: p.Y799C DBIA    Probe Info 
CORL23 SNV: p.D1608V DBIA    Probe Info 
CORL88 SNV: p.R1480S .
GAMG Insertion: p.K1780EfsTer5 .
HDQP1 SNV: p.E1308K .
HEC1 SNV: p.W1321L .
ICC137 SNV: p.H1765L .
IGROV1 Deletion: p.T1475LfsTer20 .
KMRC1 SNV: p.T1295A DBIA    Probe Info 
LNCaP clone FGC SNV: p.G1260V DBIA    Probe Info 
LS180 Deletion: p.P342QfsTer8 .
MELJUSO Substitution: p.V1698R DBIA    Probe Info 
NCIH2286 SNV: p.Y1477S DBIA    Probe Info 
PANC1 SNV: p.P593L DBIA    Probe Info 
RKO Deletion: p.I1209SfsTer47 .
SKN SNV: p.D1667E .
SNGM Deletion: p.G1525EfsTer37 DBIA    Probe Info 
SNU1196 SNV: p.E1493Ter DBIA    Probe Info 
SW1990 SNV: p.Q1337H DBIA    Probe Info 
WM2664 Insertion: p.E461RfsTer62 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.54  LDD0215  [2]
STPyne
 Probe Info  		K1571(8.33)  LDD0277  [3]
BTD
 Probe Info  		C1566(0.80)  LDD2104  [4]
AHL-Pu-1
 Probe Info  		C1566(2.22)  LDD0169  [5]
HHS-475
 Probe Info  		Y218(0.37)  LDD0264  [6]
DBIA
 Probe Info  		C161(1.24)  LDD0532  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C44(0.00); C27(0.00); C1566(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C27(0.00); C1566(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C44(0.00); C27(0.00); C1566(0.00)  LDD0037  [8]
NAIA_5
 Probe Info  		C27(0.00); C1566(0.00)  LDD2224  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
TFBX
 Probe Info  		C296(0.00); C174(0.00); C164(0.00)  LDD0148  [11]
Phosphinate-6
 Probe Info  		C27(0.00); C164(0.00); C1566(0.00); C161(0.00)  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		C161(0.00); C44(0.00)  LDD0236  [14]
AOyne
 Probe Info  		11.00  LDD0443  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [16]
HHS-482
 Probe Info  		Y883(0.68)  LDD2239  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C1566(2.22)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C299(1.05)  LDD0812  [7]
 LDCM0215  AC10 HCT 116 C161(1.24)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C161(0.60)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C161(0.45)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C161(0.54)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C161(0.62)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C161(0.63)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C161(0.71)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C161(0.61)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C161(0.72)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C161(0.44)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C161(0.58)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C161(0.95)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C161(0.45)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C161(0.45)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C161(0.73)  LDD0546  [7]
 LDCM0237  AC12 HCT 116 C161(1.19)  LDD0554  [7]
 LDCM0259  AC14 HCT 116 C161(1.40)  LDD0576  [7]
 LDCM0270  AC15 HCT 116 C161(1.36)  LDD0587  [7]
 LDCM0276  AC17 HEK-293T C299(1.08)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C299(0.64)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C299(0.85)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C299(1.24)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C299(1.43)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C299(1.09)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C299(0.84)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C299(0.80)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C299(0.76)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C299(1.17)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C299(1.18)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C299(1.26)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C299(1.27)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C299(1.12)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C299(1.14)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C299(1.08)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C299(1.11)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C299(1.02)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C299(1.04)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C299(1.02)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C27(0.93); C174(1.22)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C27(0.94); C44(1.09); C174(1.36)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C27(1.03); C44(1.03); C174(0.83); C299(1.13)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C27(1.01); C44(0.96)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C27(1.09); C44(1.02); C174(1.16); C299(1.01)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C299(1.18)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C27(1.01); C299(0.89)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C27(1.12); C174(1.09)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C27(1.09)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C27(0.99); C174(1.21)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C27(0.89); C44(1.14); C174(0.94)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C27(1.09); C44(0.94); C174(0.90); C299(1.08)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C27(1.05); C44(0.99)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C27(0.99); C44(1.05); C174(0.93); C299(0.91)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C27(0.95); C299(0.94)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C27(1.08); C174(1.09)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C299(1.21)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C27(0.99)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C27(0.94); C174(1.28)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C27(0.93); C44(1.00); C174(1.09)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C27(1.06); C44(1.00); C174(1.04); C299(1.10)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C27(0.93); C44(0.90)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C27(1.04); C44(1.05); C174(1.08); C299(0.87)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C27(0.96); C299(1.17)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C299(1.06)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C299(0.85)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C299(0.99)  LDD0920  [7]
 LDCM0323  AC6 HCT 116 C161(0.88)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C299(0.83)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C299(0.89)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C299(0.90)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C299(1.14)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C299(1.07)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C299(1.04)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C299(0.76)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C299(1.09)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C299(1.06)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C299(1.04)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C161(1.26)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C299(1.02)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C299(1.06)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C299(0.81)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C299(1.40)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C299(1.21)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C299(1.42)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C299(1.68)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C299(1.03)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C299(1.26)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C299(1.04)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C161(1.05)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C299(1.11)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C299(1.07)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C299(1.64)  LDD0946  [7]
 LDCM0365  AC98 HCT 116 C161(0.85)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C161(0.55)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C161(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C161(1.20)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C161(1.16)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 13.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C161(0.89); C296(1.19); C299(1.19)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C1566(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C161(1.07)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C161(1.08)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C299(1.06)  LDD0967  [7]
 LDCM0370  CL101 HCT 116 C161(1.32)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C161(1.15)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C161(1.23)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C161(1.43)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C299(0.59)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C299(1.43)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C299(1.97)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C299(0.69)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C299(0.82)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C161(0.75)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C299(0.83)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C299(0.87)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C299(1.13)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C299(1.16)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C299(1.12)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C299(0.99)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C299(1.21)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C27(0.94); C299(1.14)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C27(0.99); C299(0.93)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C27(1.05)  LDD1593  [19]
 LDCM0390  CL12 HCT 116 C161(0.96)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C27(1.05); C44(1.36); C174(1.03); C299(1.00)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C27(0.88); C299(1.23)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C27(0.85); C299(0.97)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C27(0.50)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C27(0.81); C44(1.00); C174(1.13); C299(1.24)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C299(0.82)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C299(0.95)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C299(0.86)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C299(1.33)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C161(0.96)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C161(0.80)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C161(0.93)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C161(1.07)  LDD0720  [7]
 LDCM0404  CL17 HEK-293T C299(1.02)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C299(1.25)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C299(1.20)  LDD1004  [7]
 LDCM0407  CL2 HCT 116 C161(1.09)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C299(1.11)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C299(1.29)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C299(1.76)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C299(1.27)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C299(1.15)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C299(1.07)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C299(1.12)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C299(1.24)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C299(1.11)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C299(1.18)  LDD1015  [7]
 LDCM0418  CL3 HCT 116 C161(1.01)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C299(1.64)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C27(0.94); C174(1.16)  LDD1624  [19]
 LDCM0421  CL32 HCT 116 C161(0.90)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C161(0.74)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C161(0.86)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C161(0.95)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C161(0.93)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C161(0.84)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C161(0.92)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C161(1.07)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C161(0.99)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C161(0.87)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C161(0.67)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C161(0.96)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C161(0.84)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C161(0.83)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C161(0.90)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C161(0.80)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C161(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C161(0.83)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C161(1.28)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C161(0.92)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C161(0.89)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C161(1.16)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C161(0.94)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C161(1.01)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C161(0.97)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C161(1.09)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C161(0.81)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C161(1.16)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C161(1.11)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C161(1.05)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C161(1.13)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C27(0.83); C299(1.11)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C27(0.98); C299(1.07)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C27(1.01)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C27(0.89); C44(0.87); C174(0.97); C299(0.95)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C27(1.25); C174(1.00)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C27(1.11)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C27(1.04); C174(1.17)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C27(1.05); C44(1.09); C174(1.08)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C27(1.20); C44(1.00); C174(0.69); C299(1.08)  LDD1664  [19]
 LDCM0462  CL7 HCT 116 C161(0.97)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C27(1.19); C44(0.97)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C27(1.32); C44(1.06); C174(1.14); C299(1.10)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C27(0.94); C299(0.90)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C27(0.76); C299(1.12)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C27(0.92); C299(0.94)  LDD1670  [19]
 LDCM0469  CL76 HCT 116 C161(0.91)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C161(0.88)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C161(0.87)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C161(0.87)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C161(0.80)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C161(0.83)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C161(0.78)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C161(1.00)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C161(0.76)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C161(0.94)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C161(1.25)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C161(1.00)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C161(0.93)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C161(0.88)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C161(0.97)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C161(0.90)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C161(0.70)  LDD0802  [7]
 LDCM0486  CL91 HEK-293T C299(1.19)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C299(1.01)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C299(1.10)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C299(1.16)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C299(1.30)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C299(1.09)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C299(1.18)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C299(1.16)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C299(1.05)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C27(0.94)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1566(1.01)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C27(0.87)  LDD1671  [19]
 LDCM0427  Fragment51 HCT 116 C161(0.86)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y218(0.37)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y218(0.06)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y218(20.00)  LDD0266  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C44(1.05)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C44(1.03)  LDD1497  [19]
 LDCM0024  KB05 COLO792 C161(1.45)  LDD3310  [20]
 LDCM0109  NEM HeLa N.A.  LDD0227  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1566(0.80)  LDD2104  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1566(0.52)  LDD2129  [4]
 LDCM0021  THZ1 HCT 116 C161(0.89); C296(1.19); C299(1.19)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/arginine-rich splicing factor 7 (SRSF7) Splicing factor SR family Q16629
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840