Details of the Target

General Information of Target

Target ID LDTP07873
Target Name Acyl-CoA dehydrogenase family member 11 (ACAD11)
Gene Name ACAD11
Gene ID 84129
Synonyms
Acyl-CoA dehydrogenase family member 11; ACAD-11; EC 1.3.8.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPGATGESDLAEVLPQHKFDSKSLEAYLNQHLSGFGAEREATLTIAQYRAGKSNPTFYL
QKGFQTYVLRKKPPGSLLPKAHQIDREFKVQKALFSIGFPVPKPILYCSDTSVIGTEFYV
MEHVQGRIFRDLTIPGLSPAERSAIYVATVETLAQLHSLNIQSLQLEGYGIGAGYCKRQV
STWTKQYQAAAHQDIPAMQQLSEWLMKNLPDNDNEENLIHGDFRLDNIVFHPKECRVIAV
LDWELSTIGHPLSDLAHFSLFYFWPRTVPMINQGSYSENSGIPSMEELISIYCRCRGINS
ILPNWNFFLALSYFKMAGIAQGVYSRYLLGNNSSEDSFLFANIVQPLAETGLQLSKRTFS
TVLPQIDTTGQLFVQTRKGQEVLIKVKHFMKQHILPAEKEVTEFYVQNENSVDKWGKPLV
IDKLKEMAKVEGLWNLFLPAVSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLH
LYGSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWSS
GAGNPKCKIAIVLGRTQNTSLSRHKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFE
IHFNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAF
KKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSK
IVDWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAKRLTAKI
Target Bioclass
Enzyme
Family
Acyl-CoA dehydrogenase family
Subcellular location
Peroxisome
Function
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable).
Uniprot ID
Q709F0
Ensemble ID
ENST00000264990.11
HGNC ID
HGNC:30211
ChEMBL ID
CHEMBL4105707

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.W305R DBIA    Probe Info 
AN3CA SNV: p.N342D DBIA    Probe Info 
COLO792 SNV: p.P609L DBIA    Probe Info 
HT115 SNV: p.D757G .
LN18 SNV: p.H672Q .
LNCaP clone FGC SNV: p.K356E .
MCC13 SNV: p.S96L .
MEWO SNV: p.Q524Ter .
MOLT4 SNV: p.E508Q .
NCIH716 SNV: p.M206K .
OVCAR4 SNV: p.R296S .
PF382 SNV: p.A173D .
SW620 SNV: p.I532N .
U2OS SNV: p.N575T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E41(10.00)  LDD2209  [1]
DBIA
 Probe Info  		C953(3.61)  LDD3310  [2]
IPM
 Probe Info  		C636(2.79); C651(0.89)  LDD1702  [3]
ATP probe
 Probe Info  		K53(0.00); K2(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		C636(0.00); C108(0.00)  LDD0165  [5]
SF
 Probe Info  		N.A.  LDD0028  [6]
1d-yne
 Probe Info  		N.A.  LDD0357  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		18.13  LDD1783  [9]
C161
 Probe Info  		10.78  LDD1841  [9]
C210
 Probe Info  		41.93  LDD1884  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C636(2.70)  LDD0372  [10]
 LDCM0214  AC1 HEK-293T C651(0.94); C176(1.21); C293(1.00)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C651(0.97)  LDD1508  [11]
 LDCM0216  AC100 HEK-293T C176(1.27)  LDD0814  [12]
 LDCM0217  AC101 HEK-293T C176(1.14)  LDD0815  [12]
 LDCM0218  AC102 HEK-293T C176(1.26)  LDD0816  [12]
 LDCM0219  AC103 HEK-293T C176(1.47)  LDD0817  [12]
 LDCM0220  AC104 HEK-293T C176(1.32)  LDD0818  [12]
 LDCM0221  AC105 HEK-293T C176(0.88)  LDD0819  [12]
 LDCM0222  AC106 HEK-293T C176(0.82)  LDD0820  [12]
 LDCM0223  AC107 HEK-293T C176(1.25)  LDD0821  [12]
 LDCM0224  AC108 HEK-293T C176(0.93)  LDD0822  [12]
 LDCM0225  AC109 HEK-293T C176(1.07)  LDD0823  [12]
 LDCM0226  AC11 HEK-293T C651(1.03)  LDD1509  [11]
 LDCM0227  AC110 HEK-293T C176(2.13)  LDD0825  [12]
 LDCM0228  AC111 HEK-293T C176(3.22)  LDD0826  [12]
 LDCM0229  AC112 HEK-293T C176(2.23)  LDD0827  [12]
 LDCM0237  AC12 HEK-293T C651(1.01); C293(1.01); C108(1.06)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C651(0.99); C293(1.10)  LDD1512  [11]
 LDCM0263  AC143 PaTu 8988t C651(1.04)  LDD1142  [12]
 LDCM0264  AC144 PaTu 8988t C651(1.02)  LDD1143  [12]
 LDCM0265  AC145 PaTu 8988t C651(1.30)  LDD1144  [12]
 LDCM0266  AC146 PaTu 8988t C651(1.08)  LDD1145  [12]
 LDCM0267  AC147 PaTu 8988t C651(1.30)  LDD1146  [12]
 LDCM0268  AC148 PaTu 8988t C651(1.13)  LDD1147  [12]
 LDCM0269  AC149 PaTu 8988t C651(1.49)  LDD1148  [12]
 LDCM0270  AC15 HEK-293T C651(0.99); C293(1.08)  LDD1513  [11]
 LDCM0271  AC150 PaTu 8988t C651(1.09)  LDD1150  [12]
 LDCM0272  AC151 PaTu 8988t C651(1.14)  LDD1151  [12]
 LDCM0273  AC152 PaTu 8988t C651(1.12)  LDD1152  [12]
 LDCM0274  AC153 PaTu 8988t C651(1.47)  LDD1153  [12]
 LDCM0621  AC154 PaTu 8988t C651(1.49)  LDD2166  [12]
 LDCM0622  AC155 PaTu 8988t C651(1.21)  LDD2167  [12]
 LDCM0623  AC156 PaTu 8988t C651(1.12)  LDD2168  [12]
 LDCM0624  AC157 PaTu 8988t C651(1.09)  LDD2169  [12]
 LDCM0276  AC17 HEK-293T C176(1.39)  LDD0874  [12]
 LDCM0277  AC18 HEK-293T C176(1.10)  LDD0875  [12]
 LDCM0278  AC19 HEK-293T C176(1.11)  LDD0876  [12]
 LDCM0279  AC2 HEK-293T C651(0.93)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C176(1.34)  LDD0878  [12]
 LDCM0281  AC21 HEK-293T C176(1.18)  LDD0879  [12]
 LDCM0282  AC22 HEK-293T C176(1.34)  LDD0880  [12]
 LDCM0283  AC23 HEK-293T C176(1.65)  LDD0881  [12]
 LDCM0284  AC24 HEK-293T C176(1.17)  LDD0882  [12]
 LDCM0285  AC25 HEK-293T C176(1.21)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C176(1.34)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C176(1.37)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C176(1.00)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C176(1.33)  LDD0887  [12]
 LDCM0290  AC3 HEK-293T C651(0.93)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C176(1.23)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C176(1.01)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C176(1.12)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C176(1.23)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C176(1.06)  LDD0893  [12]
 LDCM0296  AC35 PaTu 8988t C651(0.98)  LDD1175  [12]
 LDCM0297  AC36 PaTu 8988t C651(1.18)  LDD1176  [12]
 LDCM0298  AC37 PaTu 8988t C651(1.02)  LDD1177  [12]
 LDCM0299  AC38 PaTu 8988t C651(1.25)  LDD1178  [12]
 LDCM0300  AC39 PaTu 8988t C651(1.17)  LDD1179  [12]
 LDCM0301  AC4 HEK-293T C651(0.91); C293(1.14); C108(1.00)  LDD1540  [11]
 LDCM0302  AC40 PaTu 8988t C651(1.05)  LDD1181  [12]
 LDCM0303  AC41 PaTu 8988t C651(1.10)  LDD1182  [12]
 LDCM0304  AC42 PaTu 8988t C651(0.93)  LDD1183  [12]
 LDCM0305  AC43 PaTu 8988t C651(1.11)  LDD1184  [12]
 LDCM0306  AC44 PaTu 8988t C651(1.07)  LDD1185  [12]
 LDCM0307  AC45 PaTu 8988t C651(0.89)  LDD1186  [12]
 LDCM0308  AC46 HEK-293T C651(1.00); C293(1.08)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C651(0.99); C293(1.19)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C651(0.90); C293(1.09)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C651(0.99); C176(1.05); C293(1.01)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C651(0.94); C293(0.83)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C651(0.96)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C651(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C651(0.99); C293(1.23); C108(1.03)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C651(0.96); C293(0.87)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C651(1.01); C293(0.99)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C651(0.97); C293(1.03)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C651(0.97); C293(1.05)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C176(1.01)  LDD0918  [12]
 LDCM0321  AC58 HEK-293T C176(1.02)  LDD0919  [12]
 LDCM0322  AC59 HEK-293T C176(0.98)  LDD0920  [12]
 LDCM0323  AC6 HEK-293T C651(0.97); C293(1.12)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C176(0.86)  LDD0922  [12]
 LDCM0325  AC61 HEK-293T C176(1.40)  LDD0923  [12]
 LDCM0326  AC62 HEK-293T C176(1.06)  LDD0924  [12]
 LDCM0327  AC63 HEK-293T C176(1.18)  LDD0925  [12]
 LDCM0328  AC64 HEK-293T C176(1.07)  LDD0926  [12]
 LDCM0329  AC65 HEK-293T C176(1.25)  LDD0927  [12]
 LDCM0330  AC66 HEK-293T C176(0.97)  LDD0928  [12]
 LDCM0331  AC67 HEK-293T C176(1.13)  LDD0929  [12]
 LDCM0332  AC68 HEK-293T C176(1.11)  LDD0930  [12]
 LDCM0333  AC69 HEK-293T C176(1.08)  LDD0931  [12]
 LDCM0334  AC7 HEK-293T C651(0.95); C293(1.07)  LDD1568  [11]
 LDCM0335  AC70 HEK-293T C176(1.21)  LDD0933  [12]
 LDCM0336  AC71 HEK-293T C176(1.36)  LDD0934  [12]
 LDCM0337  AC72 HEK-293T C176(1.18)  LDD0935  [12]
 LDCM0338  AC73 HEK-293T C176(1.20)  LDD0936  [12]
 LDCM0339  AC74 HEK-293T C176(2.71)  LDD0937  [12]
 LDCM0340  AC75 HEK-293T C176(1.36)  LDD0938  [12]
 LDCM0341  AC76 HEK-293T C176(1.39)  LDD0939  [12]
 LDCM0342  AC77 HEK-293T C176(1.18)  LDD0940  [12]
 LDCM0343  AC78 HEK-293T C176(1.22)  LDD0941  [12]
 LDCM0344  AC79 HEK-293T C176(1.22)  LDD0942  [12]
 LDCM0345  AC8 HEK-293T C651(0.90); C293(0.92)  LDD1569  [11]
 LDCM0346  AC80 HEK-293T C176(1.60)  LDD0944  [12]
 LDCM0347  AC81 HEK-293T C176(1.33)  LDD0945  [12]
 LDCM0348  AC82 HEK-293T C176(1.80)  LDD0946  [12]
 LDCM0349  AC83 HEK-293T C176(1.05)  LDD0947  [12]
 LDCM0350  AC84 HEK-293T C176(1.38)  LDD0948  [12]
 LDCM0351  AC85 HEK-293T C176(1.22)  LDD0949  [12]
 LDCM0352  AC86 HEK-293T C176(1.13)  LDD0950  [12]
 LDCM0353  AC87 HEK-293T C176(1.14)  LDD0951  [12]
 LDCM0354  AC88 HEK-293T C176(1.35)  LDD0952  [12]
 LDCM0355  AC89 HEK-293T C176(1.42)  LDD0953  [12]
 LDCM0357  AC90 HEK-293T C176(1.31)  LDD0955  [12]
 LDCM0358  AC91 HEK-293T C176(1.22)  LDD0956  [12]
 LDCM0359  AC92 HEK-293T C176(1.22)  LDD0957  [12]
 LDCM0360  AC93 HEK-293T C176(1.24)  LDD0958  [12]
 LDCM0361  AC94 HEK-293T C176(1.67)  LDD0959  [12]
 LDCM0362  AC95 HEK-293T C176(1.40)  LDD0960  [12]
 LDCM0363  AC96 HEK-293T C176(1.38)  LDD0961  [12]
 LDCM0364  AC97 HEK-293T C176(1.72)  LDD0962  [12]
 LDCM0365  AC98 HEK-293T C176(1.00)  LDD0963  [12]
 LDCM0366  AC99 HEK-293T C176(0.89)  LDD0964  [12]
 LDCM0248  AKOS034007472 HEK-293T C651(1.00); C293(0.84)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C651(0.97); C176(1.16); C293(0.91)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C651(0.95); C293(1.11)  LDD1514  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 PaTu 8988t C651(0.81)  LDD1246  [12]
 LDCM0368  CL10 PaTu 8988t C651(0.93)  LDD1247  [12]
 LDCM0369  CL100 HEK-293T C651(0.86); C293(0.76)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C651(0.94); C176(1.07)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C651(1.03)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C651(1.03); C176(0.93); C293(1.05)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C651(0.98); C293(0.79)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C176(1.03)  LDD0972  [12]
 LDCM0375  CL106 HEK-293T C176(1.15)  LDD0973  [12]
 LDCM0376  CL107 HEK-293T C176(1.05)  LDD0974  [12]
 LDCM0377  CL108 HEK-293T C176(1.28)  LDD0975  [12]
 LDCM0378  CL109 HEK-293T C176(1.06)  LDD0976  [12]
 LDCM0379  CL11 PaTu 8988t C651(1.27)  LDD1258  [12]
 LDCM0380  CL110 HEK-293T C176(1.11)  LDD0978  [12]
 LDCM0381  CL111 HEK-293T C176(1.06)  LDD0979  [12]
 LDCM0382  CL112 HEK-293T C176(1.24)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C176(1.12)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C176(1.61)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C176(1.35)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C176(1.52)  LDD0984  [12]
 LDCM0387  CL117 PaTu 8988t C651(0.97)  LDD1266  [12]
 LDCM0388  CL118 PaTu 8988t C651(0.94)  LDD1267  [12]
 LDCM0389  CL119 PaTu 8988t C651(1.16)  LDD1268  [12]
 LDCM0390  CL12 PaTu 8988t C651(1.28)  LDD1269  [12]
 LDCM0391  CL120 PaTu 8988t C651(1.12)  LDD1270  [12]
 LDCM0392  CL121 HEK-293T C651(0.96); C176(0.99)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C651(1.04)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C651(1.14); C176(0.92); C293(1.01)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C651(0.95); C293(0.95)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C176(1.04)  LDD0994  [12]
 LDCM0397  CL126 HEK-293T C176(1.02)  LDD0995  [12]
 LDCM0398  CL127 HEK-293T C176(0.97)  LDD0996  [12]
 LDCM0399  CL128 HEK-293T C176(1.05)  LDD0997  [12]
 LDCM0400  CL13 PaTu 8988t C651(1.27)  LDD1279  [12]
 LDCM0401  CL14 PaTu 8988t C651(1.19)  LDD1280  [12]
 LDCM0402  CL15 PaTu 8988t C651(1.46)  LDD1281  [12]
 LDCM0403  CL16 PaTu 8988t C651(1.22)  LDD1282  [12]
 LDCM0404  CL17 PaTu 8988t C651(1.36)  LDD1283  [12]
 LDCM0405  CL18 PaTu 8988t C651(1.28)  LDD1284  [12]
 LDCM0406  CL19 PaTu 8988t C651(1.15)  LDD1285  [12]
 LDCM0407  CL2 PaTu 8988t C651(0.92)  LDD1286  [12]
 LDCM0408  CL20 PaTu 8988t C651(1.07)  LDD1287  [12]
 LDCM0409  CL21 PaTu 8988t C651(1.11)  LDD1288  [12]
 LDCM0410  CL22 PaTu 8988t C651(1.23)  LDD1289  [12]
 LDCM0411  CL23 PaTu 8988t C651(1.12)  LDD1290  [12]
 LDCM0412  CL24 PaTu 8988t C651(1.31)  LDD1291  [12]
 LDCM0413  CL25 PaTu 8988t C651(1.31)  LDD1292  [12]
 LDCM0414  CL26 PaTu 8988t C651(1.24)  LDD1293  [12]
 LDCM0415  CL27 PaTu 8988t C651(1.25)  LDD1294  [12]
 LDCM0416  CL28 PaTu 8988t C651(1.09)  LDD1295  [12]
 LDCM0417  CL29 PaTu 8988t C651(1.14)  LDD1296  [12]
 LDCM0418  CL3 PaTu 8988t C651(1.11)  LDD1297  [12]
 LDCM0419  CL30 PaTu 8988t C651(1.28)  LDD1298  [12]
 LDCM0420  CL31 PaTu 8988t C651(1.08)  LDD1299  [12]
 LDCM0421  CL32 PaTu 8988t C651(0.88)  LDD1300  [12]
 LDCM0422  CL33 PaTu 8988t C651(1.15)  LDD1301  [12]
 LDCM0423  CL34 PaTu 8988t C651(0.96)  LDD1302  [12]
 LDCM0424  CL35 PaTu 8988t C651(0.98)  LDD1303  [12]
 LDCM0425  CL36 PaTu 8988t C651(0.52)  LDD1304  [12]
 LDCM0426  CL37 PaTu 8988t C651(1.06)  LDD1305  [12]
 LDCM0428  CL39 PaTu 8988t C651(1.20)  LDD1307  [12]
 LDCM0429  CL4 PaTu 8988t C651(1.04)  LDD1308  [12]
 LDCM0430  CL40 PaTu 8988t C651(1.14)  LDD1309  [12]
 LDCM0431  CL41 PaTu 8988t C651(1.04)  LDD1310  [12]
 LDCM0432  CL42 PaTu 8988t C651(1.15)  LDD1311  [12]
 LDCM0433  CL43 PaTu 8988t C651(1.05)  LDD1312  [12]
 LDCM0434  CL44 PaTu 8988t C651(1.24)  LDD1313  [12]
 LDCM0435  CL45 PaTu 8988t C651(1.10)  LDD1314  [12]
 LDCM0436  CL46 PaTu 8988t C651(0.91)  LDD1315  [12]
 LDCM0437  CL47 PaTu 8988t C651(0.89)  LDD1316  [12]
 LDCM0438  CL48 PaTu 8988t C651(0.87)  LDD1317  [12]
 LDCM0439  CL49 PaTu 8988t C651(1.18)  LDD1318  [12]
 LDCM0440  CL5 PaTu 8988t C651(1.14)  LDD1319  [12]
 LDCM0441  CL50 PaTu 8988t C651(1.03)  LDD1320  [12]
 LDCM0442  CL51 PaTu 8988t C651(1.02)  LDD1321  [12]
 LDCM0443  CL52 PaTu 8988t C651(1.05)  LDD1322  [12]
 LDCM0444  CL53 PaTu 8988t C651(0.91)  LDD1323  [12]
 LDCM0445  CL54 PaTu 8988t C651(1.04)  LDD1324  [12]
 LDCM0446  CL55 PaTu 8988t C651(1.01)  LDD1325  [12]
 LDCM0447  CL56 PaTu 8988t C651(0.15)  LDD1326  [12]
 LDCM0448  CL57 PaTu 8988t C651(0.95)  LDD1327  [12]
 LDCM0449  CL58 PaTu 8988t C651(0.96)  LDD1328  [12]
 LDCM0450  CL59 PaTu 8988t C651(0.88)  LDD1329  [12]
 LDCM0451  CL6 PaTu 8988t C651(0.97)  LDD1330  [12]
 LDCM0452  CL60 PaTu 8988t C651(0.98)  LDD1331  [12]
 LDCM0453  CL61 PaTu 8988t C651(0.92)  LDD1332  [12]
 LDCM0454  CL62 PaTu 8988t C651(1.02)  LDD1333  [12]
 LDCM0455  CL63 PaTu 8988t C651(1.06)  LDD1334  [12]
 LDCM0456  CL64 PaTu 8988t C651(0.99)  LDD1335  [12]
 LDCM0457  CL65 PaTu 8988t C651(1.11)  LDD1336  [12]
 LDCM0458  CL66 PaTu 8988t C651(1.07)  LDD1337  [12]
 LDCM0459  CL67 PaTu 8988t C651(1.15)  LDD1338  [12]
 LDCM0460  CL68 PaTu 8988t C651(1.09)  LDD1339  [12]
 LDCM0461  CL69 PaTu 8988t C651(1.10)  LDD1340  [12]
 LDCM0462  CL7 PaTu 8988t C651(1.06)  LDD1341  [12]
 LDCM0463  CL70 PaTu 8988t C651(1.10)  LDD1342  [12]
 LDCM0464  CL71 PaTu 8988t C651(1.04)  LDD1343  [12]
 LDCM0465  CL72 PaTu 8988t C651(1.02)  LDD1344  [12]
 LDCM0466  CL73 PaTu 8988t C651(1.10)  LDD1345  [12]
 LDCM0467  CL74 PaTu 8988t C651(1.04)  LDD1346  [12]
 LDCM0469  CL76 HEK-293T C651(0.97); C293(0.72)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C651(1.07); C176(1.00); C293(0.95)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C651(0.99)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C651(1.04)  LDD1675  [11]
 LDCM0473  CL8 PaTu 8988t C651(1.00)  LDD1352  [12]
 LDCM0474  CL80 HEK-293T C651(1.11); C293(1.12); C108(1.30)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C651(1.10); C293(1.02)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C651(1.16); C293(0.92)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C651(1.08); C293(1.00)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C651(1.08); C293(0.84)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C651(0.95); C176(1.50)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C651(1.02)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C651(1.10); C176(0.92); C293(1.00)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C651(0.96); C293(0.90)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C651(1.00); C176(1.06); C293(1.10)  LDD1686  [11]
 LDCM0484  CL9 PaTu 8988t C651(1.06)  LDD1363  [12]
 LDCM0485  CL90 HEK-293T C651(1.11)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C651(1.05)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C651(1.08); C293(1.12); C108(1.34)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C651(1.25); C293(0.82)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C651(1.07); C293(1.04)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C651(1.11); C293(0.84)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C651(1.15); C293(0.86)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C651(0.94); C176(1.02)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C651(1.01)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C651(1.05); C176(0.82); C293(1.08)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C651(1.11); C176(0.87); C293(1.03)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C636(2.79); C651(0.89)  LDD1702  [3]
 LDCM0468  Fragment33 PaTu 8988t C651(1.10)  LDD1347  [12]
 LDCM0427  Fragment51 PaTu 8988t C651(1.16)  LDD1306  [12]
 LDCM0022  KB02 HEK-293T C651(0.94); C459(1.01)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C651(0.97); C459(1.15)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C953(3.61)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.