Details of the Target

General Information of Target

Target ID LDTP07267
Target Name SUMO-specific isopeptidase USPL1 (USPL1)
Gene Name USPL1
Gene ID 10208
Synonyms
C13orf22; D13S106; SUMO-specific isopeptidase USPL1; EC 3.4.22.-; Ubiquitin-specific peptidase-like protein 1; USP-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKT
YRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLA
NSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEADTV
DMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWLDC
ILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEI
FAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFE
CSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFML
HFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPCSE
RHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGDAA
SAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQ
LNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVN
TNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTS
QVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNR
NTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGPPSSNGTAA
HPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEK
KKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGV
SLYSSQTHEEILAELLSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHL
RQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNLESPMKTDIFDEFFSSSALNALANDTLD
LPHFDEYLFENY
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Nucleus, Cajal body
Function
SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies. Is a component of complexes that can bind to U snRNA genes.
Uniprot ID
Q5W0Q7
Ensemble ID
ENST00000255304.9
HGNC ID
HGNC:20294

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.D506H .
CAMA1 SNV: p.G53A .
GB1 SNV: p.E44D .
HCT15 SNV: p.I22L; p.S216G .
HDQP1 Insertion: p.N662_M663insPHIPITVFYFCFCLKE; p.N662_M663insVF .
HT SNV: p.S1001R .
HT115 SNV: p.R889C .
IGROV1 Deletion: p.G476AfsTer29 .
JHH7 SNV: p.P41S .
JM1 SNV: p.I948F .
JURKAT SNV: p.A510T .
MCC13 SNV: p.P1034L .
MFE280 SNV: p.F1084L .
MOLT4 SNV: p.P396L .
RKO SNV: p.L442I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C218(1.01); C226(1.01)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1035(0.99); C1047(0.99); C226(1.07)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C1035(1.04); C1047(1.04)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C1035(1.15); C1047(1.15); C218(1.44); C226(1.44)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C1035(1.01); C1047(1.01); C218(1.19); C226(1.19)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C1035(0.97); C1047(0.97); C218(0.90); C226(0.90)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C1035(1.33); C1047(1.33); C218(0.92); C226(0.92)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C1035(1.17); C1047(1.17); C218(1.16); C226(1.16)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C1035(1.09); C1047(1.09); C218(0.99); C226(0.99)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C1035(1.03); C1047(1.03); C218(1.19); C226(1.19)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C1035(1.01); C1047(1.01); C218(1.09); C226(1.09)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C1035(1.08); C1047(1.08); C218(1.27); C226(1.27)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C1035(1.03); C1047(1.03); C218(1.26); C226(1.26)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C1035(1.02); C1047(1.02)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C1035(1.01); C1047(1.01); C218(1.06); C226(1.06)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C1035(0.97); C1047(0.97); C218(1.06); C226(1.06)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C1035(1.33); C1047(1.33); C218(1.10); C226(1.10)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C1035(0.90); C1047(0.90); C218(1.36); C226(1.36)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C1035(0.73); C1047(0.73); C218(1.71); C226(1.71)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C1035(0.65); C1047(0.65); C218(1.62); C226(1.62)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C1035(0.84); C1047(0.84); C218(1.75); C226(1.75)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C1035(1.23); C1047(1.23); C218(1.56); C226(1.56)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C1035(0.99); C1047(0.99); C218(1.54); C226(1.54)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C1035(1.23); C1047(1.23); C218(1.67); C226(1.67)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C1035(1.02); C1047(1.02)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C1035(0.83); C1047(0.83); C218(1.41); C226(1.41)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C1035(1.77); C1047(1.77); C218(1.24); C226(1.24)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C1035(0.73); C1047(0.73); C218(1.25); C226(1.25)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C1035(2.36); C1047(2.36); C218(1.42); C226(1.42)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C1035(1.56); C1047(1.56); C218(1.40); C226(1.40)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C1035(0.55); C1047(0.55); C218(1.07); C226(1.07)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C1035(0.93); C1047(0.93); C218(1.36); C226(1.36)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C1035(1.26); C1047(1.26); C218(1.23); C226(1.23)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C218(1.06); C226(1.06)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C218(0.99); C226(0.99)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C218(1.02); C226(1.02)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C218(0.93); C226(0.93)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C218(1.03); C226(1.03)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C218(0.86); C226(0.86)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C218(1.06); C226(1.06)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C218(0.98); C226(0.98)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C218(0.91); C226(0.91)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C218(0.92); C226(0.92)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C218(1.05); C226(1.05)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C218(1.05); C226(1.05)  LDD0856  [1]
 LDCM0259  AC14 HCT 116 C1035(1.19); C1047(1.19)  LDD0576  [1]
 LDCM0260  AC140 HEK-293T C218(1.00); C226(1.00)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C218(0.98); C226(0.98)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C218(1.00); C226(1.00)  LDD0860  [1]
 LDCM0270  AC15 HCT 116 C1035(0.79); C1047(0.79)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C218(1.11); C226(1.11)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C218(1.48); C226(1.48)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C218(1.23); C226(1.23)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C1035(1.08); C1047(1.08); C226(1.23)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C218(1.29); C226(1.29)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C218(1.16); C226(1.16)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C218(0.98); C226(0.98)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C218(0.99); C226(0.99)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C218(1.11); C226(1.11)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C1035(0.97); C1047(0.97)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C1035(1.49); C1047(1.49)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C1035(1.12); C1047(1.12)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C1035(1.32); C1047(1.32)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C1035(1.00); C1047(1.00)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C1035(1.03); C1047(1.03); C226(1.08)  LDD0888  [1]
 LDCM0291  AC30 HCT 116 C1035(1.00); C1047(1.00)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C1035(1.23); C1047(1.23)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C1035(1.05); C1047(1.05)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C1035(1.20); C1047(1.20)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C1035(1.03); C1047(1.03)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C218(1.21); C226(1.21)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C218(1.12); C226(1.12)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C218(1.09); C226(1.09)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C218(1.08); C226(1.08)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C218(0.90); C226(0.90)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C1035(0.89); C1047(0.89); C226(1.06)  LDD0899  [1]
 LDCM0302  AC40 HCT 116 C218(1.36); C226(1.36)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C218(1.15); C226(1.15)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C218(1.36); C226(1.36)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C218(1.08); C226(1.08)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C218(1.28); C226(1.28)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C218(1.42); C226(1.42)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C1035(0.76); C1047(0.96); C218(1.10)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C1035(0.76); C1047(1.01); C218(1.21)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C1035(0.79); C1047(0.94); C218(1.21)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C1035(1.08); C1047(0.97); C218(1.31)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C1035(1.12); C1047(1.12); C226(1.09)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C1035(1.09); C1047(0.98); C218(1.42)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C1035(0.88); C1047(0.91); C218(1.56)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C1035(1.01); C1047(1.04); C218(1.43)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C1035(0.92); C1047(0.89); C218(1.25)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C1035(0.73); C1047(0.92); C218(1.61)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C1035(0.75); C1047(1.11); C218(1.47)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C1035(0.70); C1047(1.02); C218(1.27)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C218(0.95)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C218(0.90)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C218(0.94)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C1035(0.84); C1047(0.84)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C218(0.89)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C218(1.34)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C218(1.01)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C218(1.12)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C218(1.08)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C218(1.46)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C218(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C218(1.09)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C1035(0.91); C1047(0.82); C218(0.88)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C1035(1.09); C1047(1.16); C218(1.00)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C1035(0.90); C1047(0.90)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C1035(1.24); C1047(1.14); C218(1.49)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C1035(1.15); C1047(0.98); C218(1.32)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C1035(1.05); C1047(1.01); C218(1.15)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C1035(1.07); C1047(1.01); C218(1.39)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C1035(1.50); C1047(1.29); C218(1.34)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C1035(1.41); C1047(0.98); C218(1.11)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C1035(1.09); C1047(0.95); C218(1.05)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C1035(1.53); C1047(1.47); C218(1.12)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C1035(1.08); C1047(0.99); C218(0.96)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C1035(1.27); C1047(1.16); C218(1.07)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C1035(0.85); C1047(0.85)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C1035(1.53); C1047(1.05); C218(1.20)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C1035(1.44); C1047(1.10); C218(1.24)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C1035(2.13); C1047(1.21); C218(2.07)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C1035(0.79); C1047(0.79)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1035(0.78); C1047(0.78)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1035(0.57); C1047(0.57)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1035(0.53); C1047(0.53)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1035(0.57); C1047(0.57)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1035(0.60); C1047(0.60)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1035(0.88); C1047(0.88)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1035(0.83); C1047(0.83)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1035(0.51); C1047(0.51)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1035(0.46); C1047(0.46)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1035(0.62); C1047(0.62)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1035(0.43); C1047(0.43)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1035(0.91); C1047(0.91)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1035(0.50); C1047(0.50)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1035(0.70); C1047(0.70)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C1035(0.87); C1047(0.87); C218(1.13); C226(1.13)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C1035(0.87); C1047(0.87); C218(1.09); C226(1.09)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C1035(1.08); C1047(1.08)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C1035(1.41); C1047(1.41)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C1035(0.95); C1047(0.95)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C218(1.01); C226(1.01)  LDD0078  [1]
 LDCM0369  CL100 HEK-293T C1035(0.76); C1047(0.76); C226(1.45)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C1035(1.25); C1047(1.25)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C1035(0.76); C1047(0.76)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C1035(0.95); C1047(0.95)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C1035(0.93); C1047(0.93)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C218(1.25); C226(1.25)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C218(1.41); C226(1.41)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C218(1.22); C226(1.22)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C218(1.48); C226(1.48)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C218(1.32); C226(1.32)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C218(1.53); C226(1.53)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C218(1.28); C226(1.28)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C1035(0.95); C1047(0.95)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C1035(1.09); C1047(1.09)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C1035(1.09); C1047(1.09)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C1035(1.21); C1047(1.21)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C1035(1.33); C1047(1.33)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C218(1.60); C226(1.60)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C218(1.16); C226(1.16)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C218(1.16); C226(1.16)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C218(0.99); C226(0.99)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C1035(0.78); C1047(1.19); C218(1.50)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C1035(0.85); C1047(1.07); C218(1.24)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C1035(0.92); C1047(0.91); C218(1.15)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C1035(0.87); C1047(0.98); C218(1.35)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C218(0.98)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C218(1.11)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C218(0.99)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C218(1.10)  LDD0997  [1]
 LDCM0403  CL16 HCT 116 C1035(1.18); C1047(1.18)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1035(1.03); C1047(1.03)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C1035(1.02); C1047(1.02)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C1035(1.12); C1047(1.12)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C1035(1.04); C1047(1.04)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C1035(0.86); C1047(0.86)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C1035(0.86); C1047(0.86)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C1035(1.05); C1047(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C1035(1.63); C1047(1.63)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1035(0.90); C1047(0.90)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1035(0.83); C1047(0.83)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1035(1.15); C1047(1.15)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1035(1.22); C1047(1.22)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1035(1.27); C1047(1.27)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C1035(1.40); C1047(1.40)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C1047(1.42); C218(1.33); C226(0.82)  LDD1018  [1]
 LDCM0421  CL32 HCT 116 C1035(1.11); C1047(1.11)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1035(0.94); C1047(0.94)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1035(0.87); C1047(0.87)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1035(1.41); C1047(1.41)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1035(0.80); C1047(0.80)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1035(1.19); C1047(1.19)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1035(1.15); C1047(1.15)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C1035(0.91); C1047(0.91)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1035(1.17); C1047(1.17)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1035(0.64); C1047(0.64)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1035(1.31); C1047(1.31)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1035(1.19); C1047(1.19)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1035(1.04); C1047(1.04)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C1035(0.61); C1047(0.61)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C1035(0.78); C1047(0.78)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C1035(0.68); C1047(0.68)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C1035(0.81); C1047(0.81)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C1035(0.89); C1047(0.89)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C1035(1.14); C1047(1.14)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C1035(1.21); C1047(1.21)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C1035(0.73); C1047(0.73)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C1035(1.09); C1047(1.09)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C1035(1.04); C1047(1.04)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C1035(0.86); C1047(0.86)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C1035(0.87); C1047(0.87)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C1035(1.13); C1047(1.13)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C1035(1.06); C1047(1.06)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C511(1.05)  LDD1654  [2]
 LDCM0452  CL60 HCT 116 C1035(0.92); C1047(0.92)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C1035(0.85); C1047(0.85)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C1035(1.13); C1047(1.13)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C1035(1.25); C1047(1.25)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C1035(0.94); C1047(0.94)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C1035(0.91); C1047(0.91)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C1035(1.11); C1047(1.11)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C1035(1.08); C1047(1.08)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C1035(1.32); C1047(1.32)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C1035(0.93); C1047(0.93)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C1035(1.08); C1047(1.08)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C1035(0.89); C1047(0.89)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C1035(0.86); C1047(0.86)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C1035(1.18); C1047(1.18)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C1035(1.31); C1047(1.31)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C1035(0.84); C1047(0.84)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C1035(0.80); C1047(0.80)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C1035(0.94); C1047(0.94)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C1035(0.89); C1047(0.89)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C1035(1.20); C1047(1.20)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C1035(0.94); C1047(0.94)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C1035(0.63); C1047(0.63)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C1035(0.86); C1047(0.86)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C1035(0.86); C1047(0.86)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C1035(0.99); C1047(0.99)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C1035(0.69); C1047(0.69)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C1035(1.03); C1047(1.03)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C1035(1.07); C1047(1.07)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C1035(0.78); C1047(0.78)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C1035(0.79); C1047(0.79)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C1035(1.02); C1047(1.02); C226(1.03)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C1035(1.15); C1047(1.15); C226(1.49)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C1035(0.88); C1047(0.88); C226(1.20)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C1035(1.00); C1047(1.00); C226(1.17)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C1035(1.39); C1047(1.39); C226(1.43)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C1035(1.15); C1047(1.15); C226(1.15)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C1035(1.29); C1047(1.29); C226(1.03)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C1035(1.26); C1047(1.26); C226(1.23)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C1035(0.97); C1047(0.97); C226(1.08)  LDD1092  [1]
 LDCM0468  Fragment33 HCT 116 C1035(0.86); C1047(0.86)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C1035(0.80); C1047(0.80)  LDD0744  [1]
 LDCM0021  THZ1 HCT 116 C1035(1.27); C1047(1.27)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Small ubiquitin-related modifier 3 (SUMO3) Ubiquitin family P55854

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402