Details of the Target

General Information of Target

Target ID LDTP07022
Target Name Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (GNAS)
Gene Name GNAS
Gene ID 2778
Synonyms
GNAS1; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Adenylate cyclase-stimulating G alpha protein; Extra large alphas protein; XLalphas
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIP
VENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ
PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP
GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSP
WMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADP
DSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA
ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR
RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKR
AEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP
QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNV
PDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL
LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVI
REDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR
YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFN
DCRDIIQRMHLRQYELL
Target Bioclass
Other
Family
G-alpha family, G(s) subfamily
Subcellular location
Cell membrane
Function
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms.
Uniprot ID
Q5JWF2
Ensemble ID
ENST00000371100.9
HGNC ID
HGNC:4392
ChEMBL ID
CHEMBL4295849

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.10  LDD0402  [1]
TH211
 Probe Info  		Y961(20.00); Y954(10.47); Y1003(6.40)  LDD0260  [2]
C-Sul
 Probe Info  		2.83  LDD0066  [3]
BTD
 Probe Info  		C1022(2.94)  LDD1700  [4]
DBIA
 Probe Info  		C817(0.92)  LDD0649  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1022(1.25)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1022(1.51)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C1002(0.88); C1008(0.88)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C1002(1.32); C1008(1.32); C817(1.14)  LDD0813  [5]
 LDCM0226  AC11 HEK-293T C1002(1.03); C1008(1.03); C817(1.14)  LDD0824  [5]
 LDCM0230  AC113 HEK-293T C1002(0.85); C1008(0.85)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C1002(0.91); C1008(0.91)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C1002(0.95); C1008(0.95)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C1002(1.43); C1008(1.43)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C1002(0.82); C1008(0.82)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C1002(1.15); C1008(1.15)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C1002(0.75); C1008(0.75)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C1002(0.73); C1008(0.73); C817(1.00)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C1002(1.14); C1008(1.14)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C1002(0.96); C1008(0.96)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C1002(0.74); C1008(0.74)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C1002(1.21); C1008(1.21)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C1002(1.01); C1008(1.01)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C1002(0.99); C1008(0.99)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C1002(1.07); C1008(1.07)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C1002(0.81); C1008(0.81)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C817(1.17)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C817(0.90)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C817(1.02)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C817(1.04)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C817(1.01)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C817(0.99)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C817(1.11)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C817(1.01)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C817(0.99)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C817(0.96)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C817(1.13)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C817(0.98)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C1002(1.50); C1008(1.50); C817(1.12)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C817(0.95)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C817(1.06)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C817(1.02)  LDD0860  [5]
 LDCM0263  AC143 PaTu 8988t C817(0.75)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C817(0.77)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C817(0.89)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C817(0.88)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C817(1.20)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C817(0.56)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C817(0.38)  LDD1148  [5]
 LDCM0270  AC15 HEK-293T C1002(1.34); C1008(1.34); C817(1.02)  LDD0868  [5]
 LDCM0271  AC150 PaTu 8988t C817(0.45)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C817(0.19)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C817(0.33)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C817(0.32)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C817(0.21)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C817(0.29)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C817(0.56)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C817(0.31)  LDD2169  [5]
 LDCM0276  AC17 PaTu 8988t C817(1.20)  LDD1155  [5]
 LDCM0277  AC18 PaTu 8988t C817(0.65)  LDD1156  [5]
 LDCM0278  AC19 PaTu 8988t C817(1.00)  LDD1157  [5]
 LDCM0279  AC2 HEK-293T C1002(1.10); C1008(1.10)  LDD0877  [5]
 LDCM0280  AC20 PaTu 8988t C817(0.92)  LDD1159  [5]
 LDCM0281  AC21 PaTu 8988t C817(1.18)  LDD1160  [5]
 LDCM0282  AC22 PaTu 8988t C817(0.85)  LDD1161  [5]
 LDCM0283  AC23 PaTu 8988t C817(0.41)  LDD1162  [5]
 LDCM0284  AC24 PaTu 8988t C817(0.54)  LDD1163  [5]
 LDCM0285  AC25 HEK-293T C1002(1.09); C1008(1.09)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C1002(1.15); C1008(1.15)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C1002(1.31); C1008(1.31)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C1002(2.03); C1008(2.03)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C1002(1.19); C1008(1.19)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C1002(1.27); C1008(1.27)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C1002(1.25); C1008(1.25)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C1002(0.89); C1008(0.89)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C1002(1.04); C1008(1.04)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C1002(1.19); C1008(1.19)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C1002(1.05); C1008(1.05)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C817(1.22)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C817(1.00)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C817(0.87)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C817(0.99)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C817(1.07)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C1002(1.27); C1008(1.27)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C817(0.89)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C817(0.97)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C817(0.97)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C817(1.12)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C817(0.98)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C817(1.07)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C1002(0.83); C1008(0.83)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C1002(0.72); C1008(0.72)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C1002(0.74); C1008(0.74)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C1002(0.81); C1008(0.81)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C1002(1.06); C1008(1.06)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C1002(0.90); C1008(0.90)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C1002(0.92); C1008(0.92)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C1002(0.96); C1008(0.96)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C1002(0.90); C1008(0.90)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C1002(1.04); C1008(1.04)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C1002(0.92); C1008(0.92)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C1002(0.75); C1008(0.75)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C817(1.00); C1002(1.07)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C817(1.14); C1002(0.96)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C817(0.94); C1002(0.93)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C1002(0.98); C1008(0.98); C817(0.96)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C817(0.94); C1002(0.97)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C817(1.07); C1002(1.02)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C817(1.06); C1002(0.95)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C817(0.92); C1002(1.07)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C817(1.06); C1008(1.11); C1002(1.07)  LDD1567  [13]
 LDCM0332  AC68 HCT 116 C817(0.92)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C817(1.02)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C1002(1.01); C1008(1.01); C817(0.96)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C817(0.59)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C817(1.19)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C817(1.74)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C817(0.59)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C817(0.64)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C817(0.42)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C817(0.83)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C817(0.72)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C817(1.54)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C817(1.06)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C1002(1.20); C1008(1.20); C817(0.92)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C817(0.84)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C817(0.77)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C817(0.41)  LDD0665  [5]
 LDCM0248  AKOS034007472 HEK-293T C1002(1.00); C1008(1.00); C817(1.05)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C1002(0.97); C1008(0.97); C817(1.12)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C1002(1.11); C1008(1.11); C817(0.97)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C817(1.08)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C817(0.71)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C1002(1.03); C1008(1.03)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C1002(1.20); C1008(1.20); C817(0.86)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C1002(1.96); C1008(1.96); C817(0.95)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C1002(1.23); C1008(1.23); C817(0.93)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C1002(1.41); C1008(1.41); C817(1.00)  LDD0971  [5]
 LDCM0374  CL105 PaTu 8988t C817(0.89)  LDD1253  [5]
 LDCM0375  CL106 PaTu 8988t C817(0.85)  LDD1254  [5]
 LDCM0376  CL107 PaTu 8988t C817(0.88)  LDD1255  [5]
 LDCM0377  CL108 PaTu 8988t C817(0.81)  LDD1256  [5]
 LDCM0378  CL109 PaTu 8988t C817(0.82)  LDD1257  [5]
 LDCM0379  CL11 HCT 116 C817(0.47)  LDD0696  [5]
 LDCM0380  CL110 PaTu 8988t C817(0.56)  LDD1259  [5]
 LDCM0381  CL111 PaTu 8988t C817(0.43)  LDD1260  [5]
 LDCM0382  CL112 HEK-293T C1002(1.41); C1008(1.41)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C1002(1.07); C1008(1.07)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C1002(1.65); C1008(1.65)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C1002(1.23); C1008(1.23)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C1002(1.52); C1008(1.52)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C817(1.08)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C817(1.14)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C817(1.02)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C817(0.46)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C817(0.96)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C1002(0.77); C1008(0.77)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C1002(0.73); C1008(0.73)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C1002(1.08); C1008(1.08)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C1002(0.85); C1008(0.85)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C817(1.03); C1002(0.89)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C817(0.97); C1008(0.67); C1002(1.01)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C817(1.07); C1008(0.87); C1002(0.96)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C817(1.05); C1002(1.02)  LDD1603  [13]
 LDCM0400  CL13 HCT 116 C817(0.98)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C817(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C817(0.76)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C817(0.96)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C817(0.86)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C817(1.11)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C817(0.94)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C817(1.28)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C817(0.98)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C817(0.62)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C817(0.72)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C817(0.77)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C817(0.93)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C817(1.05)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C817(0.76)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C817(0.85)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C817(0.80)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C817(0.75)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C817(1.17)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C817(0.83)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C817(0.91)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C817(1.02)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C817(1.06)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C817(0.47)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C817(0.76)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C817(0.69)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C817(0.61)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C817(0.64)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C817(1.10)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C817(0.67)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C817(0.76)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C817(0.26)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C817(0.57)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C817(0.71)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C817(0.59)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C817(1.05); C1002(1.12)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C817(1.12); C1002(1.11)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C817(1.16); C1008(1.00); C1002(1.18)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C817(1.08); C1002(1.06)  LDD1643  [13]
 LDCM0440  CL5 HCT 116 C817(1.14)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C817(1.16); C1008(0.84); C1002(1.12)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C817(1.04); C1002(0.95)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C817(0.90); C1002(1.27)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C817(0.93); C1002(1.14)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C817(0.99); C1002(1.08)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C817(1.14); C1002(1.02)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C817(1.10); C1002(1.12)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C817(1.14); C1002(1.06)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C817(1.01); C1002(1.15)  LDD1653  [13]
 LDCM0451  CL6 HCT 116 C817(0.95)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C817(1.32); C1008(1.76); C1002(1.16)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C1002(0.79)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C1002(1.19)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C1002(1.05)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C1002(0.88)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C1002(1.09)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C1002(1.20)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C1002(1.17)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C1002(1.19)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C1002(1.07)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C817(0.60)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C1002(1.02)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C1002(1.23)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C1002(0.98)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C1002(1.15)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C1002(1.52)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C817(1.24)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C817(1.31)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C817(1.40)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C817(1.06)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C817(0.51)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C817(1.72)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C817(0.91)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C817(0.52)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C817(0.72)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C817(0.38)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C817(1.06)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C817(0.95)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C817(1.16)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C817(0.66)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C817(0.35)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C817(0.94)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C817(0.87)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C1002(1.13); C1008(1.13)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C1002(1.11); C1008(1.11)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C1002(1.12); C1008(1.12)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C1002(1.21); C1008(1.21)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C1002(1.29); C1008(1.29)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C1002(1.06); C1008(1.06)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C1002(1.45); C1008(1.45)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C1002(0.96); C1008(0.96)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C1002(1.01); C1008(1.01)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C817(1.22); C1008(0.90); C1002(1.09)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C1002(1.33)  LDD1066  [5]
 LDCM0427  Fragment51 HCT 116 C817(0.32)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C1002(1.04); C817(1.04); C1002(1.06); C1008(1.06)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C1002(1.02); C817(0.99); C1002(0.96); C1008(0.96)  LDD1497  [13]
 LDCM0024  KB05 HEK-293T C1002(1.06); C817(0.93); C1002(0.94); C1008(0.94)  LDD1502  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1022(1.49)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1022(1.32)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1022(0.67)  LDD2109  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1022(2.27)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1022(0.99)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1022(1.56)  LDD2127  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1022(0.91)  LDD2133  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1022(1.56)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1022(1.14)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1022(2.94)  LDD1700  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1022(2.20)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1022(1.19)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1022(0.43)  LDD2148  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C1022(0.34)  LDD2207  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-arrestin-1 (ARRB1) Arrestin family P49407

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.