Details of the Target

General Information of Target

Target ID LDTP06927
Target Name Shugoshin 2 (SGO2)
Gene Name SGO2
Gene ID 151246
Synonyms
SGOL2; Shugoshin 2; Shugoshin-2; Shugoshin-like 2; Tripin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
DKMRR
Target Bioclass
Other
Family
Shugoshin family
Subcellular location
Nucleus
Function
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.
Uniprot ID
Q562F6
Ensemble ID
ENST00000357799.9
HGNC ID
HGNC:30812

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Q694Ter .
42MGBA SNV: p.D1114E .
786O SNV: p.T1043I DBIA    Probe Info 
CAL27 Substitution: p.Q508R .
EGI1 SNV: p.V159F DBIA    Probe Info 
HT115 SNV: p.Q298H; p.I917M .
ICC8 SNV: p.D682E DBIA    Probe Info 
IGROV1 SNV: p.R276C .
MEC1 SNV: p.K1168E .
MOLT4 SNV: p.S53F .
NCIH1666 SNV: p.R261K DBIA    Probe Info 
SW403 SNV: p.D750Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K99(10.00)  LDD0275  [1]
AHL-Pu-1
 Probe Info  		C1041(5.71)  LDD0168  [2]
DBIA
 Probe Info  		C681(2.02)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C176(0.00); C1041(0.00)  LDD0037  [4]
IPM
 Probe Info  		C681(0.00); C813(0.00); C1249(0.00)  LDD0147  [5]
Phosphinate-6
 Probe Info  		C681(0.00); C528(0.00); C798(0.00); C176(0.00)  LDD0018  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		C1249(0.00); C3(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1041(5.71)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1041(5.85)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C681(0.91)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C681(1.05)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C681(0.73)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C681(0.76)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C681(0.81)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C681(1.16)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C681(1.13)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C681(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C681(0.97)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C681(1.03)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C681(0.61)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C681(0.68)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C681(1.54)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C681(0.68)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C681(0.61)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C681(0.87)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C681(0.80)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C681(1.02)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C681(1.14)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C681(1.25)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C681(0.97)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C681(0.94)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C681(0.96)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C681(1.36)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C681(0.86)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C681(1.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C681(0.93)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C681(0.88)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C681(0.89)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C681(1.07)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C681(1.06)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C681(1.06)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C681(1.17)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C681(1.16)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C681(0.97)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C681(1.07)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C681(1.23)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C681(1.10)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C681(1.35)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C681(1.47)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C681(1.36)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C681(1.29)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C681(1.09)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C681(1.12)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C681(1.65)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C681(1.28)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C681(1.28)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C681(1.27)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C681(1.24)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C681(0.64)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C681(0.86)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C681(0.75)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C681(1.03)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C681(0.68)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C681(0.82)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C681(0.89)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C681(0.79)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C681(0.88)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C681(1.40)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C681(1.72)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C681(1.20)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C681(0.68)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C681(1.35)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C681(0.97)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C681(1.11)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C681(1.95)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C681(1.29)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C681(1.72)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C681(1.64)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C681(1.23)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C681(1.55)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C681(1.64)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C681(1.36)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C681(1.45)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C681(1.08)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C681(1.54)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C681(0.96)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C681(1.49)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C681(1.58)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C681(1.34)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C681(1.58)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C681(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C681(0.90)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C681(1.29)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C681(1.22)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C681(1.08)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C681(0.97)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C681(0.80)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C681(1.01)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C681(1.38)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C681(0.96)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C681(1.41)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C681(1.17)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C681(0.84)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C681(0.57)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C681(0.78)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C681(1.11)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C681(0.80)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C681(0.51)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C681(0.66)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C681(0.67)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C681(0.77)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C681(0.59)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C681(0.81)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C681(0.67)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C681(0.94)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C681(1.41)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C681(1.36)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C681(0.87)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C681(0.91)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C681(1.60)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C681(0.92)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C681(1.04)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C681(0.94)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C681(1.70)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C681(1.76)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C681(1.17)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C681(1.53)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C681(1.46)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C681(1.43)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C681(1.09)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C681(1.56)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C681(1.14)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C681(0.98)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C681(0.61)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C681(0.81)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C681(0.82)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C681(0.70)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C681(0.64)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C681(0.75)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C681(0.93)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C681(1.01)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C681(1.21)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C681(1.15)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C681(1.28)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C681(2.29)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C681(0.77)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C681(1.13)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C681(0.60)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C681(1.18)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C681(1.43)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C681(1.36)  LDD0592  [3]
 LDCM0632  CL-Sc Hep-G2 C3(0.69)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C681(1.16)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C681(1.32)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C681(1.01)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C681(0.95)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C681(1.13)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C681(1.21)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C681(1.25)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C681(0.92)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C681(0.66)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C681(0.70)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C681(1.04)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C681(0.77)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C681(1.07)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C681(1.12)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C681(0.82)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C681(0.88)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C681(1.35)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C681(0.90)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C681(1.05)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C681(1.09)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C681(1.36)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C681(1.63)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C681(1.38)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C681(1.22)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C681(1.52)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C681(1.09)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C681(0.93)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C681(0.70)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C681(0.99)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C681(0.84)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C681(0.61)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C681(0.70)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C681(0.93)  LDD0997  [3]
 LDCM0400  CL13 HCT 116 C681(1.02)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C681(1.11)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C681(0.73)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C681(0.92)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C681(0.64)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C681(1.24)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C681(0.97)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C681(0.84)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C681(1.20)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C681(0.90)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C681(2.19)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C681(1.38)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C681(1.54)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C681(1.36)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C681(1.10)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C681(1.91)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C681(1.19)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C681(1.41)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C681(1.00)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C681(1.10)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C681(0.83)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C681(0.83)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C681(0.99)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C681(0.98)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C681(1.30)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C681(1.08)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C681(1.08)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C681(1.05)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C681(1.17)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C681(1.11)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C681(0.95)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C681(1.06)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C681(1.11)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C681(1.12)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C681(0.81)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C681(1.15)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C681(1.07)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C681(1.16)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C681(1.31)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C681(0.93)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C681(1.41)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C681(0.92)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C681(1.26)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C681(2.31)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C681(0.88)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C681(1.21)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C681(1.19)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C681(1.14)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C681(1.18)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C681(1.38)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C681(0.90)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C681(1.25)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C681(1.35)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C681(1.06)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C681(1.21)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C681(1.31)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C681(1.18)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C681(1.08)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C681(1.43)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C681(0.94)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C681(1.14)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C681(1.08)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C681(1.15)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C681(1.17)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C681(1.60)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C681(1.13)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C681(1.09)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C681(0.78)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C681(0.74)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C681(0.51)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C681(0.75)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C681(1.15)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C681(1.12)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C681(1.39)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C681(1.12)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C681(0.90)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C681(1.68)  LDD0795  [3]
 LDCM0479  CL85 HEK-293T C954(0.88); C798(0.96)  LDD1682  [9]
 LDCM0480  CL86 HCT 116 C681(0.84)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C681(1.03)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C681(1.44)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C681(1.47)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C681(0.95)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C681(0.64)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C681(1.31)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C681(1.05)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C681(1.14)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C681(1.10)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C681(0.92)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C681(1.20)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C681(1.18)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C681(1.13)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C681(0.94)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C954(0.83); C176(1.05); C528(1.06)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C798(2.00)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C681(1.20)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C681(0.89)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C681(2.02)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C681(1.34)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C681(1.41)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Borealin (CDCA8) Borealin family Q53HL2
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
MAD2L1-binding protein (MAD2L1BP) MAD2L1BP family Q15013

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761