Details of the Target

General Information of Target

Target ID LDTP06725
Target Name Transcriptional regulator QRICH1 (QRICH1)
Gene Name QRICH1
Gene ID 54870
Synonyms
Transcriptional regulator QRICH1; Glutamine-rich protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGN
CIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLS
PQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQI
QAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTAS
VLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGT
ITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEK
MVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQ
QPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLE
VWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEG
EPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLP
SHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSN
PKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGR
NDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth.
Uniprot ID
Q2TAL8
Ensemble ID
ENST00000357496.6
HGNC ID
HGNC:24713

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y337(20.00); Y706(9.61); Y597(6.15)  LDD0257  [2]
STPyne
 Probe Info  		K246(1.71); K28(1.06)  LDD0277  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
Probe 1
 Probe Info  		Y688(12.14)  LDD3495  [5]
HHS-475
 Probe Info  		Y337(0.64); Y597(1.21)  LDD0264  [6]
HHS-465
 Probe Info  		Y337(10.00)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0223  [8]
DBIA
 Probe Info  		C611(2.01)  LDD0080  [9]
ATP probe
 Probe Info  		K246(0.00); K247(0.00); K28(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C701(0.00); C611(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C611(1.24)  LDD0531  [9]
 LDCM0215  AC10 PaTu 8988t C611(1.20)  LDD1094  [9]
 LDCM0226  AC11 PaTu 8988t C611(1.05)  LDD1105  [9]
 LDCM0237  AC12 PaTu 8988t C611(1.14)  LDD1116  [9]
 LDCM0246  AC128 PaTu 8988t C611(1.10)  LDD1125  [9]
 LDCM0247  AC129 PaTu 8988t C611(1.01)  LDD1126  [9]
 LDCM0249  AC130 PaTu 8988t C611(1.05)  LDD1128  [9]
 LDCM0250  AC131 PaTu 8988t C611(1.32)  LDD1129  [9]
 LDCM0251  AC132 PaTu 8988t C611(0.84)  LDD1130  [9]
 LDCM0252  AC133 PaTu 8988t C611(1.26)  LDD1131  [9]
 LDCM0253  AC134 PaTu 8988t C611(1.30)  LDD1132  [9]
 LDCM0254  AC135 PaTu 8988t C611(1.27)  LDD1133  [9]
 LDCM0255  AC136 PaTu 8988t C611(1.16)  LDD1134  [9]
 LDCM0256  AC137 PaTu 8988t C611(1.20)  LDD1135  [9]
 LDCM0257  AC138 PaTu 8988t C611(1.06)  LDD1136  [9]
 LDCM0258  AC139 PaTu 8988t C611(1.00)  LDD1137  [9]
 LDCM0259  AC14 PaTu 8988t C611(1.13)  LDD1138  [9]
 LDCM0260  AC140 PaTu 8988t C611(1.09)  LDD1139  [9]
 LDCM0261  AC141 PaTu 8988t C611(1.08)  LDD1140  [9]
 LDCM0262  AC142 PaTu 8988t C611(1.14)  LDD1141  [9]
 LDCM0263  AC143 HCT 116 C611(0.72)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C611(0.65)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C611(0.68)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C611(0.56)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C611(0.60)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C611(0.70)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C611(0.73)  LDD0586  [9]
 LDCM0270  AC15 PaTu 8988t C611(1.23)  LDD1149  [9]
 LDCM0271  AC150 HCT 116 C611(0.97)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C611(0.72)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C611(0.61)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C611(0.90)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C611(0.63)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C611(0.85)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C611(0.67)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C611(0.85)  LDD2161  [9]
 LDCM0276  AC17 HEK-293T C611(0.95); C529(0.91); C554(0.69)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C611(0.90); C529(0.99); C554(0.94)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C611(0.87); C529(0.94); C554(0.69)  LDD1517  [15]
 LDCM0279  AC2 HCT 116 C611(1.07)  LDD0596  [9]
 LDCM0280  AC20 HEK-293T C611(1.00); C529(1.04)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C611(0.98); C529(0.91); C554(0.88)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C611(0.90); C529(1.05); C554(1.04)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C611(0.90); C529(1.02); C554(1.21)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C611(0.95); C529(1.22); C554(1.18)  LDD1523  [15]
 LDCM0285  AC25 PaTu 8988t C611(0.97)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C611(1.13)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C611(1.09)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C611(1.04)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C611(1.38)  LDD1168  [9]
 LDCM0290  AC3 HCT 116 C611(0.98)  LDD0607  [9]
 LDCM0291  AC30 PaTu 8988t C611(1.05)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C611(0.85)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C611(0.93)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C611(0.99)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C611(1.01)  LDD1174  [9]
 LDCM0296  AC35 HEK-293T C611(0.96); C529(1.00); C554(1.17)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C611(0.97); C529(0.96)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C611(0.93); C529(1.10); C554(0.96)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C611(0.98); C529(1.10); C554(1.21)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C611(1.04); C529(1.13); C554(0.97)  LDD1539  [15]
 LDCM0301  AC4 HCT 116 C611(1.18)  LDD0618  [9]
 LDCM0302  AC40 HEK-293T C611(0.91); C529(1.23); C554(0.81)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C611(0.88); C529(1.03); C554(0.71)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C611(0.87); C529(1.06); C554(1.02)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C611(0.96); C529(1.05); C554(0.88)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C611(1.00); C529(1.02)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C611(0.90); C529(0.99); C554(1.00)  LDD1546  [15]
 LDCM0308  AC46 PaTu 8988t C611(1.11)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C611(1.18)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C611(1.34)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C611(1.26)  LDD1190  [9]
 LDCM0312  AC5 HCT 116 C611(1.22)  LDD0629  [9]
 LDCM0313  AC50 PaTu 8988t C611(1.31)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C611(0.79)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C611(1.22)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C611(1.26)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C611(1.39)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C611(1.51)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C611(1.33)  LDD1198  [9]
 LDCM0320  AC57 PaTu 8988t C611(0.77)  LDD1199  [9]
 LDCM0321  AC58 PaTu 8988t C611(0.68)  LDD1200  [9]
 LDCM0322  AC59 PaTu 8988t C611(0.78)  LDD1201  [9]
 LDCM0323  AC6 PaTu 8988t C611(0.98)  LDD1202  [9]
 LDCM0324  AC60 PaTu 8988t C611(0.53)  LDD1203  [9]
 LDCM0325  AC61 PaTu 8988t C611(0.98)  LDD1204  [9]
 LDCM0326  AC62 PaTu 8988t C611(0.52)  LDD1205  [9]
 LDCM0327  AC63 PaTu 8988t C611(0.60)  LDD1206  [9]
 LDCM0328  AC64 PaTu 8988t C611(0.56)  LDD1207  [9]
 LDCM0329  AC65 PaTu 8988t C611(0.71)  LDD1208  [9]
 LDCM0330  AC66 PaTu 8988t C611(0.55)  LDD1209  [9]
 LDCM0331  AC67 PaTu 8988t C611(0.49)  LDD1210  [9]
 LDCM0332  AC68 HCT 116 C611(0.56)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C611(0.57)  LDD0650  [9]
 LDCM0334  AC7 PaTu 8988t C611(0.90)  LDD1213  [9]
 LDCM0335  AC70 HCT 116 C611(0.62)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C611(0.68)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C611(0.64)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C611(0.61)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C611(0.63)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C611(0.63)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C611(0.61)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C611(0.56)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C611(0.59)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C611(0.67)  LDD0661  [9]
 LDCM0345  AC8 PaTu 8988t C611(0.97)  LDD1224  [9]
 LDCM0346  AC80 HCT 116 C611(0.61)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C611(0.61)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C611(0.78)  LDD0665  [9]
 LDCM0248  AKOS034007472 PaTu 8988t C611(1.12)  LDD1127  [9]
 LDCM0356  AKOS034007680 PaTu 8988t C611(1.10)  LDD1235  [9]
 LDCM0275  AKOS034007705 PaTu 8988t C611(1.01)  LDD1154  [9]
 LDCM0156  Aniline NCI-H1299 14.51  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C611(0.88)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C611(0.68)  LDD1247  [9]
 LDCM0369  CL100 HCT 116 C611(1.13)  LDD0686  [9]
 LDCM0370  CL101 PaTu 8988t C611(1.10)  LDD1249  [9]
 LDCM0371  CL102 PaTu 8988t C611(0.90)  LDD1250  [9]
 LDCM0372  CL103 PaTu 8988t C611(1.18)  LDD1251  [9]
 LDCM0373  CL104 PaTu 8988t C611(0.93)  LDD1252  [9]
 LDCM0374  CL105 HEK-293T C611(0.95); C529(1.03); C554(1.05)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C611(0.95); C529(0.86); C554(0.75)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C611(0.93); C529(0.94); C554(1.03)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C611(0.95); C529(1.30); C554(1.02)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C611(1.09); C529(1.03); C554(1.63)  LDD1582  [15]
 LDCM0379  CL11 PaTu 8988t C611(0.74)  LDD1258  [9]
 LDCM0380  CL110 HEK-293T C611(0.93); C529(0.83); C554(0.56)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C611(0.91); C529(1.20); C554(1.13)  LDD1585  [15]
 LDCM0382  CL112 PaTu 8988t C611(0.98)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C611(1.00)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C611(0.98)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C611(0.94)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C611(1.07)  LDD1265  [9]
 LDCM0387  CL117 HEK-293T C611(0.94); C529(1.08); C554(1.04)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C611(0.94); C529(0.96); C554(0.85)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C611(0.94); C529(1.00); C554(1.00)  LDD1593  [15]
 LDCM0390  CL12 PaTu 8988t C611(1.45)  LDD1269  [9]
 LDCM0391  CL120 HEK-293T C611(0.96); C529(0.98); C554(0.67)  LDD1595  [15]
 LDCM0392  CL121 PaTu 8988t C611(1.21)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C611(1.14)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C611(1.22)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C611(1.16)  LDD1274  [9]
 LDCM0396  CL125 PaTu 8988t C611(0.64)  LDD1275  [9]
 LDCM0397  CL126 PaTu 8988t C611(0.37)  LDD1276  [9]
 LDCM0398  CL127 PaTu 8988t C611(0.54)  LDD1277  [9]
 LDCM0399  CL128 PaTu 8988t C611(0.74)  LDD1278  [9]
 LDCM0400  CL13 PaTu 8988t C611(1.20)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C611(1.56)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C611(0.80)  LDD1281  [9]
 LDCM0403  CL16 PaTu 8988t C611(1.01)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C611(1.08)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C611(1.01)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C611(1.07)  LDD1285  [9]
 LDCM0407  CL2 PaTu 8988t C611(0.87)  LDD1286  [9]
 LDCM0408  CL20 PaTu 8988t C611(1.19)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C611(1.22)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C611(1.12)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C611(1.11)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C611(1.04)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C611(1.07)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C611(1.00)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C611(1.19)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C611(1.30)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C611(1.32)  LDD1296  [9]
 LDCM0418  CL3 PaTu 8988t C611(0.58)  LDD1297  [9]
 LDCM0419  CL30 PaTu 8988t C611(1.16)  LDD1298  [9]
 LDCM0420  CL31 HCT 116 C611(1.02)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C611(1.02)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C611(0.90)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C611(0.94)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C611(1.13)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C611(1.06)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C611(1.05)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C611(0.97)  LDD0745  [9]
 LDCM0429  CL4 PaTu 8988t C611(1.38)  LDD1308  [9]
 LDCM0430  CL40 HCT 116 C611(0.91)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C611(1.02)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C611(1.01)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C611(0.86)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C611(0.93)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C611(0.86)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C611(0.89)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C611(0.95)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C611(0.83)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C611(0.80)  LDD0756  [9]
 LDCM0440  CL5 PaTu 8988t C611(1.04)  LDD1319  [9]
 LDCM0441  CL50 HCT 116 C611(0.83)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C611(0.79)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C611(0.80)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C611(1.32)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C611(0.91)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C611(0.98)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C611(1.01)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C611(1.00)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C611(0.93)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C611(0.97)  LDD0767  [9]
 LDCM0451  CL6 PaTu 8988t C611(0.67)  LDD1330  [9]
 LDCM0452  CL60 HCT 116 C611(0.79)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C611(0.95)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C611(0.84)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C611(0.85)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C611(0.96)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C611(0.94)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C611(0.98)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C611(1.03)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C611(1.05)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C611(0.94)  LDD0778  [9]
 LDCM0462  CL7 PaTu 8988t C611(0.94)  LDD1341  [9]
 LDCM0463  CL70 HCT 116 C611(0.97)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C611(0.93)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C611(0.91)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C611(0.98)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C611(1.01)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C611(1.07)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C611(0.98)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C611(0.85)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C611(1.00)  LDD0789  [9]
 LDCM0473  CL8 PaTu 8988t C611(0.64)  LDD1352  [9]
 LDCM0474  CL80 HCT 116 C611(1.02)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C611(0.88)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C611(0.91)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C611(1.10)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C611(1.14)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C611(1.14)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C611(0.92)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C611(1.03)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C611(1.09)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C611(1.09)  LDD0800  [9]
 LDCM0484  CL9 PaTu 8988t C611(0.89)  LDD1363  [9]
 LDCM0485  CL90 HCT 116 C611(0.87)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C611(0.96)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C611(0.84)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C611(0.92)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C611(1.04)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C611(0.99)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C611(0.97)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C611(1.16)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C611(1.10)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C611(1.14)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C611(0.93); C529(1.37); C554(0.78)  LDD1698  [15]
 LDCM0625  F8 Ramos C701(1.36); C611(0.49)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C701(1.19)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C701(0.71); C611(0.29)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C701(1.26)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C701(0.63)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C701(0.65); C611(0.74)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C701(0.82)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C701(0.82)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C701(0.80)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C701(0.59)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C701(1.32); C611(0.59)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C701(0.83)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C701(0.66)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C701(2.29)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C611(0.95)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C701(0.50)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C701(1.87); C611(0.57)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C611(1.21)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C701(0.64)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C701(0.74)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C701(1.35); C611(0.55)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C701(1.57)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y337(0.64); Y597(1.21)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y337(0.45); Y597(0.80)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y337(0.57); Y597(1.34)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y337(0.49); Y597(0.94)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y597(1.25); Y337(1.91)  LDD0268  [6]
 LDCM0022  KB02 HCT 116 C611(2.01)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C611(2.47)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C611(1.86)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C713(0.72)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase NLK (NLK) CMGC Ser/Thr protein kinase family Q9UBE8
Selenide, water dikinase 1 (SEPHS1) Selenophosphate synthase 1 family P49903
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor 1 X-type (NFIX) CTF/NF-I family Q14938
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Homeobox protein MOX-1 (MEOX1) . P50221
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
TOX high mobility group box family member 4 (TOX4) . O94842
Transcription factor LBX1 (LBX1) . P52954
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Piercer of microtubule wall 2 protein (PIERCE2) PIERCE2 family H3BRN8
Dynein axonemal assembly factor 6 (DNAAF6) PIH1 family Q9NQM4
Poly(U)-binding-splicing factor PUF60 (PUF60) RRM half pint family Q9UHX1
Selenoprotein V (SELENOV) SelWTH family P59797
Heat shock protein beta-8 (HSPB8) Small heat shock protein (HSP20) family Q9UJY1
Tektin-5 (TEKT5) Tektin family Q96M29
Zyxin (ZYX) Zyxin/ajuba family Q15942
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
Four and a half LIM domains protein 2 (FHL2) . Q14192
Four and a half LIM domains protein 3 (FHL3) . Q13643
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
LIM domain transcription factor LMO4 (LMO4) . P61968
Splicing factor 45 (RBM17) . Q96I25
Steroid receptor-associated and regulated protein (SRARP) . Q8NEQ6
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.