Details of the Target

General Information of Target

Target ID LDTP06480
Target Name Tubulin-specific chaperone C (TBCC)
Gene Name TBCC
Gene ID 6903
Synonyms
Tubulin-specific chaperone C; Tubulin-folding cofactor C; CFC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFF
VATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL
QAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP
SWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPV
STSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEID
KDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD
Target Bioclass
Other
Family
TBCC family
Subcellular location
Cytoplasm
Function Tubulin-folding protein; involved in the final step of the tubulin folding pathway.
Uniprot ID
Q15814
Ensemble ID
ENST00000372876.2
HGNC ID
HGNC:11580

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K140(5.82)  LDD0277  [2]
DBIA
 Probe Info  		C284(1.77); C184(1.25)  LDD0080  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
1d-yne
 Probe Info  		N.A.  LDD0356  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		C214(0.00); C184(0.00); C233(0.00); C6(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C184(1.21); C214(0.87)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C184(1.03)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C184(0.65)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C184(0.67)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C184(0.68)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C184(0.88)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C184(0.79)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C184(0.78)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C184(0.72)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C184(0.95)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C184(0.55)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C184(0.60)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C184(1.23)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C184(0.57)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C184(0.67)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C184(0.79)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C184(0.95)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C184(1.10)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C184(1.08)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C184(1.07)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C184(1.09)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C184(1.01)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C184(1.06)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C184(0.84)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C184(1.02)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C184(1.01)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C184(0.93)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C184(0.94)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C184(0.96)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C184(1.04)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C184(0.96)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C184(0.92)  LDD1124  [3]
 LDCM0246  AC128 HCT 116 C184(1.18)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C184(0.72)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C184(0.88)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C184(0.64)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C184(0.73)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C184(1.23)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C184(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C184(0.88)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C184(0.90)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C184(1.00)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C184(0.99)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C184(1.06)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C184(0.98)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C184(1.09)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C184(0.83)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C184(0.82)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C184(0.94); C214(1.03)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C184(0.88); C214(1.46)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C184(0.84); C214(1.44)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C184(0.98); C214(1.59)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C184(1.10); C214(1.40)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C214(1.14); C184(1.20)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C184(0.96); C214(1.20)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C184(0.94)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C184(0.90); C214(1.06)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C184(0.95); C214(1.13)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C184(0.94); C214(1.18)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C184(1.11); C214(1.16)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C184(0.98); C214(1.14)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C184(0.95); C214(1.31)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C184(0.89); C214(1.21)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C184(0.87); C214(1.38)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C214(0.84); C184(1.29)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C214(0.86); C184(1.18)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C214(1.02); C184(1.24)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C214(0.86); C184(1.05)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C214(0.84); C184(1.34)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C214(0.78); C184(1.20)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C214(0.68); C184(0.97)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C184(0.95); C214(1.07)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C214(0.76); C184(1.13)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C184(1.19)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C184(1.11)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C184(1.16)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C184(1.21)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C184(1.50)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C214(0.91); C184(1.05)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C184(1.06)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C184(0.91)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C184(0.92)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C184(1.19)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C184(1.16)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C214(0.68); C184(0.99)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C214(0.63); C184(1.01)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C214(0.93); C184(1.03)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C214(0.72); C184(1.12)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C214(0.68); C184(1.10)  LDD1179  [3]
 LDCM0301  AC4 HCT 116 C214(1.07); C184(1.13)  LDD0618  [3]
 LDCM0302  AC40 PaTu 8988t C214(0.66); C184(1.20)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C214(0.96); C184(1.06)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C214(0.91); C184(1.13)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C214(1.02); C184(1.23)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C214(0.96); C184(1.30)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C214(1.02); C184(1.12)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C214(0.92); C284(1.23); C184(1.04)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C214(0.85); C284(0.88); C184(1.15)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C214(0.93); C284(1.03); C184(1.38)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C214(1.02); C284(1.36); C184(1.25)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C214(0.95); C184(1.21)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C214(0.85); C284(1.00); C184(1.25)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C214(0.79); C284(0.85); C184(1.15)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C214(0.88); C284(1.11); C184(1.20)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C214(0.79); C284(0.91); C184(1.47)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C214(1.12); C284(0.82); C184(1.57)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C214(0.94); C284(0.89); C184(1.16)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C214(0.72); C284(1.41); C184(1.07)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C214(0.80)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C214(0.77)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C214(1.24)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C184(1.16)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C214(1.33)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C214(0.51)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C214(0.93)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C214(0.82)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C214(0.89)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C214(0.83)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C214(0.84)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C214(0.86)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C184(1.40)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C184(0.84)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C214(0.54)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C214(0.58)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C214(0.58)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C214(0.95)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C214(0.73)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C214(0.91)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C214(0.59)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C214(1.25)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C214(0.88)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C214(0.80)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C214(1.10)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C214(0.65)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C214(0.54)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C214(0.69)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C214(0.79)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C184(0.72)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C184(0.61)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C184(1.26)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C184(0.88)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C184(1.18)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C184(1.86); C184(1.40); C6(0.89); C214(0.79)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C214(0.83)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C214(0.87)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C214(0.88); C184(1.12)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C184(0.93)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C184(1.01)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C184(0.73)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C184(0.86)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C214(1.01); C184(1.15)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C214(0.90); C184(1.25)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C214(0.90); C184(1.43)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C214(1.02); C184(1.59)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C214(0.79); C184(1.36)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C214(0.92)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C214(0.90); C184(1.04)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C214(0.92); C184(1.11)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C184(1.48)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C184(1.05)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C184(1.52)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C184(1.20)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C184(1.56)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C214(1.15); C184(0.96)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C214(1.06); C184(0.98)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C214(0.87); C184(1.16)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C214(0.95)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C214(0.77); C184(1.10)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C214(0.85); C284(1.09); C184(1.15)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C214(0.78); C284(1.98); C184(1.06)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C214(0.84); C284(0.84); C184(1.21)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C214(0.85); C284(0.73); C184(1.22)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C214(1.32)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C214(0.71)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C214(0.85)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C214(0.77)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C214(1.01)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C214(0.83)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C214(0.89)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C284(0.75); C184(1.02)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C284(0.80); C184(1.04)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C284(0.83); C184(0.94)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C284(0.88); C184(1.36)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C214(0.72)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C284(0.79); C184(1.27)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C284(0.87); C184(1.49)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C284(0.80); C184(1.24)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C284(0.76); C184(1.28)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C284(0.79); C184(1.27)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C284(0.66); C184(1.41)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C284(0.79); C184(1.21)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C284(1.01); C184(1.47)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C284(0.76); C184(0.99)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C284(0.95); C184(1.22)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C214(0.76)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C284(0.71); C184(1.31)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C214(0.81)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C214(0.51)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C214(0.57)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C214(0.75)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C214(0.77)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C214(0.88)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C214(0.80)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C214(0.79)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C214(0.92)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C214(0.77)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C214(0.78)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C214(0.73)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C214(0.72)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C214(0.68)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C214(0.65)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C284(1.32)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C284(1.12)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C284(1.48)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C284(1.01)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C214(1.07)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C284(1.17)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C284(1.01)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C284(0.92)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C284(0.99)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C284(0.97)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C284(1.04)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C284(1.07)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C284(1.03)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C284(0.92)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C284(1.02)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C214(0.84)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C284(1.17)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C184(0.86)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C184(0.99)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C184(0.97)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C184(1.23)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C184(1.07)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C184(1.59)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C184(1.11)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C184(1.00)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C184(1.13)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C214(1.08)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C184(0.99)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C184(1.19)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C184(1.20)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C184(1.03)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C184(0.87)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C184(1.41)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C184(1.16)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C184(1.04)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C184(1.37)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C214(0.82)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C184(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C184(1.41)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C184(2.10)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C184(1.74)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C184(1.59)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C184(1.23)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C184(1.21)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C184(1.37)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C184(1.45)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C184(2.05)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C214(0.84)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C184(1.13)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C184(0.99); C214(0.90)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C184(1.15); C214(1.05)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C184(1.11); C214(1.29)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C184(1.33); C214(0.87)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C184(1.20); C214(1.02)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C184(1.05); C214(0.92)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C184(1.13); C214(0.87)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C184(1.19); C214(0.92)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C184(1.08); C214(0.97)  LDD0811  [3]
 LDCM0634  CY-0357 Hep-G2 C6(0.59)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C184(0.91); C214(0.92)  LDD1698  [13]
 LDCM0625  F8 Ramos C184(0.42)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C184(0.33)  LDD2190  [14]
 LDCM0576  Fragment14 Ramos C184(1.02)  LDD2193  [14]
 LDCM0586  Fragment28 Ramos C184(0.91)  LDD2198  [14]
 LDCM0468  Fragment33 HCT 116 C184(0.92)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C184(0.50)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C214(0.81)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C184(0.42)  LDD2186  [14]
 LDCM0022  KB02 HCT 116 C284(1.77); C184(1.25)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C284(1.74); C184(1.14)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C284(1.82); C184(1.39)  LDD0082  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C6(0.80)  LDD2206  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C6(1.24)  LDD2207  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.