Details of the Target

General Information of Target

Target ID LDTP06452
Target Name ETS-related transcription factor Elf-2 (ELF2)
Gene Name ELF2
Gene ID 1998
Synonyms
NERF; ETS-related transcription factor Elf-2; E74-like factor 2; New ETS-related factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSAVVDSGGTILELSSNGVENQEESEKVSEYPAVIVEPVPSARLEQGYAAQVLVYDDET
YMMQDVAEEQEVETENVETVEASVHSSNAHCTDKTIEAAEALLHMESPTCLRDSRSPVEV
FVPPCVSTPEFIHAAMRPDVITETVVEVSTEESEPMDTSPIPTSPDSHEPMKKKKVGRKP
KTQQSPISNGSPELGIKKKPREGKGNTTYLWEFLLDLLQDKNTCPRYIKWTQREKGIFKL
VDSKAVSKLWGKHKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKDMPKNIVVID
DDKSETCNEDLAGTTDEKSLERVSLSAESLLKAASSVRSGKNSSPINCSRAEKGVARVVN
ITSPGHDASSRSPTTTASVSATAAPRTVRVAMQVPVVMTSLGQKISTVAVQSVNAGAPLI
TSTSPTTATSPKVVIQTIPTVMPASTENGDKITMQPAKIITIPATQLAQCQLQTKSNLTG
SGSINIVGTPLAVRALTPVSIAHGTPVMRLSMPTQQASGQTPPRVISAVIKGPEVKSEAV
AKKQEHDVKTLQLVEEKPADGNKTVTHVVVVSAPSAIALPVTMKTEGLVTCEK
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.; Isoform 2 may function in repression of RUNX1-mediated transactivation.
Uniprot ID
Q15723
Ensemble ID
ENST00000358635.7
HGNC ID
HGNC:3317

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.44  LDD0403  [1]
BTD
 Probe Info  		C110(1.02)  LDD2137  [2]
DBIA
 Probe Info  		C348(2.28); C470(2.16)  LDD0080  [3]
IA-alkyne
 Probe Info  		C224(0.00); C110(0.00); C348(0.00)  LDD0165  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_5
 Probe Info  		C470(0.00); C591(0.00); C110(0.00)  LDD2224  [6]
TFBX
 Probe Info  		C348(0.00); C470(0.00)  LDD0027  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C110(0.00); C348(0.00); C470(0.00)  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C470(1.25); C110(0.95); C591(1.02); C307(1.26)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C348(1.10)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C348(1.40)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C348(0.76)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C348(1.22)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C348(1.19)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C348(1.52)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C348(1.20)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C348(1.53)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C348(1.35)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C348(1.38)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C348(1.67)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C348(1.03)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C348(1.34)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C348(1.34)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C348(1.04)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C348(1.20)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C348(1.42)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C348(1.38)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C348(0.67)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C348(0.72)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C348(1.14)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C348(1.06)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C348(1.11)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C348(0.83)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C348(1.27)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C348(0.61)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C348(1.02)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C348(0.72)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C348(0.97)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C348(1.07)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C348(1.48)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C348(1.08)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C348(1.09)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C348(1.01)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C348(1.29)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C348(0.64)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C348(0.71)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C348(0.66)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C470(0.90); C110(1.02); C591(0.96); C348(1.00)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C348(0.77)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C348(0.70)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C348(0.61)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C348(0.58)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C348(0.63)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C348(1.59)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C348(1.41)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C348(1.45)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C348(1.18)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C348(1.78)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C470(1.03); C110(1.00); C591(1.02); C348(1.07)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C348(1.13)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C348(1.35)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C348(1.33)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C348(1.57)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C348(1.15)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C470(1.07); C110(1.02); C591(1.05); C348(1.12)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C470(0.97); C110(1.09); C591(1.00); C348(1.00)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C470(0.90); C110(0.95); C591(0.97); C307(1.13)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C470(1.32); C110(0.97); C591(1.02); C348(1.02)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C110(0.98); C591(1.02); C348(1.14); C307(1.16)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C470(1.08); C110(0.97); C591(0.95); C348(1.04)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C110(1.04); C591(0.97); C348(1.18); C307(0.95)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C470(0.94); C110(0.96); C591(1.14); C307(1.49)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C470(0.88); C110(1.02); C591(1.10); C348(1.10)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C470(1.09); C110(0.98); C591(1.11); C348(1.14)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C470(1.00); C110(1.07); C591(1.08); C348(1.01)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C470(0.98); C110(0.98); C591(1.10); C307(1.24)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C470(1.53); C110(1.03); C591(1.07); C348(1.16)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C110(1.00); C591(1.05); C348(1.09); C307(1.28)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C110(0.95); C591(1.02); C348(1.20); C307(0.97)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C470(1.03); C110(1.04); C591(1.07); C307(1.43)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C470(0.94); C110(1.00); C591(1.01); C307(0.93)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C470(1.08); C110(1.00); C591(1.01); C348(1.10)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C470(1.03); C110(0.98); C591(1.01); C348(1.21)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C470(0.98); C110(1.04); C591(1.04); C348(1.08)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C470(0.94); C110(0.99); C591(1.02); C307(1.16)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C470(1.15); C110(0.96); C591(1.04); C348(1.07)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C110(0.92); C591(1.01); C348(1.00); C307(1.16)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C110(1.13); C591(1.03); C348(1.04); C307(0.96)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C470(1.14); C110(0.98); C591(1.04); C307(1.12)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C470(1.08); C110(0.98); C591(1.00); C348(1.03)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C470(1.08); C110(0.99); C591(0.98); C348(1.08)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C348(1.47)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C470(1.13); C110(0.99); C591(1.01); C348(0.98)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C470(1.04); C110(0.97); C591(0.94); C307(1.22)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C470(1.00); C110(1.07); C591(1.04); C348(0.97)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C110(1.01); C591(0.98); C348(1.06); C307(1.05)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C110(0.99); C591(0.99); C348(1.07); C307(0.93)  LDD1567  [11]
 LDCM0332  AC68 HEK-293T C470(0.90)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C470(0.83)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C348(1.69)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C470(0.80)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C470(0.85)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C470(0.87)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C470(0.61)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C470(0.83)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C470(0.68)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C470(0.85)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C470(0.81)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C470(0.85)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C470(0.81)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C348(1.31)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C470(0.93)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C470(0.94)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C470(0.86)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C348(2.03)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C348(1.70)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C348(1.71)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C348(1.84)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C348(1.55)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C348(2.03)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C348(2.04)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C348(2.41)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C348(1.53)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C348(1.63)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C348(2.02)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C348(1.38)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C348(2.33)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C348(1.26)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C348(1.54)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C348(1.62)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C348(1.09)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C348(2.04)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 14.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C348(1.12)  LDD2171  [3]
 LDCM0632  CL-Sc Hep-G2 C470(2.16)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C348(0.97)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C348(1.44)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C470(1.03); C110(0.94); C348(0.89); C307(1.32)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C348(1.31)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C348(1.24)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C348(1.14)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C348(1.09)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C348(0.68)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C348(0.59)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C348(0.69)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C348(0.59)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C348(0.85)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C348(1.18)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C348(0.65)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C348(0.58)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C348(1.11)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C348(1.11)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C348(1.47)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C348(1.63)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C348(1.21)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C470(1.08); C110(0.93); C591(0.99)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C470(1.14); C110(1.06); C591(1.03); C348(1.05)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C470(1.06); C110(1.01); C591(1.03); C307(1.10)  LDD1593  [11]
 LDCM0390  CL12 HCT 116 C348(1.23)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C470(1.02); C110(1.00); C348(0.99); C307(1.11)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C470(1.16); C110(0.94); C591(1.02)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C470(1.06); C110(0.94); C591(0.98); C348(1.15)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C470(0.99); C110(0.94); C591(0.93); C307(1.09)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C470(1.05); C110(0.92); C348(1.07); C307(1.48)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C470(0.93); C110(0.92); C591(1.10)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C470(1.07); C110(1.00); C591(0.95); C348(1.10)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C470(1.18); C110(0.98); C591(1.03); C307(1.12)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C470(1.07); C110(1.00); C348(1.02); C307(1.30)  LDD1603  [11]
 LDCM0400  CL13 HCT 116 C348(1.02)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C348(1.44)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C348(1.56)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C348(1.11)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C348(0.80)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C348(1.16)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C348(1.08)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C348(1.37)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C348(1.43)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C348(1.23)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C348(1.54)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C348(1.12)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C348(1.38)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C348(1.37)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C348(1.68)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C348(1.33)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C348(1.31)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C348(1.52)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C348(1.28)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C348(1.55)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C470(1.08); C110(1.03); C591(1.16); C348(1.16)  LDD1624  [11]
 LDCM0421  CL32 HCT 116 C348(0.89)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C348(1.53)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C348(1.30)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C348(2.82)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C348(1.06)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C348(1.22)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C348(1.24)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C348(1.16)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C348(1.05)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C348(1.28)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C348(1.28)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C348(1.35)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C348(1.17)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C348(1.38)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C470(1.14)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C470(1.02)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C470(0.93)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C470(1.04)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C348(1.21)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C470(0.86)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C470(0.99)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C470(1.08)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C470(1.08)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C470(1.00)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C470(1.03)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C470(0.97)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C470(1.19)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C470(1.10)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C470(0.93)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C348(1.69)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C470(0.93)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C470(1.11)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C470(0.77)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C470(0.96)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C470(1.11)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C470(0.89)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C470(0.73)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C470(0.80)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C470(0.61)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C470(0.86)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C348(1.23)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C470(0.90)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C470(0.69)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C470(0.94)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C470(0.83)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C470(0.55)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C348(0.87)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C348(1.03)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C348(1.22)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C348(1.44)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C348(1.46)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C348(0.95)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C348(0.86)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C348(1.12)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C348(0.78)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C348(0.95)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C348(0.77)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C348(1.00)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C348(0.93)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C348(0.75)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C348(1.12)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C348(1.17)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C348(1.12)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C470(1.24); C110(0.96); C591(1.03); C348(1.05)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C470(1.04); C110(1.01); C591(0.99); C348(0.99)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C470(0.99); C110(0.90); C591(0.93); C307(1.03)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C470(1.19); C110(1.03); C591(1.02); C348(1.05)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C110(1.00); C591(0.90); C348(0.92); C307(0.96)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C110(1.00); C591(0.87); C348(1.13); C307(1.02)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C470(1.11); C110(0.93); C591(1.01)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C470(1.04); C110(0.97); C591(0.94); C348(0.97)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C470(1.11); C110(0.95); C591(0.93); C307(1.18)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C470(0.95); C110(0.98); C591(1.01); C307(1.24)  LDD1698  [11]
 LDCM0625  F8 Ramos C470(1.00)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C470(0.57)  LDD2189  [12]
 LDCM0574  Fragment12 Ramos C470(0.79)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C470(0.84)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C470(1.59)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C470(0.53)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C470(0.76)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C470(0.96)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C470(0.67)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C470(0.21)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C470(0.68)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C470(0.91)  LDD2200  [12]
 LDCM0468  Fragment33 HEK-293T C470(0.88)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C470(0.74)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C470(0.84)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C348(0.99)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C470(0.67)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C470(0.41)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C470(1.82)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C470(0.66)  LDD2188  [12]
 LDCM0022  KB02 HCT 116 C348(2.28); C470(2.16)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C348(1.64); C470(1.57)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C348(2.11); C470(1.70)  LDD0082  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C110(1.02)  LDD2137  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C470(0.43)  LDD2207  [13]
 LDCM0021  THZ1 HCT 116 C348(1.12)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Runt-related transcription factor 1 (RUNX1) . Q01196

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.