Details of the Target

General Information of Target

Target ID LDTP05120
Target Name Melanoma antigen preferentially expressed in tumors (PRAME)
Gene Name PRAME
Gene ID 23532
Synonyms
MAPE; OIP4; Melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4; OIP-4; Preferentially expressed antigen of melanoma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAA
FDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQ
VLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVD
LFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEV
TCTWKLPTLAKFSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQA
LYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVM
LTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISI
SALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMV
WLSANPCPHCGDRTFYDPEPILCPCFMPN
Target Type
Clinical trial
Target Bioclass
Other
Family
PRAME family
Subcellular location
Nucleus
Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
TTD ID
T03189
Uniprot ID
P78395
DrugMap ID
TTPH7T0
Ensemble ID
ENST00000398741.5
HGNC ID
HGNC:9336

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C188(1.63)  LDD2157  [1]
m-APA
 Probe Info  		10.51  LDD0403  [2]
DBIA
 Probe Info  		C487(1.71); C490(1.71)  LDD0533  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
Lodoacetamide azide
 Probe Info  		C188(0.00); C80(0.00)  LDD0037  [4]
IPM
 Probe Info  		C188(0.00); C332(0.00)  LDD2156  [5]
AOyne
 Probe Info  		14.40  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C487(0.82)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C487(1.01); C490(1.01)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C487(1.71); C490(1.71)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C487(1.25); C490(1.25)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C487(1.18); C490(1.18)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C487(2.38); C490(2.38)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C487(1.06); C490(1.06)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C487(1.38); C490(1.38)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C487(2.35); C490(2.35)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C487(1.29); C490(1.29)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C487(1.75); C490(1.75)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C487(1.27); C490(1.27)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C487(0.88); C490(0.88)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C487(1.54); C490(1.54)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C487(1.85); C490(1.85)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C487(1.61); C490(1.61)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C487(0.69); C490(0.69)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C487(0.94); C490(0.98)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C487(0.94); C490(0.88)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C487(0.86); C490(1.07)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C487(0.86); C490(1.03)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C487(0.89); C490(0.98)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C487(0.79); C490(0.82)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C487(1.29); C490(1.29)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C487(1.01); C490(0.90)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C487(0.96); C490(1.04)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C487(1.02); C490(1.24)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C487(0.96); C490(1.10)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C487(0.90); C490(1.32)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C487(0.95); C490(1.21)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C487(1.09); C490(1.21)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C487(0.97); C490(1.14)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C487(1.54); C490(1.54)  LDD0857  [3]
 LDCM0263  AC143 HCT 116 C487(0.90); C490(0.90)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C487(0.60); C490(0.60)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C487(0.55); C490(0.55)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C487(0.77); C490(0.77)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C487(0.70); C490(0.70)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C487(0.58); C490(0.58)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C487(0.70); C490(0.70)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C487(1.20); C490(1.20)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C487(0.65); C490(0.65)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C487(3.82); C490(3.82)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C487(0.68); C490(0.68)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C487(0.60); C490(0.60)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C487(0.59); C490(0.59)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C487(1.35); C490(1.35)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C487(0.84); C490(0.84)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C487(0.52); C490(0.52)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C487(0.88); C490(0.88)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C487(0.83); C490(0.83)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C487(1.00); C490(1.00)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C487(0.86)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C487(1.25); C490(1.25)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C487(1.12); C490(1.12)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C487(1.38); C490(1.38)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C487(0.89); C490(0.89)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C487(1.11); C490(1.11)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C487(0.89); C490(0.89)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C487(1.13); C490(1.13)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C487(1.13); C490(1.13)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C487(2.23); C490(2.23)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C487(1.43); C490(1.43)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C487(1.06)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C487(1.59); C490(1.59)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C487(1.35); C490(1.35)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C487(1.25); C490(1.25)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C487(1.18); C490(1.18)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C487(1.58); C490(1.58)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C487(1.07); C490(1.07)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C487(0.70); C490(0.70)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C487(1.09); C490(1.09)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C487(1.17); C490(1.17)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C487(1.17); C490(1.17)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C487(1.05)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C487(0.82); C490(0.82)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C487(0.95); C490(0.95)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C487(0.87); C490(0.87)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C487(1.10); C490(1.10)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C487(0.96); C490(0.96)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C487(0.95); C490(0.95)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C487(0.90); C490(0.84)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C487(0.89); C490(0.89)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C487(0.90); C490(0.95)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C487(0.90); C490(1.08)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C487(0.91)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C487(0.88); C490(0.92)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C487(0.99); C490(1.05)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C487(0.83); C490(1.00)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C487(0.79); C490(0.85)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C487(0.83); C490(0.97)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C487(0.87); C490(0.95)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C487(0.93); C490(1.00)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C487(1.00); C490(1.00)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C487(1.14); C490(1.14)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C487(1.16); C490(1.16)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C487(1.02); C490(1.02)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C487(1.42); C490(1.42)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C487(1.12); C490(1.12)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C487(1.42); C490(1.42)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C487(1.15); C490(1.15)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C487(1.27); C490(1.27)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C487(1.36); C490(1.36)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C487(1.10); C490(1.10)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C487(1.12); C490(1.12)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C487(0.87); C490(0.87)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C487(0.96); C490(0.96)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C487(0.76); C490(0.76)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C487(1.16); C490(1.16)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C487(0.96); C490(0.96)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C487(1.18); C490(1.18)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C487(1.16); C490(1.16)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C487(1.33); C490(1.33)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C487(1.10); C490(1.10)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C487(0.84); C490(0.84)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C487(1.03); C490(1.03)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C487(1.01); C490(1.01)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C487(1.12); C490(1.12)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C487(1.17); C490(1.17)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C487(0.74); C490(0.74)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C487(1.07); C490(1.07)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C487(0.86); C490(0.86)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C487(2.03); C490(2.03)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C487(1.57); C490(1.57)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C487(0.84); C490(0.84)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C487(1.17); C490(1.17)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C487(1.69); C490(1.69)  LDD0873  [3]
 LDCM0156  Aniline NCI-H1299 10.51  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C487(1.23); C490(1.23)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C487(0.92); C490(0.92)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C487(0.86)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C487(0.91); C490(0.91)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C487(1.03); C490(1.03)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C487(0.71); C490(0.71)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C487(0.61); C490(0.61)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C487(1.12); C490(1.12)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C487(0.82); C490(0.82)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C487(0.90); C490(0.90)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C487(1.09); C490(1.09)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C487(1.09); C490(1.09)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C487(0.82); C490(0.82)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C487(0.89); C490(0.89)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C487(0.93); C490(0.93)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C487(1.11); C490(1.11)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C487(1.91); C490(1.91)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C487(2.01); C490(2.01)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C487(1.62); C490(1.62)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C487(1.67); C490(1.67)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C487(1.08); C490(1.08)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C487(0.76); C490(0.76)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C487(1.07); C490(1.07)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C487(0.88); C490(0.88)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C487(1.22); C490(1.22)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C487(0.85); C490(0.86)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C487(0.87); C490(1.02)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C487(0.96); C490(0.98)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C487(0.84); C490(0.92)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C487(1.21); C490(1.21)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C487(2.23); C490(2.23)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C487(1.21); C490(1.21)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C487(1.11); C490(1.11)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C487(0.67); C490(0.67)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C487(0.84); C490(0.84)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C487(1.23); C490(1.23)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C487(1.09); C490(1.09)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C487(1.23); C490(1.23)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C487(1.05); C490(1.05)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C487(0.97); C490(0.97)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C487(1.01); C490(1.01)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C487(1.20); C490(1.20)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C487(1.51); C490(1.51)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C487(1.23); C490(1.23)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C487(0.83); C490(0.83)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C487(0.80); C490(0.80)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C487(1.01); C490(1.01)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C487(0.82); C490(0.82)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C487(1.01); C490(1.01)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C487(1.26); C490(1.26)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C487(1.14); C490(1.14)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C487(0.98); C490(0.98)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C487(1.11); C490(1.11)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C487(0.92); C490(0.92)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C487(1.18); C490(1.18)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C487(1.46); C490(1.46)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C487(1.39); C490(1.39)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C487(0.97); C490(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C487(1.63); C490(1.63)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C487(1.09); C490(1.09)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C487(0.99); C490(0.99)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C487(0.98); C490(0.98)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C487(1.25); C490(1.25)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C487(1.44); C490(1.44)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C487(1.12); C490(1.12)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C487(1.04); C490(1.04)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C487(1.04); C490(1.04)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C487(0.81); C490(0.81)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C487(1.22); C490(1.22)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C487(0.90); C490(0.90)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C487(1.85); C490(1.85)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C487(1.21); C490(1.21)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C487(0.85); C490(0.85)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C487(1.05); C490(1.05)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C487(1.52); C490(1.52)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C487(1.15); C490(1.15)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C487(2.16); C490(2.16)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C487(1.29); C490(1.29)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C487(1.43); C490(1.43)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C487(1.19); C490(1.19)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C487(1.38); C490(1.38)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C487(1.32); C490(1.32)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C487(1.07); C490(1.07)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C487(1.12); C490(1.12)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C487(1.32); C490(1.32)  LDD1050  [3]
 LDCM0456  CL64 HEK-293T C188(0.94)  LDD1659  [7]
 LDCM0459  CL67 HEK-293T C332(1.16)  LDD1662  [7]
 LDCM0461  CL69 HEK-293T C188(1.11)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C487(0.91); C490(0.91)  LDD1060  [3]
 LDCM0464  CL71 HEK-293T C188(1.19)  LDD1667  [7]
 LDCM0469  CL76 HCT 116 C487(1.05); C490(1.05)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C487(1.29); C490(1.29)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C487(1.00); C490(1.00)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C487(1.25); C490(1.25)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C490(1.00)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C487(0.84); C490(0.84)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C487(1.01); C490(1.01)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C487(1.03); C490(1.03)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C487(0.94); C490(0.94)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C487(1.20); C490(1.20)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C487(1.43); C490(1.43)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C487(0.87); C490(0.87)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C487(0.84); C490(0.84)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C487(0.88); C490(0.88)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C487(1.13); C490(1.13)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C490(1.02)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C487(1.65); C490(1.65)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C487(1.07)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C487(0.99)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C487(0.98)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C487(0.80)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C487(0.87)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C487(0.90)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C487(0.86)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C487(0.93)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C487(1.02)  LDD1092  [3]
 LDCM0427  Fragment51 HCT 116 C487(0.97); C490(0.97)  LDD0744  [3]
 LDCM0022  KB02 A101D C80(1.52)  LDD2250  [8]
 LDCM0023  KB03 A101D C80(3.88)  LDD2667  [8]
 LDCM0024  KB05 MKN45 C80(5.31)  LDD3332  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Imc-f106c Recombinant protein D0X8TK
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ima 203 Cell therapy D0V6MX

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840