Details of the Target

General Information of Target

Target ID LDTP03120
Target Name 5'-nucleotidase (NT5E)
Gene Name NT5E
Gene ID 4907
Synonyms
NT5; NTE; 5'-nucleotidase; 5'-NT; EC 3.1.3.35; EC 3.1.3.5; EC 3.1.3.89; EC 3.1.3.91; EC 3.1.3.99; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase; CD antigen CD73
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGG
VARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEF
DNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKE
TPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVV
GGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNV
ISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNM
GNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGT
FDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCR
VPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYP
AVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
5'-nucleotidase family
Subcellular location
Cell membrane
Function
Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.
TTD ID
T65116
Uniprot ID
P21589
DrugMap ID
TTK0O6Y
Ensemble ID
ENST00000257770.8
HGNC ID
HGNC:8021
ChEMBL ID
CHEMBL5957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.W21C .
NCIH1944 SNV: p.V458E .
SHP77 SNV: p.N190H .
TOV21G SNV: p.Y263H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K67(1.06)  LDD0274  [1]
STPyne
 Probe Info  		K147(8.17); K262(7.69); K274(3.96); K471(0.46)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K326(1.17); K478(1.17); K536(1.24); K471(1.60)  LDD3494  [2]
m-APA
 Probe Info  		11.49  LDD0403  [3]
BTD
 Probe Info  		C476(2.19)  LDD1700  [4]
IPM
 Probe Info  		C57(2.36); C476(0.96)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C353(0.96)  LDD0531  [6]
IA-alkyne
 Probe Info  		C479(0.00); C476(0.00); C358(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C57(0.60); C353(0.53)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C57(1.03); C476(0.51)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C476(0.89)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C353(1.32); C476(1.51)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C57(0.47)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C57(0.88)  LDD2131  [4]
 LDCM0214  AC1 HCT 116 C353(0.96)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C353(1.04)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C353(1.27)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C353(1.24)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C353(1.03)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C353(1.14)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C353(0.99)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C353(1.27)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C353(0.95)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C353(1.23)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C353(1.14)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C353(0.97)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C353(1.00)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C353(1.04)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C353(0.98)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C353(1.03)  LDD0546  [6]
 LDCM0230  AC113 PaTu 8988t C358(1.10); C365(1.10)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C358(1.24); C365(1.24)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C358(1.24); C365(1.24)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C358(1.06); C365(1.06)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C358(1.33); C365(1.33)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C358(1.07); C365(1.07)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C358(1.19); C365(1.19)  LDD1115  [6]
 LDCM0237  AC12 HCT 116 C353(1.01)  LDD0554  [6]
 LDCM0238  AC120 PaTu 8988t C358(1.24); C365(1.24)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C358(1.01); C365(1.01)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C358(0.97); C365(0.97)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C358(1.05); C365(1.05)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C358(0.99); C365(0.99)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C358(1.19); C365(1.19)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C358(1.04); C365(1.04)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C358(1.34); C365(1.34)  LDD1124  [6]
 LDCM0246  AC128 HCT 116 C358(0.95); C365(0.95)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C358(0.70); C365(0.70)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C358(0.83); C365(0.83)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C358(1.02); C365(1.02)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C358(1.16); C365(1.16)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C358(0.83); C365(0.83)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C358(1.24); C365(1.24)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C358(1.43); C365(1.43)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C358(1.02); C365(1.02)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C358(1.09); C365(1.09)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C358(1.40); C365(1.40)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C358(1.48); C365(1.48)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C353(0.99)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C358(1.32); C365(1.32)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C358(1.16); C365(1.16)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C358(1.32); C365(1.32)  LDD0579  [6]
 LDCM0263  AC143 PaTu 8988t C353(1.13); C358(1.24); C365(1.24)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C353(1.26); C358(1.44); C365(1.44)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C353(0.97); C358(1.19); C365(1.19)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C353(1.04); C358(1.24); C365(1.24)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C353(1.09); C358(1.03); C365(1.03)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C353(1.17); C358(1.53); C365(1.53)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C353(1.14); C358(1.32); C365(1.32)  LDD1148  [6]
 LDCM0270  AC15 HCT 116 C353(0.94)  LDD0587  [6]
 LDCM0271  AC150 PaTu 8988t C353(1.07); C358(1.18); C365(1.18)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C353(1.19); C358(1.22); C365(1.22)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C353(1.00); C358(1.28); C365(1.28)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C353(1.14); C358(1.27); C365(1.27)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C353(1.22); C358(1.24); C365(1.24)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C353(1.12); C358(1.22); C365(1.22)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C353(1.16); C358(1.29); C365(1.29)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C353(1.28); C358(1.11); C365(1.11)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C353(0.88); C358(1.37); C365(1.37)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C353(0.95); C358(1.09); C365(1.09)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C353(0.83); C358(1.20); C365(1.20)  LDD1157  [6]
 LDCM0279  AC2 HCT 116 C353(0.91)  LDD0596  [6]
 LDCM0280  AC20 PaTu 8988t C353(0.89); C358(1.27); C365(1.27)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C353(0.81); C358(1.04); C365(1.04)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C353(0.96); C358(1.23); C365(1.23)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C353(0.96); C358(1.41); C365(1.41)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C353(1.22); C358(1.30); C365(1.30)  LDD1163  [6]
 LDCM0285  AC25 PaTu 8988t C353(1.03); C358(0.97); C365(0.97)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C353(1.40); C358(0.85); C365(0.85)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C353(1.18); C358(0.93); C365(0.93)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C353(1.19); C358(0.93); C365(0.93)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C353(1.13); C358(1.05); C365(1.05)  LDD1168  [6]
 LDCM0290  AC3 HCT 116 C353(1.04)  LDD0607  [6]
 LDCM0291  AC30 PaTu 8988t C353(1.15); C358(0.84); C365(0.84)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C353(1.07); C358(0.94); C365(0.94)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C353(1.22); C358(1.09); C365(1.09)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C353(1.36); C358(0.94); C365(0.94)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C353(1.35); C358(0.83); C365(0.83)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C353(1.18); C358(1.25); C365(1.25)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C353(1.43); C358(1.30); C365(1.30)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C353(1.21); C358(1.15); C365(1.15)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C353(1.32); C358(1.24); C365(1.24)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C353(1.49); C358(1.53); C365(1.53)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C353(1.03)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C353(1.56); C358(1.55); C365(1.55)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C353(1.35); C358(1.27); C365(1.27)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C353(1.41); C358(1.34); C365(1.34)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C353(1.26); C358(1.34); C365(1.34)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C353(1.16); C358(1.26); C365(1.26)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C353(1.34); C358(1.33); C365(1.33)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C353(1.04)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C353(1.10)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C353(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C353(0.62)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C353(1.02)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C353(0.90)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C353(0.73)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C353(0.88)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C353(1.19)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C353(1.20)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C353(1.05)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C353(0.67)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C358(0.81); C365(0.81)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C358(0.77); C365(0.77)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C358(0.86); C365(0.86)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C353(1.04)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C358(0.92); C365(0.92)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C358(1.06); C365(1.06)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C358(0.88); C365(0.88)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C358(0.88); C365(0.88)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C358(0.93); C365(0.93)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C358(0.86); C365(0.86)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C358(0.91); C365(0.91)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C358(0.84); C365(0.84)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C358(1.37); C365(1.37)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C358(1.06); C365(1.06)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C353(1.18)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C358(1.33); C365(1.33)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C358(1.66); C365(1.66)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C358(1.22); C365(1.22)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C358(1.21); C365(1.21)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C358(0.99); C365(0.99)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C358(1.03); C365(1.03)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C358(1.57); C365(1.57)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C358(1.08); C365(1.08)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C358(1.39); C365(1.39)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C358(1.24); C365(1.24)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C353(1.00)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C358(1.01); C365(1.01)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C358(1.12); C365(1.12)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C358(1.01); C365(1.01)  LDD0665  [6]
 LDCM0349  AC83 PaTu 8988t C353(1.06); C358(1.06); C365(1.06)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C353(1.25); C358(1.04); C365(1.04)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C353(1.09); C358(1.22); C365(1.22)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C353(1.08); C358(1.02); C365(1.02)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C353(1.08); C358(1.13); C365(1.13)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C353(1.21); C358(1.16); C365(1.16)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C353(1.05); C358(1.07); C365(1.07)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C353(1.07); C358(1.12); C365(1.12)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C353(1.10); C358(1.08); C365(1.08)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C353(1.11); C358(1.14); C365(1.14)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C353(1.23); C358(1.00); C365(1.00)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C353(0.95); C358(0.96); C365(0.96)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C353(1.07); C358(1.01); C365(1.01)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C353(1.05); C358(1.09); C365(1.09)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C353(0.96); C358(1.07); C365(1.07)  LDD1243  [6]
 LDCM0365  AC98 HCT 116 C353(1.40)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C353(1.34)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C476(1.02)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C353(1.02); C476(0.88)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C353(1.07)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C353(1.08)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C353(1.09)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.49  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C358(1.12); C365(1.12)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C358(1.45); C365(1.45)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C353(0.95)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C353(0.99)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C353(1.17)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C353(1.09)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C353(0.97)  LDD0690  [6]
 LDCM0374  CL105 PaTu 8988t C353(0.96); C358(1.36); C365(1.36)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C353(0.82); C358(1.44); C365(1.44)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C353(0.79); C358(1.16); C365(1.16)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C353(0.93); C358(1.51); C365(1.51)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C353(0.77); C358(1.20); C365(1.20)  LDD1257  [6]
 LDCM0379  CL11 HCT 116 C358(1.16); C365(1.16)  LDD0696  [6]
 LDCM0380  CL110 PaTu 8988t C353(0.82); C358(1.30); C365(1.30)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C353(1.05); C358(1.16); C365(1.16)  LDD1260  [6]
 LDCM0382  CL112 PaTu 8988t C353(1.45); C358(1.06); C365(1.06)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C353(1.32); C358(0.90); C365(0.90)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C353(1.50); C358(1.10); C365(1.10)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C353(0.77); C358(1.11); C365(1.11)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C353(1.27); C358(0.94); C365(0.94)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C353(1.13); C358(1.48); C365(1.48)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C353(1.35); C358(1.30); C365(1.30)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C353(1.45); C358(1.33); C365(1.33)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C358(1.37); C365(1.37)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C353(1.16); C358(1.21); C365(1.21)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C353(1.01)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C353(0.81)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C353(1.01)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C353(0.89)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C358(0.98); C365(0.98)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C358(0.95); C365(0.95)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C358(1.12); C365(1.12)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C358(1.08); C365(1.08)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C358(1.28); C365(1.28)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C358(1.51); C365(1.51)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C358(1.13); C365(1.13)  LDD0719  [6]
 LDCM0403  CL16 PaTu 8988t C353(1.12); C358(1.35); C365(1.35)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C353(0.84); C358(0.92); C365(0.92)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C353(1.03); C358(1.01); C365(1.01)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C353(0.82); C358(1.10); C365(1.10)  LDD1285  [6]
 LDCM0407  CL2 HCT 116 C358(1.12); C365(1.12)  LDD0724  [6]
 LDCM0408  CL20 PaTu 8988t C353(0.79); C358(1.00); C365(1.00)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C353(1.33); C358(0.97); C365(0.97)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C353(1.10); C358(1.14); C365(1.14)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C353(0.76); C358(0.97); C365(0.97)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C353(0.83); C358(1.12); C365(1.12)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C353(1.13); C358(1.17); C365(1.17)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C353(0.76); C358(0.92); C365(0.92)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C353(0.80); C358(1.12); C365(1.12)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C353(0.96); C358(0.90); C365(0.90)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C353(0.93); C358(0.76); C365(0.76)  LDD1296  [6]
 LDCM0418  CL3 HCT 116 C358(1.39); C365(1.39)  LDD0735  [6]
 LDCM0419  CL30 PaTu 8988t C353(1.10); C358(1.13); C365(1.13)  LDD1298  [6]
 LDCM0420  CL31 HCT 116 C353(1.47)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C353(0.94)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C353(1.10)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C353(0.97)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C353(0.92)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C353(0.89)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C353(0.64)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C353(0.63)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C358(1.24); C365(1.24)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C353(0.64)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C353(1.08)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C353(0.78)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C353(0.63)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C353(0.80)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C353(1.07)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C353(1.04)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C353(0.92)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C353(1.10)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C353(1.17)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C358(1.09); C365(1.09)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C353(1.02)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C353(1.18)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C353(1.25)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C353(1.00)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C353(1.23)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C353(0.88)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C353(0.90)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C353(1.07)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C353(1.13)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C353(1.12)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C358(1.26); C365(1.26)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C353(1.23)  LDD0769  [6]
 LDCM0453  CL61 PaTu 8988t C353(1.05)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C353(1.05)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C353(1.07)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C353(1.03)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C353(1.01)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C353(1.03)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C353(1.02)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C353(0.97)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C353(0.99)  LDD1340  [6]
 LDCM0462  CL7 HCT 116 C358(1.25); C365(1.25)  LDD0779  [6]
 LDCM0463  CL70 PaTu 8988t C353(0.98)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C353(0.91)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C353(1.09)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C353(1.34)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C353(1.16)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C353(1.26); C358(1.53); C365(1.53)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C353(1.02); C358(1.50); C365(1.50)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C353(1.12); C358(1.43); C365(1.43)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C353(1.10); C358(1.73); C365(1.73)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C358(1.18); C365(1.18)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C353(1.67); C358(1.82); C365(1.82)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C353(1.33); C358(1.56); C365(1.56)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C353(1.34); C358(1.86); C365(1.86)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C353(1.14); C358(1.86); C365(1.86)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C353(1.13); C358(1.84); C365(1.84)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C353(1.15); C358(1.42); C365(1.42)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C353(1.27); C358(1.42); C365(1.42)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C353(1.30); C358(1.84); C365(1.84)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C353(1.09); C358(1.92); C365(1.92)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C353(1.00); C358(1.38); C365(1.38)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C358(1.30); C365(1.30)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C353(1.12); C358(1.66); C365(1.66)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C353(0.79)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C353(0.79)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C353(0.91)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C353(0.83)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C353(0.66)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C353(0.86)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C353(0.72)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C353(1.12)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C353(1.00)  LDD0811  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C353(1.70); C476(0.80)  LDD1702  [4]
 LDCM0468  Fragment33 PaTu 8988t C353(0.89)  LDD1347  [6]
 LDCM0427  Fragment51 HCT 116 C353(0.41)  LDD0744  [6]
 LDCM0022  KB02 8305C C57(1.24)  LDD2248  [10]
 LDCM0023  KB03 MDA-MB-231 C57(2.36); C476(0.96)  LDD1701  [4]
 LDCM0024  KB05 HMCB C479(2.53); C353(2.02)  LDD3312  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C353(0.75)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C476(0.96)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C476(1.05)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C476(0.97)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C57(1.37)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C57(0.26)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C57(0.30)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C57(0.29)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C353(0.88); C476(0.93)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C57(0.45); C476(0.93)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C476(0.99)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C353(1.15); C476(1.03)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C476(0.93)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C476(2.53)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C476(1.02)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C57(1.06); C476(0.86)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C353(0.94)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C57(0.92); C476(1.03)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C476(1.01)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C476(0.59)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C476(1.10)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C476(1.06)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C353(1.11); C476(0.88)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C476(2.19)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C476(0.74)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C476(0.99)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C353(2.14); C476(2.62)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C57(0.29)  LDD2145  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C476(0.53)  LDD2148  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase ZNRF4 (ZNRF4) . Q8WWF5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytarabine Small molecular drug DB00987
Pentoxifylline Small molecular drug DB00806
Phase 1
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cpi-006 Antibody DKL13E
Gs-1423 Antibody DG6V7E
Nzv930 Antibody DP6GC3
Tj4309 Antibody D9IQ6N
Ab680 Small molecular drug D7CE6N
Ly3475070 . DN65GW
Oleclumab . D02GRR
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acid Blue 25 Small molecular drug D08DXA
Alphabeta-methyleneadp Small molecular drug D0O9GJ
Psb-0952 Small molecular drug D0DZ1K
Psb-0963 Small molecular drug D06GQY
Rb 2 Small molecular drug D0B0ZQ
Patented
Click To Hide/Show 34 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid28870136-compound-36 Small molecular drug D03VLV
Pmid28870136-compound-37 Small molecular drug D0X1MK
Pmid28870136-compound-38 Small molecular drug D02DLG
Pmid28870136-compound-39 Small molecular drug D0SK3R
Pmid28870136-compound-40 Small molecular drug D0AF4A
Pmid28870136-compound-41 Small molecular drug D0QL7B
Pmid28870136-compound-42 Small molecular drug D0C2UP
Pmid28870136-compound-43 Small molecular drug D0C7ON
Pmid28870136-compound-44 Small molecular drug D0CH7Z
Pmid28870136-compound-45 Small molecular drug D01OIQ
Pmid28870136-compound-46 Small molecular drug D01ADE
Pmid28870136-compound-47 Small molecular drug D0FK2Q
Pmid28870136-compound-48 Small molecular drug D0DF2M
Pmid28870136-compound-49 Small molecular drug D03XTA
Pmid28870136-compound-50 Small molecular drug D09QNH
Pmid28870136-compound-51 Small molecular drug D06YAB
Pmid28870136-compound-52 Small molecular drug D0H9IX
Pmid28870136-compound-53 Small molecular drug D01NBW
Pmid28870136-compound-54 Small molecular drug D0V5NK
Pmid28870136-compound-55 Small molecular drug D07DGB
Pmid28870136-compound-56 Small molecular drug D0U2YE
Pmid28870136-compound-57 Small molecular drug D00BQR
Pmid28870136-compound-58 Small molecular drug D0V7OE
Pmid28870136-compound-59 Small molecular drug D09XUJ
Pmid28870136-compound-60 Small molecular drug D0MA9U
Pmid28870136-compound-61 Small molecular drug D04GYR
Pmid28870136-compound-62 Small molecular drug D0Y2QO
Pmid28870136-compound-63 Small molecular drug D0Y9TP
Pmid28870136-compound-64 Small molecular drug D0LB7I
Pmid28870136-compound-65 Small molecular drug D0JF6W
Pmid28870136-compound-67 Small molecular drug D08ZDR
Pmid28870136-compound-68 Small molecular drug D04TGG
Pmid28870136-compound-69 Small molecular drug D08LPX
Pmid29166791-compound-ampcp Small molecular drug D0KS3G

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840