Details of the Target

General Information of Target

Target ID LDTP02840
Target Name SH2/SH3 adapter protein NCK1 (NCK1)
Gene Name NCK1
Gene ID 4690
Synonyms
NCK; SH2/SH3 adapter protein NCK1; Cytoplasmic protein NCK1; NCK adapter protein 1; Nck-1; SH2/SH3 adapter protein NCK-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKN
SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAE
REDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSEKLA
AVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVG
LVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERG
HEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAP
IFTSEQGEKLYLVKHLS
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
TTD ID
T70532
Uniprot ID
P16333
DrugMap ID
TTMA3VF
Ensemble ID
ENST00000288986.6
HGNC ID
HGNC:7664
ChEMBL ID
CHEMBL4846

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.D141N DBIA    Probe Info 
COLO792 SNV: p.P167L .
HT115 SNV: p.F50S DBIA    Probe Info 
NCIH2172 SNV: p.L179F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K72(8.06)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C266(2.50)  LDD0171  [3]
HHS-475
 Probe Info  		Y246(0.92); Y55(0.95)  LDD0264  [4]
HHS-465
 Probe Info  		Y55(2.79)  LDD2237  [5]
DBIA
 Probe Info  		C266(1.20)  LDD0078  [6]
ATP probe
 Probe Info  		K79(0.00); K81(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C139(0.00); C266(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C266(0.00); C340(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C139(0.00); C266(0.00)  LDD0037  [8]
1d-yne
 Probe Info  		N.A.  LDD0356  [9]
IPM
 Probe Info  		C340(0.00); C266(0.00)  LDD0147  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
AOyne
 Probe Info  		12.80  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C266(2.55)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C266(2.50)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C266(1.07)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C266(1.14)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C266(0.94)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C266(1.20)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C266(1.06)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C266(1.28)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C266(0.99)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C266(0.94)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C266(1.10)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C266(1.10)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C266(1.07)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C266(1.13)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C266(1.19)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C266(1.11)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C266(1.24)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C266(1.10)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C266(1.36)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C266(1.12)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C266(1.21)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C266(1.46)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C266(1.10)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C266(1.13)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C266(1.12)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C266(1.06)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C266(1.15)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C266(0.95)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C266(1.01)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C266(1.00)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C266(1.10)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C266(1.14)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C266(1.09)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C266(1.11)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C266(1.38)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C266(0.99)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C266(1.23)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C266(1.05)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C266(1.03)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C266(1.47)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C266(1.33)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C266(1.29)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C266(1.07)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C266(1.02)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C266(1.29)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C266(1.09)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C266(1.17)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C266(1.42)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C266(1.22)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C266(0.92)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C266(1.13)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C266(1.27)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C266(1.20)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C266(1.30)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C266(1.18)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C266(1.52)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C266(1.51)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C266(1.20)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C266(1.22)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C266(1.29)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C266(1.26)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C266(1.92)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C266(1.56)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C266(1.24)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C266(1.17)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C266(1.14)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C266(1.10)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C266(1.60)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C266(1.30)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C266(1.06)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C266(1.11)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C266(1.06)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C266(1.10)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C266(1.01)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C266(1.13)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C266(1.05)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C266(1.19)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C266(1.23)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C266(1.14)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C266(1.09)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C266(0.95)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C266(1.31)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C266(1.23)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C266(1.55)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C266(1.33)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C266(1.50)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C266(0.90)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C266(0.96)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C266(0.98)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C266(0.97)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C266(0.95)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C266(1.08)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C266(1.20)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C266(1.07)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C266(1.10)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C266(1.09)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C266(1.05)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C266(1.18)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C266(0.98)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C266(1.00)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C266(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C266(1.31)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C266(1.09)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C266(1.45)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C266(0.94)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C266(1.04)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C266(1.36)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C266(1.16)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C266(1.35)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C266(1.37)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C266(1.02)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C266(0.93)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C266(1.05)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C266(1.20)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C266(1.14)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C266(1.10)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C266(0.93)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C266(1.02)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C266(1.00)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C266(1.18)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C266(0.97)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C266(1.15)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C266(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C266(0.99)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C266(1.11)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C266(0.96)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C266(0.93)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C266(1.07)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C266(1.19)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C266(1.21)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C266(1.30)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C266(0.93)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C266(0.99)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C266(0.93)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C266(1.07)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C266(1.26)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C266(0.92)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C266(1.06)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C266(1.06)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C266(0.96)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C266(1.16)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C266(0.94)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C266(1.08)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C266(1.09)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C266(1.09)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C266(1.02)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C266(1.12)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C266(0.89)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C266(0.88)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C266(1.01)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C266(0.95)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C266(1.08)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C266(0.91)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C266(1.10)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C266(1.24)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C266(1.09)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C266(1.05)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C266(1.11)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C266(1.74)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.32  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C266(1.20)  LDD0078  [6]
 LDCM0367  CL1 HEK-293T C266(1.05)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C266(1.69)  LDD0966  [6]
 LDCM0369  CL100 HCT 116 C266(0.99)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C266(1.22)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C266(1.11)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C266(1.04)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C266(1.08)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C266(1.17)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C266(1.63)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C266(1.30)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C266(1.51)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C266(1.27)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C266(1.66)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C266(1.24)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C266(1.24)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C266(1.05)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C266(1.40)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C266(1.21)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C266(1.21)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C266(1.22)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C266(1.48)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C266(1.11)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C266(1.12)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C266(0.97)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C266(0.91)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C266(1.38)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C266(1.23)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C266(1.33)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C266(1.14)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C266(0.99)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C266(0.93)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C266(1.07)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C266(1.02)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C266(1.19)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C266(1.11)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C266(1.36)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C266(1.08)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C266(1.06)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C266(1.14)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C266(1.18)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C266(1.01)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C266(1.35)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C266(2.05)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C266(1.81)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C266(1.18)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C266(1.27)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C266(1.27)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C266(1.27)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C266(1.15)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C266(1.21)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C266(1.36)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C266(1.04)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C266(0.97)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C266(0.95)  LDD0737  [6]
 LDCM0421  CL32 HEK-293T C266(1.24)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C266(1.51)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C266(1.21)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C266(1.34)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C266(1.21)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C266(1.22)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C266(2.01)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C266(0.94)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C266(1.33)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C266(1.80)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C266(1.80)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C266(1.83)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C266(1.25)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C266(1.87)  LDD1033  [6]
 LDCM0436  CL46 HCT 116 C266(0.84)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C266(0.97)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C266(0.79)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C266(0.85)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C266(1.13)  LDD1038  [6]
 LDCM0441  CL50 HCT 116 C266(0.87)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C266(0.87)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C266(1.03)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C266(1.18)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C266(0.75)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C266(0.92)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C266(0.97)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C266(1.12)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C266(0.78)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C266(0.92)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C266(1.14)  LDD1049  [6]
 LDCM0452  CL60 HCT 116 C266(0.85)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C266(1.02)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C266(0.91)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C266(1.04)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C266(1.22)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C266(1.00)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C266(1.33)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C266(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C266(1.22)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C266(1.01)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C266(1.14)  LDD1060  [6]
 LDCM0463  CL70 HCT 116 C266(1.06)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C266(1.01)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C266(0.94)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C266(1.05)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C266(1.06)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C266(1.27)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C266(0.97)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C266(1.10)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C266(1.49)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C266(1.26)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C266(1.35)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C266(1.28)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C266(1.52)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C266(1.62)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C266(1.82)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C266(1.25)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C266(1.10)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C266(1.24)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C266(1.71)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C266(1.94)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C266(1.24)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C266(0.97)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C266(1.03)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C266(0.86)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C266(0.87)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C266(1.04)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C266(0.94)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C266(1.00)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C266(0.99)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C266(0.98)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C266(1.00)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C340(1.05)  LDD1698  [14]
 LDCM0625  F8 Ramos C266(0.70)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C266(0.97)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C266(3.31)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C266(0.70)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C266(1.33)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C266(0.83); C340(0.75)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C266(0.54)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C266(1.30)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C266(1.15)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C266(1.83)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C266(0.45)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C266(0.92)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C266(1.66)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C266(1.25)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C266(1.07)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C266(0.70)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C266(0.88)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C266(1.14)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C266(0.89)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C266(1.01)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C266(0.66); C340(0.77)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C266(0.76)  LDD2188  [15]
 LDCM0116  HHS-0101 DM93 Y246(0.92); Y55(0.95)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y55(0.78); Y246(0.87)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y55(0.80); Y246(0.85)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y246(0.73); Y55(0.84)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y55(0.75); Y246(0.94)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C340(1.04); C266(0.95)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C340(0.97); C266(1.02)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C340(0.92)  LDD3310  [16]
 LDCM0021  THZ1 HCT 116 C139(1.19)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family G member 5 (ABCG5) ABCG family Q9H222
Cell division cycle protein 27 homolog (CDC27) APC3/CDC27 family P30260
Histone-lysine N-methyltransferase SUV39H2 (SUV39H2) Histone-lysine methyltransferase family Q9H5I1
Histone-lysine N-methyltransferase 2B (KMT2B) Histone-lysine methyltransferase family Q9UMN6
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Ribonuclease P protein subunit p38 (RPP38) Eukaryotic ribosomal protein eL8 family P78345
Glutamate decarboxylase 1 (GAD1) Group II decarboxylase family Q99259
Maleylacetoacetate isomerase (GSTZ1) Zeta family O43708
mRNA-capping enzyme (RNGTT) Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family O60942
Tryptase alpha/beta-1 (TPSAB1) Peptidase S1 family Q15661
Phosphatase and actin regulator 2 (PHACTR2) Phosphatase and actin regulator family O75167
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) PI3/PI4-kinase family O00750
Protein disulfide-isomerase A2 (PDIA2) Protein disulfide isomerase family Q13087
Serine/threonine-protein kinase 38 (STK38) AGC Ser/Thr protein kinase family Q15208
Myosin light chain kinase, smooth muscle (MYLK) CAMK Ser/Thr protein kinase family Q15746
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) STE Ser/Thr protein kinase family Q9Y4K4
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Vascular endothelial growth factor receptor 2 (KDR) Tyr protein kinase family P35968
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Tyrosine-protein kinase JAK2 (JAK2) Tyr protein kinase family O60674
Dual specificity protein phosphatase 15 (DUSP15) Protein-tyrosine phosphatase family Q9H1R2
Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) Protein-tyrosine phosphatase family P29074
V(D)J recombination-activating protein 1 (RAG1) RAG1 family P15918
Ras-related protein R-Ras (RRAS) Ras family P10301
N-acetylglucosamine-6-sulfatase (GNS) Sulfatase family P15586
Synaptojanin-2 (SYNJ2) Synaptojanin family; Inositol 1,4,5-trisphosphate 5-phosphatase family O15056
Dynamin-1 (DNM1) Dynamin/Fzo/YdjA family Q05193
E3 ubiquitin-protein ligase TRAIP (TRAIP) TRAIP family Q9BWF2
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2) . Q9H9L3
Transporter and channel
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/potassium/calcium exchanger 1 (SLC24A1) Ca(2+):cation antiporter (CaCA) family O60721
T-cell surface glycoprotein CD3 zeta chain (CD247) CD3Z/FCER1G family P20963
Complement component C6 (C6) Complement C6/C7/C8/C9 family P13671
Filamin-B (FLNB) Filamin family O75369
Solute carrier family 23 member 1 (SLC23A1) Nucleobase:cation symporter-2 (NCS2) family Q9UHI7
Sorting nexin-12 (SNX12) Sorting nexin family Q9UMY4
Sorting nexin-17 (SNX17) Sorting nexin family Q15036
Sorting nexin-8 (SNX8) Sorting nexin family Q9Y5X2
Intermembrane lipid transfer protein VPS13A (VPS13A) VPS13 family Q96RL7
Dystroglycan 1 (DAG1) . Q14118
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
T-cell surface glycoprotein CD3 epsilon chain (CD3E) . P07766
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein DLX-4 (DLX4) Distal-less homeobox family Q92988
ETS domain-containing protein Elk-3 (ELK3) ETS family P41970
Homeobox protein Nkx-2.1 (NKX2-1) NK-2 homeobox family P43699
Msx2-interacting protein (SPEN) RRM Spen family Q96T58
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047
Autoimmune regulator (AIRE) . O43918
Bromodomain and PHD finger-containing protein 3 (BRPF3) . Q9ULD4
DNA-binding protein inhibitor ID-4 (ID4) . P47928
Forkhead box protein H1 (FOXH1) . O75593
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteinase-activated receptor 3 (F2RL2) G-protein coupled receptor 1 family O00254
Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) G-protein coupled receptor 2 family Q9NYQ7
Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) G-protein coupled receptor 3 family Q9UBS5
Immunoglobulin
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nephrin (NPHS1) Immunoglobulin superfamily O60500
Semaphorin-7A (SEMA7A) Semaphorin family O75326
Advanced glycosylation end product-specific receptor (AGER) . Q15109
Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) . P31994
Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C) . P31995
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 6 (FASLG) Tumor necrosis factor family P48023
Growth hormone receptor (GHR) Type I cytokine receptor family P10912
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 16 (ASB16) Ankyrin SOCS box (ASB) family Q96NS5
Chromatin assembly factor 1 subunit A (CHAF1A) CHAF1A family Q13111
Dedicator of cytokinesis protein 3 (DOCK3) DOCK family Q8IZD9
Large ribosomal subunit protein eL13 (RPL13) Eukaryotic ribosomal protein eL13 family P26373
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Histone H1.4 (H1-4) Histone H1/H5 family P10412
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LEM family P42167
Leucine-rich repeat-containing protein 3 (LRRC3) LRRC3 family Q9BY71
Negative elongation factor B (NELFB) NELF-B family Q8WX92
Contactin-associated protein 1 (CNTNAP1) Neurexin family P78357
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Periaxin (PRX) Periaxin family Q9BXM0
Matrix extracellular phosphoglycoprotein (MEPE) PF07175/osteoregulin family Q9NQ76
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Calpastatin (CAST) Protease inhibitor I27 (calpastatin) family P20810
Ras and Rab interactor 3 (RIN3) RIN (Ras interaction/interference) family Q8TB24
Disks large-associated protein 1 (DLGAP1) SAPAP family O14490
Disks large-associated protein 2 (DLGAP2) SAPAP family Q9P1A6
Disks large-associated protein 3 (DLGAP3) SAPAP family O95886
Disks large-associated protein 4 (DLGAP4) SAPAP family Q9Y2H0
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) SHANK family Q9UPX8
Protein Shroom2 (SHROOM2) Shroom family Q13796
Cytoskeleton-associated protein 5 (CKAP5) TOG/XMAP215 family Q14008
Targeting protein for Xklp2 (TPX2) TPX2 family Q9ULW0
Tubby-related protein 1 (TULP1) TUB family O00294
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) WAL family Q9UIF9
Actin nucleation-promoting factor WASL (WASL) . O00401
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1
Beta-chimaerin (CHN2) . P52757
BRD4-interacting chromatin-remodeling complex-associated protein (BICRA) . Q9NZM4
Bromodomain-containing protein 4 (BRD4) . O60885
Disabled homolog 2 (DAB2) . P98082
Epidermal growth factor receptor substrate 15 (EPS15) . P42566
FYN-binding protein 1 (FYB1) . O15117
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) . O43390
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
Microtubule-associated protein 4 (MAP4) . P27816
Protein ECT2 (ECT2) . Q9H8V3
Rap guanine nucleotide exchange factor 1 (RAPGEF1) . Q13905
Ras GTPase-activating protein 1 (RASA1) . P20936
Regulating synaptic membrane exocytosis protein 2 (RIMS2) . Q9UQ26
Rho guanine nucleotide exchange factor 11 (ARHGEF11) . O15085
Scavenger receptor class F member 2 (SCARF2) . Q96GP6
Selenoprotein N (SELENON) . Q9NZV5
Son of sevenless homolog 1 (SOS1) . Q07889
Son of sevenless homolog 2 (SOS2) . Q07890
Trans-Golgi network integral membrane protein 2 (TGOLN2) . O43493

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ax-024 . D00JDJ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840