Details of the Target

General Information of Target

Target ID LDTP01810
Target Name Antithrombin-III (SERPINC1)
Gene Name SERPINC1
Gene ID 462
Synonyms
AT3; Antithrombin-III; ATIII; Serpin C1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK
Target Type
Successful
Target Bioclass
Other
Family
Serpin family
Subcellular location
Secreted, extracellular space
Function
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
TTD ID
T73476
Uniprot ID
P01008
DrugMap ID
TTZ4MD5
Ensemble ID
ENST00000367698.4
HGNC ID
HGNC:775
ChEMBL ID
CHEMBL1950

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K260(5.60)  LDD3494  [1]
DBIA
 Probe Info  		C160(1.73)  LDD0531  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C160(1.73)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C160(1.13)  LDD1094  [2]
 LDCM0216  AC100 HEK-293T C160(1.24)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C160(1.32)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C160(1.26)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C160(1.26)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C160(0.78)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C160(1.48)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C160(2.06)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C160(1.54)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C160(1.45)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C160(0.93)  LDD0823  [2]
 LDCM0226  AC11 PaTu 8988t C160(1.00)  LDD1105  [2]
 LDCM0227  AC110 HEK-293T C160(1.15)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C160(1.39)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C160(1.17)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C160(0.92)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C160(1.04)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C160(1.27)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C160(1.50)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C160(1.27)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C160(1.36)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C160(1.79)  LDD0553  [2]
 LDCM0237  AC12 PaTu 8988t C160(0.86)  LDD1116  [2]
 LDCM0238  AC120 HCT 116 C160(1.00)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C160(1.03)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C160(1.21)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C160(0.83)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C160(0.82)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C160(1.06)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C160(1.12)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C160(1.02)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C160(1.65)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C160(0.47)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C160(0.90)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C160(0.52)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C160(1.22)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C160(1.33)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C160(1.44)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C160(1.67)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C160(1.50)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C160(1.48)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C160(1.68)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C160(1.38)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C160(1.01)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C160(1.63)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C160(1.51)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C160(1.28)  LDD0579  [2]
 LDCM0270  AC15 PaTu 8988t C160(1.22)  LDD1149  [2]
 LDCM0276  AC17 HCT 116 C160(1.53)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C160(1.05)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C160(1.19)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C160(1.25)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C160(0.87)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C160(1.01)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C160(1.18)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C160(0.97)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C160(1.01)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C160(0.87)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C160(1.20)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C160(0.92)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C160(0.92)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C160(0.99)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C160(2.09)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C160(1.21)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C160(0.98)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C160(1.09)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C160(0.86)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C160(0.63)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C160(0.69)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C160(0.71)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C160(0.42)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C160(0.63)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C160(1.64)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C160(2.43)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C160(0.75)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C160(0.90)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C160(0.62)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C160(0.64)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C160(1.04)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C160(1.02)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C160(1.30)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C160(1.49)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C160(1.23)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C160(1.13)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C160(2.73)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C160(1.02)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C160(1.08)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C160(1.26)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C160(0.88)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C160(1.29)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C160(1.43)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C160(0.89)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C160(1.16)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C160(0.86)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C160(0.92)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C160(0.80)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C160(1.15)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C160(0.89)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C160(1.19)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C160(0.76)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C160(0.82)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C160(0.94)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C160(0.76)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C160(0.96)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C160(0.79)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C160(0.96)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C160(0.81)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C160(1.79)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C160(1.19)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C160(2.43)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C160(2.26)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C160(1.73)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C160(1.21)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C160(1.29)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C160(0.72)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C160(1.08)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C160(1.31)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C160(0.88)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C160(1.64)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C160(1.40)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C160(1.50)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C160(0.84)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C160(0.98)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C160(1.00)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C160(0.81)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C160(1.10)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C160(0.94)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C160(0.96)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C160(1.67)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C160(0.76)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C160(1.02)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C160(1.12)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C160(1.20)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C160(1.25)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C160(1.20)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C160(1.32)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C160(1.08)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C160(1.16)  LDD0964  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C160(1.13)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C160(1.38)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C160(1.34)  LDD1154  [2]
 LDCM0367  CL1 HCT 116 C160(1.07)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C160(2.65)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C160(1.78)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C160(0.83)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C160(0.68)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C160(1.31)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C160(0.79)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C160(1.20)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C160(1.16)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C160(1.36)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C160(1.88)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C160(1.23)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C160(2.43)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C160(1.77)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C160(1.36)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C160(0.75)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C160(0.74)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C160(0.86)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C160(0.98)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C160(1.03)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C160(0.96)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C160(1.65)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C160(0.50)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C160(4.80)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C160(1.49)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C160(1.16)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C160(1.26)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C160(0.97)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C160(1.49)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C160(1.22)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C160(0.78)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C160(0.74)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C160(0.82)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C160(2.87)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C160(1.62)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C160(1.25)  LDD0719  [2]
 LDCM0404  CL17 HCT 116 C160(1.73)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C160(1.60)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C160(1.52)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C160(0.89)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C160(0.89)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C160(1.50)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C160(0.82)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C160(1.24)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C160(0.99)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C160(1.64)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C160(1.77)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C160(1.25)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C160(2.04)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C160(0.56)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C160(1.09)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C160(0.41)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C160(1.11)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C160(1.14)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C160(0.99)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C160(1.42)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C160(0.93)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C160(0.86)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C160(0.96)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C160(1.06)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C160(1.28)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C160(1.02)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C160(0.86)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C160(1.07)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C160(1.07)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C160(1.08)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C160(1.30)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C160(0.65)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C160(0.57)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C160(0.59)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C160(0.61)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C160(0.99)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C160(0.69)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C160(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C160(0.94)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C160(0.52)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C160(0.52)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C160(0.54)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C160(0.79)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C160(0.66)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C160(0.57)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C160(0.78)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C160(0.91)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C160(0.59)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C160(1.53)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C160(1.65)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C160(1.54)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C160(1.92)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C160(1.36)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C160(1.91)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C160(1.12)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C160(1.24)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C160(1.54)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C160(2.54)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C160(1.18)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C160(1.37)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C160(1.24)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C160(1.15)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C160(1.33)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C160(0.88)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C160(0.69)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C160(0.87)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C160(1.35)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C160(1.31)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C160(0.92)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C160(1.11)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C160(1.38)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C160(1.33)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C160(2.16)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C160(1.11)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C160(1.08)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C160(1.23)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C160(1.25)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C160(1.53)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C160(1.91)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C160(0.43)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C160(1.25)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C160(1.04)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C160(0.77)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C160(0.72)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C160(1.11)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C160(1.16)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C160(1.11)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C160(2.76)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C160(2.84)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C160(1.72)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C160(1.19)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Extracellular serine/threonine protein kinase FAM20C (FAM20C) FAM20 family Q8IXL6
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Antithrombin-III (SERPINC1) Serpin family P01008

The Drug(s) Related To This Target

Approved
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sulodexide BiotechDrug DB06271
Ardeparin Small molecular drug DB00407
Dalteparin Small molecular drug DB06779
Enoxaparin Small molecular drug DB01225
Fondaparinux Small molecular drug DB00569
Heparin Small molecular drug DB01109
Nadroparin Small molecular drug DB08813
Tinzaparin Small molecular drug DB06822
Antithrombin Iii Human . DB11598
Bemiparin . DB09258
Copper . DB09130
Danaparoid . DB06754
Protamine Sulfate . DB09141
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fitusiran Small interfering RNA D46RKC
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464
Sr-123781a . DB05361

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264