Details of the Target

General Information of Target

Target ID LDTP01755
Target Name Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3)
Gene Name APBA3
Gene ID 9546
Synonyms
MINT3; X11L2; Amyloid-beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQEL
VQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEE
CPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVP
LVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTS
TRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADI
GCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRES
GIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPT
AVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHC
PPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHA
RIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Uniprot ID
O96018
Ensemble ID
ENST00000316757.4
HGNC ID
HGNC:580

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C500(0.59); C507(0.59)  LDD0532  [1]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C500(1.06)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C500(0.59); C507(0.59)  LDD0532  [1]
 LDCM0216  AC100 PaTu 8988t C500(0.58); C507(0.58)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C500(0.74); C507(0.74)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C500(0.68); C507(0.68)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C500(0.63); C507(0.63)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C500(0.82); C507(0.82)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C500(0.69); C507(0.69)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C500(0.67); C507(0.67)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C500(0.87); C507(0.87)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C500(0.61); C507(0.61)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C500(0.67); C507(0.67)  LDD1104  [1]
 LDCM0226  AC11 HCT 116 C500(0.56); C507(0.56)  LDD0543  [1]
 LDCM0227  AC110 PaTu 8988t C500(0.74); C507(0.74)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C500(0.74); C507(0.74)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C500(0.84); C507(0.84)  LDD1108  [1]
 LDCM0230  AC113 HCT 116 C500(1.32); C507(1.32)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C500(0.89); C507(0.89)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C500(0.95); C507(0.95)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C500(1.09); C507(1.09)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C500(0.95); C507(0.95)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C500(0.96); C507(0.96)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C500(0.97); C507(0.97)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C500(0.52); C507(0.52)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C500(0.86); C507(0.86)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C500(1.10); C507(1.10)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C500(0.93); C507(0.93)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C500(1.00); C507(1.00)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C500(1.17); C507(1.17)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C500(1.12); C507(1.12)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C500(1.02); C507(1.02)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C500(0.93); C507(0.93)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C500(1.17); C507(1.17)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C500(0.74); C507(0.74)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C500(0.88); C507(0.88)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C500(1.86); C507(1.86)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C500(0.99); C507(0.99)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C500(1.00); C507(1.00)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C500(0.95); C507(0.95)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C500(1.10); C507(1.10)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C500(0.97); C507(0.97)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C500(1.01); C507(1.01)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C500(0.87); C507(0.87)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C500(0.97); C507(0.97)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C500(0.59); C507(0.59)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C500(0.95); C507(0.95)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C500(0.95); C507(0.95)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C500(0.96); C507(0.96)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C500(0.57); C507(0.57)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C500(0.35); C507(0.35)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C500(0.66); C507(0.66)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C500(0.50); C507(0.50)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C500(0.27); C507(0.27)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C500(0.40); C507(0.40)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C500(0.38); C507(0.38)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C500(0.57); C507(0.57)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C500(0.62); C507(0.62)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C500(0.49); C507(0.49)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C500(0.39); C507(0.39)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C500(0.51); C507(0.51)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C500(0.53); C507(0.53)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C500(0.51); C507(0.51)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C500(0.91); C507(0.91)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C500(0.55); C507(0.55)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C500(0.73); C507(0.73)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C500(0.73); C507(0.73)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C500(0.95); C507(0.95)  LDD1157  [1]
 LDCM0279  AC2 HEK-293T C500(1.21)  LDD0877  [1]
 LDCM0280  AC20 PaTu 8988t C500(1.01); C507(1.01)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C500(1.09); C507(1.09)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C500(1.09); C507(1.09)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C500(1.04); C507(1.04)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C500(0.86); C507(0.86)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C500(0.79); C507(0.79)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C500(0.74); C507(0.74)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C500(0.91); C507(0.91)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C500(0.75); C507(0.75)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C500(0.77); C507(0.77)  LDD1168  [1]
 LDCM0290  AC3 HEK-293T C500(1.23)  LDD0888  [1]
 LDCM0291  AC30 PaTu 8988t C500(0.79); C507(0.79)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C500(0.91); C507(0.91)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C500(0.82); C507(0.82)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C500(0.83); C507(0.83)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C500(0.84); C507(0.84)  LDD1174  [1]
 LDCM0297  AC36 HEK-293T C500(0.97)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C302(0.89)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C500(0.92)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C500(1.10)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C500(0.92)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C500(1.07)  LDD1542  [3]
 LDCM0306  AC44 HEK-293T C500(1.03)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C302(0.95)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C500(1.19)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C500(1.11)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C500(1.15)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C500(1.03)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C500(1.16)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C500(1.12)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C500(1.26)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C500(1.16)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C500(1.12)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C500(1.29)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C500(1.27)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C500(1.18)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C500(0.80)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C500(1.10)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C500(1.05)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C500(0.61); C507(0.61)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C500(0.80)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C500(1.03)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C500(1.03)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C500(0.91)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C500(1.09)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C500(0.98)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C500(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C500(1.00)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C500(0.66); C507(0.66)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C500(0.91); C507(0.91)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C500(0.52); C507(0.52)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C500(0.66); C507(0.66)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C500(0.79); C507(0.79)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C500(0.87); C507(0.87)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C500(1.09); C507(1.09)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C500(0.90); C507(0.90)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C500(1.23); C507(1.23)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C500(0.94); C507(0.94)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C500(0.73); C507(0.73)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C500(0.76); C507(0.76)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C500(1.02); C507(1.02)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C500(0.48); C507(0.48)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C500(0.79); C507(0.79)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C500(0.35); C507(0.35)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C500(0.89); C507(0.89)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C500(1.37); C507(1.37)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C500(1.22); C507(1.22)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C500(1.48); C507(1.48)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C500(1.34); C507(1.34)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C500(1.39); C507(1.39)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C500(1.35); C507(1.35)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C500(1.37); C507(1.37)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C500(2.23); C507(2.23)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C500(1.71); C507(1.71)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C500(0.97); C507(0.97)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C500(1.82); C507(1.82)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C500(1.18); C507(1.18)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C500(1.56); C507(1.56)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C500(1.77); C507(1.77)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C500(1.86); C507(1.86)  LDD1243  [1]
 LDCM0365  AC98 PaTu 8988t C500(0.62); C507(0.62)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C500(0.71); C507(0.71)  LDD1245  [1]
 LDCM0248  AKOS034007472 HCT 116 C500(0.57); C507(0.57)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C500(0.61); C507(0.61)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C500(0.55); C507(0.55)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C500(1.28); C507(1.28)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C500(1.23); C507(1.23)  LDD0685  [1]
 LDCM0369  CL100 HEK-293T C500(1.10)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C500(0.52); C507(0.52)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C500(1.00); C507(1.00)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C500(0.76); C507(0.76)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C500(0.77); C507(0.77)  LDD0690  [1]
 LDCM0374  CL105 PaTu 8988t C500(1.29); C507(1.29)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C500(0.86); C507(0.86)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C500(0.71); C507(0.71)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C500(1.21); C507(1.21)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C500(1.08); C507(1.08)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C500(1.16); C507(1.16)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C500(1.27); C507(1.27)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C500(1.26); C507(1.26)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C500(0.94); C507(0.94)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C500(0.71); C507(0.71)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C500(0.94); C507(0.94)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C500(0.89); C507(0.89)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C500(0.89); C507(0.89)  LDD1265  [1]
 LDCM0389  CL119 HEK-293T C302(1.09); C500(0.98)  LDD1593  [3]
 LDCM0390  CL12 HCT 116 C500(1.21); C507(1.21)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C500(1.07)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C500(1.29)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C500(1.09)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C500(1.20)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C500(1.18)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C500(0.87)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C500(0.88)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C500(0.84)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C500(0.85)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C500(1.13); C507(1.13)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C500(1.12); C507(1.12)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C500(1.32); C507(1.32)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C500(0.93); C507(0.93)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C500(0.78); C507(0.78)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C500(0.67); C507(0.67)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C500(0.76); C507(0.76)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C500(1.03); C507(1.03)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C500(1.27); C507(1.27)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C500(1.11); C507(1.11)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C500(0.95); C507(0.95)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C500(0.98); C507(0.98)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C500(0.80); C507(0.80)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C500(1.12); C507(1.12)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C500(0.83); C507(0.83)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C500(1.07); C507(1.07)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C500(1.05); C507(1.05)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C500(1.06); C507(1.06)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C500(0.91); C507(0.91)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C500(0.94); C507(0.94)  LDD1298  [1]
 LDCM0420  CL31 HCT 116 C500(0.83); C507(0.83)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C500(0.70); C507(0.70)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C500(1.18); C507(1.18)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C500(1.10); C507(1.10)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C500(0.99); C507(0.99)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C500(0.90); C507(0.90)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C500(1.06); C507(1.06)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C500(1.01); C507(1.01)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C500(1.03); C507(1.03)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C500(0.89); C507(0.89)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C500(0.90); C507(0.90)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C500(1.02); C507(1.02)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C500(0.83); C507(0.83)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C500(0.79); C507(0.79)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C500(0.88); C507(0.88)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C500(1.20); C507(1.20)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C500(1.02); C507(1.02)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C500(0.89); C507(0.89)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C500(0.91); C507(0.91)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C500(0.75); C507(0.75)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C500(1.05); C507(1.05)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C500(1.34); C507(1.34)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C500(0.91); C507(0.91)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C500(0.83); C507(0.83)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C500(1.09); C507(1.09)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C500(0.88); C507(0.88)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C500(0.53); C507(0.53)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C500(0.97); C507(0.97)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C500(1.11); C507(1.11)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C500(1.09); C507(1.09)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C500(0.80); C507(0.80)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C500(1.04); C507(1.04)  LDD1331  [1]
 LDCM0453  CL61 HCT 116 C500(0.89); C507(0.89)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C500(0.90); C507(0.90)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C500(0.91); C507(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C500(0.81); C507(0.81)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C500(1.04); C507(1.04)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C500(1.02); C507(1.02)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C500(0.73); C507(0.73)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C500(0.75); C507(0.75)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C500(1.23); C507(1.23)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C500(0.92); C507(0.92)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C500(0.87); C507(0.87)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C500(1.06); C507(1.06)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C500(1.17); C507(1.17)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C500(0.90); C507(0.90)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C500(0.88); C507(0.88)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C500(0.60); C507(0.60)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C500(0.82); C507(0.82)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C500(0.70); C507(0.70)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C500(0.65); C507(0.65)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C500(1.20); C507(1.20)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C500(0.61); C507(0.61)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C500(0.70); C507(0.70)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C500(0.74); C507(0.74)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C500(0.75); C507(0.75)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C500(0.92); C507(0.92)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C500(0.68); C507(0.68)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C500(0.86); C507(0.86)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C500(0.77); C507(0.77)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C500(0.72); C507(0.72)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C500(0.91); C507(0.91)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C500(0.88); C507(0.88)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C500(1.32); C507(1.32)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C500(1.07)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C500(0.95)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C500(0.95)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C500(1.22)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C500(1.15)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C500(1.09)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C500(0.97)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C500(1.07)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C500(1.09)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C302(1.09); C500(0.95)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C500(0.99); C507(0.99)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C500(0.99); C507(0.99)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C500(0.94)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C500(1.08)  LDD1497  [3]
 LDCM0024  KB05 OE33 C460(1.98)  LDD3375  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) . Q9NWT6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-terminal EF-hand calcium-binding protein 3 (NECAB3) . Q96P71
TANK-binding kinase 1-binding protein 1 (TBKBP1) . A7MCY6
TRAF family member-associated NF-kappa-B activator (TANK) . Q92844

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840