Details of the Target

General Information of Target

Target ID LDTP01321
Target Name Carbonyl reductase [NADPH] 3 (CBR3)
Gene Name CBR3
Gene ID 874
Synonyms
SDR21C2; Carbonyl reductase [NADPH] 3; EC 1.1.1.184; NADPH-dependent carbonyl reductase 3; Quinone reductase CBR3; EC 1.6.5.10; Short chain dehydrogenase/reductase family 21C member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN
MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK
NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS
IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Cytoplasm
Function
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified.
Uniprot ID
O75828
Ensemble ID
ENST00000290354.6
HGNC ID
HGNC:1549
ChEMBL ID
CHEMBL6008

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K173(6.20)  LDD0277  [1]
Probe 1
 Probe Info  		Y194(13.77)  LDD3495  [2]
BTD
 Probe Info  		C143(0.82)  LDD2099  [3]
HHS-482
 Probe Info  		Y194(1.05)  LDD0285  [4]
HHS-475
 Probe Info  		Y194(0.41)  LDD0264  [5]
IPM
 Probe Info  		C143(1.54); C227(0.97)  LDD1701  [3]
HHS-465
 Probe Info  		Y194(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C143(0.99)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
IA-alkyne
 Probe Info  		C150(0.00); C143(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C150(0.00); C143(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		C150(0.00); H60(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
NAIA_5
 Probe Info  		C150(0.00); C122(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C143(0.77)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C143(0.88); C150(1.02); C227(1.00)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C143(0.86); C227(1.00)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C143(0.99); C227(1.02)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C143(0.94); C227(1.01)  LDD1510  [16]
 LDCM0259  AC14 HEK-293T C143(0.96); C227(1.09)  LDD1512  [16]
 LDCM0270  AC15 HEK-293T C143(1.02); C227(0.96)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C143(0.94); C150(0.95); C227(1.01)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C143(0.87); C227(0.95)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C143(0.79); C227(0.79)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C143(1.00); C227(1.01)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C143(0.93); C227(1.24)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C143(0.96); C227(0.97)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C143(1.21); C227(1.17)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C143(1.03); C227(0.87)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C143(0.94); C227(1.00)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C143(0.96); C150(1.01); C227(1.06)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C143(0.91); C227(0.98)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C143(1.08); C227(0.90)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C143(0.98); C227(0.97)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C143(1.07); C227(1.35)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C143(0.89); C227(1.27)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C143(1.03); C227(1.04)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C143(1.00); C227(1.01)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C143(0.90); C227(1.08)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C143(0.96); C150(1.09); C227(0.95)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C143(1.00); C227(0.98)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C143(0.90); C227(1.02)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C143(0.95); C227(0.84)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C143(1.13); C227(1.03)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C143(0.97); C227(0.98)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C143(1.06); C227(0.90)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C143(0.83); C227(0.96)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C143(0.84); C227(0.95)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C143(0.92); C150(1.02); C227(0.91)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C143(0.95); C227(1.04)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C143(1.05); C227(1.32)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C143(1.05); C227(0.95)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C143(0.95); C227(1.20)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C143(0.91); C227(1.05)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C143(1.08); C227(0.87)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C143(1.06); C227(1.03)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C143(1.01); C150(0.95); C227(0.93)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C143(1.02); C227(1.23)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C143(0.90); C227(0.90)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C143(0.97); C227(1.04)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C143(1.07); C227(1.07)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C143(0.98); C227(1.18)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C143(1.09); C227(0.99)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C143(0.94); C227(1.02)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C143(1.08); C227(0.97)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C143(1.02); C150(1.00); C227(1.05)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C143(1.09); C227(0.92)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C143(1.04); C227(1.04)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C143(1.02); C227(1.03)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C143(1.09); C227(0.95)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C143(0.92); C227(0.87)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C143(0.94); C227(1.11)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C143(0.99); C227(0.97)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C143(0.97); C227(0.96)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C143(0.98); C227(1.19)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C143(0.82); C227(0.88)  LDD1569  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C227(0.89)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C143(0.97); C227(0.98)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C143(0.97); C150(1.02); C227(1.02)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C143(0.94); C227(1.13)  LDD1514  [16]
 LDCM0020  ARS-1620 HCC44 C143(0.99)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa H60(0.00); C122(0.00); C150(0.00)  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C143(1.02); C227(0.88)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C143(0.88); C227(1.03)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C143(0.90)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C143(1.11); C227(0.97)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C150(0.99); C227(0.91)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C150(1.21)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C143(0.90)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C143(0.94); C227(0.84)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C150(0.97); C227(0.88)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C150(0.88)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C143(1.06)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C143(0.97); C227(1.03)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C143(1.11); C227(0.98)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C150(0.94); C227(0.84)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C150(0.94)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C143(0.96)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C143(1.10); C227(0.94)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C150(1.18); C227(0.79)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C150(1.28)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C143(0.81)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C143(1.19); C227(0.99)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C150(1.14); C227(0.91)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C150(0.85)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C143(1.02); C227(0.95)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C143(0.87)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C143(1.10); C227(0.89)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C150(1.15); C227(0.72)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C150(1.28)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C143(0.95)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C143(1.07); C227(1.01)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C150(1.01); C227(1.02)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C150(0.97)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C143(1.08)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C143(1.06); C227(0.94)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C150(1.10); C227(0.94)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C150(0.79)  LDD1606  [16]
 LDCM0403  CL16 HEK-293T C143(1.32)  LDD1607  [16]
 LDCM0404  CL17 HEK-293T C143(0.89); C150(0.96); C227(0.97)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C143(1.03); C227(1.00)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C143(0.96); C227(1.15)  LDD1610  [16]
 LDCM0407  CL2 HEK-293T C150(1.14); C227(0.79)  LDD1611  [16]
 LDCM0408  CL20 HEK-293T C143(1.04); C227(0.98)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C143(0.98); C227(1.31)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C143(1.30); C227(1.35)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C143(1.11); C227(1.00)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C143(0.97); C227(0.96)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C143(0.94); C227(0.91)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C150(1.10); C227(0.99)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C150(0.85)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C143(0.94)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C143(0.99); C150(0.99); C227(1.04)  LDD1621  [16]
 LDCM0418  CL3 HEK-293T C150(0.92)  LDD1622  [16]
 LDCM0419  CL30 HEK-293T C143(0.91); C227(0.95)  LDD1623  [16]
 LDCM0420  CL31 HEK-293T C143(0.90); C227(1.17)  LDD1624  [16]
 LDCM0421  CL32 HEK-293T C143(1.04); C227(1.04)  LDD1625  [16]
 LDCM0422  CL33 HEK-293T C143(0.85); C227(0.92)  LDD1626  [16]
 LDCM0423  CL34 HEK-293T C143(0.95); C227(0.99)  LDD1627  [16]
 LDCM0424  CL35 HEK-293T C143(1.11); C227(0.95)  LDD1628  [16]
 LDCM0425  CL36 HEK-293T C143(0.99); C227(0.98)  LDD1629  [16]
 LDCM0426  CL37 HEK-293T C143(1.01); C227(0.89)  LDD1630  [16]
 LDCM0428  CL39 HEK-293T C150(1.12)  LDD1632  [16]
 LDCM0429  CL4 HEK-293T C143(1.14)  LDD1633  [16]
 LDCM0430  CL40 HEK-293T C143(1.12)  LDD1634  [16]
 LDCM0431  CL41 HEK-293T C143(0.97); C150(0.98); C227(0.98)  LDD1635  [16]
 LDCM0432  CL42 HEK-293T C143(0.84); C227(0.92)  LDD1636  [16]
 LDCM0433  CL43 HEK-293T C143(1.02); C227(1.15)  LDD1637  [16]
 LDCM0434  CL44 HEK-293T C143(0.96); C227(0.96)  LDD1638  [16]
 LDCM0435  CL45 HEK-293T C143(0.92); C227(1.22)  LDD1639  [16]
 LDCM0436  CL46 HEK-293T C143(0.82); C227(0.99)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C143(0.98); C227(0.89)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C143(1.10); C227(0.97)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C143(1.01); C227(0.98)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C143(1.03); C150(0.99); C227(1.01)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C150(1.11); C227(0.87)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C143(0.98)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C143(0.98); C150(1.11); C227(0.92)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C143(0.78); C227(0.86)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C143(0.89); C227(1.10)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C143(1.00); C227(0.93)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C143(0.90); C227(1.19)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C143(1.19); C227(1.11)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C143(1.01); C227(1.11)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C143(0.90); C227(0.90)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C143(0.98); C227(0.84)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C143(1.25); C227(1.08)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C150(1.13); C227(0.88)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C150(1.41)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C143(1.10)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C143(1.08); C150(1.04); C227(0.99)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C143(0.87); C227(0.98)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C143(0.96); C227(0.83)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C143(1.26); C227(1.15)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C143(0.69); C227(1.06)  LDD1664  [16]
 LDCM0462  CL7 HEK-293T C143(0.95); C227(0.99)  LDD1665  [16]
 LDCM0463  CL70 HEK-293T C143(0.94); C227(1.06)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C143(1.02); C227(0.95)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C143(0.97); C227(1.02)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C143(1.19); C227(0.89)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C150(1.02); C227(0.86)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C143(0.98)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C143(0.98); C150(1.01); C227(0.90)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C143(1.18); C227(0.93)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C143(0.94); C227(0.99)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C143(0.92); C227(0.66)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C143(1.07); C227(1.00)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C143(0.95); C227(0.98)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C143(1.05); C227(0.99)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C143(1.03); C227(1.00)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C143(0.99); C227(1.04)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C143(1.02); C227(1.02)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C150(1.07); C227(0.89)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C150(0.91)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C143(0.97)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C143(1.02); C150(1.04); C227(1.01)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C143(0.98); C227(1.16)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C143(0.78); C227(0.83)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C143(0.95); C227(0.93)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C143(0.65); C227(1.00)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C143(0.97); C227(1.00)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C143(0.88); C227(1.23)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C143(1.01); C227(0.75)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C143(0.92); C227(0.99)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C143(0.98); C227(0.93)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C150(1.00); C227(0.94)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C150(0.72)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C150(1.15)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C227(0.60)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C150(1.34)  LDD1671  [16]
 LDCM0427  Fragment51 HEK-293T C150(1.14); C227(0.92)  LDD1631  [16]
 LDCM0116  HHS-0101 DM93 Y194(0.41)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y194(1.03)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y194(1.20)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y194(0.41)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y194(0.91)  LDD0268  [5]
 LDCM0107  IAA HeLa H60(0.00); C150(0.00)  LDD0221  [13]
 LDCM0123  JWB131 DM93 Y194(1.05)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y194(0.46)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y194(1.10)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y194(2.69)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y194(1.86)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y194(1.03)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y194(0.38)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y194(0.86)  LDD0292  [4]
 LDCM0022  KB02 HEK-293T C143(1.01)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C143(0.96)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C143(0.84)  LDD3310  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C143(0.82)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C143(0.83)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C143(0.65)  LDD2109  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C143(1.30)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C143(0.83)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C143(0.95)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C143(0.97)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C143(0.97)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C143(1.04)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C143(0.68)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C143(0.56)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Daunorubicin Small molecular drug DB00694
Deutetrabenazine Small molecular drug DB12161
Doxorubicin Small molecular drug DB00997

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840