Details of the Target

General Information of Target

Target ID LDTP00942
Target Name tRNA wybutosine-synthesizing protein 4 (LCMT2)
Gene Name LCMT2
Gene ID 9836
Synonyms
KIAA0547; TYW4; tRNA wybutosine-synthesizing protein 4; tRNA yW-synthesizing protein 4; EC 2.1.1.290; EC 2.3.1.231; Leucine carboxyl methyltransferase 2; tRNA(Phe; 7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe; 7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRA
RAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVAR
RKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAA
SPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNS
PLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWH
LKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGH
ASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYH
TMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCW
RHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSAC
TWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLL
VGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGG
GNCFSFGTYFNPHTVTLDLSSLSAGQ
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, LCMT family
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Uniprot ID
O60294
Ensemble ID
ENST00000305641.7
HGNC ID
HGNC:17558

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C408(3.11); C396(1.23)  LDD0080  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
AOyne
 Probe Info  		10.00  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C277
 Probe Info  		9.58  LDD1947  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C408(1.09)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C408(0.94)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C408(0.88)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C408(1.12)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C408(0.96)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C408(1.10)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C408(0.97)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C408(1.02)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C408(0.98)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C408(1.09)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C408(0.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C408(0.89)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C408(0.87)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C408(0.93)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C408(0.92)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C408(1.08)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C408(0.82)  LDD0547  [1]
 LDCM0231  AC114 PaTu 8988t C408(1.15)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C408(0.71)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C408(1.03)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C408(0.86)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C408(0.88)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C408(1.18)  LDD1115  [1]
 LDCM0237  AC12 HCT 116 C408(1.02)  LDD0554  [1]
 LDCM0238  AC120 PaTu 8988t C408(1.55)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C408(1.24)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C408(0.86)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C408(1.05)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C408(1.41)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C408(0.95)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C408(0.65)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C408(1.29)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C408(1.22)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C408(1.15)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C408(1.10)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C408(1.25)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C408(1.17)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C408(2.17)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C408(1.75)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C408(1.74)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C408(1.81)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C408(1.64)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C408(1.19)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C408(1.27)  LDD1137  [1]
 LDCM0259  AC14 HCT 116 C408(0.76)  LDD0576  [1]
 LDCM0260  AC140 PaTu 8988t C408(1.30)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C408(1.25)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C408(1.40)  LDD1141  [1]
 LDCM0263  AC143 HCT 116 C408(1.24)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C408(0.88)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C408(0.98)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C408(1.15)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C408(1.10)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C408(1.30)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C408(1.50)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C408(0.91)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C408(1.00)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C408(1.05)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C408(1.13)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C408(1.28)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C408(1.12)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C408(1.11)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C408(0.99)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C408(1.10)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C408(0.91)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C408(1.24)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C408(1.00)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C408(1.06)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C408(0.62)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C408(0.92)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C408(0.75)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C408(0.86)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C408(0.87)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C408(1.06)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C408(0.99)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C408(0.75)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C408(0.89)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C408(1.23)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C408(1.16)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C408(0.96)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C408(1.19)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C408(0.95)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C408(0.93)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C408(1.18)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C408(1.08)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C408(1.03)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C408(1.04)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C408(1.04)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C408(1.02)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C408(1.30)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C408(1.10)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C408(1.02)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C408(1.21)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C408(1.10)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C408(1.19)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C408(1.26)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C408(1.08)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C408(1.09)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C408(1.16)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C408(1.46)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C408(1.36)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C408(1.34)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C408(1.01)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C408(1.12)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C408(1.52)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C408(1.21)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C408(1.25)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C408(1.68)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C408(0.95); C133(1.00); C570(1.17)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C408(1.22); C133(1.14); C570(1.05)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C408(1.00); C133(1.01); C570(0.82); C478(1.11)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C408(1.35)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C408(1.10); C133(1.10); C570(1.24)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C408(1.16); C133(1.21); C570(0.88); C396(0.91)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C408(1.27); C133(1.22); C570(0.83); C396(0.99)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C408(1.03); C133(0.94); C570(1.10); C396(0.89)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C408(0.87); C570(1.63); C396(1.10)  LDD1567  [5]
 LDCM0332  AC68 HCT 116 C408(1.23)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C408(1.27)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C408(1.03)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C408(1.56)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C408(1.09)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C408(1.21)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C408(2.82)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C408(2.23)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C408(2.25)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C408(1.70)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C408(1.60)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C408(1.08)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C408(1.39)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C408(1.13)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C408(1.34)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C408(0.93)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C408(1.87)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C408(0.93)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C408(0.87)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C408(0.88)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C408(1.01)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C408(0.87)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C408(1.23)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C408(0.93)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C408(0.84)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C408(1.09)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C408(0.90)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C408(0.79)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C408(0.86)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C408(0.89)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C408(0.99)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C408(1.09)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C408(1.28)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C408(0.87)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C408(1.00)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C408(1.06)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C408(1.14)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C408(1.26)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C408(1.07)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C408(1.00)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C408(0.94)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C408(1.01)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C408(0.91)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C408(0.88)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C408(1.04)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C408(1.44)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C408(0.99)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C408(1.46)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C408(0.86)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C408(1.01)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C408(1.19)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C408(1.12)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C408(0.80)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C408(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C408(1.64)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C408(0.97)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C408(1.23)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C408(1.06)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C408(1.11)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C408(1.07)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C408(1.31)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C408(1.09)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C408(0.80)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C408(1.17)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C408(1.69)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C408(1.43)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C408(1.39); C133(1.04); C570(1.06); C396(1.07)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C408(0.96); C570(0.82)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C408(0.95); C133(1.03); C570(0.74); C396(0.98)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C408(1.19); C570(0.75); C396(1.11)  LDD1603  [5]
 LDCM0400  CL13 HCT 116 C408(1.16)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C408(1.10)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C408(1.85)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C408(0.85)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C408(1.13)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C408(0.91)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C408(0.95)  LDD1004  [1]
 LDCM0407  CL2 HCT 116 C408(1.01)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C408(1.01)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C408(1.38)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C408(1.22)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C408(0.93)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C408(0.79)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C408(1.04)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C408(0.98)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C408(0.73)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C408(1.05)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C408(0.83)  LDD1015  [1]
 LDCM0418  CL3 HCT 116 C408(0.89)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C408(1.10)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C408(1.09)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C408(1.05)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C408(1.14)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C408(1.13)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C408(1.00)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C408(1.08)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C408(1.11)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C408(1.03)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C408(2.16)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C408(1.38)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C408(1.03)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C408(1.04)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C408(1.06)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C408(1.12)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C408(1.01)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C408(1.09)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C408(0.97)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C408(1.12)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C408(1.33)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C408(0.87)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C408(1.06)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C408(1.21)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C408(1.14)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C408(0.98)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C408(1.18)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C408(1.04)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C408(1.17)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C408(1.17)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C408(1.04)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C408(1.14)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C408(1.14)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C408(1.26)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C408(0.86)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C408(0.86)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C408(0.80)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C408(0.83)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C408(1.29)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C408(0.93)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C408(0.92)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C408(1.16)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C408(1.09)  LDD1059  [1]
 LDCM0462  CL7 HCT 116 C408(1.14)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C408(1.26)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C408(0.87)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C408(0.85)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C408(1.15)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C408(0.79)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C408(1.15); C570(1.04); C396(1.12)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C408(0.87); C133(0.72); C570(0.91)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C408(0.84); C133(1.16); C570(0.95)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C408(1.01); C133(1.15); C570(1.14); C478(1.21)  LDD1675  [5]
 LDCM0473  CL8 HCT 116 C408(0.94)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C408(1.24); C133(1.07); C570(1.25)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C408(1.16); C133(0.65); C570(1.26); C396(1.05)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C408(1.27); C133(1.05); C570(0.96); C396(1.08)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C408(0.89); C133(0.82); C570(1.31); C396(0.99)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C408(0.70); C570(1.49); C396(1.20)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C408(1.21); C133(1.29); C570(0.78); C396(1.15)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C408(1.03); C570(0.84)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C408(1.05); C133(1.04); C570(0.96); C396(1.01)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C408(1.14); C570(1.47); C396(0.94)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C408(1.09); C133(1.00); C570(1.03)  LDD1686  [5]
 LDCM0484  CL9 HCT 116 C408(1.42)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C408(1.31); C133(0.23); C570(0.83)  LDD1688  [5]
 LDCM0486  CL91 HCT 116 C408(1.15)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C408(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C408(1.21)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C408(1.01)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C408(1.45)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C408(1.03)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C408(0.98)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C408(1.16)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C408(0.91)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C408(1.28); C133(1.13); C570(1.03); C396(0.90)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C408(0.84)  LDD1066  [1]
 LDCM0427  Fragment51 HCT 116 C408(2.50)  LDD0744  [1]
 LDCM0022  KB02 HCT 116 C408(3.11); C396(1.23)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C408(1.11); C396(1.13)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C408(1.35); C396(1.08)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-4 (ACTN4) Alpha-actinin family O43707

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Leucine Small molecular drug DB00149

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402