Details of the Target

General Information of Target

Target ID LDTP00760
Target Name ER membrane protein complex subunit 8 (EMC8)
Gene Name EMC8
Gene ID 10328
Synonyms
C16orf2; C16orf4; COX4AL; COX4NB; FAM158B; NOC4; ER membrane protein complex subunit 8; Neighbor of COX4; Protein FAM158B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPL
FHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFS
DTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSY
ETLVDFDNHLDDIRNDWTNPEINKAVLHLC
Target Bioclass
Transporter and channel
Family
EMC8/EMC9 family
Subcellular location
Endoplasmic reticulum membrane
Function
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
Uniprot ID
O43402
Ensemble ID
ENST00000253457.8
HGNC ID
HGNC:7864

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.P200L DBIA    Probe Info 
MFE296 SNV: p.L75V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C12(1.76)  LDD1700  [2]
DBIA
 Probe Info  		C12(0.91); C153(0.95); C161(0.95)  LDD0531  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C136(0.00); C12(0.00); C24(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C136(0.00); C12(0.00); C24(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0147  [8]
STPyne
 Probe Info  		N.A.  LDD0009  [9]
TFBX
 Probe Info  		C12(0.00); C210(0.00)  LDD0148  [8]
Acrolein
 Probe Info  		C136(0.00); C210(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C12(0.00); C24(0.00); C210(0.00)  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C12(0.97); C210(1.23); C24(0.98)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C12(1.05)  LDD2152  [2]
 LDCM0214  AC1 HCT 116 C12(0.91); C153(0.95); C161(0.95)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C136(0.93); C24(0.89); C12(0.94); C153(1.01)  LDD1508  [13]
 LDCM0216  AC100 HCT 116 C12(1.07); C153(0.88); C161(0.88)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C12(0.90); C153(1.36); C161(1.36)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C12(1.10); C153(1.24); C161(1.24)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C12(1.00); C153(1.14); C161(1.14)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C12(1.26); C153(1.11); C161(1.11)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C12(0.86); C153(1.02); C161(1.02)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C12(0.88); C153(1.06); C161(1.06)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C12(1.04); C153(0.78); C161(0.78)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C12(0.78); C153(0.88); C161(0.88)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C12(1.18); C153(0.98); C161(0.98)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C136(0.96); C24(0.90); C12(0.97); C153(1.05)  LDD1509  [13]
 LDCM0227  AC110 HCT 116 C12(0.87); C153(1.08); C161(1.08)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C12(0.91); C153(0.92); C161(0.92)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C12(0.93); C153(0.90); C161(0.90)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C12(0.95); C153(0.95); C161(0.95)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C12(0.96); C153(0.87); C161(0.91)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C12(1.09); C153(1.06); C161(0.97)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C12(1.24); C153(0.99); C161(1.17)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C12(1.06); C153(0.82); C161(0.86)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C12(1.18); C153(0.95); C161(0.88)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C12(1.29); C153(1.01); C161(0.89)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C136(0.95); C24(0.98); C153(1.06)  LDD1510  [13]
 LDCM0238  AC120 HCT 116 C12(1.23); C153(0.87); C161(0.91)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C12(1.40); C153(0.88); C161(0.80)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C12(0.98); C153(0.91); C161(0.93)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C12(1.54); C153(0.74); C161(0.77)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C12(1.23); C153(0.85); C161(0.97)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C12(1.31); C153(0.89); C161(0.99)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C12(1.36); C153(0.98); C161(0.96)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C12(1.31); C153(0.89); C161(0.89)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C153(0.80); C161(0.80)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C153(0.61); C161(0.61)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C153(0.58); C161(0.58)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C153(0.83); C161(0.83)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C153(0.75); C161(0.75)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C153(0.74); C161(0.74)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C153(0.78); C161(0.78)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C153(0.85); C161(0.85)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C153(0.87); C161(0.87)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C153(0.51); C161(0.51)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C153(0.63); C161(0.63)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C153(0.84); C161(0.84)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C136(0.97); C24(0.97); C153(0.99)  LDD1512  [13]
 LDCM0260  AC140 HCT 116 C153(0.65); C161(0.65)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C153(0.62); C161(0.62)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C153(0.56); C161(0.56)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C136(0.94); C24(0.97); C12(0.96); C153(1.17)  LDD1513  [13]
 LDCM0276  AC17 HCT 116 C153(0.68); C161(0.68); C12(1.10)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C153(0.91); C161(0.91); C12(0.94)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C153(0.76); C161(0.76); C12(0.97)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C12(0.88); C153(1.19); C161(1.19)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C153(0.85); C161(0.85); C12(1.16)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C153(0.76); C161(0.76); C12(0.99)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C153(0.77); C161(0.77); C12(0.91)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C12(0.96); C153(0.97); C161(0.97)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C153(0.75); C161(0.75); C12(1.09)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C12(1.33)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C12(0.85)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C12(0.99)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C12(0.82)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C12(0.99)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C12(0.87); C153(1.04); C161(1.04)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C12(1.02)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C12(0.90)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C12(0.80)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C12(1.29)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C12(1.70)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C12(1.11)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C12(0.93)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C12(1.10)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C12(0.89)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C12(1.04)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C12(1.00); C153(1.01); C161(1.01)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C12(1.10)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C12(0.87)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C12(0.94)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C12(0.77)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C12(1.03)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C12(1.03)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C12(0.72)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C12(0.62)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C12(0.57)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C12(0.56)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C12(0.99); C153(1.21); C161(1.21)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C12(0.64)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C12(0.68)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C12(0.70)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C12(0.74)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C12(0.80)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C12(0.83)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C12(0.69)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C12(0.70)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C12(1.14)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C12(0.70)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C136(0.99); C24(1.05); C153(1.06)  LDD1562  [13]
 LDCM0324  AC60 HCT 116 C12(0.59)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C12(0.81)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C12(0.49)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C12(0.56)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C12(0.56)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C12(0.74)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C12(1.04)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C12(0.65)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C153(0.75); C161(0.75)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C153(0.62); C161(0.62)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C136(0.99); C24(1.07); C12(1.11); C153(1.06)  LDD1568  [13]
 LDCM0335  AC70 HCT 116 C153(0.57); C161(0.57)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C153(0.75); C161(0.75)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C153(0.66); C161(0.66)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C153(0.54); C161(0.54)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C153(0.61); C161(0.61)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C153(0.56); C161(0.56)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C153(0.63); C161(0.63)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C153(0.68); C161(0.68)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C153(0.61); C161(0.61)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C153(0.92); C161(0.92)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C136(1.09); C24(1.03); C153(1.08)  LDD1569  [13]
 LDCM0346  AC80 HCT 116 C153(0.82); C161(0.82)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C153(0.78); C161(0.78)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C153(0.49); C161(0.49)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C12(1.06); C153(1.09); C161(1.09)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C12(1.07); C153(1.17); C161(1.17)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C12(0.92); C153(0.99); C161(0.99)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C12(0.98); C153(1.19); C161(1.19)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C12(1.11); C153(1.11); C161(1.11)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C12(0.88); C153(1.23); C161(1.23)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C12(0.86); C153(1.16); C161(1.16)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C12(0.87); C153(1.25); C161(1.25)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C12(1.02); C153(1.03); C161(1.03)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C12(0.83); C153(1.06); C161(1.06)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C12(0.89); C153(0.97); C161(0.97)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C153(0.95); C161(0.95); C12(1.13)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C12(0.80); C153(1.08); C161(1.08)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C153(0.90); C161(0.90); C12(0.98)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C12(0.75); C153(1.16); C161(1.16)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C12(0.90); C153(1.15); C161(1.15)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C153(1.01); C161(1.01); C12(1.07)  LDD0683  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C12(1.03)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C136(0.96); C24(1.07); C153(1.01)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C136(1.08); C24(0.99); C12(0.99); C153(0.95)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C136(1.07); C24(0.99); C153(1.00)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.34  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C136(0.00); C210(0.00); C12(0.00)  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C136(0.98); C24(0.94); C153(1.05)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C136(0.89); C24(0.81); C153(0.75)  LDD1572  [13]
 LDCM0369  CL100 HCT 116 C12(0.88); C153(1.10); C161(1.10)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C136(0.94); C24(0.94); C153(1.10)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C136(0.82); C24(0.97); C153(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C136(0.80); C24(0.97); C153(1.02)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C136(1.04); C24(1.02); C153(1.02)  LDD1577  [13]
 LDCM0374  CL105 HCT 116 C153(0.83); C161(0.83); C12(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C153(0.80); C161(0.80); C12(0.83)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C12(0.77); C153(0.80); C161(0.80)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C153(0.80); C161(0.80); C12(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C12(0.87); C153(1.00); C161(1.00)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C136(0.98); C24(0.86); C12(0.95); C153(0.95)  LDD1583  [13]
 LDCM0380  CL110 HCT 116 C153(0.77); C161(0.77); C12(0.95)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C153(0.84); C161(0.84); C12(0.88)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C12(0.98)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C12(0.83)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C12(1.36)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C12(1.43)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C12(1.66)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C12(0.94)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C12(0.82)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C12(0.79)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C136(1.05); C24(0.96); C153(1.11)  LDD1594  [13]
 LDCM0391  CL120 HCT 116 C12(0.76)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C12(0.75)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C12(0.90)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C12(0.82)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C12(0.71)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C12(0.52)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C12(0.76)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C12(0.58)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C12(0.79)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C136(0.96); C24(0.91); C153(1.08)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C136(0.97); C24(1.00); C153(1.01)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C136(0.79); C24(0.90); C153(0.98)  LDD1606  [13]
 LDCM0403  CL16 HCT 116 C12(0.92)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C12(0.73)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C12(0.60)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C12(0.69)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C136(0.84); C24(1.07); C153(0.95)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C12(0.89)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C12(0.79)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C12(0.53)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C12(0.68)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C12(0.72)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C12(0.70)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C12(0.74)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C12(0.75)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C12(0.96)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C12(0.71)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C136(0.83); C24(0.95); C153(0.92)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C12(0.74)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C12(1.02)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C12(0.83)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C12(0.69)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C12(0.76)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C12(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C12(0.90)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C12(1.15)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C12(0.93)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C136(1.08); C24(0.99); C153(0.96)  LDD1633  [13]
 LDCM0430  CL40 HCT 116 C12(0.90)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C12(1.01)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C12(0.91)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C12(0.77)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C12(0.82)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C12(0.77)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C12(0.78)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C12(0.81)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C12(0.98)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C12(0.93)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C136(1.02); C24(0.94); C12(0.96); C153(0.99)  LDD1644  [13]
 LDCM0441  CL50 HCT 116 C12(0.92)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C12(0.89)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C12(0.78)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C12(1.39)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C12(0.96)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C12(1.05)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C12(1.02)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C12(1.02)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C12(0.87)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C12(0.99)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C136(0.89); C24(0.82); C12(0.96); C153(0.88)  LDD1654  [13]
 LDCM0452  CL60 HCT 116 C12(0.89)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C12(1.04)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C12(1.10)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C12(1.03)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C12(1.10)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C12(1.27)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C12(1.08)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C12(1.00)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C12(1.03)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C12(1.02)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C136(1.04); C24(0.87); C12(0.82); C153(1.02)  LDD1665  [13]
 LDCM0463  CL70 HCT 116 C12(0.97)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C12(1.25)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C12(1.23)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C12(1.08)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C12(1.08)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C136(1.11); C24(1.04); C153(1.06)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C136(1.04); C24(0.83); C12(1.02); C153(0.86)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C136(0.97); C24(0.99); C12(0.95); C153(1.02)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C136(0.97); C24(0.99); C12(0.85); C153(1.02)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C136(0.74); C24(0.66); C153(0.76)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C136(0.97); C24(1.02); C153(1.04)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C136(0.92); C24(0.94); C153(0.96)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C136(1.04); C24(0.92); C153(1.05)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C136(0.79); C24(0.86); C12(0.82); C153(0.95)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C136(1.01); C24(0.92); C153(1.01)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C136(1.05); C24(1.07); C153(1.56)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C136(0.88); C24(1.09); C153(1.27)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C136(0.77); C24(0.97); C153(1.13)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C136(1.17); C24(1.06); C153(1.08)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C136(0.99); C24(1.04); C12(1.03); C153(1.03)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C136(1.03); C24(0.92); C153(0.84)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C136(0.77); C24(0.77); C12(0.88); C153(0.84)  LDD1688  [13]
 LDCM0486  CL91 HCT 116 C12(1.19); C153(1.08); C161(1.08)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C12(1.19); C153(0.85); C161(0.85)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C12(1.08); C153(1.28); C161(1.28)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C12(0.90); C153(0.99); C161(0.99)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C12(1.06); C153(0.88); C161(0.88)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C12(0.94); C153(0.86); C161(0.86)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C12(0.93); C153(0.99); C161(0.99)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C12(0.86); C153(0.95); C161(0.95)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C12(0.89); C153(1.07); C161(1.07)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C136(0.76); C24(0.90); C153(0.95)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C24(3.74); C210(1.17)  LDD1702  [2]
 LDCM0625  F8 Ramos C24(0.88)  LDD2187  [14]
 LDCM0576  Fragment14 Ramos C24(1.16)  LDD2193  [14]
 LDCM0468  Fragment33 HCT 116 C12(1.23)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C24(0.93)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C12(0.82)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C24(0.59)  LDD2186  [14]
 LDCM0107  IAA HeLa C210(0.00); C12(0.00)  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C136(1.00); C24(1.04); C12(1.00); C153(0.99)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C136(0.99); C24(0.99); C12(0.89); C153(1.07)  LDD1497  [13]
 LDCM0024  KB05 HMCB C210(1.07); C136(1.52); C24(1.31)  LDD3312  [15]
 LDCM0109  NEM HeLa H157(0.00); H158(0.00)  LDD0227  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C12(1.05)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C24(0.57)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C12(0.97)  LDD2097  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C210(1.16)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C12(0.97)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C12(0.49)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C12(0.88)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C12(1.20)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C12(0.94); C210(1.25)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C12(0.22)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C12(0.79); C210(0.78)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C12(0.18)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C12(0.72)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C12(0.91)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C12(1.28)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C12(0.83)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C210(1.32)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C12(1.02); C24(1.40)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C12(0.85); C210(0.92)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C12(1.76)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C12(0.80); C210(0.74)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C210(2.33)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C12(1.01)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C12(0.76)  LDD2148  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C12(0.30)  LDD2149  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ER membrane protein complex subunit 2 (EMC2) EMC2 family Q15006

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840