Details of the Target

General Information of Target

Target ID LDTP00011
Target Name E3 ubiquitin-protein ligase TM129 (TMEM129)
Gene Name TMEM129
Gene ID 92305
Synonyms
E3 ubiquitin-protein ligase TM129; EC 2.3.2.27; RING-type E3 ubiquitin transferase TM129
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSPEVTFTLAYLVFAVCFVFTPNEFHAAGLTVQNLLSGWLGSEDAAFVPFHLRRTAATL
LCHSLLPLGYYVGMCLAASEKRLHALSQAPEAWRLFLLLAVTLPSIACILIYYWSRDRWA
CHPLARTLALYALPQSGWQAVASSVNTEFRRIDKFATGAPGARVIVTDTWVMKVTTYRVH
VAQQQDVHLTVTESRQHELSPDSNLPVQLLTIRVASTNPAVQAFDIWLNSTEYGELCEKL
RAPIRRAAHVVIHQSLGDLFLETFASLVEVNPAYSVPSSQELEACIGCMQTRASVKLVKT
CQEAATGECQQCYCRPMWCLTCMGKWFASRQDPLRPDTWLASRVPCPTCRARFCILDVCT
VR
Target Bioclass
Enzyme
Family
TMEM129 family
Subcellular location
Endoplasmic reticulum membrane
Function
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
Uniprot ID
A0AVI4
Ensemble ID
ENST00000303277.6
HGNC ID
HGNC:25137

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 Substitution: p.V191A .
HCT15 SNV: p.R116S .
KYM1 SNV: p.G73S .
L428 SNV: p.T175P .
MFE319 SNV: p.F353I .
OVK18 SNV: p.P104T .
PFSK1 SNV: p.V361L .
VCAP SNV: p.P336H; p.V344L .
WM1552C SNV: p.S194C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C346(0.96); C349(0.96)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C346(0.96); C349(0.96)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C346(1.14); C349(1.14); C354(0.95); C359(0.95)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C346(0.82); C349(0.82); C354(1.02); C359(1.02)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C346(1.03); C349(1.03); C354(1.06); C359(1.06)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C346(0.95); C349(0.95); C354(1.03); C359(1.03)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C346(0.79); C349(0.79); C354(1.07); C359(1.07)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C346(0.91); C349(0.91); C354(1.02); C359(1.02)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C346(1.07); C349(1.07); C354(1.12); C359(1.12)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C346(0.89); C349(0.97); C354(1.02); C359(1.02)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C346(1.01); C349(0.99); C354(1.04); C359(1.04)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C346(0.90); C349(0.92); C354(0.94); C359(0.94)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C346(0.95); C349(0.95)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C346(1.05); C349(1.08); C354(1.12); C359(1.12)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C346(1.02); C349(1.06); C354(1.21); C359(1.21)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C346(0.88); C349(0.96); C354(1.10); C359(1.10)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C346(1.03); C349(1.03); C354(0.95); C359(0.98)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C346(1.14); C349(1.14); C354(1.00); C359(1.06)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C346(0.95); C349(0.95); C354(1.17); C359(0.97)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C346(1.05); C349(1.05); C354(1.15); C359(1.12)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C346(0.98); C349(0.98); C354(1.09); C359(0.98)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C346(1.02); C349(1.02); C354(1.13); C359(1.09)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C346(0.97); C349(0.97); C354(1.22); C359(1.35)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C346(0.91); C349(0.91)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C346(1.14); C349(1.14); C354(1.17); C359(1.41)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C346(1.00); C349(1.00); C354(1.12); C359(0.99)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C346(1.03); C349(1.03); C354(1.14); C359(1.27)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C346(0.96); C349(0.96); C354(0.92); C359(0.90)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C346(1.01); C349(1.01); C354(1.15); C359(1.20)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C346(1.03); C349(1.03); C354(1.06); C359(1.25)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C346(0.92); C349(0.92); C354(1.17); C359(1.13)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C346(0.97); C349(0.97); C354(1.17); C359(1.15)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C354(1.08); C359(1.08)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C354(1.01); C359(1.01)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C354(0.89); C359(0.89)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C354(0.90); C359(0.90)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C354(0.94); C359(0.94)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C354(1.12); C359(1.12)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C354(0.91); C359(0.91)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C354(0.94); C359(0.94)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C354(1.03); C359(1.03)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C354(1.01); C359(1.01)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C354(1.04); C359(1.04)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C354(0.94); C359(0.94)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C346(0.96); C349(0.96)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C354(0.95); C359(0.95)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C354(0.95); C359(0.95)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C354(0.89); C359(0.89)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C354(1.11); C359(1.11)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C354(0.78); C359(0.78)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C354(0.99); C359(0.99)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C354(0.72); C359(0.72)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C354(0.80); C359(0.80)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C354(0.88); C359(0.88)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C354(1.05); C359(1.05)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C346(1.00); C349(1.00)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C354(1.18); C359(1.18)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C354(0.99); C359(0.99)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C354(1.20); C359(1.20)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C354(0.83); C359(0.83)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C354(0.72); C359(0.72)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C354(0.98); C359(0.98)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C354(0.97); C359(0.97)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C354(1.13); C359(1.13)  LDD2161  [1]
 LDCM0276  AC17 HEK-293T C301(1.24)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C301(1.09)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C301(0.97)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C121(0.98)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C301(0.89)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C301(1.17)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C301(0.90)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C301(0.95)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C301(1.21)  LDD0882  [1]
 LDCM0286  AC26 HEK-293T C121(0.97)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C121(0.98); C237(1.05)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C121(0.97)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C121(0.90)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C121(1.02); C237(0.82)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C121(0.95); C237(1.02)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C121(0.93)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C121(0.85)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C121(0.97)  LDD1534  [2]
 LDCM0296  AC35 HCT 116 C346(1.05); C349(1.05)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C346(1.01); C349(1.01)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C346(1.11); C349(1.11)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C346(1.02); C349(1.02)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C346(1.01); C349(1.01)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C121(0.95)  LDD1540  [2]
 LDCM0302  AC40 HCT 116 C346(0.98); C349(0.98)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C346(0.97); C349(0.97)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C346(0.99); C349(0.99)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C346(0.92); C349(0.92)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C346(1.07); C349(1.07)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C346(1.04); C349(1.04)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C354(0.82); C359(0.82); C346(0.94); C349(0.94)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C354(0.95); C359(0.95); C346(0.97); C349(0.97)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C354(0.74); C359(0.74); C346(0.77); C349(0.77)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C346(0.95); C349(0.95); C354(1.07); C359(1.07)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C121(0.86)  LDD1551  [2]
 LDCM0313  AC50 HCT 116 C346(0.94); C349(0.94); C354(1.08); C359(1.08)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C354(0.97); C359(0.97); C346(0.98); C349(0.98)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C354(0.94); C359(0.94); C346(1.06); C349(1.06)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C346(1.06); C349(1.06); C354(1.17); C359(1.17)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C354(1.00); C359(1.00); C346(1.03); C349(1.03)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C346(0.90); C349(0.90); C354(1.02); C359(1.02)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C346(0.90); C349(0.90); C354(1.13); C359(1.13)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C354(0.77); C359(0.77); C346(0.88); C349(0.88)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C354(0.72); C359(0.72); C346(0.97); C349(0.97)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C346(0.99); C349(0.99); C354(1.18); C359(1.18)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C346(0.94); C349(0.94)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C354(0.85); C359(0.85); C346(0.92); C349(0.92)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C354(0.71); C359(0.71); C346(0.90); C349(0.90)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C346(0.70); C349(0.70); C354(0.77); C359(0.77)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C346(0.91); C349(0.91); C354(1.10); C359(1.10)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C354(0.83); C359(0.83); C346(0.92); C349(0.92)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C354(0.65); C359(0.65); C346(0.86); C349(0.86)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C346(0.69); C349(0.69); C354(0.74); C359(0.74)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C354(0.59); C359(0.59); C346(0.61); C349(0.61)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C354(0.87); C359(0.87); C346(1.08); C349(1.08)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C354(0.82); C359(0.82); C346(0.95); C349(0.95)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C346(0.99); C349(0.99)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C354(0.73); C359(0.73); C346(0.77); C349(0.77)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C354(0.70); C359(0.70); C346(0.92); C349(0.92)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C354(0.88); C359(0.88); C346(0.95); C349(0.95)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C354(0.83); C359(0.83); C346(0.88); C349(0.88)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C354(0.82); C359(0.82); C346(0.88); C349(0.88)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C354(0.91); C359(0.91); C346(0.95); C349(0.95)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C354(0.85); C359(0.85); C346(1.16); C349(1.16)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C354(0.78); C359(0.78); C346(1.09); C349(1.09)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C354(0.68); C359(0.68); C346(0.90); C349(0.90)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C354(0.75); C359(0.75); C346(1.13); C349(1.13)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C346(0.99); C349(0.99)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C354(0.85); C359(0.85); C346(1.07); C349(1.07)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C354(0.72); C359(0.72); C346(1.65); C349(1.65)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C346(0.81); C349(0.81); C354(0.91); C359(0.91)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C346(1.07); C349(1.07)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C346(0.92); C349(0.92)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C346(0.94); C349(0.94)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C346(0.90); C349(0.90)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C346(0.94); C349(0.94)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C346(1.01); C349(1.01)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C346(0.91); C349(0.91)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C346(0.94); C349(0.94)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C346(0.92); C349(0.92)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C346(0.94); C349(0.94)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C346(1.11); C349(1.11)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C346(0.88); C349(0.88)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C346(0.87); C349(0.87)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C346(0.85); C349(0.85)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C346(0.92); C349(0.92)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C346(0.82); C349(0.82); C354(1.07); C359(1.07)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C354(1.00); C359(1.00); C346(1.15); C349(1.15)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C346(1.01); C349(1.01)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C346(0.98); C349(0.98)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C346(1.04); C349(1.04)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C354(1.19); C359(1.19)  LDD2171  [1]
 LDCM0367  CL1 HEK-293T C301(1.43); C349(1.00)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C301(1.48); C349(1.06)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C121(0.89)  LDD1573  [2]
 LDCM0370  CL101 HCT 116 C346(1.22); C349(1.22)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C346(1.07); C349(1.07)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C346(1.03); C349(1.03)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C346(0.96); C349(0.96)  LDD0690  [1]
 LDCM0374  CL105 HEK-293T C301(0.95)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C301(0.97)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C301(1.02)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C301(0.82)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C301(1.16)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C301(1.47); C349(0.89)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C301(1.25)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C301(1.18)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C121(0.94)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C121(1.00)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C121(1.03)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C121(0.93)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C121(0.87)  LDD1590  [2]
 LDCM0387  CL117 HCT 116 C346(1.00); C349(1.00)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C346(1.05); C349(1.05)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C346(1.02); C349(1.02)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C301(1.16); C349(0.87)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C346(1.00); C349(1.00)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C354(2.03); C359(2.03); C346(3.71); C349(3.71)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C354(0.88); C359(0.88); C346(0.89); C349(0.89)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C354(0.96); C359(0.96); C346(1.05); C349(1.05)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C354(0.96); C359(0.96); C346(0.98); C349(0.98)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C346(1.02); C349(1.02); C354(1.04); C359(1.04)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C354(0.84); C359(0.84); C346(1.92); C349(1.92)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C354(1.07); C359(1.07); C346(1.23); C349(1.23)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C354(0.94); C359(0.94); C346(1.00); C349(1.00)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C301(1.09); C349(1.05)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C301(1.26); C349(0.83)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C301(1.60); C349(1.03)  LDD1000  [1]
 LDCM0403  CL16 HCT 116 C346(0.96); C349(0.96)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C346(0.90); C349(0.90)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C346(0.89); C349(0.89)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C346(1.26); C349(1.26)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C301(1.22); C349(1.06)  LDD1005  [1]
 LDCM0408  CL20 HCT 116 C346(0.92); C349(0.92)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C346(0.91); C349(0.91)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C346(0.97); C349(0.97)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C346(0.88); C349(0.88)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C346(0.83); C349(0.83)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C346(0.87); C349(0.87)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C346(0.89); C349(0.89)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C346(0.97); C349(0.97)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C346(0.90); C349(0.90)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C346(1.00); C349(1.00)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C301(1.33); C349(0.95)  LDD1016  [1]
 LDCM0419  CL30 HCT 116 C346(0.90); C349(0.90)  LDD0736  [1]
 LDCM0420  CL31 PaTu 8988t C354(0.93); C359(0.93)  LDD1299  [1]
 LDCM0421  CL32 HCT 116 C346(0.90); C349(0.90)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C346(0.97); C349(0.97)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C346(0.97); C349(0.97)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C346(1.03); C349(1.03)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C346(1.00); C349(1.00)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C346(1.09); C349(1.09)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C346(1.05); C349(1.05)  LDD0745  [1]
 LDCM0429  CL4 HEK-293T C301(1.09); C349(0.96)  LDD1027  [1]
 LDCM0430  CL40 HCT 116 C346(0.95); C349(0.95)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C346(0.89); C349(0.89)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C346(0.92); C349(0.92)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C346(0.93); C349(0.93)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C346(1.06); C349(1.06)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C346(0.95); C349(0.95)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C346(0.99); C349(0.99)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C346(1.09); C349(1.09)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C346(1.09); C349(1.09)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C346(1.08); C349(1.08)  LDD1318  [1]
 LDCM0440  CL5 HEK-293T C301(1.09); C349(1.10)  LDD1038  [1]
 LDCM0441  CL50 PaTu 8988t C346(1.19); C349(1.19)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C346(1.07); C349(1.07)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C346(1.10); C349(1.10)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C346(1.08); C349(1.08)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C346(1.15); C349(1.15)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C346(1.15); C349(1.15)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C346(1.18); C349(1.18)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C346(1.07); C349(1.07)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C346(0.98); C349(0.98)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C346(1.04); C349(1.04)  LDD1329  [1]
 LDCM0451  CL6 HEK-293T C301(1.22); C349(1.05)  LDD1049  [1]
 LDCM0452  CL60 PaTu 8988t C346(1.04); C349(1.04)  LDD1331  [1]
 LDCM0453  CL61 HCT 116 C346(1.59); C349(1.59)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C346(1.20); C349(1.20)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C346(1.29); C349(1.29)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C346(1.39); C349(1.39)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C346(1.48); C349(1.48)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C346(1.36); C349(1.36)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C346(1.27); C349(1.27)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C346(1.40); C349(1.40)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C346(1.26); C349(1.26)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C301(1.24); C349(0.86)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C346(1.30); C349(1.30)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C346(1.47); C349(1.47)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C346(1.24); C349(1.24)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C346(1.29); C349(1.29)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C346(1.41); C349(1.41)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C346(0.80); C349(0.80); C354(0.82); C359(0.82)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C346(0.80); C349(0.80); C354(1.06); C359(1.06)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C346(0.83); C349(0.83); C354(1.15); C359(1.15)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C346(0.93); C349(0.93); C354(1.08); C359(1.08)  LDD0789  [1]
 LDCM0473  CL8 HEK-293T C301(0.81); C349(0.66)  LDD1071  [1]
 LDCM0474  CL80 HCT 116 C346(0.85); C349(0.85); C354(0.86); C359(0.86)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C346(0.86); C349(0.86); C354(1.15); C359(1.15)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C346(0.90); C349(0.90); C354(1.05); C359(1.05)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C346(0.91); C349(0.91); C354(0.89); C359(0.89)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C346(0.90); C349(0.90); C354(1.08); C359(1.08)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C346(0.87); C349(0.87); C354(0.87); C359(0.87)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C346(0.83); C349(0.83); C354(0.89); C359(0.89)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C346(0.86); C349(0.86); C354(1.05); C359(1.05)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C346(0.87); C349(0.87); C354(1.17); C359(1.17)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C346(0.81); C349(0.81); C354(1.09); C359(1.09)  LDD0800  [1]
 LDCM0484  CL9 HEK-293T C301(1.21); C349(0.84)  LDD1082  [1]
 LDCM0485  CL90 HCT 116 C346(0.83); C349(0.83); C354(0.90); C359(0.90)  LDD0802  [1]
 LDCM0486  CL91 HEK-293T C121(1.13); C237(0.66)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C121(1.04)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C121(1.05)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C121(1.02); C237(0.96)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C121(1.10)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C121(1.24)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C121(1.00)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C121(0.86)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C121(1.06)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C121(0.96)  LDD1698  [2]
 LDCM0468  Fragment33 HCT 116 C346(1.51); C349(1.51)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C346(0.96); C349(0.96)  LDD0744  [1]
 LDCM0022  KB02 COR-L88 C237(1.36)  LDD2311  [3]
 LDCM0023  KB03 CC-SW-1 C237(2.86)  LDD2716  [3]
 LDCM0024  KB05 MSTO-211H C237(1.48)  LDD3337  [3]
 LDCM0021  THZ1 HCT 116 C354(1.19); C359(1.19)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840